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290 records – page 1 of 29.

1,3-Butadiene: exposure estimation, hazard characterization, and exposure-response analysis.

https://arctichealth.org/en/permalink/ahliterature186649
Source
J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):55-83
Publication Type
Article
Author
K. Hughes
M E Meek
M. Walker
R. Beauchamp
Author Affiliation
Existing Substances Division, Environmental Health Directorate, Health Canada, Environmental Health Centre, Tunney's Pasture PL0802B1, Ottawa, Ontario, Canada K1A 0L2.
Source
J Toxicol Environ Health B Crit Rev. 2003 Jan-Feb;6(1):55-83
Language
English
Publication Type
Article
Keywords
Animals
Butadienes - metabolism - toxicity
Canada - epidemiology
Carcinogens, Environmental - toxicity
Environmental Exposure
Hazardous Substances - toxicity
Humans
Mutagens - toxicity
Neoplasms - chemically induced - epidemiology
Occupational Diseases - chemically induced - epidemiology
Risk assessment
Abstract
1,3-Butadiene has been assessed as a Priority Substance under the Canadian Environmental Protection Act. The general population in Canada is exposed to 1,3-butadiene primarily through ambient air. Inhaled 1,3-butadiene is carcinogenic in both mice and rats, inducing tumors at multiple sites at all concentrations tested in all identified studies. In addition, 1,3-butadiene is genotoxic in both somatic and germ cells of rodents. It also induces adverse effects in the reproductive organs of female mice at relatively low concentrations. The greater sensitivity in mice than in rats to induction of these effects by 1,3-butadiene is likely related to species differences in metabolism to active epoxide metabolites. Exposure to 1,3-butadiene in the occupational environment has been associated with the induction of leukemia; there is also some limited evidence that 1,3-butadiene is genotoxic in exposed workers. Therefore, in view of the weight of evidence of available epidemiological and toxicological data, 1,3-butadiene is considered highly likely to be carcinogenic, and likely to be genotoxic, in humans. Estimates of the potency of butadiene to induce cancer have been derived on the basis of both epidemiological investigation and bioassays in mice and rats. Potencies to induce ovarian effects have been estimated on the basis of studies in mice. Uncertainties have been delineated, and, while there are clear species differences in metabolism, estimates of potency to induce effects are considered justifiably conservative in view of the likely variability in metabolism across the population related to genetic polymorphism for enzymes for the critical metabolic pathway.
PubMed ID
12587254 View in PubMed
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[About the formation of legislation in the field of chemical and biological safety of the Russian Federation].

https://arctichealth.org/en/permalink/ahliterature290153
Source
Gig Sanit. 2016; 95(8):717-21
Publication Type
Journal Article
Author
E A Boyko
N N Goncharuk
A D Dashitsyrenova
N A Kostenko
O O Sinitsina
M P Shevyreva
Source
Gig Sanit. 2016; 95(8):717-21
Language
Russian
Publication Type
Journal Article
Keywords
Environmental Monitoring - legislation & jurisprudence - methods
Environmental Pollutants - analysis
Hazardous Substances - analysis
Humans
National Health Programs - legislation & jurisprudence
Policy Making
Public Health - legislation & jurisprudence - methods
Russia
Abstract
The realization of the package of measures directed at the consecutive decrease of the negative effect of hazardous chemical and biological factors on the population and environment to the acceptable risk level stipulates the development of standard legal regulation in the field of ensuring the chemical and biological safety. For this purpose article presents substantiation and conceptual approaches to the creation of legislation in the field of the chemical and biological security of the Russian Federation within the pursued state policy. In determination of conceptual approaches, in the article there are reported: the main idea, the purpose, a subject of legal regulation, the circle of people who will be subjected to the laws, the place offuture laws in the system of current legislation, the provisions of the Constitution of the Russian Federation, the Federal backbone laws of the Russian Federation to realization of which laws are directed, there is given the general characteristic and an assessment of a condition of legal regulation in this field, results of the analysis of the information on the need for correspondence of Russian laws to provision of international treaties, concerning prohibitions of the biological and chemical weapon, safe handling with biological agents and chemicals, and also the development of uniform procedures of ensuring chemical and biological safety. The major aspect in the shaping of the legislation is the global character ofproblems of chemical and biological safety in this connection in article there is indicated the need of rapprochement of rules of law for this area with partners in economic cooperation and integration. Taking into account an orientation of future laws on the decrease in the level of the negative impact of dangerous chemical and biological factors on the population and environment, there are designated medical, social, economic and political consequences of their implementation. There are presented the proposed structure for bills: “About biological safety”, “On Chemical Safety” and “On the National collection of pathogens.
PubMed ID
29430893 View in PubMed
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[A case study of the contents of radionuclides and of main chemical pollutants in the atmospheric air of Moscow].

