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The 12-month prevalence and characteristics of major depressive episode in a representative nationwide sample of adolescents and young adults.

https://arctichealth.org/en/permalink/ahliterature192702
Source
Psychol Med. 2001 Oct;31(7):1169-79
Publication Type
Article
Date
Oct-2001
Author
L. Haarasilta
M. Marttunen
J. Kaprio
H. Aro
Author Affiliation
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland.
Source
Psychol Med. 2001 Oct;31(7):1169-79
Date
Oct-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Cross-Sectional Studies
Depressive Disorder, Major - diagnosis - epidemiology
Female
Finland - epidemiology
Humans
Male
Population Surveillance
Prevalence
Psychiatric Status Rating Scales
Time Factors
Abstract
This study set out to estimate the 12-month prevalence of DSM-III-R major depressive episode (MDE) and to analyse factors associating with psychosocial impairment, episode duration, phenomenology and symptom severity in a representative general population sample of adolescents (15-19-year-olds) and young adults (20-24-year-olds).
The Finnish Health Care Survey '96 (FINHCS '96) was a cross-sectional nationwide epidemiological study. A random sample of 509 adolescents and 433 young adults was interviewed in 1996. MDE was assessed by University of Michigan Composite Diagnostic Interview Short-Form.
The 12-month prevalence of MDE was 5.3 % for adolescents (females 6.0%, males 4.4%) and 9.4% for young adults (females 10.7%, males 8.1%). When moderate psychosocial impairment was included in case definition, the prevalences were lowered by 20-25%. Increased impairment was associated with drunkenness at least twice a month, a higher mean number of depressive symptoms and impaired concentration. The median episode duration was 1 month. No factors associating with duration were found. With the exception of symptoms related to appetite being more common among females than males, the phenomenology of MDE was mainly independent of age and gender.
Episodes of major depression among adolescents and young adults in the general population are short but often associated with psychosocial impairment, especially if frequent drunkenness coexists.
PubMed ID
11681543 View in PubMed
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The 12-month prevalence and risk factors for major depressive episode in Finland: representative sample of 5993 adults.

https://arctichealth.org/en/permalink/ahliterature197105
Source
Acta Psychiatr Scand. 2000 Sep;102(3):178-84
Publication Type
Article
Date
Sep-2000
Author
S. Lindeman
J. Hämäläinen
E. Isometsä
J. Kaprio
K. Poikolainen
M. Heikkinen
H. Aro
Author Affiliation
National Public Health Institute, Department of Mental Health and Alcohol Research, Helsinki, Finland.
Source
Acta Psychiatr Scand. 2000 Sep;102(3):178-84
Date
Sep-2000
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Depressive Disorder, Major - epidemiology
Female
Finland - epidemiology
Humans
Male
Middle Aged
Prevalence
Risk factors
Abstract
This study reports the 12-month prevalence of major depressive episode and its risk factors in a representative nationwide sample.
A random sample of non-institutionalized Finnish individuals aged 15-75 years (N = 5993) was interviewed in 1996. Major depressive episode during the last 12 months was assessed using the Short Form of the University of Michigan version of the Composite International Diagnostic Interview (the UM-CIDI Short Form).
The population prevalence of major depressive episode was 9.3% [95% CI 8.5,10.0], and the age-adjusted prevalences for females and males were 10.9% [95% CI 9.7,12.0] and 7.2 [95% CI 6.2,8.2], respectively. In logistic regression analyses the factors associated with major depressive episode after adjustment for age were urban residency, smoking, alcohol intoxication and chronic medical conditions. In addition, being single and obese were found to be risk factors for males.
The female to male risk ratio for major depressive episode was smaller than in many previous studies. The sex-specific risk factor associations warrant further investigation into sex differences in depression.
PubMed ID
11008852 View in PubMed
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1991 Volvo Award in clinical sciences. Smoking and lumbar intervertebral disc degeneration: an MRI study of identical twins.

https://arctichealth.org/en/permalink/ahliterature65039
Source
Spine. 1991 Sep;16(9):1015-21
Publication Type
Article
Date
Sep-1991
Author
M C Battié
T. Videman
K. Gill
G B Moneta
R. Nyman
J. Kaprio
M. Koskenvuo
Author Affiliation
Department of Orthopaedics, University of Washington, Seattle.
