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80 records – page 1 of 8.

A 2-dose regimen of a recombinant hepatitis B vaccine with the immune stimulant AS04 compared with the standard 3-dose regimen of Engerix-B in healthy young adults.

https://arctichealth.org/en/permalink/ahliterature56626
Source
Scand J Infect Dis. 2002;34(8):610-4
Publication Type
Article
Date
2002
Author
K. Levie
I. Gjorup
P. Skinhøj
M. Stoffel
Source
Scand J Infect Dis. 2002;34(8):610-4
Date
2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Belgium
Comparative Study
Denmark
Dose-Response Relationship, Drug
Female
Hepatitis B - prevention & control
Hepatitis B Antibodies - analysis
Hepatitis B Surface Antigens - analysis
Hepatitis B vaccines - administration & dosage
Humans
Immunity - physiology
Immunization - methods
Immunization Schedule
Male
Reference Values
Research Support, Non-U.S. Gov't
Sensitivity and specificity
Single-Blind Method
Vaccines, Synthetic - administration & dosage
Abstract
An open-label randomized study was undertaken to compare a 2-dose regimen (Months 0 and 6) of hepatitis B surface antigen (HBsAg) vaccine formulated with a novel adjuvant (HBsAg/AS04) with a standard 3-dose regimen (Months 0, 1 and 6) of licensed recombinant HBsAg vaccine in terms of immunogenicity and reactogenicity when administered to healthy subjects aged between 15 and 40 y. At 1 and 6 months after the full vaccination course there was a 100% seroprotection rate (anti-HBs > or = 10 mIU/ml) with the HBsAg/AS04 vaccine, compared with a 99% response rate with the licensed vaccine. The corresponding geometric mean titres were significantly higher for the novel vaccine compared to the standard vaccine: 15,468 and 2,745 mIU/ml at Months 7 and 12 vs. 6,274 and 1,883 mIU/ml, respectively. There was a higher prevalence of local symptoms with the adjuvant vaccine (90% of doses) than with the standard vaccine (48% of doses). However, these symptoms (pain, swelling and redness) were predominantly of mild-to-moderate intensity and resolved rapidly without treatment. A 2-dose regimen of the new HBsAg/AS04 adjuvant vaccine therefore compared favourably to the standard regimen in healthy young adults. It is anticipated that the simplified vaccination schedule may improve compliance and reduce costs.
PubMed ID
12238579 View in PubMed
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Alanine aminotransferase, gamma-glutamyltransferase, antibodies to hepatitis B core antigen and antibodies to hepatitis C virus in blood donor screening. A prospective study in Finland.

https://arctichealth.org/en/permalink/ahliterature227650
Source
Vox Sang. 1991;60(4):219-24
Publication Type
Article
Date
1991
Author
F. Ebeling
Author Affiliation
Finnish Red Cross Blood Transfusion Service, Helsinki.
Source
Vox Sang. 1991;60(4):219-24
Date
1991
Language
English
Publication Type
Article
Keywords
Alanine Transaminase - analysis
Blood Donors
Blood Transfusion - standards
Finland
Hepacivirus - immunology
Hepatitis Antibodies - analysis
Hepatitis B Antibodies - analysis
Hepatitis B Core Antigens - immunology
Hepatitis C - transmission
Humans
Prospective Studies
gamma-Glutamyltransferase - analysis
Abstract
Alanine aminotransferase (ALT), gamma-glutamyl-transferase and hepatitis B core antibodies were evaluated as donor markers in a prospective study of 685 open-heart surgery patients. Of these three surrogate markers, only an ALT level greater than or equal to 2 SD above the log mean had a significant association with recipient non-A, non-B hepatitis (NANBH, p = 0.02). Antibodies to the hepatitis C virus (anti-HCV) were detected by an enzyme immunoassay in 7 of the 136 units transfused to the 11 NANBH patients and 29 of 3,650 not associated with hepatitis (p less than 0.001). Calculated from this subgroup of donors, the anti-HCV test would have a 15.6% positive predictive value with 0.92% donor loss and thus is superior as a primary screening marker to all the three surrogate tests. The predictive value could be substantially increased by subsequent ALT testing or by the use of a recombinant immunoblot anti-HCV assay.
Notes
Comment In: Vox Sang. 1992;62(4):246-71642006
PubMed ID
1681620 View in PubMed
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An epidemic of hepatitis B virus infection among intravenous drug users in Iceland.

