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429 records – page 1 of 43.

5-HT(1A) receptor antagonist p-MPPI attenuates acute ethanol effects in mice and rats.

https://arctichealth.org/en/permalink/ahliterature9998
Source
Neurosci Lett. 2002 Mar 29;322(1):1-4
Publication Type
Article
Date
Mar-29-2002
Author
Nina K Popova
Elena A Ivanova
Author Affiliation
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentyeva 10, 630090 Novosibirsk, Russia. npopova@bionet.nsc.ru
Source
Neurosci Lett. 2002 Mar 29;322(1):1-4
Date
Mar-29-2002
Language
English
Publication Type
Article
Keywords
Acute Disease
Alcohol-Induced Disorders, Nervous System - drug therapy - metabolism - physiopathology
Aminopyridines - pharmacology
Animals
Brain - drug effects - metabolism - physiopathology
Dose-Response Relationship, Drug
Drug Interactions - physiology
Drug Tolerance - physiology
Ethanol - pharmacology
Hypothermia - chemically induced - drug therapy - physiopathology
Male
Mice
Mice, Inbred C3H
Neurons - drug effects - metabolism
Piperazines - pharmacology
Rats
Rats, Wistar
Receptors, Serotonin - drug effects - metabolism
Receptors, Serotonin, 5-HT1
Research Support, Non-U.S. Gov't
Serotonin - metabolism
Serotonin Antagonists - pharmacology
Sleep - drug effects - physiology
Startle Reaction - drug effects - physiology
Abstract
The effect of a selective 5-HT(1A) antagonist, 4-(2'-methoxy-)phenyl-1-[2'-(N-2"-pyridinyl)-p-iodobenzamino-]ethyl-piperazine (p-MPPI), on acute ethanol-induced hypothermia, sleep and suppression of acoustic startle reflex in C3H/He mice and Wistar rats was studied. Administration of p-MPPI at the doses of 0.4, 0.7 and 1.0 mg/kg reduced in a dose-dependent manner the ethanol-induced hypothermia and the sleep time and attenuated the ethanol-induced decrease of acoustic startle reflex magnitude in mice. Similar p-MPPI (0.4 mg/kg) effects on ethanol-induced sleep and hypothermia were obtained in rats. It was concluded that 5-HT(1A) receptors were involved in the mechanisms of the ethanol-induced hypothermia and sleep, and that 5-HT(1A) antagonist increased acute ethanol tolerance.
PubMed ID
11958829 View in PubMed
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Accidental cold-related injury leading to hospitalization in northern Sweden: an eight-year retrospective analysis.

https://arctichealth.org/en/permalink/ahliterature257987
Source
Scand J Trauma Resusc Emerg Med. 2014;22:6
Publication Type
Article
Date
2014
Author
Helge Brändström
Göran Johansson
Gordon G Giesbrecht
Karl-Axel Ängquist
Michael F Haney
Author Affiliation
Department of Surgical and Perioperative Sciences, Anesthesia and Intensive Care Medicine, Faculty of Medicine, Umeå University, S-901 85 Umeå, Sweden. helge.brandstrom@vll.se.
Source
Scand J Trauma Resusc Emerg Med. 2014;22:6
Date
2014
Language
English
Publication Type
Article
Keywords
Cold Temperature - adverse effects
Follow-Up Studies
Hospital records
Hospitalization - trends
Humans
Hypothermia - epidemiology - etiology - therapy
Incidence
Retrospective Studies
Rewarming - methods
Sweden - epidemiology
Time Factors
Abstract
Cold injuries are rare but important causes of hospitalization. We aimed to identify the magnitude of cold injury hospitalization, and assess causes, associated factors and treatment routines in a subarctic region.
In this retrospective analysis of hospital records from the 4 northernmost counties in Sweden, cases from 2000-2007 were identified from the hospital registry by diagnosis codes for accidental hypothermia, frostbite, and cold-water drowning. Results were analyzed for pre-hospital site events, clinical events in-hospital, and complications observed with mild (temperature 34.9 - 32°C), moderate (31.9 - 28°C) and severe (
Notes
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PubMed ID
24460844 View in PubMed
Less detail
Source
Br Med J. 1964 Jan 4;5374:19-21
Publication Type
Article
Date
Jan-4-1964

