In the article about The First Naval Hospital, that became famous during the Great Patriotic War, the authors present the facts of the heroic work of the hospital and its staff under the hardest conditions of the Siege of Leningrad, in an atmosphere of constant shelling, its productive clinical and scientfic work during the war years (1941-1945). As a material for the preparation of this article were used documents of the Military-Medical Museum, factual information about the history of the hospital published in various sources.
Over 45 years ago, Montreal Platelet Syndrome was first described as a rare inherited platelet disorder characterised by macrothrombocytopenia with spontaneous platelet clumping, abnormal platelet shape change upon stimulation and a defect in platelet calpain. This syndrome has now been reclassified as type 2B von Willebrand disease with the V1316M VWF mutation in the only kindred ever reported. We herein revisit the historical platelet characteristics originally described in Montreal Platelet Syndrome in light of the new diagnosis. This paper will review the 45-year saga of Montreal Platelet Syndrome, a story that highlights the value of revisiting a rare diagnosis to look for a more common explanation.
For three decades after Marshall Hall's 1856 strictures against "forcing methods" and bellows for artificial ventilation (AV), human "forced respiration" (equivalent to intermittent positive pressure ventilation) was virtually abandoned. Various arm-chest manoeuvres often proved inadequate to save life. After doctor and engineer George Fell, of Buffalo (New York) (1849-1918), failed to save the life of an opiate-poisoned patient using Silvester's popular method, he resolved to try his animal laboratory AV method (bellows and tracheotomy). Following his first success in a landmark case (1887), he better adapted the apparatus for human use and soon succeeded with further difficult cases, but was unable to raise enthusiasm for his "Fell method" of AV. His reports of successful rescues to prestigious Washington Congresses met derision (1887) and indifference (1893), although by then they detailed 28 "human lives saved", mostly after opiate poisoning, and a switch from tracheotomies to face masks (simpler, but with a few complications). Continuing with rescues throughout the 1890s, Fell personally achieved recoveries after AV for as long as 73.5 hours (1896), and over 78 hours (1899). He argued for his method repeatedly with many talks, much documentation, and pleas for its use in other ventilatory crises. Despite his endeavours and successes, Fell was unable to secure widespread uptake of forced respiration, but others adopted his principles. Joseph O'Dwyer modified Fell's face mask-tracheotomy system by incorporating an intralaryngeal tube, and this "Fell-O'Dwyer apparatus" was used for neurosurgical cases (1894), also revolutionising intrathoracic surgery (1899).