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562 records – page 1 of 57.

1H MRS studies in the Finnish boron neutron capture therapy project: detection of 10B-carrier, L-p-boronophenylalanine-fructose.

https://arctichealth.org/en/permalink/ahliterature172386
Source
Eur J Radiol. 2005 Nov;56(2):154-9
Publication Type
Article
Date
Nov-2005
Author
M. Timonen
L. Kankaanranta
N. Lundbom
J. Collan
A. Kangasmäki
M. Kortesniemi
A-M Häkkinen
A. Lönngren
S. Karjalainen
M. Rasilainen
J. Leinonen
T. Huitti
J. Jääskeläinen
M. Kouri
S. Savolainen
S. Heikkinen
Author Affiliation
Department of Physical Sciences, University of Helsinki, POB 64, FIN-00014, Helsinki, Finland.
Source
Eur J Radiol. 2005 Nov;56(2):154-9
Date
Nov-2005
Language
English
Publication Type
Article
Keywords
Adult
Aged
Boron - therapeutic use
Boron Compounds - analysis - blood
Boron Neutron Capture Therapy
Brain Neoplasms - pathology - radiotherapy
Carcinoma - pathology - radiotherapy
Female
Finland
Fructose - analogs & derivatives - analysis - blood
Glioblastoma - pathology - radiotherapy
Humans
Hydrogen
Isotopes - therapeutic use
Magnetic Resonance Spectroscopy - methods
Male
Neoplasm Recurrence, Local - pathology - radiotherapy
Paranasal Sinus Neoplasms - pathology - radiotherapy
Phantoms, Imaging
Plasma
Radiopharmaceuticals - therapeutic use
Abstract
This article summarizes the current status of 1H MRS in detecting and quantifying a boron neutron capture therapy (BNCT) boron carrier, L-p-boronophenylalanine-fructose (BPA-F) in vivo in the Finnish BNCT project. The applicability of 1H MRS to detect BPA-F is evaluated and discussed in a typical situation with a blood containing resection cavity within the gross tumour volume (GTV). 1H MRS is not an ideal method to study BPA concentration in GTV with blood in recent resection cavity. For an optimal identification of BPA signals in the in vivo 1H MR spectrum, both pre- and post-infusion 1H MRS should be performed. The post-infusion spectroscopy studies should be scheduled either prior to or, less optimally, immediately after the BNCT. The pre-BNCT MRS is necessary in order to utilise the MRS results in the actual dose planning.
PubMed ID
16233888 View in PubMed
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1H NMR studies on human plasma lipids from newborn infants, healthy adults, and adults with tumors.

https://arctichealth.org/en/permalink/ahliterature25704
Source
Magn Reson Med. 1989 Jan;9(1):35-8
Publication Type
Article
Date
Jan-1989
Author
S. Eskelinen
Y. Hiltunen
J. Jokisaari
S. Virtanen
K. Kiviniitty
Author Affiliation
Department of Biomedical Physics, University of Oulu, Finland.
Source
Magn Reson Med. 1989 Jan;9(1):35-8
Date
Jan-1989
Language
English
Publication Type
Article
Keywords
Adult
Female
Humans
Hydrogen
Infant, Newborn - blood
Lactates - blood
Lipoproteins - blood
Magnetic Resonance Spectroscopy - diagnostic use
Male
Methane - blood
Neoplasms - blood
Protons
Abstract
The 1H NMR spectra of the lipid region of human plasma from healthy adults, neonates, and patients with malignant and nonmalignant tumors have been recorded on a JNM-GX400 FT spectrometer operating at 399.6 MHz for protons. The chemical shifts of methylene and methyl groups of plasma lipids were measured with respect to the higher field component of the methyl proton resonance of the lactate molecule. The results show that there are changes in the chemical shifts of the methylene proton resonances among the plasma from healthy adults, adults with tumors, and neonates. The shifts observed in the case of cancer patients and neonates are in the direction opposite to the shift measured from the plasma of healthy adults. Thus, the observed changes cannot be explained by the activity in the cell proliferation of tissues which is high in the cases of both healthy neonates and patients with malignant tumors, but they most probably reflect the different lipoprotein compositions of neonates, healthy adults, and adults with tumors.
PubMed ID
2540395 View in PubMed
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[2nd place in the contest for young scientists on gastroenterology in the 17th Congress "Man and Medicine" (April 2010, Moscow). Erosive esophagitis in children: characteristics of 24-hour pH monitoring in the the esophagus].

https://arctichealth.org/en/permalink/ahliterature146414
Source
Eksp Klin Gastroenterol. 2010;(9):129-36
Publication Type
Article
Date
2010

31P-NMR study of skeletal muscle metabolism in patients with chronic respiratory impairment.

