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2945 records – page 1 of 295.

The 5th Nordic Congress on care of the terminally ill held in Reykjavík 5-7 June 1997.

https://arctichealth.org/en/permalink/ahliterature203037
Source
Acta Oncol. 1998;37(7-8):741-2
Publication Type
Conference/Meeting Material
Article
Date
1998
Author
V. Sigurdardóttir
Author Affiliation
The Icelandic Cancer Society, Reykjavík. valgerdur@krabb.is
Source
Acta Oncol. 1998;37(7-8):741-2
Date
1998
Language
English
Publication Type
Conference/Meeting Material
Article
Keywords
Humans
Iceland
Palliative Care
Terminally ill
PubMed ID
10050996 View in PubMed
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5-year incidence of age-related maculopathy in the Reykjavik Eye Study.

https://arctichealth.org/en/permalink/ahliterature51922
Source
Ophthalmology. 2005 Jan;112(1):132-8
Publication Type
Article
Date
Jan-2005
Author
Fridbert Jonasson
Arsaell Arnarsson
Tunde Peto
Hiroshi Sasaki
Kazuyuki Sasaki
Alan C Bird
Author Affiliation
Department of Ophthalmology, University of Iceland, Reykjavik, Iceland. fridbert@landspitali.is
Source
Ophthalmology. 2005 Jan;112(1):132-8
Date
Jan-2005
Language
English
Publication Type
Article
Keywords
Age Distribution
Aged
Aged, 80 and over
Cohort Studies
Female
Humans
Iceland - epidemiology
Incidence
Macular Degeneration - classification - epidemiology
Male
Middle Aged
Population Surveillance
Prospective Studies
Research Support, Non-U.S. Gov't
Sex Distribution
Abstract
PURPOSE: To examine the age- and gender-specific 5-year incidence of age-related maculopathy (ARM) and age-related macular degeneration (AMD) in citizens of Reykjavik. DESIGN: Population-based, prospective cohort study. PARTICIPANTS: The cohort was a population-based random sample of citizens 50 years and older. Of 1379 eligible subjects, 1045 had a baseline examination in 1996; 846 of the 958 survivors (88.2%) had a 5-year follow-up examination in 2001. METHODS: The incidence of various characteristics of drusen and pigmentary changes that are typical of ARM were determined using the international classification and grading system for ARM and AMD. MAIN OUTCOME MEASURES: Early ARM and AMD were assessed by masked grading of stereo fundus photographs. RESULTS: Hypopigmentation developed at 5 years in 10.7% of people 50 to 59 years of age (95% confidence interval [CI], 6.9-14.4) and in 25.7% those 70 to 79 years of age (95% CI, 18.4-33.0) at baseline. Age-related macular degeneration developed in no one who was 50 to 59 years of age at baseline. Geographic atrophy (GA) developed in 4.6% (95% CI, 1.2-7.9) and exudative AMD in none of those who were 70 years and older at baseline. CONCLUSIONS: Geographic atrophy is the predominant type of AMD in Iceland, and the ratio of GA to neovascular AMD is higher than in racially similar populations.
PubMed ID
15629833 View in PubMed
Less detail

6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory Activity.

