Skip header and navigation

Refine By

1169 records – page 1 of 117.

The 6-min walk test: responses in healthy Canadians aged 45 to 85 years.

https://arctichealth.org/en/permalink/ahliterature130789
Source
Appl Physiol Nutr Metab. 2011 Oct;36(5):643-9
Publication Type
Article
Date
Oct-2011
Author
Kylie Hill
Lisa M Wickerson
Lynda J Woon
Afshin Heidar Abady
Tom J Overend
Roger S Goldstein
Dina Brooks
Author Affiliation
Department of Respirology, West Park Healthcare Centre, Toronto, Ontario, Canada.
Source
Appl Physiol Nutr Metab. 2011 Oct;36(5):643-9
Date
Oct-2011
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Algorithms
Exercise Test
Female
Heart rate
Humans
Male
Middle Aged
Ontario
Oxygen consumption
Physical Fitness
Reference Values
Reproducibility of Results
Respiration
Respiratory Rate
Sex Characteristics
Tidal Volume
Time Factors
Walking
Abstract
We sought to describe responses to the 6-min walk test (6MWT) in healthy Canadian adults in order to facilitate interpretation of its results in patient populations. Seventy-seven healthy Canadians aged 45 to 85 years (65 ± 11 years, 40 females) completed this study. During a single visit, three 6MWTs were undertaken. The main outcome measure was 6-min walk distance (6MWD). Age, gender, height, and weight were recorded. In 61 (79%) participants, cardiorespiratory variables were collected during the third 6MWT using a calibrated portable gas analysis system. The 6MWD increased between the first and second test (615 ± 96 to 639 ± 98 m; p
PubMed ID
21967531 View in PubMed
Less detail

The 24-hour pulse wave velocity, aortic augmentation index, and central blood pressure in normotensive volunteers.

https://arctichealth.org/en/permalink/ahliterature104335
Source
Vasc Health Risk Manag. 2014;10:247-51
Publication Type
Article
Date
2014
Author
Tatyana Y Kuznetsova
Viktoria A Korneva
Evgeniya N Bryantseva
Vitaliy S Barkan
Artemy V Orlov
Igor N Posokhov
Anatoly N Rogoza
Author Affiliation
Faculty of Medicine, Petrozavodsk State University, Petrozavodsk, Russia.
Source
Vasc Health Risk Manag. 2014;10:247-51
Date
2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Algorithms
Blood pressure
Blood Pressure Monitoring, Ambulatory - standards
Circadian Rhythm
Diastole
Female
Healthy Volunteers
Heart rate
Humans
Male
Middle Aged
Predictive value of tests
Pulse Wave Analysis - standards
Reference Values
Russia
Signal Processing, Computer-Assisted
Systole
Time Factors
Vascular Stiffness
Abstract
The purpose of this study was to examine the pulse wave velocity, aortic augmentation index corrected for heart rate 75 (AIx@75), and central systolic and diastolic blood pressure during 24-hour monitoring in normotensive volunteers. Overall, 467 subjects (206 men and 261 women) were recruited in this study. Participants were excluded from the study if they were less than 19 years of age, had blood test abnormalities, had a body mass index greater than 2 7.5 kg/m(2), had impaired glucose tolerance, or had hypotension or hypertension. Ambulatory blood pressure monitoring (ABPM) with the BPLab(®) device was performed in each subject. ABPM waveforms were analyzed using the special automatic Vasotens(®) algorithm, which allows the calculation of pulse wave velocity, AIx@75, central systolic and diastolic blood pressure for "24-hour", "awake", and "asleep" periods. Circadian rhythms and sex differences in these indexes were identified. Pending further validation in prospective outcome-based studies, our data may be used as preliminary diagnostic values for the BPLab ABPM additional index in adult subjects.
Notes
Cites: J Invasive Cardiol. 2009 Jun;21(6):270-719494403
Cites: Hypertens Res. 2012 Oct;35(10):980-722622282
Cites: Am J Hypertens. 2010 Feb;23(2):180-519959999
Cites: J Hypertens. 2013 Jul;31(7):1281-35723817082
Cites: Vasc Health Risk Manag. 2011;7:649-5622140314
Cites: Age (Dordr). 2013 Dec;35(6):2345-5523319362
Cites: Hypertension. 2013 Jun;61(6):1148-923630945
Cites: Hypertension. 2013 Jun;61(6):1168-7623630950
Cites: J Hypertens. 2013 Sep;31(9):1731-6824029863
Cites: Eur Heart J. 2010 Oct;31(19):2338-5020530030
PubMed ID
24812515 View in PubMed
Less detail

