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21 records – page 1 of 3.

[Administration of activated recombinant factor VII (novo seven) for the control of massive bleeding in gynecology]

https://arctichealth.org/en/permalink/ahliterature30053
Source
Akush Ginekol (Sofiia). 2004;43 Suppl 2:32-5
Publication Type
Article
Date
2004
Author
S. Tanchev
F. Pandurski
A. Georgiev
Iu Gesheva
V. Platikanov
P. Dinov
Source
Akush Ginekol (Sofiia). 2004;43 Suppl 2:32-5
Date
2004
Language
Bulgarian
Publication Type
Article
Keywords
Adult
Child
English Abstract
Factor VII - administration & dosage - therapeutic use
Female
Genital Diseases, Female - blood - drug therapy
Hemorrhage - blood - drug therapy
Hemostasis - drug effects
Humans
Injections, Intravenous
Middle Aged
Recombinant Proteins - administration & dosage - therapeutic use
Treatment Outcome
Abstract
We report our clinical opinion for recombinant activated factor VII (NovoSeven, Novo Nordisk, Copenhagen, Denmark) administration in gynecology patients with massive haemorrhage. 3 women with gynecology deseases and severe bleeding in recieved NovoSeven in bolus IV. The blood loss and laboratory changes in hematology and haemostasis parameters are monitored. The bleeding was ceased in all cases. Decrease in values of Hb, Er and PTT was noted. The use of recombinant factor VIIA in gynecology patients with severe bleeding is effective and safe enough and could be an alternative to the extreme surgical procedures.
PubMed ID
15518274 View in PubMed
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Antiplasmin correlates to arterial reactivity in a healthy population of 35-year-old men and women.

https://arctichealth.org/en/permalink/ahliterature10707
Source
J Intern Med. 1999 Jan;245(1):21-9
Publication Type
Article
Date
Jan-1999
Author
J. Johansson
K. Jensen-Urstad
M. Jensen-Urstad
Author Affiliation
Research Centre of General Medicine, Karolinska Hospital, Stockholm, Sweden. jjo@ame.ks.se
Source
J Intern Med. 1999 Jan;245(1):21-9
Date
Jan-1999
Language
English
Publication Type
Article
Keywords
Adult
Antifibrinolytic Agents - blood - pharmacology
Antiplasmin - metabolism - pharmacology
Brachial Artery
Cardiovascular Diseases - etiology
Endothelium, Vascular - drug effects
Female
Fibrinogen - metabolism
Fibrinolysis - drug effects
Hemostasis - drug effects
Humans
Male
Nitroglycerin - pharmacology
Plasminogen Activator Inhibitor 1 - blood
Random Allocation
Reference Values
Regression Analysis
Research Support, Non-U.S. Gov't
Risk factors
Sweden
Vasodilation - drug effects
Vasodilator Agents - pharmacology
von Willebrand Factor - metabolism
Abstract
OBJECTIVE: To study whether haemostasis function variables correlate with endothelial function and other vasomotion characteristics of the brachial artery in a randomly selected healthy population of 35-year-old men and women. DESIGN: Endothelial function was measured as flow mediated dilatation (FMD) of the brachial artery during reactive hyperaemia and the nonendothelial dependent dilatation after sublingual nitroglycerin (NTG) was administered. Haemostasis and fibrinolysis function were estimated by analysis of von Willebrand factor, plasminogen activator inhibitor-1, antiplasmin and fibrinogen. SETTING: A general medicine research centre and a university hospital. SUBJECTS: Randomly chosen men (n = 53) and women (n = 56). RESULTS: Univariate correlation analysis showed significant correlations between haemostasis factors, conventional risk factors for cardiovascular disease and indices of vasomotion of the brachial artery. In multivariate analysis, with haemostasis variables and conventional risk factors included, antiplasmin was the strongest explanatory variable for FMD. When antiplasmin was removed from the analysis, the r-value dropped from 0.46 to 0.35. Antiplasmin also correlated with NTG-induced dilatation (positively) and brachial diameter at rest (negatively), albeit less consistently. CONCLUSIONS: Antiplasmin correlates significantly and independently to FMD, reflecting endothelial function, and also to brachial artery diameter at rest and nitroglycerin-induced dilatation. In multivariate analysis these correlations of antiplasmin to arterial characteristics were stronger than for 'conventional' risk factors, such as smoking, blood pressure and serum cholesterol.
PubMed ID
10095813 View in PubMed
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Beneficial effect(s) of n-3 fatty acids in cardiovascular diseases: but, why and how?

