The authors summarize theoretical principles of increasing human resistence to toxic effects of inorganic compounds polluting occupational environment and habitat, exemplify practical use of this prophylactic trend.
Dioxins and dioxin-like substances are highly toxic and extremely dangerous chemical compounds. Dioxins are formed during the thermal process associated with the use of chlorine. 2,3,7,8-tetrachlorodibenzo-1,4-dioxin is the most toxic, the most typical and well-studied agent. The most characteristic and constant indicators of intoxication with dioxin-containing substances are altered body weight, chloracne, hepatic damage, thyroid involution, structural changes in the adrenal cortex, spleen, genitals, immunodeficiency. There is evidence for a role of these agents in the development of infertility and neonatal pathology.
Groups of pregnant women, which made up in Revda, Pervouralsk, Krasnouralsk, and Verkh-Isetsky District of Yekaterinburg, were studied. Tests of umbilical blood samples (UB) for the levels of calcium, iron, chromium, manganese, zinc, nickel, cadmium, lead, arsenic, copper, and mercury have established that the mean concentration of lead and the proportion of samples with elevated UB lead concentrations depend on how close the residential area is located to the major industrial source of emission of this toxic metal into ambient air. This correlation is less marked for other metals or it is not found. The particular position of lead is likely to be explained by the fact that it is entirely foreign to an organism and by the comparative unimportance of a contribution of the sources of exposure to this metal, which are unassociated with man-caused environmental and food pollution. As far as other metals are concerned, the situation is complicated by the fact that they are not only toxic, but when upon minor exposures, also essential biotrace elements with controlled and interdependent toxic kinetics. It is also shown that when a pregnant woman takes a complex of biological protectors promoting a reduction in her body's levels of lead, its concentrations in her body, its UB concentration is much lower than such a bioprophylactic effect is absent.