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Cardiovascular and renal complications to postsurgical hypoparathyroidism: a Danish nationwide controlled historic follow-up study.

https://arctichealth.org/en/permalink/ahliterature114013
Source
J Bone Miner Res. 2013 Nov;28(11):2277-85
Publication Type
Article
Date
Nov-2013
Author
Line Underbjerg
Tanja Sikjaer
Leif Mosekilde
Lars Rejnmark
Author Affiliation
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Tage Hansens Gade (THG), Aarhus, Denmark.
Source
J Bone Miner Res. 2013 Nov;28(11):2277-85
Date
Nov-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Cardiovascular Diseases - etiology - mortality
Case-Control Studies
Denmark - epidemiology
Female
Follow-Up Studies
Hospitalization - statistics & numerical data
Humans
Hypoparathyroidism - complications - etiology - mortality
Kidney Diseases - etiology - mortality
Male
Middle Aged
Postoperative Complications - etiology - mortality
Risk factors
Seizures - etiology
Young Adult
Abstract
We aimed to identify all patients with postsurgical hypoparathyroidism (HypoPT) and to evaluate their risks of renal complications and cardiovascular disease in relation to their disease and its treatment. We identified possible patients through the Danish National Patient Registry and a prescription database. Case status was adjudicated by review of individual patients' hospital records. For each patient with postsurgical HypoPT due to surgery for nonmalignant diseases between 1988 and 2012, three age-matched (±?2 years) and gender-matched controls were selected from the general background population. The prevalence of postsurgical HypoPT was 22 per 100,000 inhabitants. We identified 688 patients who had undergone neck surgery since 1988 with subsequent hypocalcaemia and inappropriate low parathyroid hormone (PTH) levels that necessitated treatment with calcium and/or vitamin D supplementation for more than 6 months. The average age at diagnosis was 49 years (range, 17-87 years), and 88% were women. Sixteen percent of all patients had had neck surgery prior to the operation causing HypoPT. Compared with controls, patients with HypoPT had an increased risk of renal complications (hazard ratio [HR], 3.67; 95% confidence interval [CI], 2.41-5.59) and hospitalization due to seizures (HR, 3.82; 95% CI, 2.15-6.79), whereas there was no increased risk of cardiac arrhythmias (HR, 1.11; 95% CI, 0.79-1.57) or cardiovascular disease or death (HR, 0.89; 95% CI, 0.73-1.09). In conclusion, although risk of seizures and renal complications is increased, mortality and risk of cardiovascular diseases or arrhythmias is not increased in patients with HypoPT. Further study should try to determine how to reduce the risk of seizures and renal complications in HypoPT.
PubMed ID
23661265 View in PubMed
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[Condition of teeth in inhabitants of the Prikarpat'e region with lowered function of the thyroid and parathyroid glands]

https://arctichealth.org/en/permalink/ahliterature43059
Source
Stomatologiia (Mosk). 1974 Mar-Apr;53(2):69-70
Publication Type
Article

Epidemiology and Diagnosis of Hypoparathyroidism.

https://arctichealth.org/en/permalink/ahliterature283321
Source
J Clin Endocrinol Metab. 2016 Jun;101(6):2284-99
Publication Type
Article
Date
Jun-2016
Author
Bart L Clarke
Edward M Brown
Michael T Collins
Harald Jüppner
Peter Lakatos
Michael A Levine
Michael M Mannstadt
John P Bilezikian
Anatoly F Romanischen
Rajesh V Thakker
Source
J Clin Endocrinol Metab. 2016 Jun;101(6):2284-99
Date
Jun-2016
Language
English
Publication Type
Article
Keywords
Cataract - etiology
Denmark - epidemiology
Humans
Hypoparathyroidism - complications - diagnosis - epidemiology
Incidence
Kidney Calculi - etiology
Prevalence
Renal Insufficiency - etiology
Risk
United States - epidemiology
Abstract
Hypoparathyroidism is a disorder characterized by hypocalcemia due to insufficient secretion of PTH. Pseudohypoparathyroidism is a less common disorder due to target organ resistance to PTH. This report summarizes the results of the findings and recommendations of the Working Group on Epidemiology and Diagnosis of Hypoparathyroidism.
Each contributing author reviewed the recent published literature regarding epidemiology and diagnosis of hypoparathyroidism using PubMed and other medical literature search engines.
The prevalence of hypoparathyroidism is an estimated 37 per 100 000 person-years in the United States and 22 per 100 000 person-years in Denmark. The incidence in Denmark is approximately 0.8 per 100 000 person-years. Estimates of prevalence and incidence of hypoparathyroidism are currently lacking in most other countries. Hypoparathyroidism increases the risk of renal insufficiency, kidney stones, posterior subcapsular cataracts, and intracerebral calcifications, but it does not appear to increase overall mortality, cardiovascular disease, fractures, or malignancy. The diagnosis depends upon accurate measurement of PTH by second- and third-generation assays. The most common etiology is postsurgical hypoparathyroidism, followed by autoimmune disorders and rarely genetic disorders. Even more rare are etiologies including parathyroid gland infiltration, external radiation treatment, and radioactive iodine therapy for thyroid disease. Differentiation between these different etiologies is aided by the clinical presentation, serum biochemistries, and in some cases, genetic testing.
Hypoparathyroidism is often associated with complications and comorbidities. It is important for endocrinologists and other physicians who care for these patients to be aware of recent advances in the epidemiology, diagnosis, and genetics of this disorder.
Notes
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PubMed ID
26943720 View in PubMed
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The Epidemiology of Nonsurgical Hypoparathyroidism in Denmark: A Nationwide Case Finding Study.