https://arctichealth.org/en/permalink/ahliterature3153
Source
Prostaglandins Leukot Essent Fatty Acids. 2000 Dec;63(6):351-62
Publication Type
Article
Date
Dec-2000
Author
U N Das
Author Affiliation
EFA Sciences LLC, 1420 Providence Highway, Norwood, MA 02062, USA. undurti@hotmail.com
Source
Prostaglandins Leukot Essent Fatty Acids. 2000 Dec;63(6):351-62
Date
Dec-2000
Language
English
Publication Type
Article
Keywords
Acetylcholine - physiology
Animals
Arrhythmia - epidemiology - prevention & control
Brain - physiopathology
Cardiovascular Diseases - diet therapy - epidemiology - prevention & control
Cell Adhesion Molecules - biosynthesis - genetics
Cell Division - drug effects
Clinical Trials
Cohort Studies
Cytokines - metabolism
Dietary Fats - administration & dosage - pharmacology - therapeutic use
Eicosanoids - metabolism
Endothelium, Vascular - drug effects - metabolism
Exercise
Fatty Acids, Omega-3 - administration & dosage - pharmacology - therapeutic use
Fatty Acids, Unsaturated - metabolism
Fish Oils - administration & dosage - pharmacology - therapeutic use
Gene Expression Regulation - drug effects
Greenland - epidemiology
Heart - drug effects
Hemostasis - drug effects
Humans
Hypothalamo-Hypophyseal System - drug effects - physiopathology
Inflammation - drug therapy - metabolism - prevention & control
Inuits
Japan - epidemiology
Lipid Metabolism
Models, Biological
Myocardium - metabolism
Oxidation-Reduction
Oxidative Stress
Parasympathetic Nervous System - drug effects
Pituitary-Adrenal System - drug effects - physiopathology
Rats
Sodium Channels - drug effects
Vagus Nerve - physiopathology
Abstract
Low rates of coronary heart disease was found in Greenland Eskimos and Japanese who are exposed to a diet rich in fish oil. Suggested mechanisms for this cardio-protective effect focused on the effects of n-3 fatty acids on eicosanoid metabolism, inflammation, beta oxidation, endothelial dysfunction, cytokine growth factors, and gene expression of adhesion molecules; But, none of these mechanisms could adequately explain the beneficial actions of n-3 fatty acids. One attractive suggestion is a direct cardiac effect of n-3 fatty acids on arrhythmogenesis. N-3 fatty acids can modify Na+ channels by directly binding to the channel proteins and thus, prevent ischemia-induced ventricular fibrillation and sudden cardiac death. Though this is an attractive explanation, there could be other actions as well. N-3 fatty acids can inhibit the synthesis and release of pro-inflammatory cytokines such as tumor necrosis factoralpha (TNFalpha) and interleukin-1 (IL-1) and IL-2 that are released during the early course of ischemic heart disease. These cytokines decrease myocardial contractility and induce myocardial damage, enhance the production of free radicals, which can also suppress myocardial function. Further, n-3 fatty acids can increase parasympathetic tone leading to an increase in heart rate variability and thus, protect the myocardium against ventricular arrhythmias. Increased parasympathetic tone and acetylcholine, the principle vagal neurotransmitter, significantly attenuate the release of TNF, IL-1beta, IL-6 and IL-18. Exercise enhances parasympathetic tone, and the production of anti-inflammatory cytokine IL-10 which may explain the beneficial action of exercise in the prevention of cardiovascular diseases and diabetes mellitus. TNFalpha has neurotoxic actions, where as n-3 fatty acids are potent neuroprotectors and brain is rich in these fatty acids. Based on this, it is suggested that the principle mechanism of cardioprotective and neuroprotective action(s) of n-3 fatty acids can be due to the suppression of TNFalpha and IL synthesis and release, modulation of hypothalamic-pituitary-adrenal anti-inflammatory responses, and an increase in acetylcholine release, the vagal neurotransmitter. Thus, there appears to be a close interaction between the central nervous system, endocrine organs, cytokines, exercise, and dietary n-3 fatty acids. This may explain why these fatty acids could be of benefit in the management of conditions such as septicemia and septic shock, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, diabetes mellitus, essential hypertension and atherosclerosis.
Notes
Erratum In: Prostaglandins Leukot Essent Fatty Acids 2001 Jan;64(1):74
PubMed ID
11133172 View in PubMed
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[Biochemical and hemocoagulation criteria for evaluating the risk of nephropathy development in workers with occupational exposure to dust].