https://arctichealth.org/en/permalink/ahliterature11369
Source
Eur J Epidemiol. 1995 Aug;11(4):397-402
Publication Type
Article
Date
Aug-1995
Author
A. Löve
B. Stanzeit
Author Affiliation
Department of Medical Virology, University of Iceland, Reykjavík, Iceland.
Source
Eur J Epidemiol. 1995 Aug;11(4):397-402
Date
Aug-1995
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Disease Outbreaks
Female
Hepatitis B - epidemiology - immunology - transmission
Hepatitis B Antibodies - analysis
Humans
Iceland - epidemiology
Incidence
Male
Middle Aged
Sex Distribution
Substance Abuse, Intravenous - complications
Survival Rate
Abstract
This study describes an outbreak of hepatitis B primarily among intravenous drug users in Iceland which has a population with a very low incidence of hepatitis B virus infection. The incidence of acute hepatitis B is generally low in the Nordic Countries, in the order of one to five cases per 100,000 people per year. Between 1989 and 1992 there was an outbreak of hepatitis B virus infection primarily among the intravenous drug user (IVDU) population in Iceland. At the Department of Medical Virology, University of Iceland there were 44 cases of acute hepatitis B identified during the peak year 1990, an incidence of 16.9 cases of acute hepatitis B per 100,000 people. 63.6% of these were known to be IVDUs. The seroprevalence of the hepatitis B core antibody (anti-HBc) marker was assessed among 1100 randomly selected individuals. The average prevalence of this marker was 2.9% and rose from zero at the age of 15 and younger to 6.5% at the age of 65 and older. Among IVDUs attending a detoxification clinic in 1990 the prevalence of the anti-HBc was 32%. In contrast, those attending the same clinic, due to alcoholism only, did not have a significantly higher prevalence of anti-HBc than the group used for comparison.
PubMed ID
8549706 View in PubMed
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[Antibodies against hepatitis B among health personnel at Karolinska Hospital]

https://arctichealth.org/en/permalink/ahliterature56978
Source
Lakartidningen. 1983 Sep 7;80(36):3174-5
Publication Type
Article
Date
Sep-7-1983

Antibodies against hepatitis viruses in merchant seamen.

https://arctichealth.org/en/permalink/ahliterature56804
Source
Scand J Infect Dis. 1995;27(3):191-4
Publication Type
Article
Date
1995
Author
H L Hansen
P L Andersen
L. Brandt
O. Broløs
Author Affiliation
Institute of Maritime Medicine, South Jutland University Centre, Esbjerg, Denmark.
Source
Scand J Infect Dis. 1995;27(3):191-4
Date
1995
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cross-Sectional Studies
Denmark - epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Hepacivirus - immunology
Hepatitis A - epidemiology - immunology - prevention & control
Hepatitis A Antibodies
Hepatitis Antibodies - analysis
Hepatitis B - epidemiology - immunology - prevention & control
Hepatitis B Antibodies - analysis
Hepatitis B virus - immunology
Hepatitis C - epidemiology - immunology - prevention & control
Hepatitis C Antibodies - analysis
Hepatovirus - immunology
Humans
Male
Middle Aged
Naval Medicine
Prevalence
Research Support, Non-U.S. Gov't
Risk factors
Sexual Behavior
Travel
Vaccination
Abstract
Seamen constitute a special group of international travellers who may run an increased risk of contracting hepatitis, because of visits to foreign ports and the particular environment on board ship. The purpose of the survey was to assess the prevalence of serological markers for hepatitis A, B and C virus infection among seamen and to identify present and previous risk factors for infection. 515 seamen were studied. The prevalence of antibodies against hepatitis A was 0.3% in subjects below 40 years of age, increasing with age above 40 years, and highest among those who had sailed in international trade. The prevalence of antibodies against hepatitis B was 2.7% in subjects below 40 years of age, increasing to 35.7% in the group above 60 years of age. Hepatitis C antibodies occurred in 1.2%. Vaccination of sailors against hepatitis A should follow the same recommendations as to other travellers. The prevalence of hepatitis B was higher than in reference groups of non-seamen but, because hepatitis B is only one of many blood-borne diseases, prevention should be directed towards changes in behaviour rather than vaccination, except for special groups. Young seamen in international trade were found to be most at risk of contracting sexually transmitted diseases.
PubMed ID
8539539 View in PubMed
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Antibodies to hepatitis B core in Danish blood donors: a surrogate marker for 'high-risk' behaviour?

