Skip header and navigation

Refine By

138 records – page 1 of 14.

[Acid-base state of the blood in neonates that have experienced intrauterine hypoxia after the use of halidor and rhythmic abdominal decompression]

https://arctichealth.org/en/permalink/ahliterature66209
Source
Fiziol Zh. 1976 MAR-APR;22(3):413-4
Publication Type
Article

[Activity of enzymes of tricarboxylic and pentose-phosphate cycles in dog brain with myocardial infarction]

https://arctichealth.org/en/permalink/ahliterature56070
Source
Ukr Biokhim Zh. 1977 May-Jun;49(3):51-4
Publication Type
Article
Author
M M Zanozdra
Iu V Khmelevs'kii
Source
Ukr Biokhim Zh. 1977 May-Jun;49(3):51-4
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Brain - enzymology
Cerebellum - enzymology
Cerebral Cortex - enzymology
Citric Acid Cycle
Coronary Vessels
Dogs
English Abstract
Glucosephosphate Dehydrogenase - metabolism
Hypoxia, Brain - enzymology
Ketoglutarate Dehydrogenase Complex - metabolism
Medulla Oblongata - enzymology
Mitochondria - enzymology
Myocardial Infarction - enzymology
Pentosephosphates - metabolism
Succinate Dehydrogenase - metabolism
Transaldolase - metabolism
Abstract
Under conditions of experimental myocardium infarction caused in dogs by ligation of the anterior descending branch of the left coronary artery, the activity of alpha-ketoglutarate dehydrogenase and succinate dehydrogenase in mitochondria of the cortex, cerebellum and medulla ablongata lowers most intensively on the first and fifth day after the appearance of acute myocardium infarction. Activation of the most important enzymes of the pentose-phosphate cycle (glucose-6-phosphate dehydrogenase and transketolase) which is clearly pronounced on the fifth day is observed in the mentioned sections. In the authors' opinions the above changes in the activity of the enzymes are due to the brain hypoxia which may be the main reason of disturbance in the function of the central nervous system under this disease.
PubMed ID
888227 View in PubMed
Less detail

Advances in high-altitude medicine and hypoxic physiology in China.

https://arctichealth.org/en/permalink/ahliterature295218
Source
A sponsored supplement to Science. 69 p.
Publication Type
Journal
Date
2012
: The Qinghai-Tibet Railroad 7.... Human Performance Engineering at High Altitude 9.... Intrinsic Characteristics in Tibetans of Tolerance to Hypoxia Following Long Periods at Sea Level 10.... Exploration and Evidence of High-Altitude Adaptation in Tibetan Highlanders 12.... Peopling of the
  1 document  
Source
A sponsored supplement to Science. 69 p.
Date
2012
Language
English
Publication Type
Journal
File Size
36208366
Keywords
China
Hypoxia
Hypoxic physiology
High-altitude medicine
Documents

BIBMS_booklet_hires.pdf

Read PDF Online Download PDF
Less detail

Altered cytokine profiles in patients with Chuvash polycythemia.

