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573 records – page 1 of 58.

The 5alpha-reductase type II A49T and V89L high-activity allelic variants are more common in men with prostate cancer compared with the general population.

https://arctichealth.org/en/permalink/ahliterature173682
Source
Eur Urol. 2005 Oct;48(4):679-85
Publication Type
Article
Date
Oct-2005
Author
Yvonne L Giwercman
Per-Anders Abrahamsson
Aleksander Giwercman
Virgil Gadaleanu
Göran Ahlgren
Author Affiliation
Department of Urology, Malmö University Hospital, Lund University, Wallenberg Laboratory, entrance 46, SE - 205 02 Malmö, Sweden. yvonne.giwercman@kir.mas.lu.se
Source
Eur Urol. 2005 Oct;48(4):679-85
Date
Oct-2005
Language
English
Publication Type
Article
Keywords
3-Oxo-5-alpha-Steroid 4-Dehydrogenase - blood - genetics
Aged
Alanine
Alleles
Arginine
Case-Control Studies
Dihydrotestosterone - blood
Disease Progression
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Glutamine
Humans
Leucine
Luteinizing Hormone - blood
Male
Middle Aged
Point Mutation
Polymorphism, Genetic
Prostatic Hyperplasia - blood - epidemiology - genetics
Prostatic Neoplasms - blood - epidemiology - genetics
Receptors, Androgen - blood - genetics
Risk factors
Sex Hormone-Binding Globulin - metabolism
Sweden - epidemiology
Terminal Repeat Sequences
Testosterone - blood
Threonine
Tumor Markers, Biological - blood
Valine
Abstract
To compare men with prostate disease with those from the general population regarding polymorphisms in the androgen receptor gene and in the 5alpha-reductase II (SRD5A2) gene.
The SRD5A2 polymorphisms A49T, V89L and R227Q, the androgen receptor CAG and GGN repeats and sex hormone status was investigated in men with prostate cancer (CaP) (n=89), benign prostate hyperplasia (n=45) and healthy military conscripts (n=223).
The SRD5A2 high-activity allele variants A49T AT and V89L LL were more frequent in CaP-patients compared to general population, p=0.026 and p=0.05, respectively. CaP progression was, however, independent of SRD5A2 variants. In contrary, men with GGN
PubMed ID
16039774 View in PubMed
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A 10-year follow up of reproductive function in women treated for childhood cancer.

https://arctichealth.org/en/permalink/ahliterature113054
Source
Reprod Biomed Online. 2013 Aug;27(2):192-200
Publication Type
Article
Date
Aug-2013
Author
S N Nielsen
A N Andersen
K T Schmidt
C. Rechnitzer
K. Schmiegelow
J G Bentzen
E C Larsen
Author Affiliation
The Fertility Clinic, The Juliane Marie Centre, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Source
Reprod Biomed Online. 2013 Aug;27(2):192-200
Date
Aug-2013
Language
English
Publication Type
Article
Keywords
Abortion, Spontaneous - blood - chemically induced - etiology - pathology
Adult
Anti-Mullerian Hormone - blood
Antineoplastic Agents - adverse effects - therapeutic use
Cohort Studies
Denmark
Female
Follow-Up Studies
Humans
Infertility, Female - chemically induced - complications - etiology - pathology
Live Birth
Menstruation Disturbances - chemically induced - complications - etiology - pathology
Neoplasms - complications - drug therapy - radiotherapy
Ovary - drug effects - pathology - radiation effects
Pregnancy
Primary Ovarian Insufficiency - chemically induced - complications - etiology - pathology
Remission Induction
Risk
Survivors
Young Adult
Abstract
Previously, this study group found that female childhood cancer survivors could be at risk of early cessation of fertility. The aim of the present study was to evaluate reproductive function in the same group of survivors 10 years after the initial study. Of the original cohort of 100, 71 were re-examined. Thirty-six survivors reported regular menstrual cycles. When they were compared with 210 controls, they differed significantly in antral follicle count (AFC) (median 15 versus 18, P=0.047) but not in anti-Müllerian hormone (AMH) (median 13.0 versus 17.8 pmol/l). Survivors cured with minimal gonadotoxic treatment had significantly higher AMH and AFC compared with survivors cured with either potentially gonadotoxic treatment or treatment including alkylating chemotherapy and ovarian irradiation (20.0, 5.8 and
PubMed ID
23768622 View in PubMed
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131I dose-dependent thyroid autoimmune disorders in children living around Chernobyl.

