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33 records – page 1 of 4.

Aspirin and risk for gastric cancer: a population-based case-control study in Sweden.

https://arctichealth.org/en/permalink/ahliterature19905
Source
Br J Cancer. 2001 Apr 6;84(7):965-8
Publication Type
Article
Date
Apr-6-2001
Author
K. Akre
A M Ekström
L B Signorello
L E Hansson
O. Nyrén
Author Affiliation
Department of Medical Epidemiology, Karolinska Institutet, 171 77 Stockholm, Sweden.
Source
Br J Cancer. 2001 Apr 6;84(7):965-8
Date
Apr-6-2001
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - epidemiology - prevention & control
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - adverse effects - therapeutic use
Aspirin - adverse effects - therapeutic use
Case-Control Studies
Female
Helicobacter Infections - complications - epidemiology
Helicobacter pylori
Humans
Logistic Models
Male
Middle Aged
Research Support, U.S. Gov't, P.H.S.
Risk factors
Socioeconomic Factors
Stomach Neoplasms - epidemiology - prevention & control
Sweden - epidemiology
Abstract
While aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) are associated with gastric mucosal damage, they might reduce the risk for gastric cancer. In a population-based case-control study in 5 Swedish counties, we interviewed 567 incident cases of gastric cancer and 1165 controls about their use of pain relievers. The cases were uniformly classified to subsite (cardia/non-cardia) and histological type and information collected on other known risk factors for gastric cancer. Helicobacter pylori serology was tested in a subset of 542 individuals. Users of aspirin had a moderately reduced risk of gastric cancer compared to never users; odds ratio (OR) adjusted for age, gender and socioeconomic status was 0.7 (95% CI = 0.6-1.0). Gastric cancer risk fell with increasing frequency of aspirin use (P for trend = 0.02). The risk reduction was apparent for both cardia and non-cardia tumours but was uncertain for the diffuse histologic type. No clear association was observed between gastric cancer risk and non-aspirin NSAIDs or other studied pain relievers. Our finding lends support to the hypothesis that use of aspirin reduces the risk for gastric cancer.
PubMed ID
11286478 View in PubMed
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Association between Helicobacter pylori and gastric carcinoma in the city of Malmö, Sweden. A prospective study.

https://arctichealth.org/en/permalink/ahliterature21840
Source
Scand J Gastroenterol. 1997 Dec;32(12):1215-21
Publication Type
Article
Date
Dec-1997
Author
J H Simán
A. Forsgren
G. Berglund
C H Florén
Author Affiliation
Dept. of Medicine, Lund University, Malmö University Hospital, Sweden.
Source
Scand J Gastroenterol. 1997 Dec;32(12):1215-21
Date
Dec-1997
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - complications - epidemiology - microbiology
Adult
Aged
Antibodies - blood
Case-Control Studies
Female
Helicobacter Infections - complications - epidemiology
Helicobacter pylori - immunology - isolation & purification
Humans
Male
Middle Aged
Prospective Studies
Stomach Neoplasms - complications - epidemiology - microbiology
Sweden - epidemiology
Abstract
BACKGROUND: We have investigated the association between Helicobacter pylori and gastric carcinoma through a nested case-control study in a single city. METHODS: From a cohort of 32,906 residents recruited from 1974 through 1992, 56 cases of gastric adenocarcinoma and 224 matched controls were selected. The mean interval between serum collection and diagnosis was 5.7 years. Frozen serum or plasma samples were analysed for IgG antibodies against H. pylori with an enzyme-linked immunosorbent assay. RESULTS: The overall seropositivity prevalence in gastric cancer cases was 82%, compared with 49% in controls, giving an odds ratio (OR) of 5.0 (95% confidence interval (CI), 2.2-11.5). Partial gastrectomy because of peptic ulcer 5 to 36 year before diagnosis of gastric cancer could be a confounding factor. With exclusion of 10 such cases, H. pylori seropositivity among cases was 78%, as compared with 50% in matched controls (OR, 3.9; 95% CI, 1.7-9.2). Tumours of the cardia were not associated with H. pylori (OR, 0.92; 95% CI, 0.23-3.7), which is in contrast to tumours of the fundus, corpus, and antrum, which were significantly associated (OR, 11.1; 95% CI, 2.4-71.8). This difference in location was significant (P
PubMed ID
9438319 View in PubMed
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Association of alcohol consumption and Helicobacter pylori infection in young adulthood and early middle age among patients with gastric complaints. A case-control study on Finnish conscripts, officers and other military personnel.