[Accidental hypothermia. 2 case reports]

https://arctichealth.org/en/permalink/ahliterature57293
Source
Lakartidningen. 1993 Jun 2;90(22):2157-8
Publication Type
Article
Date
Jun-2-1993

Accidental hypothermia. An Alaskan problem.

https://arctichealth.org/en/permalink/ahliterature5765
Source
Alaska Med. 2001 Jul-Sep;43(3):73-5
Publication Type
Article
Author
R T Gregory
Author Affiliation
Arctic Medical Research Laboratory, Alaska Fort Wainwright, Alaska 99703 USA.
Source
Alaska Med. 2001 Jul-Sep;43(3):73-5
Language
English
Publication Type
Article
Keywords
Accidents
Alaska - epidemiology
Death
Diagnosis, Differential
Humans
Hypothermia - diagnosis - epidemiology
PubMed ID
11710085 View in PubMed
Less detail

Accidental hypothermia and death from cold in urban areas.

https://arctichealth.org/en/permalink/ahliterature12050
Source
Int J Biometeorol. 1991 Mar;34(4):242-6
Publication Type
Article
Date
Mar-1991
Author
M. Tanaka
S. Tokudome
Author Affiliation
Department of Hygiene and Preventive Medicine, Fukushima Medical College, Japan.
Source
Int J Biometeorol. 1991 Mar;34(4):242-6
Date
Mar-1991
Language
English
Publication Type
Article
Keywords
Accidents - mortality
Cold Climate - adverse effects
Female
Humans
Hypothermia - mortality
Japan - epidemiology
Male
Urban Population
Abstract
Hypothermia is considered a serious problem in big cities. In order to clarify factors contributing to urban hypothermia and death from cold, which will continue to be an issue in cities in the future, we analyzed autopsy reports recorded in the Tokyo Medical Examiner's Office from 1974 to 1983. In a total of 18,346 autopsy reports 157 deaths had been diagnosed as due to exposure to cold. Of these cases, the greatest number were males in their forties and fifties, and most of these were inebriated and/or homeless. Eighty-four percent of urban hypothermia cases occurred when the outdoor temperature was below 5 degrees C, and 50% of deaths from cold occurred when the outdoor temperature was between 0 degrees and 5 degrees C. There were no incidences of death from cold when the minimum outdoor temperature had remained above 16 degrees C. Seventy-four percent of deaths from cold occurred during the winter months of December, January and February, and most of the remaining deaths occurred in March and November. There were no deaths from cold from June to August. More than half of all deaths from cold occurred from 3.00 a.m. to 9.00 a.m., with the peak occurring at 5.00 a.m. A blood alcohol concentration of over 2.5 mg/ml had often been found in those in their forties and fifties who had died from hypothermia, and autopsy had often revealed disorders of the liver, digestive system, and circulatory system. Chronic lesions of the liver, probably due to alcoholism, were found in many cases; few cases showed no evidence of alcoholism and these were significantly different from the former group.
PubMed ID
2055665 View in PubMed
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Accidental hypothermia: factors related to long-term hospitalization. A retrospective study from northern Finland.