https://arctichealth.org/en/permalink/ahliterature144486
Source
Med Tr Prom Ekol. 2010;(1):27-31
Publication Type
Article
Date
2010
Author
E A Tsikalenko
S A Peskov
E L Poteriaeva
E L Smirnova
A Ia Poliakov
E V Gerasimova
A N Bondar'
Source
Med Tr Prom Ekol. 2010;(1):27-31
Date
2010
Language
Russian
Publication Type
Article
Keywords
Biological Markers - blood
Blood Platelets - metabolism
Dust - analysis
Female
Hemostasis - drug effects
Humans
Incidence
Kidney Diseases - blood - chemically induced - epidemiology
Lipid Peroxidation
Male
Middle Aged
Occupational Diseases - blood - epidemiology - etiology
Occupational Exposure - adverse effects
Oxidative Stress
Prognosis
Risk factors
Siberia - epidemiology
Abstract
The authors present main mechanisms and leading pathogenetic factors underlying occupationally mediated dust nephropathies. The article covers results of analysis concerning biochemical and hemocoagulation criteria to evaluate the risk of nephropathy in workers exposed to high concentrations of industrial dust aerosols.
PubMed ID
20364471 View in PubMed
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[Changes in arterial blood fibrinolytic activity in patients with unstable angina on various molecular-weight heparins]

https://arctichealth.org/en/permalink/ahliterature46076
Source
Lik Sprava. 2001 May-Jun;(3):122-30
Publication Type
Article
Author
Ie V Kolodchenko
Source
Lik Sprava. 2001 May-Jun;(3):122-30
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Angina, Unstable - blood - drug therapy
Anticoagulants - therapeutic use
Arteries
Aspirin - therapeutic use
Comparative Study
Drug Therapy, Combination
English Abstract
Fibrinolysis - drug effects
Fibrinolytic Agents - therapeutic use
Hemostasis - drug effects
Heparin - therapeutic use
Humans
Male
Middle Aged
Molecular Weight
Nadroparin - therapeutic use
Time Factors
Veins
Abstract
As many as 40 patients with unstable angina (UA) were examined having been admitted into the clinic during the first twelve hours from the onset of ischemic manifestations. Depending on the type of therapy instituted, the patients were divided into two groups. Group I patients (n = 24) received acetylsalicylic acid (ASA), 160-325 mg daily, and a standard heparin in prescribed doses, group II patients (n = 16) was placed on a combination of ASA plus low-molecular heparin (LMH), nadroparin calcii, 0.1 mg/kg daily. It has been found out that anticoagulant treatment with different forms of heparin with a positive dynamics of general coagulating activity of the blood results in distinct changes in the system of fibrinolysis. Administration of a standard heparin is accompanied by exhaustion of the antithrombin activity of the blood and depression of fibrinolysis, which event comes to be especially dangerous in the arterial vessels. LMH (nadroparin calcii) therapy allows the negative sequelae to be prevented, and, quite the reverse, effects an intensification of fibrinolysis in the artery, this being particularly manifest at day 10 of the illness. A conclusion suggests itself that LMH has a beneficial effect on the system of hemostasis in general and on its fibrinolytic link in particular. Taking into account that the mechanism of action of LMH is toward the arterial blood, the above group of anticoagulants can be regarded as drugs of choice in those settings involving development of UA.
PubMed ID
11559998 View in PubMed
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The effect of acute ingestion of a large dose of alcohol on the hemostatic system and its circadian variation.