https://arctichealth.org/en/permalink/ahliterature34164
Source
Clin Immunol Immunopathol. 1997 Sep;84(3):251-9
Publication Type
Article
Date
Sep-1997
Author
E V Vykhovanets
V P Chernyshov
I I Slukvin
Y G Antipkin
A N Vasyuk
H F Klimenko
K W Strauss
Author Affiliation
Laboratory of Immunology, Institute of Pediatrics, Obstetrics and Gynecology, Kiev, Ukraine.
Source
Clin Immunol Immunopathol. 1997 Sep;84(3):251-9
Date
Sep-1997
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Adolescent
Autoantibodies - blood
Autoimmune Diseases - etiology
Child
Humans
Iodine Radioisotopes - adverse effects
Lymphocyte Count
Lymphocyte Subsets - chemistry - immunology
Radioactive fallout
Radioactive Pollutants - adverse effects
Thyroglobulin - immunology
Thyroid Diseases - immunology
Thyroid Gland - ultrasonography
Thyroid Hormones - blood
Thyrotropin - blood
Ukraine
Abstract
We assessed the major lymphocyte subsets in the peripheral blood, thyroid ultrasonography, levels of serum autoantibodies to thyroglobulin (AbTg), thyroid hormones, and thyroid-stimulating hormone (TSH) in 53 children without any chronic diseases living continuously around Chernobyl. The subjects ranged in age from 7 to 14 years and had different doses of 131I to their thyroid. Healthy children living on noncontaminated areas were assessed as controls. The majority of children with doses of 131I had normal levels of thyroid hormones. However, the percentages of positive sera for AbTg, TSH levels, ultrasonographic thyroid abnormalities, and abnormal echogenicity were significantly higher in children with doses of 131I than in controls. The dose of 131I to thyroid correlated positively with serum AbTg levels, percentage of CD3+CD4+ cells, and CD3+CD4+/CD3+CD8+ cell ratio and negatively with number of CD3+CD8+ and CD3-/CD16, CD56+ cells. Thus, our study demonstrates an association between dose of 131I and autoimmune thyroid disorders in this population of children.
PubMed ID
9281383 View in PubMed
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The A1330V polymorphism of the low-density lipoprotein receptor-related protein 5 gene (LRP5) associates with low peak bone mass in young healthy men.

https://arctichealth.org/en/permalink/ahliterature165637
Source
Bone. 2007 Apr;40(4):1006-12
Publication Type
Article
Date
Apr-2007
Author
Anne Saarinen
Ville-Valtteri Välimäki
Matti J Välimäki
Eliisa Löyttyniemi
Kirsi Auro
Piia Uusen
Mairi Kuris
Anna-Elina Lehesjoki
Outi Mäkitie
Author Affiliation
Folkhälsan Institute of Genetics and Department of Medical Genetics, University of Helsinki, Helsinki, Finland.
Source
Bone. 2007 Apr;40(4):1006-12
Date
Apr-2007
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Alleles
Bone Density - genetics
Calcifediol - blood
Finland
Fractures, Bone - etiology - genetics
Gene Frequency
Humans
LDL-Receptor Related Proteins - genetics
Low Density Lipoprotein Receptor-Related Protein-5
Male
Military Personnel
Osteoporosis - etiology - genetics
Parathyroid Hormone - blood
Polymorphism, Single Nucleotide
Risk factors
Abstract
Polymorphisms in the gene coding for low-density lipoprotein receptor-related protein 5 (LRP5) contribute to variation in bone mass in the general population. Whether this is due to influence on bone mass acquisition or on bone loss thereafter has not been established.
We studied the association of LRP5 polymorphisms with peak bone mass in young men. The study included 235 Finnish men, aged 18.3 to 20.6 years. Lifestyle factors and fracture history were recorded. Bone mineral content (BMC), density (BMD) and scan area were measured for the lumbar spine and proximal femur by dual energy X-ray absorptiometry (DXA). Blood and urine were collected for determination of bone turnover markers, serum 25-OHD and PTH. Genomic DNA was extracted from peripheral blood for genetic analysis of LRP5. Ten single nucleotide polymorphisms in LRP5 were analyzed and correlated with bone parameters.
Only the A1330V polymorphism of LRP5 significantly associated with bone parameters. In comparison with subjects with the AlaAla genotype (n=215), those with AlaVal genotype (n=20) had lower femoral neck BMC (P=0.029) and BMD (P=0.012), trochanter BMC (P=0.0067) and BMD (P=0.015), and total hip BMC (P=0.0044) and BMD (P=0.0089). Fracture history was similar for the genotypes.
The polymorphic valine variant at position 1330 of LRP5 was significantly associated with reduced BMC and BMD values in healthy young Finnish men. The results provide evidence for the crucial role of LRP5 in peak bone mass acquisition.
PubMed ID
17223614 View in PubMed
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Accelerated pubertal development in patients with shunted hydrocephalus.

