Skip header and navigation

1 records – page 1 of 1.

Serum ALT levels as a surrogate marker for serum HBV DNA levels in HBeAg-negative pregnant women.

https://arctichealth.org/en/permalink/ahliterature56587
Source
Scand J Infect Dis. 2004;36(3):182-5
Publication Type
Article
Date
2004
Author
Per Sangfelt
Madeleine Von Sydow
Ingrid Uhnoo
Ola Weiland
Gudrun Lindh
Björn Fischler
Susanne Lindgren
Olle Reichard
Author Affiliation
Department of Medical Sciences, Section of Infectious Diseases, Akademiska Hospital, Uppsala, Sweden. per.sangfelt@medsci.uu.se
Source
Scand J Infect Dis. 2004;36(3):182-5
Date
2004
Language
English
Publication Type
Article
Keywords
Adult
Alanine Transaminase - blood
Base Sequence
Biological Markers - blood
Carrier State - transmission
Case-Control Studies
Confidence Intervals
DNA, Viral - analysis
Disease Transmission, Vertical - prevention & control
Female
Hepatitis B - prevention & control - transmission
Hepatitis B e Antigens - analysis
Hepatitis B virus - immunology - isolation & purification
Humans
Infant, Newborn
Mass Screening
Molecular Sequence Data
Polymerase Chain Reaction - methods
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy outcome
Prenatal Care
Probability
Reference Values
Research Support, Non-U.S. Gov't
Retrospective Studies
Sensitivity and specificity
Serologic Tests
Statistics, nonparametric
Sweden
Abstract
In Stockholm, Sweden, the majority of pregnant women positive for hepatitis B surface antigen (HBsAg) are hepatitis Be antigen (HBeAg) negative. Newborns to HBeAg positive mothers receive vaccination and hepatitis B immunoglobulin (HBIg). Newborns to HBeAg negative mothers receive vaccine and HBIg only if the mothers have elevated ALT levels. The aim of this study was to retrospectively evaluate ALT levels as a surrogate marker for HBV DNA levels in HBeAg negative carrier mothers. Altogether 8947 pregnant women were screened for HBV markers from 1999 to 2001 at the Virology Department, Karolinska Hospital. Among mothers screened 192 tested positive for HBsAg (2.2%). 13 of these samples could not be retrieved. Of the remaining 179 sera, 8 (4%) tested positive for HBeAg and 171 (95.5%) were HBeAg negative. Among the HBeAg negative mothers, 9 had HBV DNA levels > 10(5) copies/ml, and of these 7 had normal ALT levels indicating low sensitivity of an elevated ALT level as a surrogate marker for high HBV DNA level. Furthermore, no correlation was found between ALT and HBV DNA levels. Hence, it is concluded that the use of ALT as a surrogate marker for high viral replication in HBeAg negative mothers could be questioned.
PubMed ID
15119362 View in PubMed
Less detail