https://arctichealth.org/en/permalink/ahliterature10445
Source
Stroke. 2000 Jun;31(6):1269-73
Publication Type
Article
Date
Jun-2000
Author
H. Numminen
M. Syrjälä
G. Benthin
M. Kaste
M. Hillbom
Author Affiliation
Department of Neurology, Oulu University Hospital, Finland.
Source
Stroke. 2000 Jun;31(6):1269-73
Date
Jun-2000
Language
English
Publication Type
Article
Keywords
6-Ketoprostaglandin F1 alpha - analogs & derivatives - urine
Acute Disease
Adult
Alcoholic Intoxication - blood
Biological Markers
Cerebrovascular Accident - blood - epidemiology
Circadian Rhythm - drug effects
Creatinine - urine
Cross-Over Studies
Disease Susceptibility
Drug Administration Schedule
Ethanol - administration & dosage - adverse effects - pharmacology
Fibrinolysis - drug effects
Hemorheology - drug effects
Hemostasis - drug effects - physiology
Humans
Male
Myocardial Infarction - blood - epidemiology
Plasminogen Activator Inhibitor 1 - analysis
Platelet Activation - drug effects
Platelet Aggregation - drug effects
Research Support, Non-U.S. Gov't
Supine Position
Thromboxane B2 - analogs & derivatives - urine
Abstract
BACKGROUND AND PURPOSE: Heavy binge drinking may trigger the onset of embolic stroke and acute myocardial infarction, but the underlying mechanisms are unclear. The effects of binge drinking on the hemostatic system and its circadian variation have not been investigated. We investigated the effects of an acute intake of a large dose of alcohol (1.5 g/kg). METHODS: Twelve healthy, nonsmoking men participated in sessions where they were served ethanol in fruit juice or served fruit juice alone and, lying in a supine position, were followed up for 12 to 24 hours. The treatments were randomized and separated from each other by a 1-week washout period. Blood and urine were collected for hemostatic measurements. RESULTS: The urinary excretion of the platelet thromboxane A(2) metabolite 2, 3-dinor-thromboxane B(2) was significantly (P
PubMed ID
10835443 View in PubMed
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The effect of a menhaden oil-containing diet on hemostatic and lipid parameters of nonhuman primates with atherosclerosis.

https://arctichealth.org/en/permalink/ahliterature238111
Source
Atherosclerosis. 1985 Nov;57(2-3):325-35
Publication Type
Article
Date
Nov-1985
Author
M V Ward
T B Clarkson
Source
Atherosclerosis. 1985 Nov;57(2-3):325-35
Date
Nov-1985
Language
English
Publication Type
Article
Keywords
Animals
Arteriosclerosis - blood - diet therapy - etiology
Bleeding time
Blood Platelets - cytology - drug effects
Cell Survival - drug effects
Diet, Atherogenic
Dietary Fats - pharmacology
Erythrocebus patas
Fish Oils
Greenland
Hemostasis - drug effects
Humans
Inuits
Lipids - blood
Macaca fascicularis
Macaca mulatta
Male
Oils - pharmacology
Platelet Aggregation - drug effects
Abstract
Three species of nonhuman primates were fed an atherogenic diet for 6 months (baseline period) and a menhaden oil (EPA)-containing diet for 8 weeks (test period) during which various hemostatic and lipid parameters were compared. The EPA-rich diet prolonged bleeding times, inhibited platelet aggregation response to ADP and collagen, and increased mean platelet lifespan. This diet elicited an increase in the polyunsaturated fatty acids C20:5 (EPA) and C22:6 (docosahexaenoic acid) at the expense of C18:2 (linoleic acid) and C20:4 (arachidonic acid) in pooled samples of platelet membranes, creating an increase in the ratio of n-3/n-6 polyunsaturated fatty acids. The serum lipid response to a menhaden oil diet comprised a nonsignificant decrease in total serum cholesterol and a significant decrease in HDL cholesterol.
PubMed ID
4084362 View in PubMed
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[Effect of perindopril on hemostasis and functional status of pancreas in patients with ischemic heart disease]

https://arctichealth.org/en/permalink/ahliterature53196
Source
Lik Sprava. 2004 Oct-Nov;(7):34-6
Publication Type
Article
Author
V I Koshlia
L M Zelens'ka
I V Zaïka
A V Zaïka
Source
Lik Sprava. 2004 Oct-Nov;(7):34-6
Language
Ukrainian
Publication Type
Article
Keywords
Angiotensin-Converting Enzyme Inhibitors - administration & dosage - therapeutic use
Biological Markers - analysis
Drug Administration Schedule
English Abstract
Hemostasis - drug effects
Humans
Middle Aged
Myocardial Ischemia - blood - drug therapy - physiopathology
Pancreas - drug effects - physiopathology
Perindopril - administration & dosage - therapeutic use
Treatment Outcome
von Willebrand Factor - analysis
Abstract
Systemic circulation compromise in patients with cardiac insufficiency results in disturbances of functional state of pancreas. The Willebrand's Factor takes a definite role in this pathological process. The usage of Peridopril 4 mg daily during the treatment decreases significantly Willebrand's Factor activity and normalizes function of the pancreas.
PubMed ID
15724609 View in PubMed
Less detail

