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Directions in QSAR modeling for regulatory uses in OECD member countries, EU and in Russia.

https://arctichealth.org/en/permalink/ahliterature156589
Source
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Apr-Jun;26(2):201-36
Publication Type
Article
Author
Natalja Fjodorova
Marjana Novich
Marjan Vrachko
Vjacheslav Smirnov
Nina Kharchevnikova
Zoya Zholdakova
Sergei Novikov
Natalja Skvortsova
Dmitrii Filimonov
Vladimir Poroikov
Emilio Benfenati
Author Affiliation
National Institute of Chemistry, Ljubljana, Slovenia. natalja.fjodorova@ki.si
Source
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Apr-Jun;26(2):201-36
Language
English
Publication Type
Article
Keywords
Animal Experimentation
Animal Use Alternatives
Animals
Europe
Hazardous Substances - classification - toxicity
Humans
Models, Biological
Predictive value of tests
Product Labeling
Public Policy
Quantitative Structure-Activity Relationship
Risk assessment
Russia
Toxicity Tests
Abstract
The aim of this article is to show the main aspects of quantitative structure activity relationship (QSAR) modeling for regulatory purposes. We try to answer the question; what makes QSAR models suitable for regulatory uses. The article focuses on directions in QSAR modeling in European Union (EU) and Russia. Difficulties in validation models have been discussed.
PubMed ID
18569330 View in PubMed
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Regulatory assessment of chemicals within OECD member countries, EU and in Russia.

https://arctichealth.org/en/permalink/ahliterature158448
Source
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jan-Mar;26(1):40-88
Publication Type
Article
Author
Natalja Fjodorova
Marjana Novich
Marjan Vrachko
Nina Kharchevnikova
Zoya Zholdakova
Oxana Sinitsyna
Emilio Benfenati
Author Affiliation
National Institute of Chemistry, Ljubljana, Slovenia. natalja.fjodorova@ki.si
Source
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2008 Jan-Mar;26(1):40-88
Language
English
Publication Type
Article
Keywords
Commerce
Europe
Hazardous Substances - classification - toxicity
Humans
Product Labeling
Public Policy
Risk Assessment - methods
Russia
Toxicity Tests
Abstract
The chemical risk assessment is essesntial part of new chemical legislation registration, evaluation, and authorization of chemicals (REACH). The article presents a review of chemical legislation policies in the European Union (EU) and in Russia, and changes in chemicals regulations to meet the requirement of REACH. The risk assessment paradigm, toxicological parameters, safe limits and classification criteria used by different agencies and authorities in different countries are reported. Our investigation also focuses on comparison of chemical risk assessment criteria used in OECD member countries and in Russia. Tendencies in harmonization in accordance with the globally harmonized system of classification and labeling of chemicals (GHS) are discussed.
PubMed ID
18322867 View in PubMed
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