https://arctichealth.org/en/permalink/ahliterature56634
Source
Vox Sang. 2002 Apr;82(3):161; author reply 161
Publication Type
Article
Date
Apr-2002
Author
C. Moore
J. Barbara
P. Hewitt
Source
Vox Sang. 2002 Apr;82(3):161; author reply 161
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Biological Markers - analysis
Blood Donors
Denmark
Eligibility Determination
Female
Hepatitis B Antibodies - analysis
Humans
Male
Prostitution
Risk-Taking
Tattooing
Notes
Comment On: Vox Sang. 1997;72(4):207-109228709
Comment On: Vox Sang. 2001 Nov;81(4):222-711903997
PubMed ID
11952992 View in PubMed
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Antibody to hepatitis B antigen (Australia antigen) among residents of a Finnish institution for the mentally retarded.

https://arctichealth.org/en/permalink/ahliterature252553
Source
Med Biol. 1975 Feb;53(1):51-9
Publication Type
Article
Date
Feb-1975
Author
M. Tevaluoto-Aarnio
B. Werner
W T London
Source
Med Biol. 1975 Feb;53(1):51-9
Date
Feb-1975
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Antibodies - analysis
Carrier state
Child
Child, Preschool
Down Syndrome - immunology
Finland
Hemagglutination inhibition tests
Hepatitis B Antibodies - analysis
Hepatitis B Antigens - analysis
Hepatitis Viruses - immunology
Hospitals, Psychiatric
Humans
Immune Sera
Immunodiffusion
Infant
Intellectual Disability - immunology
Sex Factors
Abstract
Sera from 521 residents of an institution for the mentally retarded near Helsinki, Finland were examined by a hemagglutination assay to determine the distribution and titers of antibodies to hepatitis B surface antigen (anti-HBs). 36.1% were found to contain anti-HBs. Factors were identified which are related to the presence or absence of anti-HBs in this population. A documented past history of hepatitis, living in "asocial" wards in which at least one HBsAg carrier was present, long institutionalization (is greater than 10 yrs.), admission to the institution between ages 5 and 19, a present age between 20 and 39, and being male were associated with the presence of anti-HBs. 43.5% of the males but only 22.2% of the females had antibody. Down's syndrome patients had lower titers but not lower frequencies of anti-HBs than the non Down's patients.
PubMed ID
124806 View in PubMed
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Antibody to hepatitis C virus in selected groups of a Canadian urban population.

https://arctichealth.org/en/permalink/ahliterature224471
Source
Int J Epidemiol. 1992 Feb;21(1):142-5
Publication Type
Article
Date
Feb-1992
Author
C M Anand
K. Fonseca
R P Walle
S. Powell
M. Williams
Author Affiliation
Provincial Laboratory of Public Health for Southern Alberta, Calgary, Canada.
Source
Int J Epidemiol. 1992 Feb;21(1):142-5
Date
Feb-1992
Language
English
Publication Type
Article
Keywords
Alberta - epidemiology
Female
Hepacivirus - immunology
Hepatitis Antibodies - analysis
Hepatitis B Antibodies - analysis
Hepatitis B virus - immunology
Homosexuality
Humans
Male
Prisoners
Risk factors
Seroepidemiologic Studies
Substance Abuse, Intravenous - immunology
Urban Population - statistics & numerical data
Abstract
In an anonymous survey, 433 sera from Canadian individuals of selected categories were tested for the presence of antibody to hepatitis C virus (HCV) using a recombinant antigen-based immunoassay. About 50% of intravenous drug abusers (IVDA), 10% of transfusion recipients and an overall average of 7.9% of male homosexuals were reactive for antibody to HCV. Individuals with jaundice and negative hepatitis B virus (HBV) serology were not reactive for antibody to HCV compared with 26.7% of those with positive HBV serology. Similarly 58% of male Federal prisoners with positive HBV serology were also HCV-antibody reactive compared with 15% of those with negative HBV serology. A prevalence of 1.2% was recorded for individuals not in any of the above groups. Of 433 sera, 92 were reactive and the discrimination in absorbance values between reactive and not reactive samples was good except for 13 sera, eight of which gave values considerably higher than the average negative value and five which were just above the positive threshold.
PubMed ID
1312068 View in PubMed
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Anti-HIV antibodies and other serological and immunological parameters among normal Haitians in Montreal.

