Skip header and navigation

Refine By

71 records – page 1 of 8.

[3',5'-cAMP phosphodiesterase inhibitors in the combined treatment of patients with rheumatoid arthritis]

https://arctichealth.org/en/permalink/ahliterature14188
Source
Lik Sprava. 1998 Aug;(6):34-7
Publication Type
Article
Date
Aug-1998
Author
O I Bakaliuk
M I Shved
M V Hrebenyk
Source
Lik Sprava. 1998 Aug;(6):34-7
Date
Aug-1998
Language
Ukrainian
Publication Type
Article
Keywords
3',5'-Cyclic-Nucleotide Phosphodiesterase - antagonists & inhibitors
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy - immunology - metabolism
Combined Modality Therapy
Comparative Study
Drug Evaluation
English Abstract
Glucosephosphate Dehydrogenase - blood - drug effects
Humans
Immunity, Cellular - drug effects
Immunity, Natural - drug effects
Lipid Peroxidation - drug effects
Papaverine - therapeutic use
Phosphodiesterase Inhibitors - therapeutic use
Prospidium - therapeutic use
Abstract
A study was made of clinical effectiveness and mechanism of action of the inhibitor of the specific 3',5'-cAMP phosphodiesterase papaverine in a therapeutic complex of measures designed to treat RA patients involving an immunodepressive preparation free from any cytopenic effect prospidin as a basic mediator. It has been shown that the papaverine antiarthritic action is associated with its positive effects on the unspecific component of the immune-complex inflammation, viz. processes of lipid peroxidation, activity of the antioxidant system of defence as well as on the vascular tone and microcirculation. All this improves tissue metabolism, and in this way enhances efficiency of RA basic therapy.
PubMed ID
9844866 View in PubMed
Less detail

Altered lignin structure and resistance to pathogens in spi 2-expressing tobacco plants.

https://arctichealth.org/en/permalink/ahliterature69056
Source
Planta. 2002 Mar;214(5):708-16
Publication Type
Article
Date
Mar-2002
Author
Malin Elfstrand
Folke Sitbon
Catherine Lapierre
Arnaud Bottin
Sara von Arnold
Author Affiliation
Department of Forest Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Source
Planta. 2002 Mar;214(5):708-16
Date
Mar-2002
Language
English
Publication Type
Article
Keywords
DNA, Complementary - genetics
Gene Expression Regulation, Plant
Histocytochemistry
Immunity, Natural
Lignin - chemistry - metabolism
Pectobacterium carotovorum - growth & development - immunology
Peroxidase - metabolism
Peroxidases - genetics - physiology
Phytophthora - growth & development - immunology
Picea - genetics - physiology
Plant Diseases - microbiology
Plant Proteins
Plant Roots - physiology
Plant Stems - physiology
Plants, Genetically Modified
Research Support, Non-U.S. Gov't
Tobacco - genetics - microbiology
Abstract
The physiological role of the Norway spruce [ Picea abies (L.) Karst.] spi 2 gene, encoding a defense-related cationic peroxidase was examined in transgenic tobacco (Nicotiana tabacum L.). Expression of spi 2, under control of the 35S promoter, in tobacco plants resulted in higher total peroxidase activities. The phenotype of the spi 2-transformed lines was normal. The spi 2-transformed lines displayed lignin levels similar to levels in the control line, but with some alteration in lignin histochemistry and structure. These changes were associated with reduced flexibility of the tobacco stems. The defense against pathogenic microorganisms was altered in the transgenic tobacco plants compared with control plants. High peroxidase activities increased the susceptibility to the pathogenic oomycete Phytophthora parasitica var. nicotianae, but increased the ability of the tobacco plants to suppress growth of the pathogenic bacterium Erwinia carotovora.
PubMed ID
11882939 View in PubMed
Less detail

Amniotic fluid antibacterial activity and nutritional parameters in term Mozambican and Swedish pregnant women.

https://arctichealth.org/en/permalink/ahliterature62014
Source
Gynecol Obstet Invest. 1996;42(1):24-7
Publication Type
Article
Date
1996
Author
P. Axemo
E. Rwamushaija
M. Pettersson
L. Eriksson
S. Bergström
Author Affiliation
Department of Obstetrics and Gynaecology, University Hospital, Uppsala, Sweden.
Source
Gynecol Obstet Invest. 1996;42(1):24-7
Date
1996
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Amniotic Fluid - immunology
Anthropometry
Bacterial Infections - immunology
Female
Humans
Immunity, Natural
Inflammation - pathology
Mozambique
Nutritional Status
Parity
Placenta Diseases - pathology
Pregnancy
Sweden
Abstract
Randomly selected parturients with term singleton pregnancies from two different settings, 83 from Mozambique and 90 from Sweden, entered the study. All of them underwent elective cesarean section, which enabled sterile harvesting of amniotic fluid (AF). AF samples were then tested for antibacterial activity (ABA). Background data and nutritional status were compared. Average age was 32.7 and 30.7 years (n.s.), average parity 6.6 and 1.6 (p
PubMed ID
8840173 View in PubMed
Less detail

Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2-positive patients with insulin-dependent diabetes mellitus.

https://arctichealth.org/en/permalink/ahliterature35717
Source
Tissue Antigens. 1994 Aug;44(2):110-9
Publication Type
Article
Date
Aug-1994
Author
C B Sanjeevi
T P Lybrand
M. Landin-Olsson
I. Kockum
G. Dahlquist
W A Hagopian
J P Palmer
A. Lernmark
Author Affiliation
Karolinska Institute, Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden.
Source
Tissue Antigens. 1994 Aug;44(2):110-9
Date
Aug-1994
Language
English
Publication Type
Article
Keywords
Alleles
Animals
Antibodies, Monoclonal - immunology
Base Sequence
Cricetinae
Diabetes Mellitus, Type 1 - genetics - immunology
Disease Susceptibility - immunology
Genes, MHC Class II
Genetic Predisposition to Disease
HLA-DQ Antigens - genetics
HLA-DR Antigens - genetics
HLA-DR2 Antigen - chemistry - genetics
Haplotypes - genetics
Humans
Immunity, Natural - genetics - immunology
Models, Molecular
Molecular Sequence Data
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Protein Conformation
Recombination, Genetic
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Sweden
Abstract
HLA-DR2 is negatively associated with insulin-dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2-positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched controls. HLA-DRB, -DQA and -DQB were determined by Taq I restriction fragment length polymorphism analysis. Amplification by polymerase chain reaction (PCR) and hybridization with sequence-specific oligonucleotide probes was done for DQA1, DQB1 and DRB1 and DRB5. DR2 was positive in 11/425 patients (3%) and 101/367 (28%) controls (OR 0.07, p
PubMed ID
7817375 View in PubMed
Less detail

[An evaluation of the action of new nutritional compounds with a radioprotective use on the body's immune state]

https://arctichealth.org/en/permalink/ahliterature49239
Source
Fiziol Zh. 1998;44(1-2):77-80
Publication Type
Article
Date
1998
Author
I V Kononko
O I Vinars'ka
Author Affiliation
Ukrainian State Medical Centre of Environmental Health, Ministry of Public Health of Ukraine, Kiev.
Source
Fiziol Zh. 1998;44(1-2):77-80
Date
1998
Language
Ukrainian
Publication Type
Article
Keywords
Adjuvants, Immunologic - pharmacology
Animals
B-Lymphocytes - drug effects - immunology
English Abstract
Food, Fortified
Immunity, Cellular - drug effects
Immunity, Natural - drug effects
Radiation-Protective Agents - pharmacology
Rats
T-Lymphocytes - drug effects - immunology
Time Factors
Abstract
Examination of radiosafety effect of the new nutrition compositions were carried out in the experiments. The immunomodifying influence of this products were established. It is shown the possibility of their addition to the ration of population from the polluted territory.
PubMed ID
9619412 View in PubMed
Less detail

Changes in host chitinase isoforms in relation to wounding and colonization by Heterobasidion annosum: early and strong defense response in 33-year-old resistant Norway spruce clone.