https://arctichealth.org/en/permalink/ahliterature290758
Source
Intern Emerg Med. 2017 Dec; 12(8):1225-1233
Publication Type
Journal Article
Date
Dec-2017
Author
Jari Pirnes
Tero Ala-Kokko
Author Affiliation
Division of Intensive Care Medicine, and Medical Research Center Oulu, Department of Anaesthesiology, Oulu University Hospital and Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, Box 21, OUH, 90029, Oulu, Finland. jari.pirnes@fimnet.fi.
Source
Intern Emerg Med. 2017 Dec; 12(8):1225-1233
Date
Dec-2017
Language
English
Publication Type
Journal Article
Keywords
Acidosis, Lactic - etiology - mortality
Adolescent
Adult
Aged
Chi-Square Distribution
Cohort Studies
Female
Finland
Hospitalization - statistics & numerical data
Humans
Hypothermia - mortality
Intensive Care Units - organization & administration - statistics & numerical data
Male
Middle Aged
Prognosis
Renal Insufficiency - complications - mortality
Retrospective Studies
Rhabdomyolysis - complications - mortality
Statistics, nonparametric
Abstract
Accidental hypothermia has a low incidence, but is associated with a high mortality rate. Knowledge about concomitant factors, complications, and length of hospital stay is limited. A retrospective cohort study on patients with accidental hypothermia admitted to Oulu University Hospital in Finland, over a 5-year period. Patients were categorized as short-stay patients (7 days or less) and long-stay patients (more than 7 days) according to their length of stay in hospital. From a total of 105 patients, 67 patients were included in the analyses. Alcohol abuse was the most common concomitant factor (54 %). Median length of hospital stay was 4 days, and 16 patients (24 %) stayed in hospital over 7 days (median 15 days). Thirty-day mortality was low (14/105, 13 %). Patients with long-term hospitalization had a lower initial temperature (28.4 versus 31.2 °C, p = 0.011), a lower level of consciousness (GCS score 8.4 versus 12.8, p = 0.003), more severe acidosis (pH 7.08 versus 7.28, p = 0.005, and lactate 7.2 versus 3.9, p = 0.043), and a lower level of platelets (183 versus 242, p = 0.041) on admission compared with short-stay patients. Thirty-six patients (54 %) had at least one complication, and this prolonged median hospital treatment for 2.5 days (p 
Notes
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PubMed ID
27677616 View in PubMed
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[Accidental hypothermia from immersion]

https://arctichealth.org/en/permalink/ahliterature57314
Source
Ugeskr Laeger. 1985 Aug 5;147(32):2503-8
Publication Type
Article
Date
Aug-5-1985
Author
P E Jørgensen
B. Jessen
L. Vanggaard
Source
Ugeskr Laeger. 1985 Aug 5;147(32):2503-8
Date
Aug-5-1985
Language
Danish
Publication Type
Article
Keywords
Denmark
English Abstract
Humans
Hypothermia - etiology - physiopathology - therapy
Immersion
PubMed ID
4060318 View in PubMed
Less detail

Accidental hypothermia. I. An Alaskan problem.

https://arctichealth.org/en/permalink/ahliterature5800
Source
Alaska Med. 1971 Oct;13(4):134-6
Publication Type
Article
Date
Oct-1971
Author
R T Gregory
Source
Alaska Med. 1971 Oct;13(4):134-6
Date
Oct-1971
Language
English
Publication Type
Article
Keywords
Accidents
Alaska
Humans
Hypothermia - diagnosis - epidemiology - mortality
PubMed ID
5121541 View in PubMed
Less detail

[Accidental hypothermia in the elderly]

https://arctichealth.org/en/permalink/ahliterature57258
Source
Tidsskr Nor Laegeforen. 2002 Mar 10;122(7):715-7
Publication Type
Article
Date
Mar-10-2002
Author
Anette Hylen Ranhoff
Author Affiliation
Mottagelsen Ullevål universitetssykehus 0407 Oslo. anettehylen.ranhoff@ulleval.no
Source
Tidsskr Nor Laegeforen. 2002 Mar 10;122(7):715-7
Date
Mar-10-2002
Language
Norwegian
Publication Type
Article
Keywords
Accidents
Aged
Aged, 80 and over
English Abstract
Female
Humans
Hypothermia - diagnosis - etiology - therapy
Prognosis
Rewarming - methods
Risk factors
Abstract
BACKGROUND: Accidental hypothermia is unintended body core temperature of 35 degrees C or below, a known hazard to elderly people in temperate and cold climates. MATERIAL AND METHODS: We present two old patients with severe hypothermia and a review of the literature focusing on risk factors, clinical presentation, and the treatment of hypothermia in the elderly. RESULTS: Two patients, aged 90 and 102 years, with body core temperature
PubMed ID
11998737 View in PubMed
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429 records – page 1 of 43.