https://arctichealth.org/en/permalink/ahliterature218551
Source
Eur J Epidemiol. 1994 Apr;10(2):205-9
Publication Type
Article
Date
Apr-1994
Author
M. Paunio
J. Höök-Nikanne
T U Kosunen
U. Vainio
M. Salaspuro
J. Mäkinen
O P Heinonen
Author Affiliation
Department of Public Health, University of Helsinki, Finland.
Source
Eur J Epidemiol. 1994 Apr;10(2):205-9
Date
Apr-1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age Factors
Alcoholism - classification - complications - epidemiology
Case-Control Studies
Confidence Intervals
Endoscopy, Gastrointestinal
Finland - epidemiology
Helicobacter Infections - complications - epidemiology
Helicobacter pylori
Humans
Middle Aged
Military Personnel
Multivariate Analysis
Odds Ratio
Risk factors
Severity of Illness Index
Stomach Diseases - diagnosis - epidemiology - etiology
Abstract
There is growing evidence that Helicobacter pylori is responsible for a variety of gastric and duodenal changes which can eventually lead to stomach cancer. Little is known about risk factors for H. pylori infection. We re-analyzed the association of alcohol with H. pylori positivity in 451 conscripts, officers and other military personnel endoscoped due to gastric complaints in the Central Military Hospital of Finland in 1987 and 1988. Serology and culture were done in all patients. Alcohol consumption histories were obtained by use of a self-administered questionnaire. We observed a high odds ratio (OR) of H. pylori infection among young adults who were heavy alcohol consumers compared to non-drinkers (OR 5.32, 95% confidence interval: 1.09-25.95). There was evidence of a dose response when heavy and moderate drinkers were compared to non-drinkers (Mantel-Haenszel chi 2 for trend, p = 0.02) in young adulthood. A subgroup of young respondents who reported drinking all classes of alcohol (including hard liquor) showed an even stronger association and more significant dose-response. Multivariate techniques revealed a qualitative interaction of alcohol with H. pylori positivity in different age groups and among old people an inverse association of H. pylori and alcohol consumption was observed. These findings, if confirmed independently, might have implications for preventing a variety of gastric and duodenal lesions, since they allow identification of high risk groups.
PubMed ID
7813699 View in PubMed
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Chronic gastritis in dermatitis herpetiformis: a controlled study.

https://arctichealth.org/en/permalink/ahliterature124218
Source
Clin Dev Immunol. 2012;2012:640630
Publication Type
Article
Date
2012
Author
Anna Alakoski
Teea T Salmi
Kaisa Hervonen
Hannu Kautiainen
Maarit Salo
Katri Kaukinen
Timo Reunala
Pekka Collin
Author Affiliation
Department of Dermatology, Tampere University Hospital, 33521 Tampere, Finland.
Source
Clin Dev Immunol. 2012;2012:640630
Date
2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Autoimmunity
Child
Chronic Disease
Dermatitis Herpetiformis - complications - epidemiology - pathology
Female
Finland
Gastritis - complications - epidemiology - pathology
Gastrointestinal Tract - microbiology - pathology
Helicobacter Infections - complications - epidemiology - pathology
Helicobacter pylori
Humans
Male
Middle Aged
Prevalence
Young Adult
Abstract
Previous small studies suggest that chronic atrophic gastritis is common in dermatitis herpetiformis (DH). We here examined the frequency and topography of chronic gastritis in 93 untreated DH subjects and in 186 controls with dyspepsia.
Specimens were drawn from the gastric corpus and antrum and examined for atrophy, intestinal metaplasia, and Helicobacter pylori. Duodenal biopsies were taken.
Atrophic corpus gastritis was more frequent in DH than in controls (16.0% and 2.7%, resp., P
Notes
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PubMed ID
22611420 View in PubMed
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Clinical significance of widespread gastric metaplasia in the duodenal bulb.