Effects of alcohol and the evening meal on shear-induced platelet aggregation and urinary excretion of prostanoids.

https://arctichealth.org/en/permalink/ahliterature10334
Source
Alcohol Alcohol. 2000 Nov-Dec;35(6):594-600
Publication Type
Article
Author
H. Numminen
M. Kobayashi
S. Uchiyama
M. Iwata
Y. Ikeda
A. Riutta
M. Syrjälä
R. Kekomäki
M. Hillbom
Author Affiliation
Department of Neurology, Oulu University Hospital, Oulu, Finland.
Source
Alcohol Alcohol. 2000 Nov-Dec;35(6):594-600
Language
English
Publication Type
Article
Keywords
Adult
Analysis of Variance
Ethanol - pharmacology
Hemostasis - drug effects - physiology
Humans
Male
Middle Aged
Plasminogen Activator Inhibitor 1 - blood
Platelet Aggregation - drug effects - physiology
Postprandial Period
Prostaglandins - urine
Research Support, Non-U.S. Gov't
Triglycerides - blood
Wine
von Willebrand Factor - analysis
Abstract
Moderate regular alcohol intake has been found to be associated with a decreased risk for coronary heart disease and stroke. We investigated the effects of acute intake of red wine (60 g ethanol) and a standard dinner under controlled conditions on haemostatic factors. Shear-induced platelet aggregation (SIPA) decreased after the intake of alcohol irrespective of whether the subjects were fasting or not, and also after the intake of food. The intake of alcohol inhibited the postprandial increase of von Willebrand factor multimers. Plasma levels of plasminogen activator inhibitor 1 activity (PAI-1) and serum triglycerides were increased by alcohol. Excretion of the platelet thromboxane A(2) metabolites 11-dehydrothromboxane B(2) and 2,3-dinorthromboxane B(2), as well as the endothelial prostacyclin metabolite 2, 3-dinor-6-ketoprostaglandin F(1)alpha, into urine was not influenced by either alcohol or food. We conclude that eating a dinner together with red wine has no untoward effect on SIPA and that the decrease of SIPA is not specific for alcohol.
PubMed ID
11093967 View in PubMed
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Hemostatic factors and renin in Greenland Eskimos on a high eicosapentaenoic acid intake. Results of the Fifth UmanaK Expedition.

https://arctichealth.org/en/permalink/ahliterature237868
Source
Acta Med Scand. 1986;219(5):473-9
Publication Type
Article
Date
1986
Author
K A Jørgensen
A. Høj Nielsen
J. Dyerberg
Source
Acta Med Scand. 1986;219(5):473-9
Date
1986
Language
English
Publication Type
Article
Keywords
Adult
Animals
Antithrombin III - analysis
Aspirin - pharmacology
Bleeding time
Blood Platelets - analysis
Blood Pressure - drug effects
Denmark
Eicosapentaenoic Acid - administration & dosage
Female
Fishes
Food Habits
Greenland
Hemostasis - drug effects
Humans
Inuits
Lipids - blood
Male
Prostaglandins - biosynthesis
Renin - blood
Abstract
The Fifth UmanaK expedition compared the fatty acid composition of platelets, bleeding times before and after ingestion of acetylsalicylic acid, 24-hour urinary tetranorprostanedioate, creatinine and Na output, as well as plasma renin, serum electrolytes and antithrombin III in 20 Greenland Eskimos and 20 Danes. The results indicate that the prostaglandin production was not inhibited in the Eskimos, and that the antiaggregatory prostanoids predominate in Eskimos compared to Danes. Although blood pressure and 24-hour urinary Na output were similar, the plasma renin level was significantly higher in the Eskimos on a high eicosapentaenoic acid intake.
PubMed ID
3017055 View in PubMed
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21 records – page 1 of 3.