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112 records – page 1 of 12.

Abnormal glycosylation and altered Golgi structure in colorectal cancer: dependence on intra-Golgi pH.

https://arctichealth.org/en/permalink/ahliterature19175
Source
FEBS Lett. 2002 Apr 10;516(1-3):217-24
Publication Type
Article
Date
Apr-10-2002
Author
Sakari Kellokumpu
Raija Sormunen
Ilmo Kellokumpu
Author Affiliation
Department of Biochemistry, University of Oulu, P.O. Box 3000, FIN-90014, Oulu, Finland. sakari.kellokumpu@oulu.fi
Source
FEBS Lett. 2002 Apr 10;516(1-3):217-24
Date
Apr-10-2002
Language
English
Publication Type
Article
Keywords
Animals
Antigens, Tumor-Associated, Carbohydrate - metabolism
Breast Neoplasms - immunology - metabolism - ultrastructure
COS Cells
Cells, Cultured
Colorectal Neoplasms - immunology - metabolism - ultrastructure
Female
Glycosylation
Golgi Apparatus - immunology - metabolism - ultrastructure
Humans
Hydrogen-Ion Concentration
Ion Transport
Microscopy, Electron
Rats
Research Support, Non-U.S. Gov't
Tumor Cells, Cultured
Abstract
Abnormal glycosylation of cellular glycoconjugates is a common phenotypic change in many human tumors. Here, we explore the possibility that an altered Golgi pH may also be responsible for these cancer-associated glycosylation abnormalities. We show that a mere dissipation of the acidic Golgi pH results both in increased expression of some cancer-associated carbohydrate antigens and in structural disorganization of the Golgi apparatus in otherwise normally glycosylating cells. pH dependence of these alterations was confirmed by showing that an acidification-defective breast cancer cell line (MCF-7) also displayed a fragmented Golgi apparatus, whereas the Golgi apparatus was structurally normal in its acidification-competent subline (MCF-7/AdrR). Acidification competence was also found to rescue normal glycosylation potential in MCF-7/AdrR cells. Finally, we show that abnormal glycosylation is also accompanied by similar structural disorganization and fragmentation of the Golgi apparatus in colorectal cancer cells in vitro and in vivo. These results suggest that an inappropriate Golgi pH may indeed be responsible for the abnormal Golgi structure and lowered glycosylation potential of the Golgi apparatus in malignant cells.
PubMed ID
11959136 View in PubMed
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[Acid-base state of the blood in neonates that have experienced intrauterine hypoxia after the use of halidor and rhythmic abdominal decompression]

https://arctichealth.org/en/permalink/ahliterature66209
Source
Fiziol Zh. 1976 MAR-APR;22(3):413-4
Publication Type
Article

Acidification of animal slurry--a review.

https://arctichealth.org/en/permalink/ahliterature263539
Source
J Environ Manage. 2015 Feb 1;149:46-56
Publication Type
Article
Date
Feb-1-2015
Author
David Fangueiro
Maibritt Hjorth
Fabrizio Gioelli
Source
J Environ Manage. 2015 Feb 1;149:46-56
Date
Feb-1-2015
Language
English
Publication Type
Article
Keywords
Acids - chemistry
Agriculture - methods
Ammonia - analysis - chemistry
Animals
Denmark
Environmental pollution - prevention & control
Hydrogen-Ion Concentration
Manure - analysis
Soil - chemistry
Abstract
Ammonia emissions are a major problem associated with animal slurry management, and solutions to overcome this problem are required worldwide by farmers and stakeholders. An obvious way to minimize ammonia emissions from slurry is to decrease slurry pH by addition of acids or other substances. This solution has been used commonly since 2010 in countries such as Denmark, and its efficiency with regard to the minimization of NH3 emissions has been documented in many studies. Nevertheless, the impact of such treatment on other gaseous emissions during storage is not clear, since the studies performed so far have provided different scenarios. Similarly, the impact of the soil application of acidified slurry on plant production and diffuse pollution has been considered in several studies. Also, the impact of acidification upon combination with other slurry treatment technologies (e.g. mechanical separation, anaerobic digestion …) is important to consider. Here, a compilation and critical review of all these studies has been performed in order to fully understand the global impact of slurry acidification and assess the applicability of this treatment for slurry management.
PubMed ID
25463570 View in PubMed
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Source
Can Med Assoc J. 1981 Aug 15;125(4):338
Publication Type
Article
Date
Aug-15-1981
Author
P K Basu
Source
Can Med Assoc J. 1981 Aug 15;125(4):338
Date
Aug-15-1981
Language
English
Publication Type
Article
Keywords
Acids - adverse effects
Animals
Canada
Eye Diseases - etiology
Humans
Hydrogen-Ion Concentration
Rabbits
Rain
Swimming
Weather
Notes
Cites: Can J Ophthalmol. 1978 Oct;13(4):247-933753
PubMed ID
7272884 View in PubMed
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[Activities of proteinases in invertebrate animals--potential objects of fish nutrition. Effects of temperature, pH, and heavy metals]