https://arctichealth.org/en/permalink/ahliterature168427
Source
J Clin Gastroenterol. 2006 Jul;40(6):510-4
Publication Type
Article
Date
Jul-2006
Author
Lea Veijola
Anna Sankila
Hilpi Rautelin
Timo U Kosunen
Pentti Sipponen
Hannu Hyvärinen
Reijo Tilvis
Seppo Sarna
Perttu E T Arkkila
Kari Seppälä
Author Affiliation
Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland. lea.veijola@helsinki.fi
Source
J Clin Gastroenterol. 2006 Jul;40(6):510-4
Date
Jul-2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Duodenal Ulcer - epidemiology - microbiology - pathology
Duodenum - innervation - microbiology - pathology
Finland - epidemiology
Gastric Mucosa - innervation - microbiology - pathology
Gastritis - epidemiology - microbiology - pathology
Helicobacter Infections - complications - epidemiology - pathology
Helicobacter pylori - isolation & purification
Humans
Metaplasia - epidemiology - microbiology - pathology
Middle Aged
Prevalence
Retrospective Studies
Vagotomy
Vagotomy, Proximal Gastric
Vagotomy, Truncal
Abstract
All the risk factors of peptic ulcer disease are not thoroughly understood.
To assess duodenal gastric metaplasia (DGM) in relation to Helicobacter pylori status and endoscopy findings with special reference to the effects of highly selective vagotomy.
The study population consisted of 1056 adult patients and an additional 154 patients who had had a highly selective vagotomy. Their clinical and endoscopy records as well as the histology of gastric and duodenal biopsies were evaluated retrospectively. H. pylori infection had been determined by serology and culture.
Widespread (more than 20%) DGM was strongly associated with H. pylori positive duodenal ulcer disease (in 59.7% of patients). The prevalence of DGM diminished progressively the more proximally the ulcer was located in the stomach, and was 2.5% in proximal gastric ulcers patients. In vagotomized patients, the prevalence of widespread DGM (8.4% of patients, median 14 years after operation and the majority still H. pylori positive) was close to that of patients with H. pylori gastritis without peptic ulcer disease (4.5%).
Widespread DGM is an indicator for an increased risk of duodenal ulcer among H. pylori positive patients and it could be used to select patients for eradication therapy.
PubMed ID
16825933 View in PubMed
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Comparison of fecal occult blood tests for colorectal cancer screening in an Alaska Native population with high prevalence of Helicobacter pylori infection, 2008-2012.

https://arctichealth.org/en/permalink/ahliterature259482
Source
Prev Chronic Dis. 2014;11:E56
Publication Type
Article
Date
2014
  1 document  
Author
Diana Redwood
Ellen Provost
Elvin Asay
Diana Roberts
Donald Haverkamp
David Perdue
Michael G Bruce
Frank Sacco
David Espey
Source
Prev Chronic Dis. 2014;11:E56
Date
2014
Language
English
Geographic Location
U.S.
Publication Type
Article
File Size
588738
Keywords
Adult
Alaska
Colorectal Neoplasms - diagnosis
Early Detection of Cancer - methods
Feces - chemistry
Female
Helicobacter Infections - complications - epidemiology - microbiology
Helicobacter pylori
Humans
Indians, North American
Male
Middle Aged
Occult Blood
Abstract
Alaska Native colorectal cancer (CRC) incidence and mortality rates are the highest of any ethnic/racial group in the United States. CRC screening using guaiac-based fecal occult blood tests (gFOBT) are not recommended for Alaska Native people because of false-positive results associated with a high prevalence of Helicobacter pylori-associated hemorrhagic gastritis. This study evaluated whether the newer immunochemical FOBT (iFOBT) resulted in a lower false-positive rate and higher specificity for detecting advanced colorectal neoplasia than gFOBT in a population with elevated prevalence of H. pylori infection.
We used a population-based sample of 304 asymptomatic Alaska Native adults aged 40 years or older undergoing screening or surveillance colonoscopy (April 2008-January 2012).
Specificity differed significantly (P
Notes
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PubMed ID
24721216 View in PubMed
Documents
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Decreasing prevalence of helicobacter antibodies in Finland, with reference to the decreasing incidence of gastric cancer.

