Skip header and navigation

Refine By

48 records – page 1 of 5.

Allele and haplotype frequencies of HLA-A, -B, -C, -DRB1, -DQB1 in Northern Ossetians from Vladikavkaz, Russia.

https://arctichealth.org/en/permalink/ahliterature296552
Source
Hum Immunol. 2018 Oct; 79(10):709-710
Publication Type
Journal Article
Date
Oct-2018
Author
Elena Kuzminova
Ekaterina Khamaganova
Tatiana Gaponova
Valeriy Savchenko
Author Affiliation
Research Center for Hematology, Novy Zykovsky proezd 4, Moscow, 125167, Russian Federation. Electronic address: kotvanka@gmail.com.
Source
Hum Immunol. 2018 Oct; 79(10):709-710
Date
Oct-2018
Language
English
Publication Type
Journal Article
Keywords
Alleles
Gene Frequency
Genetic Variation
Genetics, Population
HLA-A Antigens - genetics
HLA-B Antigens - genetics
HLA-C Antigens - genetics
HLA-DQ beta-Chains - genetics
HLA-DRB1 Chains - genetics
Haplotypes
Histocompatibility Antigens Class I - genetics
Humans
Russia
Tissue Donors
Abstract
This report shows the HLA-A, -B, -C, -DRB1 and -DQB1 allele and haplotype frequencies in a population of 127 healthy Ossetian donors of blood marrow from Vladikavkaz, Russia. First- and second-field (for HLA-C locus) HLA genotyping was performed by polymerase chain reaction sequence-specific priming and/or oligonucleotide probes. Statistical analysis were performed using gene counting and Arlequin software packages. There was no deviation from Hardy-Weinberg equilibrium for all tested loci. The HLA genotypic and haplotypic data of the Ossetians reported here are available in free access at the Allele Frequencies Net Database (http://www.allelefrequencies.net). This data can serve as a reference database for further HLA-based studies in population genetics.
PubMed ID
30081065 View in PubMed
Less detail

Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis.