https://arctichealth.org/en/permalink/ahliterature5321
Source
Am Rev Respir Dis. 1992 Oct;146(4):1019-24
Publication Type
Article
Date
Oct-1992
Author
T. Kutsuzawa
S. Shioya
D. Kurita
M. Haida
Y. Ohta
H. Yamabayashi
Author Affiliation
Department of Respiratory Medicine, Tokai University School of Medicine, Isehara, Japan.
Source
Am Rev Respir Dis. 1992 Oct;146(4):1019-24
Date
Oct-1992
Language
English
Publication Type
Article
Keywords
Aged
Anaerobic Threshold - physiology
Energy Metabolism - physiology
Exercise - physiology
Forearm
Glycolysis - physiology
Humans
Hydrogen-Ion Concentration
Lung Diseases, Obstructive - metabolism
Magnetic Resonance Spectroscopy - diagnostic use
Male
Middle Aged
Muscles - metabolism
Phosphates - metabolism
Phosphocreatine - metabolism
Research Support, Non-U.S. Gov't
Abstract
To evaluate the energy metabolism of peripheral skeletal muscle during exercise in patients with chronic respiratory impairment, the 31P-nuclear magnetic resonance (NMR) spectra of forearm muscle were investigated in nine patients and nine age-matched control subjects. We calculated the phosphocreatine (PCr) to PCr + inorganic phosphate (PI) ratio, the time constant of PCr recovery and the intracellular pH. The exercise consisted of repetitive hand grips against a 2-kg load every 3 s for 6 min (0.33 W). The patients showed a marked decrease in the PCr/(PCr + PI) ratio and pH in the muscle during exercise in contrast to the control subjects whose PCr/(PCr + PI) showed a minor decrease without any change in pH. The relationship between PCr utilization and pH demonstrated that anaerobic glycolysis switched on earlier in patients with chronic respiratory impairment. A split PI peak was observed in five of nine patients during exercise. The PCr/(PCr + PI) ratio during the last minute of exercise correlated significantly with the vital capacity (% predicted), with the FEV1/FVC, with the body weight, with the maximum strength of hand grip, and with the muscle mass. The results indicate impaired oxidative phosphorylation and the early activation of anaerobic glycolysis in the muscles of patients with chronic respiratory impairment. Several factors related to chronic respiratory impairment, such as disuse, malnutrition and dysoxia, would contribute to the metabolic changes observed in the muscles examined.
PubMed ID
1416390 View in PubMed
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Abnormal glycosylation and altered Golgi structure in colorectal cancer: dependence on intra-Golgi pH.

https://arctichealth.org/en/permalink/ahliterature19175
Source
FEBS Lett. 2002 Apr 10;516(1-3):217-24
Publication Type
Article
Date
Apr-10-2002
Author
Sakari Kellokumpu
Raija Sormunen
Ilmo Kellokumpu
Author Affiliation
Department of Biochemistry, University of Oulu, P.O. Box 3000, FIN-90014, Oulu, Finland. sakari.kellokumpu@oulu.fi
Source
FEBS Lett. 2002 Apr 10;516(1-3):217-24
Date
Apr-10-2002
Language
English
Publication Type
Article
Keywords
Animals
Antigens, Tumor-Associated, Carbohydrate - metabolism
Breast Neoplasms - immunology - metabolism - ultrastructure
COS Cells
Cells, Cultured
Colorectal Neoplasms - immunology - metabolism - ultrastructure
Female
Glycosylation
Golgi Apparatus - immunology - metabolism - ultrastructure
Humans
Hydrogen-Ion Concentration
Ion Transport
Microscopy, Electron
Rats
Research Support, Non-U.S. Gov't
Tumor Cells, Cultured
Abstract
Abnormal glycosylation of cellular glycoconjugates is a common phenotypic change in many human tumors. Here, we explore the possibility that an altered Golgi pH may also be responsible for these cancer-associated glycosylation abnormalities. We show that a mere dissipation of the acidic Golgi pH results both in increased expression of some cancer-associated carbohydrate antigens and in structural disorganization of the Golgi apparatus in otherwise normally glycosylating cells. pH dependence of these alterations was confirmed by showing that an acidification-defective breast cancer cell line (MCF-7) also displayed a fragmented Golgi apparatus, whereas the Golgi apparatus was structurally normal in its acidification-competent subline (MCF-7/AdrR). Acidification competence was also found to rescue normal glycosylation potential in MCF-7/AdrR cells. Finally, we show that abnormal glycosylation is also accompanied by similar structural disorganization and fragmentation of the Golgi apparatus in colorectal cancer cells in vitro and in vivo. These results suggest that an inappropriate Golgi pH may indeed be responsible for the abnormal Golgi structure and lowered glycosylation potential of the Golgi apparatus in malignant cells.
PubMed ID
11959136 View in PubMed
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Abnormality of energy metabolism in the skeletal muscle of patients with liver cirrhosis and changes under administration of glucose and branched-chain amino acids.

