During a four year period, 60 patients with premature rupture of membranes (PROM) met the inclusion criteria of having a single living fetus with gestational age between 25 to 36 weeks and more than 24 hours between PROM and delivery were admitted in Karolinska Hospital, Sweden. These cases were reviewed retrospectively. Five neonates died postnatally and the total survival rate was 91.7%. Three of them had major malformations and one died of hyaline membrane disease with 29 weeks of gestational age. In only one case the immediate cause of death was due to infection. The present protocol of expectant treatment for PROM in this hospital tends to be a minimum of unnecessary intervention for obtaining a high survival rate.
The Second International Congress was held in August, 1909 in Norway. Zheng Hao was dispatched by the Qing Government to attend the Congress as a representative. Through the Congress, Chinese people got to understand the latest ideas of prevention and treatment of leprosy in international medical field, and the approaches they adopted as well at that time. Meanwhile, Zheng Hao frankly confessed the backward status on the prevention and treatment in leprosy in China, and expressed the strong will to learn from the western world in this regard. This historical event, commonly ignored, manifested the fact that, beginning from the late Qing Dynasty, the involvement of Chinese medicine into the world medical trend as a whole was proceeding. By seizing this rare chance of participating the international meeting, the outstanding Chinese medical persons, with Zheng Hao as its representative, made up their mind to keep up with the international medical advanced pace, learning lessons, and pushing forward the development of Chinese medicine.
By epidemiological investigation to Gardnerella vaginalis disease of fox of civil main farms raising foxes, this disease was showed to be susceptible to silver foxes, arctic foxes, red foxes and color foxes, the disease was mostly transmitted by copulation, infected foxes played the leading role in epidemic of the disease. Investigative results of all farms raising foxes showed infection rate of fox groups was 0.9-21.9%, resulting in abortion rate was 1.5-14.7%, empty rate was 3.2-47.5%. Serious harm was revealed to the disease. By serology and causative agent isolation, we had proved that the disease was able to infect feeder and manager, it belongs to zoonosis. Racoondog. mink and canine infect with the disease besides fox. White mouse, big white rat, gopher, guinea pig and rabbit for laboratory are not infected with the disease.
To develop a simplified Chinese version of the 32-item Quebec sleep questionnaire (QSQ) and to examine the reliability and validity.
A cross-sectional sample of 141 patients [22 simple snorers and 119 obstructive sleep apnea hypopnea syndrome (OSAHS)] and a longitudinal sample of 55 patients [35 in uvulopalatopharyngoplasty (UPPP) group and 20 in control group] completed the simplified Chinese version of QSQ for assessment of its feasibility, reliability, validity and responsiveness.
QSQ had good feasibility. All internal consistency coefficients exceeded 0.65. Intraclass correlation coefficients of five domains for test-retest reliability ranged from 0.82 - 0.91. There were significant differences in four domains (daytime sleepiness, diurnal symptoms, nocturnal symptoms and social interactions) among patients with different severity of apnea hypopnea index (AHI) and lowest saturation of arterial oxygen (LSaO2, P
The microbial flora and counting were studied in split porcine skin. The results indicated that the routine method for the preparation of porcine heterograft could not reduce the indigenous flora in the dermal appendages efficiently. The indigenous flora of porcine skin consists of not only Gram positive cocci and Gram negative rods, fungus are the another predominant ones, the later may contribute to the frequent complication of fungal infection and the early rejection of porcine heterograft. A tincture of iodine compound was prepared and used for the purpose of disinfection, a better result was obtained.
Cd translocation through soil-food crop-diet is considered as one of most important pathway for human Cd exposure. Rice is considered as a particular crop with high Cd uptake and accumulation in grains among the main food crops. In this study, a pot experiment was conducted to elucidate mutual interaction of soil and cultivars on uptake and grain accumulation of Cd by hybrid rice with or without Cd spiking at 2.5 mg x kg(-1) under continuous submerging condition. Two hybrid rice cultivars (Shanyou 63, a common hybrid rice and II Youming 86, a super-rice) and two paddy soils (a Wushantu, Gleyic Stagnic Anthrosols and a Hongshanitian, Ultic Stagnic Anthrosols) were used. The results show significant differences in Cd uptake and grain partitioning between soils, cultivars and the soil-cultivar interactions. The cultivars effect on uptake of indigenous soil Cd seems stronger than the soil effect while soil effect turns significant over that of cultivars on spiked Cd. However, intense Cd accumulation in grains is found under the positive interaction of soil with high Cd availability and cultivar with high Cd affinity (super rice on acidic paddy soil). This study demonstrates a phenomenon of intense Cd uptake and grain accumulation by super rice and, thus, imposing a very high Cd exposure risk (as several times as the acceptable daily intake, ADI) to subsistence-diet farmers. The low Cd cultivar Shanyou 63 tends to hamper the up-taken Cd in root while the super rice II Youming 86 promotes higher partitioning to grain. Furthermore, the difference in total biomass between the two cultivars is small compared to that in total Cd uptake under Cd spiking. It is suggested that the Cd uptake behavior should be taken into account in super rice breeding and practical measures should be taken while spread of super rice cultivars in rice areas with acidic soils and under Cd pollution in order to control the human Cd exposure by diet.