Source
Spine. 1991 Sep;16(9):1015-21
Date
Sep-1991
Language
English
Publication Type
Article
Keywords
Awards and Prizes
Comparative Study
Diseases in Twins - epidemiology
Finland - epidemiology
Humans
Intervertebral Disk Displacement - diagnosis - epidemiology - etiology
Lumbar Vertebrae - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Smoking - adverse effects
Sweden
Twins, Monozygotic
Abstract
The primary objective of this study was to determine whether disc degeneration, as assessed through magnetic resonance imaging, is greater in smokers than in nonsmokers. To control for the maximum number of potentially confounding variables, pairs of identical twins highly discordant for cigarette smoking were selected as study subjects. Data analyses revealed 18% greater mean disc degeneration scores in the lumbar spines of smokers as compared with nonsmokers. The effect was present across the entire lumbar spine, implicating a mechanism acting systemically. This investigation demonstrates the efficiency of using carefully selected controls in studying conditions of multifactorial etiology, such as disc degeneration.
PubMed ID
1948392 View in PubMed
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Acquired liver fat is a key determinant of serum lipid alterations in healthy monozygotic twins.

https://arctichealth.org/en/permalink/ahliterature113714
Source
Obesity (Silver Spring). 2013 Sep;21(9):1815-22
Publication Type
Article
Date
Sep-2013
Author
S M Kaye
M. Maranghi
L H Bogl
J. Kaprio
A. Hakkarainen
J. Lundbom
N. Lundbom
A. Rissanen
M R Taskinen
K H Pietiläinen
Author Affiliation
Obesity Research Unit, Department of Medicine, Division of Endocrinology, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.
Source
Obesity (Silver Spring). 2013 Sep;21(9):1815-22
Date
Sep-2013
Language
English
Publication Type
Article
Keywords
Abdominal Fat
Adult
Apolipoproteins B - blood
Body mass index
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Exercise
Fatty Liver - blood - complications - genetics - metabolism
Female
Finland
Humans
Liver - metabolism
Male
Multivariate Analysis
Obesity - blood - complications - genetics - metabolism
Subcutaneous Fat
Twins, Monozygotic
Young Adult
Abstract
The effects of acquired obesity on lipid profile and lipoprotein composition in rare BMI-discordant monozygotic (MZ) twin pairs were studied.
Abdominal fat distribution, liver fat (magnetic resonance imaging and spectroscopy), fasting serum lipid profile (ultracentrifugation, gradient gel-electrophoresis, and colorimetric enzymatic methods), and lifestyle factors (questionnaires and diaries) were assessed in 15 BMI-discordant (within-pair difference [?] in BMI >3 kg/m2) and nin concordant (?BMI
PubMed ID
23696329 View in PubMed
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Adipocyte morphology and implications for metabolic derangements in acquired obesity.

https://arctichealth.org/en/permalink/ahliterature264941
Source
Int J Obes (Lond). 2014 Nov;38(11):1423-31
Publication Type
Article
Date
Nov-2014
Author
S. Heinonen
L. Saarinen
J. Naukkarinen
A. Rodríguez
G. Frühbeck
A. Hakkarainen
J. Lundbom
N. Lundbom
K. Vuolteenaho
E. Moilanen
P. Arner
S. Hautaniemi
A. Suomalainen
J. Kaprio
A. Rissanen
K H Pietiläinen
Source
Int J Obes (Lond). 2014 Nov;38(11):1423-31
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Adipocytes - metabolism
Adipose Tissue - metabolism
Adult
Body mass index
Body Weight
Energy Metabolism
Female
Finland - epidemiology
Gene Expression
Gene-Environment Interaction
Genetic Predisposition to Disease
Humans
Longitudinal Studies
Male
Metabolome
Obesity - complications - genetics - metabolism
Twins, Monozygotic
Abstract
Adipocyte size and number have been suggested to predict the development of metabolic complications in obesity. However, the genetic and environmental determinants behind this phenomenon remain unclear.
We studied this question in rare-weight discordant (intra-pair difference (?) body mass index (BMI) 3-10 kg m(-2), n=15) and concordant (?BMI 0-2 kg m(-)(2), n=5) young adult (22-35 years) monozygotic twin pairs identified from 10 birth cohorts of Finnish twins (n=5 500 pairs). Subcutaneous abdominal adipocyte size from surgical biopsies was measured under a light microscope. Adipocyte number was calculated from cell size and total body fat (D ? A).