https://arctichealth.org/en/permalink/ahliterature5271
Source
Tokai J Exp Clin Med. 2004 Dec;29(4):191-8
Publication Type
Article
Date
Dec-2004
Author
Jun Doi
Koichi Shiraishi
Munetaka Haida
Shohei Matsuzaki
Author Affiliation
Department of Gastroenterology, Tokai University Hachioji Hospital, Hachioji, Tokyo 192-0032, Japan.
Source
Tokai J Exp Clin Med. 2004 Dec;29(4):191-8
Date
Dec-2004
Language
English
Publication Type
Article
Keywords
Aged
Amino Acids, Branched-Chain - administration & dosage
Case-Control Studies
Citric Acid Cycle
Comparative Study
Energy Metabolism
Exercise
Fasting
Female
Glucose - administration & dosage - metabolism
Humans
Hydrogen-Ion Concentration
Liver Cirrhosis - metabolism
Magnetic Resonance Spectroscopy
Male
Middle Aged
Muscle, Skeletal - metabolism
Oxygen - metabolism
Phosphocreatine - metabolism
Spectroscopy, Near-Infrared
Abstract
We assessed changes in skeletal muscle energy metabolism by 31P-magnetic resonance spectroscopy (31P-MRS) and oxygen supply by near-infrared spectroscopy (NIR), after exercise and after administration of glucose and a branched-chain amino acids (BCAA), in healthy volunteers and patients with liver cirrhosis. As for the patients with liver cirrhosis, 4 were classified in Child-Pugh Grade A and the other 4 in Grade B. In patients with liver cirrhosis, the intramuscular pH and PCr index (PCr/PCr + Pi) were lower than in healthy subjects after exercise in the fasting state; the deltapH and deltaPCr index were statistically siginificant (p
PubMed ID
15717491 View in PubMed
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[Abundance and diversity of methanotrophic Gammaproteobacteria in northern wetlands].

https://arctichealth.org/en/permalink/ahliterature259581
Source
Mikrobiologiia. 2014 Mar-Apr;83(2):204-14
Publication Type
Article
Author
O V Danilova
S N Dedysh
Source
Mikrobiologiia. 2014 Mar-Apr;83(2):204-14
Language
Russian
Publication Type
Article
Keywords
Biodiversity
Fresh Water - microbiology
Gammaproteobacteria - genetics - isolation & purification - metabolism
Hydrogen-Ion Concentration
In Situ Hybridization, Fluorescence
Methane - metabolism
Methylococcaceae - genetics
Methylocystaceae - genetics
Molecular Sequence Data
Oxygenases - genetics
Phylogeny
RNA, Ribosomal, 16S
Russia
Wetlands
Abstract
Numeric abundance, identity and pH preferences of methanotrophic Gammaproteobacteria (type I methanotrophs) inhabiting the northern acidic wetlands were studied. The rates of methane oxidation by peat samples from six-wetlands of European Northern Russia (pH 3.9-4.7) varied from 0.04 to 0.60 µg CH4 g(-1) peat h(-1). The number of cells revealed by hybridization with fluorochrome-labeled probes M84 + M705 specific for type I methanotrophs was 0.05-2.16 x 10(5) cells g(-1) dry peat, i.e. 0.4-12.5% of the total number of methanotrophs and 0.004-0.39% of the total number of bacteria. Analysis of the fragments of the pmoA gene encoding particulate methane monooxygenase revealed predominance of the genus Methylocystis (92% of the clones) in the studied sample of acidic peat, while the proportion of the pmoA sequences of type I methanotrophs was insignificant (8%). PCR amplification of the 16S rRNA gene fragments of type I methanotrophs with TypeIF-Type IR primers had low specificity, since only three sequences out of 53 analyzed belonged to methanotrophs and exhibited 93-99% similarity to those of Methylovulum, Methylomonas, and Methylobacter species. Isolates of type I methanotrophs obtained from peat (strains SH10 and 83A5) were identified as members of the species Methylomonaspaludis and Methylovulum miyakonense, respectively. Only Methylomonaspaludum SH10 was capable of growth in acidic media (pH range for growth 3.8-7.2 with the optimum at pH 5.8-6.2), while Methylovulum miyakonense 83A5 exhibited the typical growth characteristics of neutrophilic methanotrophs (pH range for growth 5.5-8.0 with the optimum at pH 6.5-7.5).
PubMed ID
25423724 View in PubMed
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[Acid-base state of the blood in neonates that have experienced intrauterine hypoxia after the use of halidor and rhythmic abdominal decompression]

https://arctichealth.org/en/permalink/ahliterature66209
Source
Fiziol Zh. 1976 MAR-APR;22(3):413-4
Publication Type
Article