https://arctichealth.org/en/permalink/ahliterature153848
Source
Am J Hematol. 2009 Feb;84(2):74-8
Publication Type
Article
Date
Feb-2009
Author
Xiaomei Niu
Galina Y Miasnikova
Adelina I Sergueeva
Lydia A Polyakova
Daniel J Okhotin
Nikolai V Tuktanov
Mehdi Nouraie
Tatiana Ammosova
Sergei Nekhai
Victor R Gordeuk
Author Affiliation
Center for Sickle Cell Disease and Department of Medicine, Howard University, Washington, District of Columbia 20060, USA.
Source
Am J Hematol. 2009 Feb;84(2):74-8
Date
Feb-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Basic Helix-Loop-Helix Transcription Factors - physiology
CD4-CD8 Ratio
Cell Hypoxia - genetics
Child
Cytokines - biosynthesis - blood - genetics
Erythropoietin - biosynthesis - blood - genetics
Ethnic Groups - genetics
Exons - genetics
Female
Genotype
Humans
Hypoxia-Inducible Factor 1, alpha Subunit - physiology
Interleukins - biosynthesis - blood - genetics
Male
Middle Aged
Point Mutation
Polycythemia - blood - ethnology - genetics
Russia - epidemiology
Tumor Necrosis Factor-alpha - analysis - biosynthesis - genetics
Vascular Endothelial Growth Factor A - biosynthesis - blood - genetics
Von Hippel-Lindau Tumor Suppressor Protein - genetics - physiology
Young Adult
Abstract
Chuvash polycythemia results from a homozygous 598C>T mutation in exon 3 of the von Hippel-Lindau (VHL) gene. This disrupts the normoxia pathway for degrading hypoxia inducible factor (HIF)-1alpha and HIF-2alpha causing altered expression of HIF-1 and HIF-2 inducible genes. As hypoxia induces expression of pro-inflammatory cytokines, we hypothesized that there might be an elevation of Th1 cytokines in the setting of Chuvash polycythemia. We analyzed plasma concentrations of Th1 (interleukins-2 and 12, interferon-gamma, granulocyte-monocyte colony-stimulating factor, tumor necrosis factor-alpha) and Th2 cytokines (interleukins-4, 5, 10, and 13) using the Bio-Plex multiplex suspension array system in 34 VHL598C>T homozygotes and 32 VHL wild-type participants from Chuvashia. Concentrations of all the Th1 and Th2 cytokines measured were elevated in the VHL598C>T homozygotes compared with the control wild-type participants, but the ratios of Th1 to Th2 cytokines did not differ by genotype. In parallel, peripheral blood concentrations of CD4 positive T-helper cells and CD4/CD8 ratio were lower in the VHL598C>T homozygotes. In conclusion, the up-regulated hypoxic response in Chuvash polycythemia is associated with increased plasma products of both the Th1 and Th2 pathways, but the balance between the two pathways seems to be preserved.
Notes
Cites: Med Sci Sports Exerc. 2005 May;37(5):768-7415870630
Cites: Genes Dev. 2000 Aug 15;14(16):1983-9110950862
Cites: BMC Pulm Med. 2005;5:815978129
Cites: Exp Physiol. 2005 Nov;90(6):791-716157658
Cites: Cancer Res. 2006 Mar 1;66(5):2600-716510578
Cites: Haematologica. 2006 Jun;91(6):744-916769575
Cites: Hepatobiliary Pancreat Dis Int. 2006 Aug;5(3):416-2116911942
Cites: J Immunol. 2006 Oct 15;177(8):4962-517015677
Cites: Int J STD AIDS. 2000 Jan;11(1):49-5110667901
Cites: J Clin Invest. 1996 Feb 1;97(3):649-558609219
Cites: J Exp Med. 2000 Dec 4;192(11):F31-411104811
Cites: Curr Opin Hematol. 2001 Jan;8(1):47-5111138626
Cites: Am J Respir Crit Care Med. 2001 Jan;163(1):115-2111208635
Cites: Blood Cells Mol Dis. 2002 Jan-Feb;28(1):57-6211987242
Cites: Eur J Immunol. 2002 Oct;32(10):2866-7312355439
Cites: J Biol Chem. 2002 Oct 18;277(42):39792-80012181324
Cites: Curr Pharm Des. 2003;9(7):511-912570799
Cites: Genes Dev. 2003 Nov 1;17(21):2614-2314597660
Cites: J Cell Physiol. 1997 Dec;173(3):335-429369946
Cites: Am J Respir Cell Mol Biol. 1999 Apr;20(4):561-7210100987
Cites: J Immunol. 1999 Jul 1;163(1):491-910384153
Cites: Proc Natl Acad Sci U S A. 2004 Nov 30;101(48):16768-7315556999
Cites: Blood. 2005 Jan 15;105(2):659-6915374877
Cites: J Cell Physiol. 2007 May;211(2):439-4717167775
Cites: J Appl Physiol (1985). 2007 Jul;103(1):305-1417463301
Cites: Brain Res. 2007 Sep 26;1171:111-2117761153
Cites: J Clin Invest. 2007 Dec;117(12):3879-8917992257
Cites: Blood. 2008 May 15;111(10):5205-1418270324
Cites: Blood. 2004 May 15;103(10):3924-3214726398
Cites: Mol Cell Biol. 2004 Oct;24(20):9038-4715456877
Cites: Clin Microbiol Rev. 2004 Oct;17(4):1012-30, table of contents15489359
Cites: J Immunol. 1986 Apr 1;136(7):2348-572419430
Cites: J Pathol. 2005 Jul;206(3):291-30415906272
PubMed ID
19062180 View in PubMed
Less detail

Analysis of 127 peripartum hypoxic brain injuries from closed claims registered by the Danish Patient Insurance Association.