https://arctichealth.org/en/permalink/ahliterature103658
Source
J Acquir Immune Defic Syndr. 1990;3(2):166-72
Publication Type
Article
Date
1990
Author
L. Frappier-Davignon
M C Walker
A. Adrien
L A el Badraoui
M. Desrosiers
M V O'Shaughnessy
F. Affoyon
J M Dupuy
Author Affiliation
Preventive Medicine and Epidemiology Research Center, Institut Armand-Frappier, Université du Québec, Laval, Canada.
Source
J Acquir Immune Defic Syndr. 1990;3(2):166-72
Date
1990
Language
English
Publication Type
Article
Keywords
Adult
Animals
Antibodies, Protozoan - analysis
Antibodies, Viral - analysis
Case-Control Studies
Cross-Sectional Studies
Cytomegalovirus - immunology
Female
Follow-Up Studies
HIV Antibodies - analysis
HIV Seroprevalence
Haiti - ethnology
Hepatitis B Antibodies - analysis
Humans
Leukocyte Count
Lymphocytes
Male
Middle Aged
Quebec
Questionnaires
Random Allocation
Toxoplasma - immunology
Abstract
A matched-pair, cross-sectional study of lymphocyte and serological parameters associated with acquired immune deficiency syndrome (AIDS) in 189 randomly chosen, ostensibly healthy adult Haitian immigrants residing in Montreal matched for sex, age (within 5 years), and neighborhood of residence to 189 non-Haitian (Caucasian) controls was done in 1983-1984. Three years later (1986-1987), 41 of the Haitian study subjects and 83 of the non-Haitian controls participated in a follow-up study centered on lymphocyte parameters. A significantly greater number of Haitians than controls had produced antibodies to Toxoplasma gondii. In addition, a greater percentage of the Haitians than the controls were also producing antibodies to two other opportunistic pathogens frequently encountered in AIDS, cytomegalovirus and hepatitis B virus, implying that the Haitians in general had had greater exposure to a variety of infectious agents than had the controls. A few study participants were producing antibodies against two viruses that are related to the human immunodeficiency virus-type 1 (HIV-1), the human T-cell lymphotropic viruses I and II (HTLV-I and -II). Two Haitians and one control were producing antibodies against HTLV-I. One study subject and four controls were HTLV-II seropositive. The most interesting and surprising finding was that four (2.1%) of the Haitian study subjects but none of the controls were seropositive for HIV-1. These individuals, two of whom were women and two men, were asymptomatic. Although their individual lymphocyte parameter values fell in the normal range, as a group they had statistically significantly lower average values for their lymphocyte parameters than did the HIV-seronegative Haitian study objects.(ABSTRACT TRUNCATED AT 250 WORDS)
PubMed ID
2153200 View in PubMed
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[Choice of the suitability criteria of polystyrene-based solid-phase carriers for performing immunoenzyme analyses]

https://arctichealth.org/en/permalink/ahliterature56933
Source
Zh Mikrobiol Epidemiol Immunobiol. 1987 Sep;(9):8-11
Publication Type
Article
Date
Sep-1987
Author
K L Shakhanina
A A Sokolenko
I P Pavlova
L F Evseeva
N S Umnova
Source
Zh Mikrobiol Epidemiol Immunobiol. 1987 Sep;(9):8-11
Date
Sep-1987
Language
Russian
Publication Type
Article
Keywords
Adsorption
Antibodies, Bacterial - analysis
Antibody Specificity
Comparative Study
English Abstract
Evaluation Studies
Francisella tularensis - immunology
Hepatitis B Antibodies - analysis
Hepatitis B Surface Antigens - analysis
Humans
Immunoenzyme Techniques - instrumentation - standards
Indicators and Reagents
Polystyrenes
Reagent kits, diagnostic
Abstract
The authors discuss a tentative approach to the choice of criteria indicating the optimal suitability of different solid-phase carriers made of polystyrene for use in the enzyme immunoassay (EIA), viz. the dependence of specificity, sensitivity, reproducibility and reliability of EIA results on the adsorption properties, transparency expressed in percent and transparency variations of the plates under test. The evaluation of the carriers by four parameters is proposed with the use of assay plates manufactured by Nunc A/S (Denmark) for control. To ensure the objective evaluation of the suitability of polystyrene plates for use in EIA, the choice of uniform criteria is necessary.
PubMed ID
3318247 View in PubMed
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80 records – page 1 of 8.