https://arctichealth.org/en/permalink/ahliterature83008
Source
Tree Physiol. 2006 Feb;26(2):169-77
Publication Type
Article
Date
Feb-2006
Author
Fossdal Carl Gunnar
Hietala Ari M
Kvaalen Harald
Solheim Halvor
Author Affiliation
Norwegian Forest Research Institute, Høgskoleveien 8, N-1432, As, Norway. carl.fossdal@skogforsk.no
Source
Tree Physiol. 2006 Feb;26(2):169-77
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Basidiomycota - genetics - growth & development
Chitinase - metabolism
DNA, Fungal - analysis
DNA, Plant - analysis
Immunity, Natural
Isoelectric Focusing
Isoenzymes - metabolism
Picea - enzymology - metabolism - microbiology
Plant Bark - enzymology - metabolism - microbiology
Plant Diseases - genetics - microbiology
Plant Proteins - metabolism
Stress, mechanical
Time Factors
Tissue Culture Techniques
Abstract
We studied the defense reactions of 33-year-old susceptible and resistant clones of Norway spruce (Picea abies (L.) Karst.) to the major root-rot fungus Heterobasidion annosum (Fr.) Bref. and determined if tissue cultures can be used as a model system for studying defense responses of mature trees at the molecular level. Quantitative PCR analysis of genomic DNA obtained from samples taken at different times along the lesion length in living bark indicated that the fungus was present in higher amounts and extended further into the host tissue in the susceptible clone than in the resistant clone. In protein extracts from the same lesion samples, there were differences in temporal and spatial changes in host chitinase isoform profiles between the resistant and susceptible clones. Host chitinase isoforms with pI values approximately 4.8, 4.4 and 3.7 increased more during the first 7 days after wounding and inoculation and extended further along the lesion length in the resistant clone than in the susceptible clone. These results suggest that the time from wounding and infection to induction of defense-related expression is shorter in the resistant clone indicating a more efficient host defense response than in the susceptible clone. Tissue cultures from the same clones were not resistant to H. annosum and showed no difference in the timing of the increase in chitinase isoforms in response to the pathogen. However, tissue cultures from both clones showed an increase in chitinase isoforms within 6 to 24 h past inoculation, indicating that increased chitinase expression in response to the pathogen is part of a general defense response common to both mature clones and tissue cultures.
PubMed ID
16356913 View in PubMed
Less detail

[Characteristics of the radio-ecologic situation in the area of Totsk nuclear explosion and the immune status of schoolchildren residing in the vicinity]

https://arctichealth.org/en/permalink/ahliterature33926
Source
Gig Sanit. 1998 Jan-Feb;(1):47-9
Publication Type
Article
Author
V M Boev
E V Popova
A I Smoliagin
E N Tiurin
A G Korneev
N M Livshits
I N Chainikova
Source
Gig Sanit. 1998 Jan-Feb;(1):47-9
Language
Russian
Publication Type
Article
Keywords
Adolescent
Age Factors
Cesium radioisotopes
Child
Comparative Study
English Abstract
Humans
Immunity
Immunity, Natural
Plutonium
Radioactive fallout
Siberia
Soil Pollutants, Radioactive
Time Factors
Water Pollutants, Chemical
Water pollutants, radioactive
Water supply
Abstract
Environmental pollution caused by radioactive and non-radioactive chemicals, and the immunity of schoolchildren who reside in the area exposed to the Totsk nuclear explosion (1954) are comparatively analyzed. The results indicate that the area under study has higher levels of 137Cs than that of a control area. There were immunological changes in children, which are obviously associated with the nuclear explosion.
PubMed ID
9560941 View in PubMed
Less detail

[Chemotherapy of experimental rickettsial infection under the influence of small doses of radiation]

https://arctichealth.org/en/permalink/ahliterature74915
Source
Mikrobiol Z. 2003 Sep-Oct;65(5):36-40
Publication Type
Article
Author
N I Basarab
Author Affiliation
Lviv Research Institute of Epidemiology and Hygiene, Ministry of Public Health of Ukraine, 12 Zelena St., Lviv, 79005, Ukraine.
Source
Mikrobiol Z. 2003 Sep-Oct;65(5):36-40
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Anti-Bacterial Agents - therapeutic use
Disease Models, Animal
Doxycycline - therapeutic use
English Abstract
Guinea Pigs
Immunity, Natural - radiation effects
Immunocompromised Host
Male
Rickettsia Infections - drug therapy - immunology
Abstract
Radiation is of particular importance among a lot of environment factors dangerous for human health, including the effect of small dozes of radiation. State of rickettsial infection under the influence of small dozes of radiation and under administration of immunostimulator Imunal and antibiotic doxycyclin has been studied. Researches were conducted on guinea pigs, using the experimental rickettsial infection. Researches have shown that the use of immunostimulator Imunal and antibiotic doxycyclin had positive effect on the immunity indices of the experimental rickettsial infection in animals in the conditions of influence of small dozes of radiation.
PubMed ID
14723161 View in PubMed
Less detail

[Clinical importance of immunobiological reactivity indices in children who have had staphylococcal pneumonia in the 1st year of life]

https://arctichealth.org/en/permalink/ahliterature41915
Source
Pediatr Akus Ginekol. 1977 Jul-Aug;(4):5-7
Publication Type
Article

71 records – page 1 of 8.