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Approaches for studying radiation-induced leukemia.

https://arctichealth.org/en/permalink/ahliterature22293
Source
Stem Cells. 1997;15 Suppl 2:243-9
Publication Type
Article
Date
1997
Author
D F Gluzman
Author Affiliation
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Ukraine.
Source
Stem Cells. 1997;15 Suppl 2:243-9
Date
1997
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Apoptosis
Drug Resistance, Multiple - genetics
Genetic Techniques
Hematopoietic Stem Cells - pathology - radiation effects
Humans
Incidence
Japan
Leukemia, Radiation-Induced - diagnosis - epidemiology - etiology - physiopathology
Myelodysplastic Syndromes - etiology - pathology
Nuclear Warfare
Oncogenes
Pilot Projects
Power Plants
Radiation, Ionizing
Survivors
Ukraine
Abstract
According to the conclusion of the International Programme on the Health Effects of the Chernobyl Accident (IPHECA) Haematology Pilot Project (1991-1995), there was no increase in the incidence of malignant disease in hematopoietic and lymphoid tissues after the Chernobyl accident. Nevertheless, since studies of A-bomb survivors indicate that the peak in morbidity may occur more than 10 years after radiation exposure, long-term studies of hemoblastoses and myelodysplastic syndromes are needed today. Study of these leukemias and lymphomas that are potentially induced by ionizing radiation must include both fundamental and applied approaches, i.e., A) epidemiological design; B) utilization of modern methods of diagnosis (cytomorphology, immunocytochemistry, cytogenetics); C) studies of gene mutations, mechanisms of apoptosis, and G1 delay; D) monitoring of oncogene and multidrug resistance gene expression, and E) tracking changes in cell-cell signaling in the bone marrow microenvironment.
PubMed ID
9368309 View in PubMed
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