https://arctichealth.org/en/permalink/ahliterature184554
Source
Gig Sanit. 2003 May-Jun;(3):19-20
Publication Type
Article
Author
I P Korenkov
O S Chapkovich
P A Briukhanov
F I Pasechnik
N K Shandala
Source
Gig Sanit. 2003 May-Jun;(3):19-20
Language
Russian
Publication Type
Article
Keywords
Air - analysis
Air Pollutants - adverse effects
Air Pollutants, Radioactive - adverse effects
Hazardous Substances - adverse effects
Humans
Public Health
Russia
Abstract
The article contains data on monitoring the atmospheric air pollution in Moscow. Thus, the below figures are presented: beta ranges from 2.6 E-0.5 to 5.7 E-0.04 Bk/m3, airborne pollutants amount to 3-80 mkg/m3, sulfates--0.002-1.58 mkg(S)/m3, nitrates--0.05-0.75 mkg(N2)/m3 ammonium ions--0.12-1.20 mkg (N2)/m3, sulfuric dioxides--0.11-1.20 mkg (S)/m3. nitric dioxides--0.05-0.5 mlg (N2)/m3 and nitric acid--0.01-0.08 mkg (N2)/m3. The concentration of airborne pollutants exceeds the regional European level (22 mkg/m3) and that of Russia's European part (12 ... 28 mkg/m3) approximately by 1.5 times. It is noteworthy that it reaches 50 ... 70 mkg/m3 in large industrial centers of Europe. The share of sulfuric and nitric acids in the total concentration of airborne pollutants is (by weight) 13%. 0.8 g of sulfur per m2/year and 0.34 g of nitrogen per m2/year fall in the area of Sport-and-Recreation Complex No. 3 with precipitations; the average total beta-activity of atmospheric precipitations amounts to 1.2 Bk/m2 per day. An analysis of relationships between the air dustiness, the ashes samples' weight (of the air) and cuvette (precipitations) is indicative of their direct and tense correlation: the correlation coefficient between dust and ashes samples is 0.716, and between dust and ashes samples of cuvettes--0.559. At the same time, an extremely weak correlation should be pointed out between air dustiness and the total beta-activity of samples--the correlation coefficient is 0.184 (during a warm year season), as well as between dustiness and the beta-activity of cuvettes--0.346.
PubMed ID
12852032 View in PubMed
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[Actual problem of methodology and development of evidence-based health risk assessment associated with chemical exposure].

https://arctichealth.org/en/permalink/ahliterature290154
Source
Gig Sanit. 2016; 95(8):711-6
Publication Type
Journal Article
Author
S M Novikov
M V Fokin
T N Unguryanu
Source
Gig Sanit. 2016; 95(8):711-6
Language
Russian
Publication Type
Journal Article
Keywords
Environmental Exposure - prevention & control - standards
Environmental Pollutants - analysis - standards
Evidence-Based Practice
Hazardous Substances - analysis - standards
Humans
Hygiene - standards
Public Health - methods
Risk Assessment - methods - standards
Russia
Abstract
Paramount problems of the development of the assessment of population health risks associated with the chemical exposure in Russia are considered on the ground of critical analysis of reports devoted to methodological issues of the risk assessment and guidelines published since 2010. Causes of the lack in progress of risk assessment are discussed. The information of executed research revealed the significant retardation number of Russian publications devoted to the evidence-based health risk assessment compare to worldwide trend. The analysis of publications according to evidence-based health risk assessment in Russia in 1998 - 2012 demonstrated methodical problems to be leading to the underestimation of the real risk to population’s health. There are demonstrated directions in the renewal of methodology and practice of hygienic standardization on the basis of the risk assessment. The comparative analysis of values of uncertainty factors (modifying factors, conversion factors) used for extrapolation and accepted in different countries and organizations was made. The system of extrapolation coefficients of DNEL (Derive No-Effect Level) is presented. The leading principles of modern toxicology and risk assessment based on strict scientific proofs are showed. Criteria of evidence-based toxicology and risk assessment are presented.Among actual problems which demand their decision there are considered: the assessment of combined action in regulatory toxicology; expansion of spheres of the application of health risk assessment methodology; the improvement ofpreparation and certification of experts in the field of health risk assessment; need of check of dispersion models and their replacement by more modern models; the improvement of exposure assessment with taking into account the international requirements; the assessment of regional exposure factors; expansion of atmospheric air monitoring in all the large cities of Russia.
PubMed ID
29430892 View in PubMed
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[Acute chemical poisoning of humans as a medico-ecological problem].