The concordant pairs were remarkably similar for adipocyte size and number (intra-class correlations 0.91-0.92, P
PubMed ID
24549139 View in PubMed
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Adolescent flexibility, endurance strength, and physical activity as predictors of adult tension neck, low back pain, and knee injury: a 25 year follow up study.

https://arctichealth.org/en/permalink/ahliterature171052
Source
Br J Sports Med. 2006 Feb;40(2):107-13
Publication Type
Article
Date
Feb-2006
Author
L O Mikkelsson
H. Nupponen
J. Kaprio
H. Kautiainen
M. Mikkelsson
U M Kujala
Author Affiliation
Pajulahti Sports Center, Nastola, Finland. kesto@sci.fi
Source
Br J Sports Med. 2006 Feb;40(2):107-13
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aging - physiology
Child
Female
Finland
Follow-Up Studies
Humans
Knee Injuries - etiology
Low Back Pain - etiology
Male
Motor Activity - physiology
Muscle Contraction - physiology
Neck Pain - etiology
Odds Ratio
Physical Endurance - physiology
Pliability
Questionnaires
Recurrence
Risk factors
Sex Factors
Abstract
To examine whether adolescent flexibility, endurance strength, and physical activity can predict the later occurrence of recurrent low back pain, tension neck, or knee injury.
In 1976, 520 men and 605 women participated in a sit and reach test (flexibility) and a 30 second sit up test (endurance strength). In 1976 and 2001 (aged 37 and 42 years) they completed a questionnaire. Lifetime occurrence and risk of self reported low back pain and self reported, physician diagnosed tension neck and knee injury were calculated for subjects divided into tertiles by baseline results of strength and flexibility tests.
Men from the highest baseline flexibility tertile were at lower risk of tension neck than those from the lowest tertile (odds ratio (OR) 0.51, 95% confidence interval (CI) 0.28 to 0.93). Women from the highest baseline endurance strength tertile were at lower risk of tension neck than those from the lowest tertile (OR 0.60, 95% CI 0.40 to 0.91). Men from the highest baseline endurance strength tertile were at higher risk of knee injury than those from the lowest tertile (OR 1.96, 95% CI 1.05 to 3.64). Men who at school age participated in physical activity were at lower risk of recurrent low back pain (OR 0.61; 95% CI 0.42 to 0.88) than those who did not.
Overall good flexibility in boys and good endurance strength in girls may contribute to a decreased risk of tension neck. High endurance strength in boys may indicate an increased risk of knee injury.
Notes
Cites: Spine (Phila Pa 1976). 1998 Jan 15;23(2):235-439474732
Cites: Med Sci Sports Exerc. 1997 Aug;29(8):1062-89268964
Cites: Arch Dis Child. 1999 Feb;80(2):188-9110325741
Cites: Int J Obes Relat Metab Disord. 1999 Apr;23 Suppl 3:S55-6310368004
Cites: Spine (Phila Pa 1976). 1999 Jul 1;24(13):1343-810404577
Cites: J Bone Miner Res. 1999 Oct;14(10):1672-910491214
Cites: Scand J Work Environ Health. 2004 Oct;30(5):399-40915529803
Cites: Arthritis Rheum. 2001 Feb;44(2):481-511229481
Cites: Am J Hum Biol. 2001 Mar-Apr;13(2):162-7211460860
Cites: Am J Hum Biol. 2001 Mar-Apr;13(2):180-911460862
Cites: J Rheumatol. 2002 Mar;29(3):557-6311908573
Cites: Clin Rehabil. 2002 Nov;16(7):772-912428826
Cites: JAMA. 2003 May 21;289(19):2509-1612759322
Cites: Occup Environ Med. 2003 Jul;60(7):475-8212819280
Cites: Sports Med. 2003;33(12):869-7512974655
Cites: Med Sci Sports Exerc. 2003 Nov;35(11):1914-2214600559
Cites: J Appl Physiol (1985). 2004 Jan;96(1):173-8012959964
Cites: Arthritis Rheum. 2004 Feb;50(2):613-2314872506
Cites: Twin Res. 2004 Feb;7(1):16-2615053850
Cites: Arthritis Rheum. 2004 Apr 15;51(2):160-715077255