https://arctichealth.org/en/permalink/ahliterature274141
Source
J Bone Miner Res. 2015 Sep;30(9):1738-44
Publication Type
Article
Date
Sep-2015
Author
Line Underbjerg
Tanja Sikjaer
Leif Mosekilde
Lars Rejnmark
Source
J Bone Miner Res. 2015 Sep;30(9):1738-44
Date
Sep-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Cardiovascular Diseases - complications
Case-Control Studies
Cataract - complications
Child
Child, Preschool
Data Collection
Denmark - epidemiology
Female
Follow-Up Studies
Fractures, Bone - complications - epidemiology
Humans
Hypocalcemia - complications - epidemiology
Hypoparathyroidism - complications - epidemiology
Infant
Infant, Newborn
Male
Mental Disorders - complications
Middle Aged
Mutation
Neoplasms - complications
Proportional Hazards Models
Registries
Renal Insufficiency - complications
Retrospective Studies
Seizures - complications
Young Adult
Abstract
Nonsurgical hypoparathyroidism (HypoPT) is a rare disorder most often caused by mutations in different genes. It is characterized by hypocalcaemia with inappropriately low PTH levels. Knowledge about this group of patients, including their mortality and morbidity, is very sparse. The aim was to identify all patients diagnosed with nonsurgical HypoPT in Denmark and assess their mortality and risk of complications. Through registers and review of individual patient hospital charts we identified all patients diagnosed with nonsurgical HypoPT in Denmark between 1977 and 2012. We assessed their mortality and morbidity by comparing them with a group of age- and gender-matched population-based controls. We identified a total of 180 patients with nonsurgical HypoPT among whom 123 (68%) were alive at the date of follow-up (prevalence of 2.3/100,000 inhabitants). Compared with controls, mortality was not increased, but patients had a significantly increased risk of renal insufficiency (hazard ratio [HR] 6.01), cardiovascular diseases (HR 1.91), neuropsychiatric complications (HR 2.45), infections (HR 1.94), seizures (HR 10.05), cataract (HR 4.21), and fractures at the upper extremities (HR 1.93). In contrast patients had significantly reduced risk of malignant diseases (HR 0.44). In conclusion, nonsurgical HypoPT is a rare disease associated with a number of complications that should be considered when taking care of these patients.
PubMed ID
25753591 View in PubMed
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Hyperparathyroidism secondary to maternal hypoparathyroidism and vitamin D deficiency: an uncommon cause of neonatal respiratory distress.

https://arctichealth.org/en/permalink/ahliterature88954
Source
Ann Trop Paediatr. 2009 Jun;29(2):149-54
Publication Type
Article
Date
Jun-2009
Author
Demirel N.
Aydin M.
Zenciroglu A.
Okumus N.
Cetinkaya S.
Yildiz Y T
Ipek M S
Author Affiliation
Department of Neonatology, Dr Sami Ulus Maternity and Children's Hospital, Ankara, Turkey.
Source
Ann Trop Paediatr. 2009 Jun;29(2):149-54
Date
Jun-2009
Language
English
Publication Type
Article
Keywords
Adult
Bone Density
Calcium Compounds - administration & dosage
Female
Humans
Hyperparathyroidism, Secondary - congenital
Hypoparathyroidism - complications
Infant, Newborn
Lactates - administration & dosage
Male
Pregnancy
Pregnancy Complications - etiology
Respiratory Distress Syndrome, Newborn - etiology
Rickets - congenital
Treatment Outcome
Vitamin D - administration & dosage
Vitamin D Deficiency - etiology
Abstract
A 4-day-old neonate presented with respiratory distress owing to chest wall deformity associated with metabolic bone disease. He was found to have congenital hyperparathyroidism and his mother was suffering from post-surgical hypoparathyroidism and vitamin D deficiency. The patient was given calcium lactate and maintenance doses of vitamin D. The respiratory distress subsided, the parathyroid hormone level returned to normal and by 4 weeks of age bone mineral content had improved. Congenital hyperparathyroidism should be considered in neonates presenting with respiratory distress and chest deformity.
PubMed ID
19460269 View in PubMed
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Hypocalcaemia with zonular cataract due to idiopathic hypoparathyroidism. With a note on the prevalence of severe hypocalcaemia in a health screening.