https://arctichealth.org/en/permalink/ahliterature195086
Source
Epidemiol Infect. 2001 Feb;126(1):37-42
Publication Type
Article
Date
Feb-2001
Author
L. Rehnberg-Laiho
H. Rautelin
P. Koskela
S. Sarna
E. Pukkala
A. Aromaa
P. Knekt
T U Kosunen
Author Affiliation
Department of Bacteriology and Immunology, Haartmnan Institute, University of Helsinki, Finland.
Source
Epidemiol Infect. 2001 Feb;126(1):37-42
Date
Feb-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Antibodies, Bacterial - blood
Female
Finland - epidemiology
Helicobacter Infections - complications - epidemiology
Helicobacter pylori - immunology - isolation & purification
Humans
Immunoenzyme Techniques - methods
Immunoglobulin G - blood
Incidence
Middle Aged
Pregnancy
Risk factors
Seroepidemiologic Studies
Stomach Neoplasms - epidemiology - etiology
Time Factors
Abstract
Time trends and geographical variation of Helicobacter pylori antibodies in Finland were investigated by enzyme immunoassay in 20- to 34-year-old randomly selected females from six localities during 1969-73 (n = 375), and 15- to 45-year-old females representing nine communities and four geographical areas in 1983 (n = 882) and 1995 (n = 842). In the six communities investigated at three different time points, the overall prevalence declined from 38 to 12%, with an emphasis on the latter 12 years. The regionally varying rate of decrease in helicobacter prevalence changed the pre-existing geographical variation, leaving northern Finland with the highest rate. A 10%-units higher local helicobacter prevalence seemed to predict a 23% (95% CI 3-44%) higher gastric cancer incidence 20 years later. The overall decline in helicobacter seropositivity is consistent with earlier reports from Finland and other developed countries, and supports the cohort theory as an explanation for the age-related increase in H. pylori seroprevalence.
PubMed ID
11293681 View in PubMed
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Dental caries is common in Finnish children infected with Helicobacter pylori.

https://arctichealth.org/en/permalink/ahliterature192202
Source
Scand J Infect Dis. 2001;33(11):815-7
Publication Type
Article
Date
2001
Author
K L Kolho
P. Hölttä
S. Alaluusua
H. Lindahl
E. Savilahti
H. Rautelin
Author Affiliation
Hospital for Children and Adolescents, Helsinki University Central Hospital, Finland.
Source
Scand J Infect Dis. 2001;33(11):815-7
Date
2001
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Child, Preschool
Cross-Sectional Studies
Dental Caries - epidemiology - microbiology
Female
Finland - epidemiology
Helicobacter Infections - complications - epidemiology - microbiology
Helicobacter pylori - isolation & purification
Humans
Male
Risk factors
Streptococcus mutans - isolation & purification
Abstract
Childhood factors such as low socioeconomic status are risk factors for Helicobacter pylori infection and Streptococcus mutans-related dental caries. We examined whether H. pylori infection and dental caries are present today in the same group of children examined previously. We reviewed the public dental health service files of 21 H. pylori-positive children (upper gastrointestinal endoscopy at a median age of 13.5 y) and 27 H. pylori-negative children (endoscopy at a median age of 12.5 y) examined during 1995-98 at the Helsinki University Central Hospital, Finland. All H. pylori-positive children had experienced dental caries in their primary or permanent teeth or in both whereas among H. pylori-negative children the respective proportion was 70% (p
PubMed ID
11760160 View in PubMed
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Does the risk of stomach cancer remain among second-generation immigrants in Sweden?

https://arctichealth.org/en/permalink/ahliterature130810
Source
Gastric Cancer. 2012 Apr;15(2):213-5
Publication Type
Article
Date
Apr-2012
Author
Seyed Mohsen Mousavi
Kristina Sundquist
Kari Hemminki
Author Affiliation
Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), CO50, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany. m.mousavi@dkfz.de
Source
Gastric Cancer. 2012 Apr;15(2):213-5
Date
Apr-2012
Language
English
Publication Type
Article
Keywords
Emigrants and Immigrants - statistics & numerical data
Helicobacter Infections - complications - epidemiology
Helicobacter pylori
Humans
Incidence
Risk
Stomach Neoplasms - epidemiology - etiology
Sweden - epidemiology
Abstract
The observed increased risks of noncardia stomach cancer among foreign-born second-generation immigrants compared to the Swedes suggest that these immigrants were infected by Helicobacter pylori before immigration.
PubMed ID
21964647 View in PubMed
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33 records – page 1 of 4.