https://arctichealth.org/en/permalink/ahliterature298348
Source
Mar Drugs. 2018 Nov 08; 16(11):
Publication Type
Journal Article
Date
Nov-08-2018
Author
Xiaxia Di
Caroline Rouger
Ingibjorg Hardardottir
Jona Freysdottir
Tadeusz F Molinski
Deniz Tasdemir
Sesselja Omarsdottir
Author Affiliation
Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland. xid1@hi.is.
Source
Mar Drugs. 2018 Nov 08; 16(11):
Date
Nov-08-2018
Language
English
Publication Type
Journal Article
Keywords
Alkaloids - chemistry - isolation & purification - pharmacology
Animals
Anti-Inflammatory Agents - chemistry - isolation & purification - pharmacology
Aquatic Organisms
CD4-Positive T-Lymphocytes - drug effects - metabolism
Cell Differentiation - drug effects
Cells, Cultured
Coculture Techniques
Dendritic Cells
Geodia
Humans
Iceland
Indoles - chemistry
Inhibitory Concentration 50
Interleukin-10 - metabolism
Interleukin-12 Subunit p40 - metabolism
Peptides, Cyclic - chemistry - isolation & purification - pharmacology
Stereoisomerism
Abstract
An UPLC-qTOF-MS-based dereplication study led to the targeted isolation of seven bromoindole alkaloids from the sub-Arctic sponge Geodia barretti. This includes three new metabolites, namely geobarrettin A?C (1?3) and four known compounds, barettin (4), 8,9-dihydrobarettin (5), 6-bromoconicamin (6), and l-6-bromohypaphorine (7). The chemical structures of compounds 1?7 were elucidated by extensive analysis of the NMR and HRESIMS data. The absolute stereochemistry of geobarrettin A (1) was assigned by ECD analysis and Marfey's method employing the new reagent l-Na-(1-fluoro-2,4-dinitrophenyl)tryptophanamide (l-FDTA). The isolated compounds were screened for anti-inflammatory activity using human dendritic cells (DCs). Both 2 and 3 reduced DC secretion of IL-12p40, but 3 concomitantly increased IL-10 production. Maturing DCs treated with 2 or 3 before co-culturing with allogeneic CD4? T cells decreased T cell secretion of IFN-?, indicating a reduction in Th1 differentiation. Although barettin (4) reduced DC secretion of IL-12p40 and IL-10 (IC50 values 11.8 and 21.0 µM for IL-10 and IL-12p40, respectively), maturing DCs in the presence of 4 did not affect the ability of T cells to secrete IFN-? or IL-17, but reduced their secretion of IL-10. These results indicate that 2 and 3 may be useful for the treatment of inflammation, mainly of the Th1 type.
PubMed ID
30413031 View in PubMed
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A 6-year longitudinal study of caries in teenagers and the effect of "dropouts" on the findings.

https://arctichealth.org/en/permalink/ahliterature139575
Source
Community Dent Health. 2010 Sep;27(3):172-7
Publication Type
Article
Date
Sep-2010
Author
I B Arnadóttir
W P Holbrook
H. Agústsdóttir
S R Saemundsson
Author Affiliation
Faculty of Odontology, University of Iceland Reykjavík, Iceland. iarnad@hi.is
Source
Community Dent Health. 2010 Sep;27(3):172-7
Date
Sep-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Adolescent Behavior
Confounding Factors (Epidemiology)
DMF Index
Dental Caries - epidemiology - radiography
Fisheries
Humans
Iceland - epidemiology
Incidence
Longitudinal Studies
Patient Dropouts - psychology - statistics & numerical data
Prevalence
Questionnaires
Reproducibility of Results
Research Subjects - psychology
Risk-Taking
Rural Population
Urban Population
Young Adult
Abstract
To investigate attrition of subjects in a longitudinal study of caries.
A radiographic study of caries and caries-associated factors was carried out in subjects, initially aged 14 years, and followed-up for six years. Attrition of subjects occurred at the last stage of the study.
A nationwide survey of subjects living in fishing, rural farming, and urban communities in Iceland.
A sub-sample of the nationwide random sample comprising 150 subjects was investigated using bitewing radiographs and a structured questionnaire to determine caries-risk factors. Subjects were re-examined at 16 years and 20 years using the same methods.
Mean caries increment from 14-16 years was 3.0 lesions (1.5 lesions/subject/year) but reduced to 2.6 lesions (0.7 lesions/subject/ year) by 20y. The proportion of subjects found to be caries-free at 14 years, 16 years and 20 years, was 29%, 17% and 10%, respectively. "Dropouts" from this study occurred mostly after 16 years. Analysis of subjects dropping out showed that they were least likely to be from the rural farming community but most likely from the fishing community. Those dropping out attended their dentist less frequently, had a higher consumption of carbonated drinks and a higher prevalence and incidence of caries by 16 years.
Subjects with high-risk behaviours, or residents in a fishing community were more likely to drop out of the study. Recognised advantages of conducting longitudinal studies of caries may, therefore, be lost.
PubMed ID
21046910 View in PubMed
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15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculia.