https://arctichealth.org/en/permalink/ahliterature34773
Source
Arch Dis Child. 1996 Jun;74(6):490-6
Publication Type
Article
Date
Jun-1996
Author
T. Löppönen
A L Saukkonen
W. Serlo
P. Tapanainen
A. Ruokonen
M. Knip
Author Affiliation
Department of Paediatrics, University of Oulu, Finland.
Source
Arch Dis Child. 1996 Jun;74(6):490-6
Date
Jun-1996
Language
English
Publication Type
Article
Keywords
Adolescent
Anthropometry
Breast - growth & development
Cerebrospinal Fluid Shunts
Child
Cross-Sectional Studies
Female
Gonadal Steroid Hormones - blood
Gonadotropins, Pituitary - blood
Humans
Hydrocephalus - complications - physiopathology - surgery
Male
Menarche - physiology
Puberty - physiology
Puberty, Precocious - etiology
Research Support, Non-U.S. Gov't
Testis - growth & development
Abstract
OBJECTIVE: To evaluate pubertal development and peripheral concentrations of gonadotrophins and sex hormones in children with shunted hydrocephalus compared with healthy controls. STUDY DESIGN: 114 patients (52 females, 62 males) and 73 healthy controls (35 females, 38 males) aged 5 to 20 years were analysed for stage of puberty, age at menarche, testicular volume, basal serum follicle stimulating hormone (FSH), luteinising hormone (LH), sex hormone binding globulin (SHBG), testosterone and oestradiol concentrations, and free androgen index. RESULTS: Male gonadal and male and female pubic hair development occurred significantly earlier in the patients than in the controls. The mean age at menarche was significantly lower in the female patients than in their controls (11.7 v 13.2 years; p
PubMed ID
8758123 View in PubMed
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[Activity of enzymatic antioxidant system in the rat tissues under conditions of over- and restricted nutrition]

https://arctichealth.org/en/permalink/ahliterature97370
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Publication Type
Article
Author
Iu V Nikitchenko
V M Dziuba
A S Popovych
V V Bondar
H O Sheremet
Source
Ukr Biokhim Zh. 2009 Nov-Dec;81(6):104-10
Language
Ukrainian
Publication Type
Article
Keywords
Animals
Animals, Newborn
Antioxidants - metabolism
Caloric Restriction
Glutathione Peroxidase - metabolism
Lipid Peroxides - blood - metabolism
Liver - enzymology - metabolism
Male
Overnutrition - blood - enzymology
Oxidation-Reduction
Rats
Rats, Wistar
Thyroid Hormones - blood
Abstract
The state of enzymatic antioxidant system and thyroid status in the rat tissues under early postnatal overnutrition leading to shortening of life-span and calorie-restricted diet extending lifespan have been studied. It was found that the concentration of thyroxine, body weight and content of lipid hydroperoxides in the blood serum and liver post-mitochondrial fraction of rats had been reliably increased. At the same time the concentration of GSH and GSSG, superoxide dismutase, Se-dependent glutathione peroxidase (GP) activities in the liver and GP activity in the blood serum of experimental rats were reduced. The use of calorie-restricted diet for 2 months showed considerable decrease of thyroxine and triiodothyronine concentration, body weight and the content of lipid hydroperoxides in the blood serum of experimental rats compared with control. At the same time GP activity in the liver, Se-dependent GP activity and content of ceruloplasmin in blood of experimental rats were essentially enhanced. The obtained results allow to conclude that from all studied indices the activity of GSH-dependent antioxidant system (especially Se-dependent GP activity) and thyroid status revealed the most sensible changes in response to the used kind of nutrition. Unlike hypocaloric diet overnutrition results in a decrease of Se-dependent GP activity in the liver and blood of rats. That may be the most crucial moment in the maintenance of prooxidant-antioxidant balance of tissues.
PubMed ID
20387664 View in PubMed
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Activity of the pituitary-gonadal axis is increased prior to the onset of spawning migration of chum salmon.