https://arctichealth.org/en/permalink/ahliterature210154
Source
Med Tr Prom Ekol. 1997;(2):1-7
Publication Type
Article
Date
1997
Author
N N Litvinov
Source
Med Tr Prom Ekol. 1997;(2):1-7
Date
1997
Language
Russian
Publication Type
Article
Keywords
Acute Disease
Adult
Alcoholism - epidemiology
Ecology
Environmental Pollutants - poisoning
Hazardous Substances - poisoning
Humans
International Cooperation
Pesticides - poisoning
Poison Control Centers
Poisoning - epidemiology - etiology - prevention & control
Risk factors
Russia
Abstract
Anthropogenic acute chemical exposures have become an important socioeconomic and environmental factor on the national, regional and global level. They present an actual or potential danger to vital activity and health of large population groups and normal operation of the Biosphere and natural components. Hence a problem of prevention and elimination of acute technogenic exposures hazardous for human health has expanded beyond the medical competence and grown to a major environmental issue.
PubMed ID
9156767 View in PubMed
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Acute poisonings in Iceland: a prospective nationwide study.

https://arctichealth.org/en/permalink/ahliterature86765
Source
Clin Toxicol (Phila). 2008 Feb;46(2):126-32
Publication Type
Article
Date
Feb-2008
Author
Kristinsson Jakob
Palsson Runolfur
Gudjonsdottir Gudborg A
Blondal Margret
Gudmundsson Sigurdur
Snook Curtis P
Author Affiliation
Institute of Pharmacy, Pharmacology and Toxicology, University of Iceland, Reykjavik, Iceland.
Source
Clin Toxicol (Phila). 2008 Feb;46(2):126-32
Date
Feb-2008
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Adult
Age Factors
Alcoholic Beverages - poisoning
Child
Child, Preschool
Circadian Rhythm
Counseling - methods
Data Collection - methods - statistics & numerical data
Emergency Service, Hospital - statistics & numerical data
Female
Hazardous Substances - classification - poisoning
Humans
Iceland - epidemiology
Incidence
Male
Middle Aged
Patient Admission - statistics & numerical data
Poison Control Centers - utilization
Poisoning - epidemiology - prevention & control
Prospective Studies
Rural Health Services - statistics & numerical data
Sex Factors
Suicide, Attempted - statistics & numerical data
Abstract
INTRODUCTION: Poisoning is a common cause of emergency visits and hospital admission in Western countries. The purpose of this study was to assess the incidence and type of toxic exposures presenting to emergency medical facilities in Iceland. MATERIALS AND METHODS: The study was prospective and included all patients with confirmed or suspected poisoning presenting to hospitals and rural medical centers providing emergency services in Iceland during the twelve-month period from April 2001 until March 2002. RESULTS: A total of 1,121 toxic exposures were documented representing an incidence of 3.91 cases per 1,000 inhabitants per year. The female to male ratio was 1.23. The majority of exposures (56.7%) occurred in the patient's home, 60% were deliberate, 72% had drugs and/or alcohol as their main cause, and 11% involved illicit drugs. Exposures to chemicals other than drugs were usually unintentional. CONCLUSION: Toxic exposures requiring emergency medical care are common in Iceland. Self-poisonings by ingestion of prescription drugs and/or alcohol accounted for the majority of cases.
PubMed ID
18259960 View in PubMed
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[Adaptive immune response of people living near chemically hazardous object].

https://arctichealth.org/en/permalink/ahliterature127016
Source
Voen Med Zh. 2011 Oct;332(10):15-23
Publication Type
Article
Date
Oct-2011
Author
S V Petlenko
M B Ivanov
Iu B Goverdovskii
E G Bogdanova
A V Golubkov
Source
Voen Med Zh. 2011 Oct;332(10):15-23
Date
Oct-2011
Language
Russian
Publication Type
Article
Keywords
Environmental Exposure - adverse effects
Female
Hazardous Substances - adverse effects
Humans
Immunity, Cellular - drug effects
Male
Russia
Time Factors
Abstract
The article presents data dynamics of adaptive immune responses of people for a long time living in adverse environmental conditions caused by pollution of the environment by industrial toxic waste. It is shown that in the process of adaptation to adverse environmental factors, changes in the immune system are in the phase fluctuations of immunological parameters that are accompanied by changes in the structure of immunodependent pathology. Most sensitive to prolonged exposure to toxic compounds are the cellular mechanisms of immune protection. Violations of the structural and quantitative and functional parameters of the link of the immune system are leading to the formation of immunopathological processes.
PubMed ID
22332391 View in PubMed
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[Administration of essential phospholipids in persons exposed to chemical industrial pollutants].