https://arctichealth.org/en/permalink/ahliterature287813
Source
Transl Psychiatry. 2017 Apr 25;7(4):e1109
Publication Type
Article
Date
Apr-25-2017
Author
M O Ulfarsson
G B Walters
O. Gustafsson
S. Steinberg
A. Silva
O M Doyle
M. Brammer
D F Gudbjartsson
S. Arnarsdottir
G A Jonsdottir
R S Gisladottir
G. Bjornsdottir
H. Helgason
L M Ellingsen
J G Halldorsson
E. Saemundsen
B. Stefansdottir
L. Jonsson
V K Eiriksdottir
G R Eiriksdottir
G H Johannesdottir
U. Unnsteinsdottir
B. Jonsdottir
B B Magnusdottir
P. Sulem
U. Thorsteinsdottir
E. Sigurdsson
D. Brandeis
A. Meyer-Lindenberg
H. Stefansson
K. Stefansson
Source
Transl Psychiatry. 2017 Apr 25;7(4):e1109
Date
Apr-25-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Chromosome Aberrations
Chromosome Deletion
Chromosomes, Human, Pair 15 - genetics
Cognition - physiology
DNA Copy Number Variations - genetics
Developmental Disabilities - genetics
Dyscalculia - genetics
Dyslexia - genetics
Female
Functional Neuroimaging - methods - standards
Heterozygote
Humans
Iceland - epidemiology
Intellectual Disability - genetics
Magnetic Resonance Imaging - methods
Male
Middle Aged
Neuropsychological Tests - standards
Phenotype
Temporal Lobe - anatomy & histology - diagnostic imaging
Young Adult
Abstract
Several copy number variants have been associated with neuropsychiatric disorders and these variants have been shown to also influence cognitive abilities in carriers unaffected by psychiatric disorders. Previously, we associated the 15q11.2(BP1-BP2) deletion with specific learning disabilities and a larger corpus callosum. Here we investigate, in a much larger sample, the effect of the 15q11.2(BP1-BP2) deletion on cognitive, structural and functional correlates of dyslexia and dyscalculia. We report that the deletion confers greatest risk of the combined phenotype of dyslexia and dyscalculia. We also show that the deletion associates with a smaller left fusiform gyrus. Moreover, tailored functional magnetic resonance imaging experiments using phonological lexical decision and multiplication verification tasks demonstrate altered activation in the left fusiform and the left angular gyri in carriers. Thus, by using convergent evidence from neuropsychological testing, and structural and functional neuroimaging, we show that the 15q11.2(BP1-BP2) deletion affects cognitive, structural and functional correlates of both dyslexia and dyscalculia.
Notes
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PubMed ID
28440815 View in PubMed
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20 years follow-up after the first microsurgical lumbar discectomies in Iceland.

https://arctichealth.org/en/permalink/ahliterature165998
Source
Acta Neurochir (Wien). 2007 Jan;149(1):51-8; discussion 57-8
Publication Type
Article
Date
Jan-2007
Author
M. Jensdottir
K. Gudmundsson
B. Hannesson
G. Gudmundsson
Author Affiliation
Department of Neurosurgery, Landspítali University Hospital, Reykjavík, Iceland. margretjens@gmail.com
Source
Acta Neurochir (Wien). 2007 Jan;149(1):51-8; discussion 57-8
Date
Jan-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Diskectomy
Employment
Female
Follow-Up Studies
Humans
Iceland
Intervertebral Disc Displacement - surgery
Lumbar Vertebrae
Male
Microsurgery
Middle Aged
Patient satisfaction
Recurrence
Retrospective Studies
Treatment Outcome
Abstract
Microsurgical discectomies are an established procedure in spinal surgery. This operating technique was first used in the Department of Neurosurgery in Iceland in 1981 and has become standard operative treatment for herniated lumbar discs. There is a great variability in outcome reports regarding recurrence rate and re-operation rate. Few articles are based on follow-up of more than 10 years. This article presents the results of a 20 years follow-up study.
A retrospective study of all patients undergoing microsurgical discectomy for herniated lumbar disc, from June 1, 1981 to December 31, 1984. Outcome, based on recurrence rate, return to work and patient satisfaction was determined by a self-evaluation questionnaire, phone interviews and patient medical records.
Of the 170 patients, 134 (78.8%) were included in the study (M:F, 58:42%). Preoperative symptoms: back pain with sciatica 108 (80.6%), sciatica 20 (14.9%), back pain 2 (1.5%). Mean follow-up time was 20.7 years (19.5-22.8). Recurrence rate was 12.7%. 19 patients (14.2%) underwent a subsequent lumbar operation at a different level or side. A majority of patients 108 (80.6%) returned to previous level of work, 26 (19.4%) lost some or all working capabilities. Patient satisfaction was high, 91.1% reporting excellent (68.7%) or good (22.4%) results. 5.2% of patients rated the outcome fair and 3.7% poor. Women reported worse outcome than men, excellent M:F 74.7:60.7%, and poor 7.1:1.3%. There was no significant difference in patient satisfaction in patients undergoing additional operations or those with recurrence of the herniated disc.
Outcome was very good with 92.0% return to work and 91.1% patient satisfaction. The recurrence rate was 12.7% with a substantial number of cases occurring 10-20 years after operation. To conclude, microsurgical discectomies maintain a high success rate in the long-term.
PubMed ID
17180308 View in PubMed
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The -629C>A polymorphism in the CETP gene does not explain the association of TaqIB polymorphism with risk and age of myocardial infarction in Icelandic men.