https://arctichealth.org/en/permalink/ahliterature90768
Source
J Exp Biol. 2009 Jan;212(Pt 1):56-70
Publication Type
Article
Date
Jan-2009
Author
Onuma Takeshi A
Sato Shunpei
Katsumata Hiroshi
Makino Keita
Hu Weiwei
Jodo Aya
Davis Nancy D
Dickey Jon T
Ban Masatoshi
Ando Hironori
Fukuwaka Masa-Aki
Azumaya Tomonori
Swanson Penny
Urano Akihisa
Author Affiliation
Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, Fukuoka 812-8581, Japan. takeshikiai@msn.com
Source
J Exp Biol. 2009 Jan;212(Pt 1):56-70
Date
Jan-2009
Language
English
Publication Type
Article
Keywords
Age Factors
Analysis of Variance
Animal Migration - physiology
Animals
DNA Primers - genetics
DNA, Mitochondrial - genetics
Follicle Stimulating Hormone, beta Subunit - metabolism
Gonadal Steroid Hormones - blood
Gonads - metabolism - physiology
Haplotypes - genetics
Microarray Analysis
Oncorhynchus keta - physiology
Pacific Ocean
Pituitary Gland - metabolism - physiology
RNA, Messenger - metabolism
Radioimmunoassay
Reverse Transcriptase Polymerase Chain Reaction
Seasons
Sexual Behavior, Animal - physiology
Abstract
The activity of the pituitary-gonadal axis (PG axis) in pre-migratory and homing chum salmon was examined because endocrine mechanisms underlying the onset of spawning migration remain unknown. Pre-migratory fish were caught in the central Bering Sea in June, July and September 2001, 2002 and 2003, and in the Gulf of Alaska in February 2006. They were classified into immature and maturing adults on the basis of gonadal development. The maturing adults commenced spawning migration to coastal areas by the end of summer, because almost all fish in the Bering Sea were immature in September. In the pituitaries of maturing adults, the copy numbers of FSHbeta mRNA and the FSH content were 2.5- to 100-fold those of the immature fish. Similarly, the amounts of LHbeta mRNA and LH content in the maturing adults were 100- to 1000-fold those of immature fish. The plasma levels of testosterone, 11-ketotestosterone and estradiol were higher than 10 nmol l(-1) in maturing adults, but lower than 1.0 nmol l(-1) in immature fish. The increase in the activity of the PG-axis components had already initiated in the maturing adults while they were still in the Gulf of Alaska in winter. In the homing adults, the pituitary contents and the plasma levels of gonadotropins and plasma sex steroid hormones peaked during upstream migration from the coast to the natal hatchery. The present results thus indicate that the seasonal increase in the activity of the PG axis is an important endocrine event that is inseparable from initiation of spawning migration of chum salmon.
PubMed ID
19088211 View in PubMed
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Actual practice vs guidelines in laboratory monitoring of older patients with primary hypothyroidism in primary care.

https://arctichealth.org/en/permalink/ahliterature169851
Source
Aging Clin Exp Res. 2006 Feb;18(1):34-9
Publication Type
Article
Date
Feb-2006
Author
Seija I Eskelinen
Raimo E Isoaho
Sirkka-Liisa Kivelä
Kerttu M Irjala
Author Affiliation
Department of Family Medicine, University of Turku, Lemminkiisenkatu 1, FIN-20014 Turku, Finland. seija.eskelinen@utu.fi
Source
Aging Clin Exp Res. 2006 Feb;18(1):34-9
Date
Feb-2006
Language
English
Publication Type
Article
Keywords
Adult
Aged
Female
Finland
Follow-Up Studies
Guidelines as Topic
Hormone Replacement Therapy
Humans
Hypothyroidism - blood - therapy
Laboratories - standards
Male
Middle Aged
Primary Health Care
Thyroid Function Tests
Thyrotropin-Releasing Hormone - blood
Thyroxine - blood - therapeutic use
Abstract
Clinical guidelines are produced in order to achieve an acceptable standard of care, especially for patients with common diseases in primary care. The treatment of primary hypothyroidism serves as an example of the content of clinical guidelines and actual practice. The aim of this study was to compare the follow-up of primary hypothyroidism by thyroid function tests, serum TSH and serum-free T4, in older patients managed in primary care, with recommendations in treatment guidelines and textbooks.
Participation rate 82% (n=1260), mean age 74 years, (range 64-100 yrs). Patients with primary hypothyroidism were identified by means of cross-sectional survey (Lieto Study 1998-1999) and 4-year retrospective collection of laboratory database medical records (1994-1998), performed in autumn 2003.
In most stable (=treated for more than 14 months) thyroxine users, both serum TSH (mean 1.4 measurements/year) and serum-free T4 (mean 0.8 measurements/year) values were measured over the 4-year period of thyroxine treatment. 66.4% of serum TSH and 85.3% of serum-free T4 values were within normal range. 41.7% of serum-free T4 determinations had been performed without indication (=with TSH in normal range).
Compared with the recommended testing frequency given in various guidelines, a considerable number of extra measurements, especially serum-free T4, were performed. However, some key issues in the recommendations were difficult to interpret, and the age or other main characteristics of the patient were not taken into consideration adequately.
PubMed ID
16608134 View in PubMed
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[A diagnostic oriented approach to amenorrhea].