Cites: Med Sci Sports Exerc. 2004 Sep;36(9):1559-6615354038
Cites: JAMA. 1978 Oct 27;240(18):1975-6691219
Cites: Prog Clin Biol Res. 1981;69 Pt C:37-467198250
Cites: J Chronic Dis. 1987;40(4):289-962951392
Cites: Ann Med. 1989 Oct;21(5):393-82605032
Cites: Spine (Phila Pa 1976). 1991 Sep;16(9):1056-611835161
Cites: Acta Genet Med Gemellol (Roma). 1991;40(1):83-901835236
Cites: Eur J Appl Physiol Occup Physiol. 1992;64(6):538-451618193
Cites: Exerc Sport Sci Rev. 1992;20:27-581623888
Cites: Eur Spine J. 1994;3(3):155-617866827
Cites: BMJ. 1995 Dec 2;311(7018):1465-88520333
Cites: Med Sci Sports Exerc. 1996 Feb;28(2):165-708775149
Cites: Eur J Appl Physiol Occup Physiol. 1996;73(5):452-88803506
Cites: Scand J Med Sci Sports. 1996 Jun;6(3):145-558827843
Cites: Med Sci Sports Exerc. 1996 Dec;28(12):1479-918970142
Cites: Am J Phys Med Rehabil. 1997 Jan-Feb;76(1):52-89036912
Cites: Med Sci Sports Exerc. 1998 May;30(5):724-319588615
PubMed ID
16431995 View in PubMed
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Age at natural menopause and sociodemographic status in Finland.

https://arctichealth.org/en/permalink/ahliterature219109
Source
Am J Epidemiol. 1994 Jan 1;139(1):64-76
Publication Type
Article
Date
Jan-1-1994
Author
R. Luoto
J. Kaprio
A. Uutela
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Am J Epidemiol. 1994 Jan 1;139(1):64-76
Date
Jan-1-1994
Language
English
Publication Type
Article
Keywords
Age Factors
Analysis of Variance
Body mass index
Educational Status
Female
Finland
Humans
Menopause
Middle Aged
Smoking
Social Class
Socioeconomic Factors
Abstract
Differences in age at natural menopause by occupation, education, and place of residence were examined using a cross-sectional population sample of Finnish women aged 45-64 years (n = 1,713, response rate 86%). The sample was selected at random from the Finnish Population Register in 1989 (final n = 1,505, 75%). Kaplan-Meier estimates showed the median age at natural menopause to be 51 years for all women (95% confidence interval (CI) 50.6-51.4). The median menopausal age of smokers and nulliparous women was 50 years; that of nonsmokers and women whose first full-term pregnancy occurred before the age of 25 years was 52 years. Differences between occupational and educational groups were statistically significant (Mantel-Cox test for occupation, p 11 years) it was 0.75 (95% CI 0.59-0.96), adjusted to reflect smoking, use of hormones, body mass index, and age at first full-term pregnancy. Sociodemographic variables appear to be associated with age at natural menopause in a representative sample of Finnish women.
PubMed ID
8296776 View in PubMed
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Alcohol intake, drinking patterns, and prostate cancer risk and mortality: a 30-year prospective cohort study of Finnish twins.

https://arctichealth.org/en/permalink/ahliterature283880
Source
Cancer Causes Control. 2016 Sep;27(9):1049-58
Publication Type
Article
Date
Sep-2016
Author
BA Dickerman
SC Markt
M. Koskenvuo
E. Pukkala
LA Mucci
J. Kaprio
Source
Cancer Causes Control. 2016 Sep;27(9):1049-58
Date
Sep-2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol Drinking - adverse effects
Cohort Studies
Female
Finland - epidemiology
Humans
Male
Middle Aged
Models, Theoretical
Prospective Studies
Prostatic Neoplasms - epidemiology - mortality
Risk
Surveys and Questionnaires
Abstract
Alcohol intake may be associated with cancer risk, but epidemiologic evidence for prostate cancer is inconsistent. We aimed to prospectively investigate the association between midlife alcohol intake and drinking patterns with future prostate cancer risk and mortality in a population-based cohort of Finnish twins.