Objective: To report clinical feature and results of genetic analysis of 3 patients from 2 families with Finnish variant late infantile neuronal ceroid lipofuscinosis. Methods: The clinical and ultrastructural features of 3 patients with progressive neurodegenerative diseases were retrospectively analyzed from October 2014 to December 2016 in Department of Genetics and Endocrinology, Guangzhou Women and Children's Medical Center. The whole exon sequencing and Sanger sequencing were used to analyze the molecular genetics of the patients and their parents. Results: The probands were 11 years and 3 moths, 9 years and 1 month,10 years and 1 month old. All were normal at birth, and from 5-6 years old they began to develop "regression of cognition and motion, impaired vision". Physical examination at the first consultation: clear minded butignorant, unable to speak and understand instructions, unable to stand up and sit alone, unable to maintain postureupright. The brain magnetic resonance imaging(MRI) indicated diffuse cerebral and cerebellar atrophy, white matter damage. Blood biochemistry, lactic acid, acid-base balancewere normal. Electron microscopic examination of peripheral blood lymphocytes showed swelling of the nucleus, autophagy, intracellular massive deposits and abnormal vacuoles. Two compound heterozygous c.334C> T (p.Arg112Cys) and c.595C> T (p.Arg199Ter) mutations of CLN5 gene were identified in the two siblings, and the proband 3 was c.335G> A (p.Arg199His) homozyousmutation, which were inherited from their unaffected parents. Conclusions: The 3 cases with Finnish variant late infantileneuronal ceroid lipofuscinosises were normal at birth, cognitive and motor function was regressed at preschool age.Brain MRI showed whole brain atrophy, white matter lesions, there were no bovious difference from other neurodegenerative diseases. Blood biochemistry and pathological examination of lymphocytes had no specific changes. The pathogenic genes were CLN5,most are inherited in autosomal recessive way.
According to the detection of hearings ability of children in iodine deficiency areas who was born before and after iodine supplement, the effects of iodine supplement on hearing system development was evaluated. METHOD: Hearing was tested by AS-72 type pure zone diagnostic audiometer(made in Denmark). Hearing of 11-14 years old students were tested before iodine supplement in iodine deficiency areas in 1984, the control was students living in non-iodine deficiency areas. Iodine salt (50 mg/kg) were supplied by the end of 1984, the hearings of children born after one year of iodine supplied were tested in 1999. The result showed that the average hearing threshold of students before iodine supplied in iodine deficiency areas was significance higher than of non-iodine deficiency areas. The hearing of children born after one year of iodine salt supplied in deficient areas had no significant difference from that of normal areas. The development of hearing system might be deteriorated by iodine deficiency during pregnant. It was able to meet the need of iodine that pregnant women ate 1:20 thousands iodine salt.
Total serum IgE and house dust-specific IgE antibodies were checked in 217 healthy subjects aged from birth to 39 years and 67 newly diagnosed asthmatic children in order to study their developmental patterns in normal Chinese and evaluate their clinical usefulness in the diagnosis and treatment of bronchial asthma. The serum IgG concentrations were determined by using Phadebas IgE PRIST kits and specific IgE antibodies by Phadebas RAST kits purchased from Pharmacia, Sweden. The results showed: 1) The serum IgE increased gradually after birth, approached adult level at 3-4 years of age, continued to rise to peak at 14-16 years of age and then declined to the adult level; 2) The house dust-specific IgE antibodies increased after birth, peaked at 5-6 years of age and then declined; 3) The serum IgE was increased (greater than mean + 2SD) in 64.2% (43/67) of asthmatic children and house dust-specific IgE antibody in 62.7% (42/67) and 4) While in asthmatic children, there was a positive correlation (r = + 0.67) between serum IgE concentrations and house dust specific IgE antibodies, no such relation was found for healthy children. It is, therefore, concluded that determinations of serum IgE and house dust-specific IgE antibody are of help in the diagnosis and treatment of childhood asthma.