https://arctichealth.org/en/permalink/ahliterature84976
Source
Zh Evol Biokhim Fiziol. 2007 Sep-Oct;43(5):404-9
Publication Type
Article
Author
Kuz'mina V V
Ushakova N V
Source
Zh Evol Biokhim Fiziol. 2007 Sep-Oct;43(5):404-9
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological
Animals
Cold Climate
Digestive Physiology
Digestive System - enzymology
Evolution
Fishes
Food chain
Hydrogen-Ion Concentration
Invertebrates - drug effects - enzymology - physiology
Metals, Heavy - toxicity
Peptide Hydrolases - metabolism
Phylogeny
Temperature
Water Pollutants, Chemical - toxicity
Abstract
Differences in the degree of separate and combined effects of temperature, pH, and heavy metals (zinc, copper) on the trypsin- and chymotrypsin-like proteinase activities have been established in the whole body of some invertebrate animals - potential objects of fish nutrition: pond snail Lymnaeae stagnalis, orb snail Planorbis purpura, zebra mussel Dreissena polymorpha, oligochaetae Tubifex sp. and Lumbriculus sp. in total, chironomid larvae Chironimus sp. and Ch. riparus, as well as crustacean zooplankton. It has been shown that enzymes of the potential victim at a low temperature can compensate low activity of intestinal proteinases of fish bentho- and planktophages.
PubMed ID
18038636 View in PubMed
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Ah receptor ligands in tobacco smoke.

https://arctichealth.org/en/permalink/ahliterature69114
Source
Toxicol Lett. 1988 Aug;42(2):131-6
Publication Type
Article
Date
Aug-1988
Author
G. Löfroth
A. Rannug
Author Affiliation
Nordic School of Public Health, Gothenburg, Sweden.
Source
Toxicol Lett. 1988 Aug;42(2):131-6
Date
Aug-1988
Language
English
Publication Type
Article
Keywords
Animals
Binding Sites
Binding, Competitive
Cytosol - analysis
Hydrogen-Ion Concentration
Liver - analysis
Plants, Toxic
Rats
Receptors, Aryl Hydrocarbon
Receptors, Drug - analysis
Smoke - analysis
Tars - analysis
Tobacco
Abstract
Tar particulates from cigarette smoke contain compounds with affinity for the Ah receptor. The sidestream activity is larger than that of the mainstream with a ratio of about 5. The compounds causing the affinity appear in the neutral fraction after chemical fractionation excluding basic and acidic components as major contributors to the affinity. The affinity cannot be explained by benzo[a]pyrene and other polycyclic aromatic hydrocarbons but it might be caused by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds and by oxidized tryptophan derivatives.
PubMed ID
2841776 View in PubMed
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Amphibian recovery after a decrease in acidic precipitation.