Data were drawn from the Older Finnish Twin Cohort and included 11,372 twins followed from 1981 to 2012. Alcohol consumption was assessed by questionnaires administered at two time points over follow-up. Over the study period, 601 incident cases of prostate cancer and 110 deaths from prostate cancer occurred. Cox regression was used to evaluate associations between weekly alcohol intake and binge drinking patterns with prostate cancer risk and prostate cancer-specific mortality. Within-pair co-twin analyses were performed to control for potential confounding by shared genetic and early environmental factors.
Compared to light drinkers (=3 drinks/week; non-abstainers), heavy drinkers (>14 drinks/week) were at a 1.46-fold higher risk (HR 1.46; 95 % CI 1.12, 1.91) of prostate cancer, adjusting for important confounders. Among current drinkers, binge drinkers were at a significantly increased risk of prostate cancer (HR 1.28; 95 % CI 1.06, 1.55) compared to non-binge drinkers. Abstainers were at a 1.90-fold higher risk (HR 1.90; 95 % CI 1.04, 3.47) of prostate cancer-specific mortality compared to light drinkers, but no other significant associations for mortality were found. Co-twin analyses suggested that alcohol consumption may be associated with prostate cancer risk independent of early environmental and genetic factors.
Heavy regular alcohol consumption and binge drinking patterns may be associated with increased prostate cancer risk, while abstinence may be associated with increased risk of prostate cancer-specific mortality compared to light alcohol consumption.
Notes
Cites: Adv Exp Med Biol. 2015;815:59-7025427901
Cites: Am J Epidemiol. 2002 Dec 1;156(11):985-9312446254
Cites: Br J Cancer. 2015 Feb 3;112(3):580-9325422909
Cites: Eur J Cancer Prev. 2012 Jul;21(4):350-922095143
Cites: Nutr Cancer. 2006;56(1):50-617176217
Cites: Int J Cancer. 2006 Sep 15;119(6):1501-416615108
Cites: Hum Hered. 1978;28(4):241-54566252
Cites: Epidemiol Rev. 2001;23(1):110-411588834
Cites: Urology. 2004 Oct;64(4):717-2215491708
Cites: Am J Epidemiol. 2010 Oct 1;172(7):773-8020813803
Cites: Mol Nutr Food Res. 2009 Feb;53(2):240-5519156715
Cites: N Engl J Med. 2009 Mar 26;360(13):1310-919297565
Cites: Cancer Epidemiol. 2015 Dec;39 Suppl 1:S67-7426115567
Cites: Cancer. 2009 Aug 15;115(16):3661-919598210
Cites: BMJ. 2014 Jul 10;349:g416425011450
Cites: Br J Cancer. 1994 Feb;69(2):327-328297729
Cites: Prostate. 2002 Sep 1;52(4):297-30412210490
Cites: Nutr Cancer. 1998;30(1):1-139507506
Cites: CA Cancer J Clin. 1997 Sep-Oct;47(5):273-879314822
Cites: Am J Epidemiol. 1996 Apr 1;143(7):692-78651231
Cites: Adv Exp Med Biol. 2015 ;815:41-5825427900
Cites: Ann Epidemiol. 2000 Aug;10(6):361-910964002
Cites: Clin Cancer Res. 2003 Jul;9(7):2435-912855615
Cites: J Med Screen. 2011;18(1):46-921536817
Cites: Cancer Causes Control. 2013 Mar;24(3):451-6123271409
Cites: Int J Epidemiol. 2001 Aug;30(4):749-5511511598
Cites: Am J Epidemiol. 2004 Mar 1;159(5):444-5314977640
PubMed ID
27351919 View in PubMed
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Alcohol-related diseases associated with ischaemic heart disease: a three-year follow-up of middle-aged male hospital patients.