https://arctichealth.org/en/permalink/ahliterature87733
Source
Acta Obstet Gynecol Scand. 2008;87(1):72-5
Publication Type
Article
Date
2008
Author
Hove Lars Dahlgaard
Bock Johannes
Christoffersen Jens Krogh
Hedegaard Morten
Author Affiliation
Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. ldhove@hotmail.com
Source
Acta Obstet Gynecol Scand. 2008;87(1):72-5
Date
2008
Language
English
Publication Type
Article
Keywords
Brain Injury, Chronic - etiology
Cardiotocography - methods - standards
Delivery, Obstetric - methods - standards
Denmark
Female
Humans
Hypoxia, Brain - etiology
Infant, Newborn
Insurance, Health
Retrospective Studies
Abstract
BACKGROUND: One of the most feared complications in medicine is hypoxic brain damage to a newborn. The authors investigated the circumstances of registered peripartum hypoxic brain injuries in order to identify potential opportunities to improve patient safety and prevent injuries. METHODS: The authors retrospectively investigated peripartum hypoxic brain injuries registered by the Danish Patient Insurance Association. RESULTS: From 1992 to 2004, 127 approved claims concerning peripartum hypoxic brain injuries were registered and subsequently analysed. Thirty-eight newborns died, and a majority of the 89 surviving children suffered from major handicaps, primarily cerebral palsy. In 69 of the cases, misinterpretation of or late action on an abnormal cardiotocography (CTG) were the reasons for the majority of the hypoxic brain injuries. CONCLUSIONS: All injuries could potentially have been avoided using established obstetric practice. CTGs are often misinterpreted. In the authors' opinion, education and training in CTG interpretation is essential. The use of ST-analysis of the fetus ECG (STAN) could probably reduce the number of these injuries.
PubMed ID
18158631 View in PubMed
Less detail

Analysis of malpractice claims with a focus on oxytocin use in labour.

https://arctichealth.org/en/permalink/ahliterature78439
Source
Acta Obstet Gynecol Scand. 2007;86(3):315-9
Publication Type
Article
Date
2007
Author
Jonsson Maria
Nordén Solveig Lindeberg
Hanson Ulf
Author Affiliation
Department of Women's and Children's Health, Uppsala University Hospital, Uppsala, Sweden. maria.jonsson@akademiska.se
Source
Acta Obstet Gynecol Scand. 2007;86(3):315-9
Date
2007
Language
English
Publication Type
Article
Keywords
Cerebral Palsy - epidemiology
Delivery, Obstetric
Female
Fetal Death - epidemiology
Fetal Distress - epidemiology
Fetal Monitoring
Humans
Hypoxia, Brain - epidemiology
Labor, Obstetric
Malpractice - statistics & numerical data
Midwifery - statistics & numerical data
Oxytocics - adverse effects
Oxytocin - adverse effects
Physicians - statistics & numerical data
Pregnancy
Pregnancy, High-Risk
Sweden - epidemiology
Abstract
BACKGROUND: The objective of this study was to analyse the motives behind disciplinary action in obstetric malpractice cases concerning delivery, and to evaluate the frequency of inappropriate oxytocin use in these cases. METHODS: An analysis of all malpractice claims resulting in disciplinary action against physicians and midwives during the period 1996-2003. Investigations and decisions made by the Board of Medical Responsibility were reviewed with special focus on the use of oxytocin. RESULTS: Of 77 cases, 60 regarded patients in labour. In the majority, there had been a normal pregnancy and spontaneous start of labour (78%). At the beginning of labour, 87% showed a normal fetal heart rate (FHR) pattern, indicating fetal well-being. In 70%, there was adverse fetal outcome with brain damage or death. The most common reason for disciplinary action was improper interpretation of fetal monitor tracings and corresponding failure to recognise fetal distress (76%). Injudicious use of oxytocin was common (68.5%), and was the primary reason for disciplinary action in 33% of the cases. CONCLUSION: In a Swedish setting, a few common clinical problems pervade; interpretation of FHR patterns and the use of oxytocin account for the majority of rulings of negligence in malpractice cases regarding delivery. Analysis of the cases suggests that the adverse fetal outcomes could possibly have been prevented.
PubMed ID
17364306 View in PubMed
Less detail

Ante- and intrapartum risk factors for neonatal hypoxic ischemic encephalopathy.

https://arctichealth.org/en/permalink/ahliterature295085
Source
J Matern Fetal Neonatal Med. 2018 Jun; 31(12):1595-1601
Publication Type
Journal Article
Date
Jun-2018
Author
Cecilia Lundgren
Lars Brudin
Anna-Stina Wanby
Marie Blomberg
Author Affiliation
a Department of Obstetrics and Gynecology , Kalmar County Hospital , Kalmar , Sweden.
Source
J Matern Fetal Neonatal Med. 2018 Jun; 31(12):1595-1601
Date
Jun-2018
Language
English
Publication Type
Journal Article
Keywords
Adult
Female
Humans
Hypoxia-Ischemia, Brain - epidemiology
Incidence
Infant, Newborn
Pregnancy
Retrospective Studies
Risk factors
Sweden - epidemiology
Abstract
To identify obstetrical risk factors for the diagnosis of neonatal hypoxic ischemic encephalopathy (HIE). A secondary aim was to determine the incidence of HIE.
A retrospective cohort study including 36,086 women with singleton term pregnancies giving live births in Sweden between 2009 and 2013. Cases of HIE were identified from three different sources. Risk factors for HIE were evaluated using univariate and multivariate analyses. Cases of HIE were extracted from available Swedish Medical Health registers to determine incidence.
A diagnosis of HIE was associated with: acute obstetrical events, mode of delivery other than unassisted vaginal birth, abnormal CTG admission test, and nulliparity. The incidence of HIE was 1.7/1000 infants born.
Acute obstetrical events will always occur, and some of the risk factors for these events are not responsive to interventions, but a careful risk assessment could lower the risk associated with acute obstetrical events. By alertness to early symptoms and timely measures taken by a trained staff at the delivery unit, damage could be reduced.
PubMed ID
28486858 View in PubMed
Less detail