25 years of implanted intracardiac pacers.

https://arctichealth.org/en/permalink/ahliterature55503
Source
Lancet. 1988 Mar 19;1(8586):636-8
Publication Type
Article
Date
Mar-19-1988
Author
H. Lagergren
Author Affiliation
Department of Surgery, Huddinge University Hospital, Karolinska Institute, Sweden.
Source
Lancet. 1988 Mar 19;1(8586):636-8
Date
Mar-19-1988
Language
English
Publication Type
Article
Keywords
Aged
Animals
Arrhythmia - physiopathology - therapy
Cardiac Pacing, Artificial - history - methods
Dogs
Electrodes, Implanted
Heart Block - physiopathology - therapy
Heart rate
History, 20th Century
Humans
Pacemaker, Artificial - history
Sweden
Abstract
In 1962, a simplified method of transvenously inserting an intracardiac electrode and implanting the whole pacemaker system under local anaesthesia was reported from the Karolinska Hospital in Stockholm. This simplified method has been universally adopted and pacemakers are now probably implanted too freely in many places. In the Stockholm area pacemakers are implanted half as frequently as in the rest of Sweden and as often as in the United Kingdom.
PubMed ID
2894560 View in PubMed
Less detail

164Ile allele in the beta2-Adrenergic receptor gene is associated with risk of elevated blood pressure in women. The Copenhagen City Heart Study.

https://arctichealth.org/en/permalink/ahliterature173671
Source
Pharmacogenet Genomics. 2005 Sep;15(9):633-45
Publication Type
Article
Date
Sep-2005
Author
Amar A Sethi
Anne Tybjaerg-Hansen
Gorm B Jensen
Børge G Nordestgaard
Author Affiliation
Department of Clinical Biochemistry, Herlev University Hospital, Herlev, Denmark.
Source
Pharmacogenet Genomics. 2005 Sep;15(9):633-45
Date
Sep-2005
Language
English
Publication Type
Article
Keywords
Alleles
Arginine - chemistry
Blood pressure
Body mass index
Denmark
Female
Gene Expression Regulation
Gene Frequency
Genetic Variation
Genotype
Glutamic Acid - chemistry
Glutamine - chemistry
Glycine - chemistry
Haplotypes
Heart rate
Heterozygote
Humans
Hypertension - genetics
Isoleucine - chemistry
Linkage Disequilibrium
Male
Receptors, Adrenergic, beta-2 - genetics
Risk
Risk factors
Sequence Analysis, DNA
Sex Factors
Time Factors
Abstract
Since beta2-adrenergic receptors are important regulators of blood pressure, genetic variation in this receptor could explain risk of elevated blood pressure in selected individuals. We tested the hypothesis that Gly16Arg, Gln27Glu, and Thr164Ile in the beta2-adrenergic receptor gene associated with elevated blood pressure.
We genotyped 9185 individuals from the adult Danish general population.
Allele frequencies of 16Arg, 27Glu, and 164Ile were 0.38, 0.44, and 0.01, respectively. Among women never treated with antihypertensive medication those heterozygous for Thr164Ile versus non-carriers had increased diastolic blood pressure (P=0.02). Women heterozygous for Thr164Ile versus non-carriers had an odds ratio for elevated blood pressure of 1.93 (95% CI: 1.30-2.86). Finally, women double heterozygous for Thr164Ile and Gln27Glu or Gly16Arg versus non-carriers at all 3 loci had an odds ratio for elevated blood pressure of 2.49 (1.28-4.85) or 3.19 (1.46-6.97). In men, blood pressure was not influenced by this genetic variation.
In women Thr164Ile heterozygosity is associated with increased diastolic blood pressure, and represent a risk factor for elevated blood pressure in women in the general population. This was most pronounced in those women also heterozygous for Gln27Glu or Gly16Arg.
PubMed ID
16041242 View in PubMed
Less detail