https://arctichealth.org/en/permalink/ahliterature53840
Source
Atherosclerosis. 2001 Nov;159(1):187-92
Publication Type
Article
Date
Nov-2001
Author
G. Eiriksdottir
M K Bolla
B. Thorsson
G. Sigurdsson
S E Humphries
V. Gudnason
Author Affiliation
Molecular Genetics Laboratory, Hjartavernd, Icelandic Heart Association, Lagmuli 9, 108, Reykjavik, Iceland. gudny@hjarta.is
Source
Atherosclerosis. 2001 Nov;159(1):187-92
Date
Nov-2001
Language
English
Publication Type
Article
Keywords
Aged
Carrier Proteins - genetics
Gene Frequency
Genotype
Glycoproteins
Homozygote
Humans
Iceland
Linkage Disequilibrium
Lipids - blood
Lipoproteins, HDL Cholesterol - blood
Male
Myocardial Infarction - blood - genetics
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions (Genetics) - genetics
Prospective Studies
Research Support, Non-U.S. Gov't
Risk factors
Abstract
The aim of this study was to examine whether the well-established effect of the common TaqIB polymorphism in intron 1 of the gene for cholesterol ester transfer protein (CETP) on high density lipoprotein cholesterol (HDL-C) concentration and increased risk of myocardial infarction (MI), could be explained by the recently identified -629C>A functional polymorphism in the promoter. Non-fatal MI cases (388 male) and a control group of 794 healthy men were recruited from the 30 year long prospective Reykjavik Study. In the healthy men the frequency of the TaqIB B2 allele was 0.47 (95% CI: 0.44-0.50) and there was a strong allelic association with the -629A allele (D=-0.21, P
PubMed ID
11689220 View in PubMed
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ABH secretion polymorphism in Icelanders, Aland Islanders, Finns, Finnish Lapps, Komi and Greenland Eskimos: a review and new data.

https://arctichealth.org/en/permalink/ahliterature237022
Source
Ann Hum Biol. 1986 May-Jun;13(3):273-85
Publication Type
Article
Author
A W Eriksson
K. Partanen
R R Frants
J C Pronk
P J Kostense
Source
Ann Hum Biol. 1986 May-Jun;13(3):273-85
Language
English
Publication Type
Article
Keywords
ABO Blood-Group System - genetics
Adult
Aged
Alleles
Asian Continental Ancestry Group
European Continental Ancestry Group
Finland
Greenland
Humans
Iceland
Inuits
Male
Polymorphism, Genetic
Saliva - immunology
Sweden - ethnology
Abstract
The secretion of the ABH antigens in saliva was tested in indigenous individuals of several populations: Icelanders in Reykjavik and Husavik (northeastern Iceland), Aland Islanders, Finno-Ugrians (Finns, Finnish Lapps, Komi) and Eskimos (Augpilagtok, northwestern Greenland). The frequencies of ABH non-secretors among the Icelanders (28-36%) were among the highest ever noted in Europeans. Among Alanders and Swedes on the Finnish mainland the frequency (around 20%) was comparable to Swedish values but considerably higher than among Finns (13-14%). The values among northeastern Finns and Komi (about 9%) were intermediate between values among Lapps (below 5%) and Scandinavians (15-26%), excluding Icelanders (28-41%). The average frequency of non-secretors among Lapps in Finland (2.2 +/- 0.5%) was the lowest observed among white populations. Like many other arctic populations of the Mongolian race, the Greenland Eskimos had a very low frequency of non-secretors. It is probable that the non-secretor allele ABH*se was absent from the ancient Lapps and Greenland Eskimos but introduced by invading populations. It is concluded that the ABH*se allele frequencies vary much more among northern European populations than hitherto appreciated. Recent studies indicate that the non-secretor status of the ABH blood group substances in mucous body fluids is associated with pathological conditions of the mucous membranes of the embryologically related digestive and respiratory systems, particularly with duodenal ulcer and gastric (pre)malignancies but probably also with pulmonary dysfunction. In view of these disadvantages of the ABH non-secretor status the high frequency of ABH*se in Icelanders is a paradoxical phenomenon. The frequency of ABH non-secretors among the founders (Vikings) of Iceland may have been considerably higher than among the present populations in northwestern Europe. The increase in northwestern direction of the ABH*se allele frequencies supports this hypothesis; the dilution effect has not been as strong in Iceland as on the European continent.
PubMed ID
3752918 View in PubMed
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Abnormally invasive placenta-prevalence, risk factors and antenatal suspicion: results from a large population-based pregnancy cohort study in the Nordic countries.