Antepartum risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy: a Swedish national cohort study.

https://arctichealth.org/en/permalink/ahliterature295711
Source
Acta Obstet Gynecol Scand. 2018 May; 97(5):615-623
Publication Type
Journal Article
Date
May-2018
Author
Lena Liljestrom
Anna-Karin Wikstrom
Johan Agren
Maria Jonsson
Author Affiliation
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Source
Acta Obstet Gynecol Scand. 2018 May; 97(5):615-623
Date
May-2018
Language
English
Publication Type
Journal Article
Keywords
Adult
Body Height
Body mass index
Female
Humans
Hypoxia-Ischemia, Brain - diagnosis - epidemiology - etiology
Infant, Newborn
Logistic Models
Male
Overweight - complications
Pregnancy
Prenatal Exposure Delayed Effects - diagnosis - epidemiology - etiology
Registries
Risk factors
Severity of Illness Index
Sweden - epidemiology
Abstract
Our aim was to identify antepartum risk factors for neonatal hypoxic ischemic encephalopathy, with a focus on maternal body mass index and height.
National population-based cohort study of 692 428 live-born infants =36 gestational weeks in Sweden, 2009-2015. Data from the Swedish Medical Birth Register and the Swedish Neonatal Quality Register were linked. Short maternal stature was defined as =155 cm, and overweight as body mass index =25 kg/m2 . Therapeutic hypothermia served as surrogate marker of moderate to severe hypoxic ischemic encephalopathy. Associations between maternal and infant characteristics and hypoxic ischemic encephalopathy were calculated with logistic regression analyses, and risks were presented as odds ratios with 95% confidence intervals.
Moderate to severe hypoxic ischemic encephalopathy occurred in 0.67/1000 infants. Nulliparity, previous cesarean delivery, short stature, overweight, gestational age, occiput posterior presentation and birthweight were all independently associated with hypoxic ischemic encephalopathy. The risk of hypoxic ischemic encephalopathy increased with decreasing maternal height and increasing body mass index. Compared with non-short women (=156 cm) with normal weight (body mass index
PubMed ID
29450878 View in PubMed
Less detail

Application and validation of the barrow neurological institute screen for higher cerebral functions in a control population and in patient groups commonly seen in neurorehabilitation.

https://arctichealth.org/en/permalink/ahliterature161683
Source
J Rehabil Med. 2007 Sep;39(7):547-53
Publication Type
Article
Date
Sep-2007
Author
Caisa Hofgren
Eva Esbjörnsson
Hans Aniansson
Katharina Stibrant Sunnerhagen
Author Affiliation
Institute of Neuroscience and Physiology-Rehabilitation Medicine, Guldhedsgatan 19, Goteborg, Sweden. caisa.hofgren@rehab.gu.se
Source
J Rehabil Med. 2007 Sep;39(7):547-53
Date
Sep-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Brain - physiology
Brain Injuries - physiopathology - psychology - rehabilitation
Case-Control Studies
Cognition Disorders - etiology - physiopathology - rehabilitation
Female
Humans
Hypoxia, Brain - physiopathology - psychology - rehabilitation
Male
Mental Status Schedule
Middle Aged
Neuropsychological Tests
Parkinson Disease - physiopathology - psychology - rehabilitation
Sensitivity and specificity
Stroke - physiopathology - psychology - rehabilitation
Abstract
To determine whether the Barrow Neurological Institute Screen for Higher Cerebral Functions (BNIS) can differentiate brain-dysfunctional patients from controls.
A case-control study.
A total of 92 controls and 120 patients from a neuro-rehabilitation clinic with a diagnosis of: right and left hemisphere stroke, traumatic brain injury, Parkinson's disease or anoxic brain damage.
The BNIS has a maximum total score of 50 points,
PubMed ID
17724554 View in PubMed
Less detail

138 records – page 1 of 14.