Abnormalities in beat to beat complexity of heart rate dynamics in patients with a previous myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature54616
Source
J Am Coll Cardiol. 1996 Oct;28(4):1005-11
Publication Type
Article
Date
Oct-1996
Author
T H Mäkikallio
T. Seppänen
M. Niemelä
K E Airaksinen
M. Tulppo
H V Huikuri
Author Affiliation
Department of Medicine, Oulu University, Finland.
Source
J Am Coll Cardiol. 1996 Oct;28(4):1005-11
Date
Oct-1996
Language
English
Publication Type
Article
Keywords
Adult
Electrocardiography, Ambulatory
Entropy
Female
Heart Rate - physiology
Humans
Male
Models, Statistical
Myocardial Infarction - physiopathology
Research Support, Non-U.S. Gov't
Signal Processing, Computer-Assisted
Abstract
OBJECTIVES: The purpose of this research was to study possible abnormalities in the beat to beat complexity of heart rate dynamics in patients with a previous myocardial infarction. BACKGROUND: Analysis of approximate entropy of time series data provides information on the complexity of both deterministic and random processes. It has been proposed that regularity or loss of complexity of RR interval dynamics may be related to pathologic states, but this hypothesis has not been well tested in cardiovascular disorders. METHODS: Approximate entropy and conventional time and frequency domain measures of RR interval variability were compared between 40 healthy subjects with no evidence of heart disease and 40 patients with coronary artery disease and a previous Q wave myocardial infarction. The groups were matched with respect to age, and cardiac medication was discontinued in the patients with coronary artery disease before the 24-h electrocardiographic recordings. RESULTS: Approximate entropy was significantly higher in the postinfarction patients (1.21 +/- 0.18 [mean +/- SD]) than in the healthy subjects (1.05 +/- 0.11, p
PubMed ID
8837582 View in PubMed
Less detail

Abnormalities in beat-to-beat dynamics of heart rate before the spontaneous onset of life-threatening ventricular tachyarrhythmias in patients with prior myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature54658
Source
Circulation. 1996 May 15;93(10):1836-44
Publication Type
Article
Date
May-15-1996
Author
H V Huikuri
T. Seppänen
M J Koistinen
J. Airaksinen
M J Ikäheimo
A. Castellanos
R J Myerburg
Author Affiliation
Department of Medicine, University of Oulu, Finland.
Source
Circulation. 1996 May 15;93(10):1836-44
Date
May-15-1996
Language
English
Publication Type
Article
Keywords
Aged
Electrocardiography
Female
Heart rate
Humans
Male
Middle Aged
Myocardial Infarction - physiopathology
Research Support, Non-U.S. Gov't
Tachycardia, Ventricular - physiopathology
Abstract
BACKGROUND: Beat-to-beat analysis of RR intervals can reveal patterns of heart-rate dynamics, which are not easily detected by summary measures of heart-rate variability. This study was designed to test the hypothesis that alterations in RR-interval dynamics occur before the spontaneous onset of ventricular tachyarrhythmias (VT). METHODS AND RESULTS: Ambulatory ECG recordings from 15 patients with prior myocardial infarction (MI) who had spontaneous episodes of sustained VT during the recording and VT inducible by programmed electrical stimulation (VT group) were analyzed by plotting each RR interval of a sinus beat as a function of the previous one (Poincaré plot). Poincaré plots were also generated for 30 post-MI patients who had no history of spontaneous VT events and no inducible VT (MI control subjects) and for 30 age-matched subjects without heart disease (normal control subjects). The MI control subjects and VT group were matched with respect to age and severity of underlying heart disease. All the healthy subjects and MI control subjects showed fan-shaped Poincaré plots characterized by an increased next-interval difference for long RR intervals relative to short ones. All the VT patients had abnormal plots: 9 with a complex pattern, 3 ball-shaped, and 3 torpedo-shaped. Quantitative analysis of the Poincare plots showed the SD of the long-term RR-interval variability (SD2) to be smaller in all VT patients (52+/-14 ms; range, 31 to 75 ms) than in MI control subjects (110+/-24 ms; range, 78 to 179 ms, P
PubMed ID
8635263 View in PubMed
Less detail

[Accelerated senescence of armed conflicts participants suffering from the consequences of war cranial-cerebral trauma and alcoholism].

https://arctichealth.org/en/permalink/ahliterature160567
Source
Adv Gerontol. 2007;20(1):112-7
Publication Type
Article
Date
2007
Author
V S Miakotnykh
V V Iampol'skaia
V N Samoilova
A A Bal'bert
T A Borovkova
V N Meshchaninov
O N Matveeva
Source
Adv Gerontol. 2007;20(1):112-7
Date
2007
Language
Russian
Publication Type
Article
Keywords
Adult
Aging, Premature - diagnosis - etiology
Alcoholism - complications
Antioxidants - analysis - metabolism
Brain Injuries - complications
Female
Heart rate
Humans
Lipid Peroxidation
Male
Middle Aged
Russia
War
Abstract
The matter under studies was the way accelerated senescence of armed conflicts participants with brain injuries depends on alcohol addiction developed after the injuries and on dysfunction of neurohumoral regulation of heart activity. It has been established that the posttraumatic alcohol addiction considerably activates the processes of accelerated senescence and lipid peroxidation connected with it, depresses the system of antioxidant protection and enhances the progress of dysfunctions in neurohumoral regulation of heart activity.
PubMed ID
17969594 View in PubMed
Less detail