https://arctichealth.org/en/permalink/ahliterature180414
Source
Ter Arkh. 2004;76(2):63-6
Publication Type
Article
Date
2004
Author
L A Shpagina
S V Bobrov
Source
Ter Arkh. 2004;76(2):63-6
Date
2004
Language
Russian
Publication Type
Article
Keywords
Antioxidants - administration & dosage - therapeutic use
Hazardous Substances - poisoning
Humans
Liver Function Tests
Occupational Diseases - drug therapy - etiology
Occupational Exposure - adverse effects
Phosphatidylcholines - administration & dosage - therapeutic use
Poisoning - drug therapy - etiology
Russia
Treatment Outcome
Abstract
To examine efficacy of the drug essliver-forte in patients with chronic intoxication by a complex of such toxicants as soluble and unsoluble compounds of uranium, lead and mercury.
The examination of bilirubin, synthesis of proteins and enzyme production by the liver, activity of free radical lipid oxidation and antioxidant defence was conducted in 42 persons (mean age 66.4 +/- 4.2 years) occupationally exposed to chemicals (compounds of uranium, lead and mercury) for 12.6 +/- 1.8 years. The patients were divided into two equal groups: patients of group 1 received standard therapy with enterosorbents, cerebral angioprotectors and alpha-tocopherol; patients of group 2 instead of alpha-tocopherol were given essliver-forte (2 capsules twice a day).
Patients of group 2 had significantly less frequent complaints for fatigue, anxiety, dyspnea, sleep disorders; improvement was observed in peripheral blood counts, in concentrations of alpha 2- and gamma-globulins, sulfhydril and catalase activity of erythrocytes; transaminase activity and intensity of saponin hemolysis went down.
Essliver-forte is effective in persons occupationally exposed to chemicals.
PubMed ID
15106419 View in PubMed
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Airway symptoms and lung function among male workers in an area polluted from an oil tank explosion.

https://arctichealth.org/en/permalink/ahliterature267816
Source
J Occup Environ Med. 2014 Sep;56(9):953-8
Publication Type
Article
Date
Sep-2014
Author
Jens-Tore Granslo
Magne Bråtveit
Bjørg Eli Hollund
Stein Håkon Låstad Lygre
Cecilie Svanes
Bente Elisabeth Moen
Source
J Occup Environ Med. 2014 Sep;56(9):953-8
Date
Sep-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Air Pollutants, Occupational - adverse effects
Cross-Sectional Studies
Explosions
Hazardous Substances - adverse effects
Humans
Lung Diseases - chemically induced
Male
Middle Aged
Norway
Occupational Exposure - analysis
Petroleum - adverse effects
Respiratory Function Tests
Respiratory System
Young Adult
Abstract
To assess whether working in an industrial harbor where an oil tank exploded was associated with more airway symptoms and lower lung function in men 1.5 years later.
In a cross-sectional study of 180 men, 18 to 67 years old, airway symptoms and lung function among men who worked in the industrial harbor at the time of the explosion was compared with those of working men with residence more than 20 km away. Regression analyses are adjusted for smoking, occupational exposure, atopy, recent infection, and age.
Exposed men had significantly more upper (ORirritated nose = 2.89 [95% confidence interval = 1.31 to 6.37]) and lower (ORdyspnea uphill = 3.79 [95% confidence interval = 1.69 to 8.46]) airway symptoms, and some indication of more reversible airway obstruction than unexposed workers.
Men working in an area with an oil tank explosion had more airway symptoms and indication of more airway obstruction 1.5 years after the event.
PubMed ID
25153304 View in PubMed
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[Alternative methodologies for standardization of deleterious environmental factors].

https://arctichealth.org/en/permalink/ahliterature183949
Source
Gig Sanit. 2003 Jul-Aug;(4):45-7
Publication Type
Article
Author
P G Tkachev
A A Liapkalo
I P L'gova
V N Riabchikov
Source
Gig Sanit. 2003 Jul-Aug;(4):45-7
Language
Russian
Publication Type
Article
Keywords
Air Pollutants - adverse effects - standards
Conservation of Natural Resources - legislation & jurisprudence
Environmental Illness - etiology - prevention & control
Hazardous Substances - adverse effects
Humans
Russia
Abstract
Some ecologists propose in recent papers to replace the ideology of the maximum allowable concentrations (MAC) by a new biotic concept of regional environmental monitoring by the method of ecologically allowable levels (EAL). By comparing the basic provisions of MAC and EAL methodologies, by taking into account their advantages and disadvantages, the authors conclude that there is no alternative to the hygienic MAC concept. The principles of EAL substantiation have no well-grounded scientific-and-practical methodology. New concepts of the common control of environmental quality, the health status of man, animals, plants, and the microworld should be sought by using the existing regulations.
PubMed ID
12934287 View in PubMed
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290 records – page 1 of 29.