Skip header and navigation

Refine By

2 records – page 1 of 1.

Specific IgE positivity against inhalant allergens and development of autoimmune disease.

https://arctichealth.org/en/permalink/ahliterature271586
Source
Autoimmunity. 2015;48(5):282-8
Publication Type
Article
Date
2015
Author
Tea Skaaby
Lise Lotte Nystrup Husemoen
Betina Heinsbæk Thuesen
Runa Vavia Fenger
Allan Linneberg
Source
Autoimmunity. 2015;48(5):282-8
Date
2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Allergens - immunology
Antibody Specificity - immunology
Autoimmune Diseases - epidemiology - etiology
Denmark - epidemiology
Female
Humans
Hypersensitivity - complications - immunology
Immunoglobulin E - immunology
Male
Middle Aged
Population Surveillance
Proportional Hazards Models
Registries
Risk factors
Surveys and Questionnaires
Young Adult
Abstract
Allergic and autoimmune diseases have been suggested to be inversely associated. We investigated the association between atopy and development of any and specific types of autoimmune disease.
We included a total of 14,849 individuals from five population-based studies with measurements of atopy defined as specific IgE positivity against inhalant allergens. We followed the participants by linkage to the Danish National Patient Register (median follow-up time 11.2 years). Hazard ratio (HR) and 95% confidence interval (CI) of autoimmune disease were estimated by Cox regression.
The risk for atopics versus non-atopics was: for any autoimmune disease (HR?=?0.99, 95% CI: 0.83, 1.18), thyrotoxicosis (HR?=?0.69, 95% CI: 0.34, 1.37), type 1 diabetes (HR?=?1.16, 95% CI: 0.84, 1.60), multiple sclerosis (HR?=?1.97, 95% CI: 0.95, 4.11), iridocyclitis (HR?=?0.82, 95% CI: 0.38, 1.74), Crohn's disease (HR?=?1.03, 95% CI: 0.47, 2.25), ulcerative colitis (HR?=?0.93, 95% CI: 0.52, 1.69), psoriasis vulgaris (HR?=?1.50, 95% CI: 0.86, 2.62), seropositive rheumatoid arthritis (HR?=?0.74, 95% CI: 0.48, 1.14) and polymyalgia rheumatica (HR?=?0.79, 95% CI: 0.44, 1.44).
We found no statistically significant associations between atopy and autoimmune disease, but we cannot exclude relatively small to moderate effects - protective or promotive - of atopy on autoimmune disease.
PubMed ID
25600125 View in PubMed
Less detail