Acidemia at birth, related to obstetric characteristics and to oxytocin use, during the last two hours of labor.

https://arctichealth.org/en/permalink/ahliterature92839
Source
Acta Obstet Gynecol Scand. 2008;87(7):745-50
Publication Type
Article
Date
2008
Author
Jonsson Maria
Nordén-Lindeberg Solveig
Ostlund Ingrid
Hanson Ulf
Author Affiliation
Department of Women's and Children's Health Uppsala University, Uppsala, Sweden. maria.jonsson@kbh.uu.se
Source
Acta Obstet Gynecol Scand. 2008;87(7):745-50
Date
2008
Language
English
Publication Type
Article
Keywords
Acidosis - etiology
Adult
Cardiotocography
Case-Control Studies
Female
Humans
Hydrogen-Ion Concentration
Labor Stage, Second
Multivariate Analysis
Oxytocics - administration & dosage - adverse effects
Oxytocin - administration & dosage - adverse effects
Pregnancy
Risk factors
Umbilical Arteries - chemistry
Umbilical Cord
Uterine Contraction
Abstract
OBJECTIVE: Evaluate obstetric characteristics during the last two hours of labor in neonates born with acidemia. DESIGN: Case-control study. SETTING: Delivery units at two university hospitals in Sweden. STUDY POPULATION: Out of 28,486 deliveries during 1994-2004, 305 neonates had an umbilical artery pH value or = 7.05 and an Apgar score > or =7 at 5 minutes. Obstetric characteristics, cardiotocographic patterns and oxytocin treatment during the last two hours of labor were recorded. RESULTS: In the univariate analysis, > or =6 contractions/10 minutes (odds ratio (OR) 4.94, 95% confidence interval (CI) 3.25-7.49), oxytocin use (OR 2.20, 95% CI 1.66-2.92), bearing down > or =45 minutes (OR 1.77, 95% CI 1.31-2.38) and occipito-posterior position (OR 2.18, 95% CI 1.19-3.98) were associated with acidemia at birth. In the multivariate analysis, only > or =6 contractions/10 minutes (OR 5.36, 95% CI 3.32-8.65) and oxytocin use (OR 1.89, 95% CI 1.21-2.97) were associated with acidemia at birth. Among cases with > or =6 contractions/10 minutes, 75% had been treated with oxytocin. Pathological cardiotocographic patterns occurred in 68.8% of cases and in 26.1% of controls (p
PubMed ID
18607817 View in PubMed
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Acidic deposition and human exposure to toxic metals.

https://arctichealth.org/en/permalink/ahliterature234401
Source
Sci Total Environ. 1987 Dec;67(2-3):101-15
Publication Type
Article
Date
Dec-1987
Author
B G Svensson
A. Björnham
A. Schütz
U. Lettevall
A. Nilsson
S. Skerfving
Author Affiliation
Department of Occupational Medicine, University Hospital, Lund, Sweden.
Source
Sci Total Environ. 1987 Dec;67(2-3):101-15
Date
Dec-1987
Language
English
Publication Type
Article
Keywords
Cadmium - blood
Environmental Exposure
Health status
Humans
Hydrogen-Ion Concentration
Lead - blood
Life Style
Mercury - blood
Metals - analysis - blood
Questionnaires
Selenium - blood
Sweden
Water Pollutants - analysis
Water Pollutants, Chemical - analysis
Water Supply - analysis
Abstract
Acid precipitation affects the solubility of several metals in aquatic systems and in soil. Cadmium levels in tap water samples from geological areas having low resistance to acidic pollution were significantly higher than those in samples from a neighbouring reference area where there was a different geological structure. The median cadmium levels and pH values were 0.14 microgram l-1 and 5.6 respectively, for the acidic areas compared with 0.07 microgram l-1 and 6.4 respectively for the reference area. Further, there was a significant inverse relationship between both cadmium and lead contents and the pH values of the samples. The mobility of the metals was thus dependent on the acidity. The blood lead levels in 195 subjects from the acidic areas were lower than those in 91 subjects from the reference area (medians 60 vs. 70 micrograms l-1); no significant differences were found in blood cadmium or blood mercury levels. Subjects in the acidic areas had lower plasma selenium levels than those from the reference area (medians 85 vs. 90 micrograms l-1); the difference was mainly attributed to subjects with private wells. The data may indicate a negative effect of the acidic pollution on selenium intake via water and/or foods. There was also a positive relationship between intake of fish on the one hand and blood mercury and plasma selenium on the other, which is in accordance with the role of fish as a source of these metals.
PubMed ID
3438737 View in PubMed
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562 records – page 1 of 57.