https://arctichealth.org/en/permalink/ahliterature244482
Source
S Afr Med J. 1981 May 16;59(21):741-6
Publication Type
Article
Date
May-16-1981
Author
J V van der Merwe
Source
S Afr Med J. 1981 May 16;59(21):741-6
Date
May-16-1981
Language
Afrikaans
Publication Type
Article
Keywords
Amenorrhea - classification - diagnosis - epidemiology - etiology
Diagnosis, Differential
Female
Humans
Luteinizing Hormone - blood
Menotropins - blood
Progesterone - diagnostic use
Sweden
Abstract
A practical approach to the diagnosis of amenorrhea is presented. By utilizing a flow-chart 410 patients with amenorrhea were categorized in the following groups: (i) polycystic ovarian disease; (ii) hypergonadotrophic amenorrhoea; (iii) hyperprolactinaemic amenorrhoea; (iv) normogonadotrophic amenorrhoea; and (v) hypergonadotrophic amenorrhoea. This approach helps the practising physician to come to a logical aetiological diagnosis in each category and saves time as well as money. This approach depends on clinical as well as appropriate laboratory examinations, most of which can be done by the private practitioner. Only a minority of patients need sophisticated and costly examinations.
PubMed ID
6785889 View in PubMed
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Adrenal incidentaloma - follow-up results from a Swedish prospective study.

https://arctichealth.org/en/permalink/ahliterature82738
Source
Eur J Endocrinol. 2006 Mar;154(3):419-23
Publication Type
Article
Date
Mar-2006
Author
Bülow Birgitta
Jansson Svante
Juhlin Claes
Steen Lars
Thorén Marja
Wahrenberg Hans
Valdemarsson Stig
Wängberg Bo
Ahrén Bo
Author Affiliation
Department of Medicine, Ryhov Hospital, Jönköping, Sweden. b.bulow@telia.com
Source
Eur J Endocrinol. 2006 Mar;154(3):419-23
Date
Mar-2006
Language
English
Publication Type
Article
Keywords
Adrenal Cortex Hormones - blood
Adrenal Gland Neoplasms - epidemiology - pathology - surgery
Adrenalectomy
Adult
Aged
Aged, 80 and over
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prospective Studies
Risk assessment
Sweden - epidemiology
Tomography, X-Ray Computed
Abstract
OBJECTIVES: To examine the risk of developing adrenal carcinomas and clinically overt hypersecreting tumours during short-term follow-up in patients with adrenal incidentalomas. DESIGN: 229 (98 males and 131 females) patients with adrenal incidentalomas were investigated in a prospective follow-up study (median time 25 months; range 3-108 months). The patients were registered between January 1996 and July 2001 and followed until December 2004. Twenty-seven Swedish hospitals contributed with follow-up results. METHODS: Diagnostic procedures were undertaken according to a protocol including reinvestigation with computed tomography scans after 3-6 months, 15-18 months and 27-30 months, as well as hormonal evaluation at baseline and after 27-30 months of follow-up. Operation was recommended when the incidentaloma size increased or if there was a suspicion of a hypersecreting tumour. RESULTS: The median age at diagnosis of the 229 patients included in the follow-up study was 64 years (range 28-84 years) and the median size of the adrenal incidentalomas when discovered was 2.5 cm (range 1-8 cm). During the follow-up period, an increase in incidentaloma size of > or =0.5 cm was reported in 17 (7.4%) and of > or =1.0 cm was reported in 12 (5.2%) of the 229 patients. A decrease in size was seen in 12 patients (5.2%). A hypersecreting tumour was found in 2% of the hormonally investigated patients: Cushing's syndrome (n = 2) and phaeochromocytoma (n = 1). Eleven patients underwent adrenalectomy, but no cases of primary adrenal malignancy were observed. CONCLUSIONS: Patients with adrenal incidentaloma had a low risk of developing malignancy or hormonal hypersecretion during a short-term follow-up period.
PubMed ID
16498055 View in PubMed
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573 records – page 1 of 58.