Acclimatization to cold in man induced by frequent scuba diving in cold water.

https://arctichealth.org/en/permalink/ahliterature293858
Source
Journal of Applied Physiology. 1968 Feb;24(2):177-81.
Publication Type
Article
Date
1968

Acetate-induced changes in cardiac energy metabolism and hemodynamics in the rat.

https://arctichealth.org/en/permalink/ahliterature12462
Source
Basic Res Cardiol. 1988 Jul-Aug;83(4):431-44
Publication Type
Article
Author
K T Kiviluoma
M. Karhunen
T. Lapinlampi
K J Peuhkurinen
I E Hassinen
Author Affiliation
Department of Medical Biochemistry, University of Oulu, Finland.
Source
Basic Res Cardiol. 1988 Jul-Aug;83(4):431-44
Language
English
Publication Type
Article
Keywords
Acetic Acid
Acetic Acids - pharmacology
Adenosine - metabolism
Animals
Cardiac Output - drug effects
Epinephrine - blood
Heart - drug effects - physiology
Heart Rate - drug effects
Hemodynamic Processes
In Vitro
Myocardium - metabolism
Oxygen Consumption - drug effects
Phosphorylation
Rats
Rats, Inbred Strains
Time Factors
Abstract
The hemodynamic and metabolic effects of acetate were studied in rats in vivo and in the isolated perfused heart. Hemodynamic parameters, myocardial phosphagens, inorganic phosphate, and adenosine were measured in vivo. Acetate uptake, coronary flow, O2 consumption, parameters of the cellular energy state, and hypoxanthine compounds and their washout were measured in heart perfusion experiments. Heart rate (HR), cardiac output, and the peak derivative of the left ventricular pressure rise (dP/dtmax) increased significantly during acetate infusion in vivo, but mean arterial pressure, systolic arterial pressure, and systemic vascular resistance decreased. Heart muscle ATP concentrations decreased after 7 min of acetate infusion. In vivo cardiac work load (HR.(peak left ventricular pressure] showed a positive correlation with tissue adenosine concentration and a negative correlation with phosphorylation potential. Acetate uptake in the perfused hearts was about 2.5 mumol/min per gram wet weight. Acetate perfusion increased O2 consumption and coronary flow concomitantly with a decrease in tissue ATP concentration. Tissue AMP and perfusate effluent adenosine concentration and adenosine output increased significantly, perfusate adenosine showing a non-linear positive correlation with coronary flow. The results demonstrate that acetate induces considerable changes in hemodynamics and metabolism in the heart.
PubMed ID
3190660 View in PubMed
Less detail

Acetylcholine receptor M2 gene variants, heart rate recovery, and risk of cardiac death after an acute myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature91406
Source
Ann Med. 2009;41(3):197-207
Publication Type
Article
Date
2009
Author
Hautala Arto J
Tulppo Mikko P
Kiviniemi Antti M
Rankinen Tuomo
Bouchard Claude
Mäkikallio Timo H
Huikuri Heikki V
Author Affiliation
Department of Exercise and Medical Physiology, Verve Research, Kasarmintie 13, Oulu, Finland. arto.hautala@verve.fi
Source
Ann Med. 2009;41(3):197-207
Date
2009
Language
English
Publication Type
Article
Keywords
Exercise Test
Female
Heart rate
Humans
Male
Middle Aged
Myocardial Infarction - diagnosis - mortality - physiopathology
Polymorphism, Genetic
Predictive value of tests
Prognosis
Receptor, Muscarinic M2 - genetics
Risk factors
Abstract
BACKGROUND AND AIMS: We aimed to replicate the previously observed association between acetylcholine receptor subtype M2 (CHRM2) gene polymorphisms and heart rate recovery (HRR) after exercise in patients with a recent acute myocardial infarction (AMI) and assess the prognostic significance of CHRM2 gene variants after AMI. METHODS: HRR was determined as the difference between maximal heart rate and heart rate at 1 minute after the symptom-limited bicycle exercise test in 192 post-AMI patients. Genetic variants at the CHRM2 locus in intron 5 (rs324640) and the 3'-UTR of exon 6 (rs8191992) were assessed. RESULTS: The rs324640 C/C and rs8191992 A/A homozygotes had more than a 3-fold risk of being in the lowest HRR quartile (
PubMed ID
18979273 View in PubMed
Less detail

1169 records – page 1 of 117.