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[CHROMOSOMAL DISORDERS IN WORKERS OF CHEMICALLY HAZARDOUS ENTERPRISES WITH THE DIFFERENT HEALTH STATUS].

https://arctichealth.org/en/permalink/ahliterature270128
Source
Gig Sanit. 2015;94(8):31-5
Publication Type
Article
Date
2015
Author
T V Kharchenko
L G Arzhavkina
D A Siniachkin
A V Yazenok
Source
Gig Sanit. 2015;94(8):31-5
Date
2015
Language
Russian
Publication Type
Article
Keywords
Chromosome Disorders - chemically induced - diagnosis - epidemiology
Cytogenetic Analysis
Female
Hazardous Substances - adverse effects
Health status
Humans
Incidence
Male
Occupational Diseases - chemically induced - diagnosis - epidemiology
Occupational Exposure - adverse effects
Russia - epidemiology
Abstract
OBJECTIVES. Chromosomal aberrations (CAs) are the one of the most sensitive biomarikers of biological effects from the hazardous environmental exposure. In this relation the comparison of cytogenetical indices in persons, exposed to the complex of factors of chemically hazard enterprises, with the presence of occupationally caused diseases seems to be very perspective for the understanding of the role of the contribution of genotoxical impact of occupational factors into staff morbidity. METHODS. Cytogenetical analysis was performed in 138 employees of chemically hazardous enterprises, including 84 patients, who need for establishment of the causation of diseases with the work in conditions of chemical plant and 54 persons without need for hospitalization according to results of the previous examination. Comparison group was consisted of 55 persons. There was performed the comparison of cytogenetical indices and commensuration of ratios of persons with individual high CAs levels and also carriers of exchange aberrations of chromosomal type in different groups of examined cases. RESULTS. There was shown statistically significant increase of the rate of CAs level including unexpectedly high level of dicentric and ring chromosomes in the group of 84 hospitalized patients. There was revealed statistically significant gain in the share of persons with CAs rate more then 5% (p
PubMed ID
26856169 View in PubMed
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[Cytogenetic examination of the workers of higher chemical hazard enterprises and the population of the nearby territories].

https://arctichealth.org/en/permalink/ahliterature128610
Source
Gig Sanit. 2011 Sep-Oct;(5):42-4
Publication Type
Article
Author
T V Kharchenko
L G Arzhavkina
M B Ivanov
A V Iazenok
Iu B Goverdovskii
A S Kriuchkova
D A Siniachkin
A E Sosiukin
Source
Gig Sanit. 2011 Sep-Oct;(5):42-4
Language
Russian
Publication Type
Article
Keywords
Adult
Case-Control Studies
Chemical Industry
Chromosome Aberrations - chemically induced - statistics & numerical data
Cytogenetic Analysis
Hazardous Substances - toxicity
Humans
Lymphocytes - drug effects - ultrastructure
Male
Middle Aged
Occupational Exposure - adverse effects
Russia
Workplace - standards
Young Adult
Abstract
Cytogenetical examination was made in 49 workers of higher chemical hazard enterprises and 26 dwellers from industrial communities, who were engaged in enterprise security. Analysis of chromosome aberrations (CA) in the examined groups revealed a 1.8-fold increase in total CA rates in the industrial community dwellers securing the enterprise as compared to the controls mainly due to the rise in the rate of single fragments. At the same time in the enterprise workers, the total level of CA was 2.36- and 4.1-fold greater than that in the population of industrial communities and in the controls, respectively; and it was also characterized by a broad spectrum of CA with the increased number of both chromatid and chromosomal exchange aberrations.
PubMed ID
22185001 View in PubMed
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