https://arctichealth.org/en/permalink/ahliterature294473
Source
BJOG. 2016 Jul; 123(8):1348-55
Publication Type
Journal Article
Video-Audio Media
Date
Jul-2016
Author
L Thurn
P G Lindqvist
M Jakobsson
L B Colmorn
K Klungsoyr
R I Bjarnadóttir
A M Tapper
P E Børdahl
K Gottvall
K B Petersen
L Krebs
M Gissler
J Langhoff-Roos
K Källen
Author Affiliation
Department of Obstetrics and Gynaecology, Blekinge Hospital, Karlskrona, Sweden.
Source
BJOG. 2016 Jul; 123(8):1348-55
Date
Jul-2016
Language
English
Publication Type
Journal Article
Video-Audio Media
Keywords
Adult
Cesarean Section - statistics & numerical data
Cohort Studies
Denmark - epidemiology
Female
Finland - epidemiology
Humans
Hysterectomy - statistics & numerical data
Iceland - epidemiology
Incidence
Norway - epidemiology
Peripartum Period
Placenta Accreta - diagnostic imaging - epidemiology
Postpartum Hemorrhage - epidemiology
Pregnancy
Prevalence
Risk factors
Sweden - epidemiology
Ultrasonography
Ultrasonography, Prenatal
Uterine Rupture - epidemiology
Young Adult
Abstract
The objective was to investigate prevalence, estimate risk factors, and antenatal suspicion of abnormally invasive placenta (AIP) associated with laparotomy in women in the Nordic countries.
Population-based cohort study.
A 3-year Nordic collaboration among obstetricians to identify and report on uterine rupture, peripartum hysterectomy, excessive blood loss, and AIP from 2009 to 2012 The Nordic Obstetric Surveillance Study (NOSS).
In the NOSS study, clinicians reported AIP cases from maternity wards and the data were validated against National health registries.
Prevalence, risk factors, antenatal suspicion, birth complications, and risk estimations using aggregated national data.
A total of 205 cases of AIP in association with laparotomy were identified, representing 3.4 per 10 000 deliveries. The single most important risk factor, which was reported in 49% of all cases of AIP, was placenta praevia. The risk of AIP increased seven-fold after one prior caesarean section (CS) to 56-fold after three or more CS. Prior postpartum haemorrhage was associated with six-fold increased risk of AIP (95% confidence interval 3.7-10.9). Approximately 70% of all cases were not diagnosed antepartum. Of these, 39% had prior CS and 33% had placenta praevia.
Our findings indicate that a lower CS rate in the population may be the most effective way to lower the incidence of AIP. Focused ultrasound assessment of women at high risk will likely strengthen antenatal suspicion. Prior PPH is a novel risk factor associated with an increased prevalence of AIP.
An ultrasound assessment in women with placenta praevia or prior CS may double the awareness for AIP.
Notes
CommentIn: BJOG. 2016 May;123(6):1032 PMID 27101265
CommentIn: BJOG. 2016 May;123(6):1031-2 PMID 27101264
CommentIn: BJOG. 2017 Jan;124(1):164-165 PMID 28009121
PubMed ID
26227006 View in PubMed
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Abortion, sterilization, and sex education.

https://arctichealth.org/en/permalink/ahliterature250232
Source
Int Dig Health Legis. 1977;28(3): 614-620 1977):Unknown
Publication Type
Article
Date
1977

2945 records – page 1 of 295.