https://arctichealth.org/en/permalink/ahliterature74541
Source
Acta Med Scand. 1978;203(3):223-6
Publication Type
Article
Date
1978
Author
B. Philipson
B. Angelin
T. Christensson
K. Einarsson
B. Leijd
Source
Acta Med Scand. 1978;203(3):223-6
Date
1978
Language
English
Publication Type
Article
Keywords
Cataract - etiology
Female
Humans
Hypocalcemia - epidemiology - etiology
Hypoparathyroidism - complications
Male
Mass Screening
Middle Aged
Sweden
Abstract
A 59-year-old woman with idiopathic hypoparathyroidism who had tetany and zonular cataract is described. Twelve years ago she had had a period with cramps and convulsions, followed by an absence of symptoms for several years. Judging from the distance between the opacity of cataract and the surface of the lens, the onset of the cataract was estimated to have occurred 11 years ago and the apparent cessation of cataract development 10 years ago. It is suggested that the absence of hypocalcaemic symptoms during the last 10 years was associated with an increase in serum calcium levels, possibly connected with the onset of menopause. The occurrence of hypocalcaemia was analyzed in a health-screened population of 15 903 persons. Nine of the subjects were found to have a serum calcium level of less than 2.10 mmol/l, giving a prevalence of 0.6%0. None had primary hypoparathyroidism, which illustrates the rarity of this condition.
PubMed ID
636916 View in PubMed
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[Permanent hypoparathyroidism due to thyroid cancer surgical procedures in patients exposed to radiation in the Chernobyl, Ukraine, nuclear reactor accident]

https://arctichealth.org/en/permalink/ahliterature16672
Source
Dtsch Med Wochenschr. 2005 Nov 4;130(44):2501-6
Publication Type
Article
Date
Nov-4-2005
Author
T. Bohrer
I. Pasteur
O. Lyutkevych
P. Fleischmann
M. Tronko
Author Affiliation
Klinik und Poliklinik für Herz- und Thoraxchirurgie, Julius Maximilians Universität Würzburg. bohrer_t.htc@klinik.uni-wuerzburg.de
Source
Dtsch Med Wochenschr. 2005 Nov 4;130(44):2501-6
Date
Nov-4-2005
Language
German
Publication Type
Article
Keywords
Adolescent
Adult
Arthralgia - etiology
Chernobyl Nuclear Accident
Child
Dental Enamel - pathology
Depression - etiology
English Abstract
Female
Humans
Hypoparathyroidism - complications - etiology - psychology
Lymph Node Excision - adverse effects
Male
Middle Aged
Neoplasms, Radiation-Induced - etiology - surgery
Paresthesia - etiology
Postoperative Complications - etiology - psychology
Questionnaires
Risk factors
Thyroid Neoplasms - etiology - surgery
Thyroidectomy - adverse effects
Ukraine
Abstract
BACKGROUND AND OBJECTIVE: Postoperative hypoparathyroidism is a rare, but complex endocrine disorder. The purpose of this case series study was to evaluate the symptoms, signs and sequelae of the disease in a major homogeneous patient group after the Chernobyl accident in the Ukraine. PATIENTS AND METHODS: This study is based on a random sample of 25 patients with symptomatic permanent hypoparathyroidism after surgical procedures on the thyroid for carcinoma following the Chernobyl accident in May 1986. They underwent physical examination and their parathyroid hormone and calcium levels in serum were determined. The signs, symptoms and sequelae of their disease were systematically assessed by a validated specific questionnaire. The extent of individual distress by the symptoms and signs were analysed by using a Likert scale (points between 1 = no and 5 = maximal distress). RESULTS: In 14 patients (56%) (age at time of operation: 18.24 +/- 4.26 years) paresthesias occurred at least every third day. Very frequent general symptoms were joint pains and hair loss (in 17 patients / 68%). 19 patients (76%) had enamel defects, 17 (68%) increasingly dry skin since the operation. Psychical symptoms like excitability (20 patients / 80%) and depressed mood since the operation (16 patients / 64%) were strikingly frequent. The patients were affected more by dry skin (2,76 on the Likert scale) than by paraesthesias (2,56) or joint pains (2,68) and most of all by depressive mood (2.96) and excitability (3.38). 4 patients (16%) had kidney stones, while osteoporosis and osteosclerosis occurred in 7 (28%) respectively 3 persons (12%). 6 patients (24%) had cataracts and 3 (12%) had basal ganglia calcification. Interestingly, 1/3 of all patients had only non-characteristic symptoms of the disease consistent with a latent form of hypoparathyroidism. CONCLUSIONS: Our data partly show a severe form of hypoparathyroidism of very young persons in the Chernobyl region, a finding which strongly supports the need of exact diagnosis and interdisciplinary treatment options of this postoperative disorder.
PubMed ID
16252209 View in PubMed
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8 records – page 1 of 1.