https://arctichealth.org/en/permalink/ahliterature295731
Source
Ambio. 2018 Apr; 47(3):355-367
Publication Type
Journal Article
Date
Apr-2018
Author
Dag Dolmen
Anders Gravbrøt Finstad
Jon Kristian Skei
Author Affiliation
Norwegian University of Science and Technology, NTNU University Museum, 7491, Trondheim, Norway. dag.dolmen@ntnu.no.
Source
Ambio. 2018 Apr; 47(3):355-367
Date
Apr-2018
Language
English
Publication Type
Journal Article
Keywords
Amphibians
Animals
Hydrogen-Ion Concentration
Norway
Population Dynamics
Rain
Scandinavian and Nordic Countries
Abstract
We here report the first sign of amphibian recovery after a strong decline due to acidic precipitation over many decades and peaking around 1980-90. In 2010, the pH level of ponds and small lakes in two heavily acidified areas in southwestern Scandinavia (Aust-Agder and Østfold in Norway) had risen significantly at an (arithmetic) average of 0.14 since 1988-89. Parallel with the general rise in pH, amphibians (Rana temporaria, R. arvalis, Bufo bufo, Lissotriton vulgaris, and Triturus cristatus) had become significantly more common: the frequency of amphibian localities rose from 33% to 49% (n = 115), and the average number of amphibian species per locality had risen from 0.51 to 0.88. In two other (reference) areas, one with better buffering capacity (Telemark, n = 21) and the other with much less input of acidic precipitation (Nord-Trøndelag, n = 106), there were no significant changes in pH or amphibians.
Notes
Cites: BMC Evol Biol. 2011 Dec 19;11:366 PMID 22182445
Cites: Ecotoxicology. 1993 Mar;2(1):65-77 PMID 24203120
Cites: Environ Sci Technol. 2011 Oct 1;45(19):8403-10 PMID 21851093
Cites: Environ Pollut. 1991;71(2-4):305-28 PMID 15092122
Cites: ILAR J. 2007;48(3):270-7 PMID 17592188
Cites: Science. 2004 Dec 3;306(5702):1783-6 PMID 15486254
Cites: Environ Toxicol Chem. 2012 Jun;31(6):1416-21 PMID 22488839
Cites: J Evol Biol. 2011 Apr;24(4):699-711 PMID 21272107
Cites: Nature. 2000 Oct 19;407(6806):856-7; discussion 857-8 PMID 11057655
Cites: Ambio. 2013 Sep;42(5):577-86 PMID 23288615
PubMed ID
29164539 View in PubMed
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[An assessment of acid-base imbalance in body tissues and fluids]

https://arctichealth.org/en/permalink/ahliterature56693
Source
Fiziol Zh. 1999;45(3):103-9
Publication Type
Article
Date
1999
Author
V O Pakhomova
H F Biloklyts'ka
O O Protunkevych
V A Rozanov
O O Pakhomova
I L Hruzova
D O Mel'nychuk
Author Affiliation
Institute of Stomatology, Ministry of Public Health of Ukraine, Odessa.
Source
Fiziol Zh. 1999;45(3):103-9
Date
1999
Language
Ukrainian
Publication Type
Article
Keywords
Acid-Base Imbalance - diagnosis - metabolism
Animals
Body Fluids - chemistry - metabolism
Disease Models, Animal
English Abstract
Gluconeogenesis
Glycolysis
Hydrogen-Ion Concentration
Rats
Rats, Wistar
Spectrophotometry
Viscera - chemistry - metabolism
Abstract
Ions hydrogene concentration in fluids and tissues is one of the strict regulated physiological organism variables. Most common man and animal diseases are accompanied with compensated acid-base balance shift development. But diagnosis of metabolic acidosis and alkalosis with blood indices (pH, pCO2, HCO3) doesn't reflect true tissue condition that is connected not only with respiratory and excretion system functioning but with hypercompensation of metabolic processes. Excess organic acid formation in case of metabolic alkalosis formation in tissues directed to support pH leads to acidification, what brings an essential mistake in pathogenesis understanding of such diseases as cardiomyopathy, ischemic cardiac disease, myocardial infarction, hepatitis, collagenosis, caries, peptic ulcer, macula dystrophy, atherosclerosis, virus diseases, radiation damages. Ignorance primary tissue damages doesn't allow to conduct necessary preventive measures and to cure disease. It is suggested to assess development of metabolic acidosis and alkalosis by compensated changes of regulation acid-base homeostasis system, which is the basis of all future damages and development of different diseases against this background.
PubMed ID
10439299 View in PubMed
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112 records – page 1 of 12.