https://arctichealth.org/en/permalink/ahliterature237641
Source
Alcohol Alcohol. 1986;21(3):251-6
Publication Type
Article
Date
1986
Author
M. Koskenvuo
J. Kaprio
A. Kesaniemi
K. Poikolainen
Source
Alcohol Alcohol. 1986;21(3):251-6
Date
1986
Language
English
Publication Type
Article
Keywords
Adult
Alcoholism - complications - mortality
Coronary Disease - chemically induced - epidemiology - mortality
Finland
Follow-Up Studies
Hospitalization
Humans
Male
Middle Aged
Risk
Abstract
Mortality and morbidity from ischaemic heart disease (IHD) was studied in 5404 Finnish males aged 35-64 years who had been hospitalised for alcohol-related disease in 1972 without any admissions for IHD during that same period. By record-linkage, morbidity and mortality were followed up to the end of 1975. The mortality of patients with alcohol-related diseases was compared to 1120 patients with acute appendicitis by calculating indirectly age-standardised mortality ratios (SMR). The mortality and morbidity of 5963 patients with acute myocardial infarction or angina pectoris was also studied. The following SMRs for IHD mortality, non-fatal-IHD-hospitalisation and for mortality from all causes respectively, were found: acute myocardial infarction 11.6, 7.2 and 7.2; alcohol intoxication 6.0, 4.5 and 4.5; angina pectoris 5.2, 10.5 and 3.4; liver cirrhosis 2.2, 2.5 and 11.8; alcoholism 1.9, 1.9 and 3.6; pancreatitis 1.8, 1.2 and 4.4; alcohol psychosis 1.7, 2.5 and 4.2. IHD mortality and morbidity appeared to be more prevalent in patients hospitalised with alcohol intoxication than in patients with other alcohol-related diseases. This suggests that rapid drinking predisposes both to serious intoxication and to fatal disturbances of cardiac rhythm.
PubMed ID
3768098 View in PubMed
Less detail
Source
Lancet. 1996 Mar 2;347(9001):573-8
Publication Type
Article
Date
Mar-2-1996
Author
I. Raiha
J. Kaprio
M. Koskenvuo
T. Rajala
L. Sourander
Author Affiliation
Department of Geriatrics, University of Turku, Finland.
Source
Lancet. 1996 Mar 2;347(9001):573-8
Date
Mar-2-1996
Language
English
Publication Type
Article
Keywords
Age of Onset
Aged
Aged, 80 and over
Alzheimer Disease - etiology - genetics
Cohort Studies
Dementia - etiology - genetics
Dementia, Vascular - etiology - genetics
Diseases in Twins
Female
Finland
Humans
Male
Middle Aged
Twins, Dizygotic
Twins, Monozygotic
Abstract
The genetics of Alzheimer's disease (AD) are obscure. Although most cases are sporadic half the patients with sporadic AD have a positive family history. The mode of genetic transmission and the role of environmental factors are unknown. The purpose of this study was to examine the contribution of genetic factors to the pathogenesis of AD in a twin cohort.
The Finnish Twin Cohort consists of all Finnish same-sexed twin pairs born before 1958 with both co-twins alive in 1975. The total number of twin pairs is 13 888, of whom 4307 are monozygotic (MZ) and 9581 ar dizygotic (DZ). These data were linked with the Hospital Discharge Register from 1972 to 1991 to identify twins who had dementia or related disease as a discharge diagnosis. The linkage of the registries yielded a total of 285 twin individuals. The medical records of these twins and their co-twins were reviewed to confirm and classify dementia (AD, vascular dementia, mixed dementia, and other dementia). The incidence, concordance, and age at onset of AD were examined.
The incidence of AD was significantly higher in MZ than in DZ twin individuals, with and adjusted MZ/DZ incidence ratio of 1.8 (95% confidence intervals 1.2 to 2.7). In contrast, the incidence of vascular or mixed dementia did not differ between MZ and DZ individuals (MZ/DZ ratio 0.6 [0.3 to 1.2]) for vascular and 1.0 [0.5 to 2.1] for mixed dementia). The pairwise concordance for AD was 18.6% in MZ pairs and 4.7% in DZ pairs and the corresponding probandwise concordance rates were 31.3% and 9.3%. The pairwise concordance for vascular dementia was 18.2% in MZ pairs and 6.7% in DZ pairs with corresponding probandwise rates of 30.8% and 12.5%. The onset age of AD concordant MZ pairs was identical in two pairs and diverged by up to 15 years.
The higher incidence of AD in MZ individuals than in DZ individuals may provide a clue to the aetiology of AD. The higher concordance rate of MZ pairs confirms the contribution of the major genetic component while indicating the need to identify environmental triggers.
Notes
Comment In: Lancet. 1996 Apr 6;347(9006):975-68598792
Comment In: Lancet. 1996 Apr 6;347(9006):9768598793
PubMed ID
8596319 View in PubMed
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211 records – page 1 of 22.