https://arctichealth.org/en/permalink/ahliterature287067
Source
Arthritis Res Ther. 2016 Jun 03;18(1):127
Publication Type
Article
Date
Jun-03-2016
Author
Linda Johansson
Federico Pratesi
Mikael Brink
Lisbeth Ärlestig
Claudia D'Amato
Debora Bartaloni
Paola Migliorini
Solbritt Rantapää-Dahlqvist
Source
Arthritis Res Ther. 2016 Jun 03;18(1):127
Date
Jun-03-2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Arthritis, Rheumatoid - genetics - immunology
Autoantibodies - immunology
Autoantigens - immunology
Case-Control Studies
Citrulline - immunology
Enzyme-Linked Immunosorbent Assay
Female
HLA-DRB1 Chains - genetics
Humans
Male
Middle Aged
Peptides, Cyclic - immunology
Sweden
Abstract
Anti-citrullinated-peptide antibodies (ACPA) have been detected in individuals with developing rheumatoid arthritis (RA) before the onset of symptom, with an initially limited spectrum of reactivities that gradually broadens. The aim was to analyze the evolution of ACPA response pre-dating symptom onset, using four selected citrullinated exogenous and endogenous antigens.
A cohort of 521 individuals sampled before symptoms of RA appeared and 272 population controls were identified from the Biobank of Northern Sweden; 241 samples from patients with early RA were also collected. ACPA were detected by ELISA on viral citrullinated peptides (VCP) derived from Epstein-Barr-virus nuclear antigen (EBNA)1 and EBNA2 (VCP1 and VCP2) and histone-4-derived citrullinated peptides (HCP1 and HCP2).
In pre-symptomatic individuals vs. patients with early RA, anti-VCP1 antibodies were detected in 10.4 % vs. 36.1 %, anti-VCP2 in 17.1 % vs. 52.3 %, anti-HCP1 in 10.2 % vs. 37.3 %, and anti-HCP2 in 16.3 % vs. 48.5 %, respectively. Anti-VCP and anti-HCP concentrations were significantly increased in pre-symptomatic individuals vs. controls (p?
Notes
Cites: Ann Rheum Dis. 2010 Sep;69(9):1580-820699241
Cites: J Rheumatol. 2012 Jul;39(7):1490-322753806
Cites: Nat Genet. 2012 Dec;44(12):1336-4023143596
Cites: Immunol Rev. 2010 Jan;233(1):9-3320192990
Cites: Ann Rheum Dis. 2005 Feb;64(2):179-8215286006
Cites: Autoimmun Rev. 2010 Jan;9(3):158-6019540364
Cites: Arthritis Rheum. 2013 Apr;65(4):899-91023310951
Cites: Clin Exp Immunol. 2011 Jun;164(3):337-4521413944
Cites: Arthritis Rheum. 2004 Feb;50(2):380-614872479
Cites: Arthritis Rheum. 2012 May;64(5):1323-822130974
Cites: Ann Rheum Dis. 2006 Apr;65(4):453-816176994
Cites: Biochem J. 2014 Nov 15;464(1):3-1125181554
Cites: Immunol Lett. 2015 Feb;163(2):214-2025562673
Cites: Ann Rheum Dis. 2014 Jul;73(7):1414-2223727635
Cites: Sci Transl Med. 2013 Mar 27;5(178):178ra4023536012
Cites: Arthritis Rheum. 2006 Mar;54(3):733-4116508937
Cites: Arthritis Res Ther. 2010;12(1):20320236483
Cites: Nat Genet. 2010 Oct;42(10):814-6; author reply 81620877316
Cites: Joint Bone Spine. 2007 Oct;74(5):418-2617625943
Cites: Arthritis Rheum. 1988 Mar;31(3):315-243358796
Cites: Nat Clin Pract Rheumatol. 2006 Aug;2(8):425-3316932734
Cites: Arthritis Rheum. 2003 Oct;48(10):2741-914558078
Cites: Arthritis Res Ther. 2007;9(3):R5617553139
Cites: Arthritis Rheum. 2012 Apr;64(4):982-9222034172
Cites: Am J Hum Genet. 2007 Sep;81(3):559-7517701901
Cites: Ann Rheum Dis. 2016 Oct;75(10):1866-7526659717
Cites: Ann Rheum Dis. 2005 Apr;64(4):587-9315485997
Cites: Ann Rheum Dis. 2013 Sep 1;72(9):1559-6823268369
Cites: Arthritis Res Ther. 2012 Nov 19;14(6):R25023164236
Cites: Arthritis Rheum. 1999 Jul;42(7):1485-9610403278
Cites: Clin Exp Immunol. 2015 Nov;182(2):119-3126149185
Cites: Ann Rheum Dis. 2010 Aug;69(8):1554-6120448290
Cites: Arthritis Res Ther. 2015 May 20;17:12525990747
PubMed ID
27255888 View in PubMed
Less detail

Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis.

https://arctichealth.org/en/permalink/ahliterature287540
Source
Liver Int. 2017 Mar;37(3):458-465
Publication Type
Article
Date
Mar-2017
Author
Johannes R Hov
Kirsten M Boberg
Eli Taraldsrud
Mette Vesterhus
Maria Boyadzhieva
Inger Camilla Solberg
Erik Schrumpf
Morten H Vatn
Benedicte A Lie
Øyvind Molberg
Tom H Karlsen
Source
Liver Int. 2017 Mar;37(3):458-465
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Antibodies, Antineutrophil Cytoplasmic - blood
Biomarkers
Case-Control Studies
Cholangitis, Sclerosing - blood - genetics
Cross-Sectional Studies
Databases, Factual
Female
Fluorescent Antibody Technique, Indirect
Genotype
HLA-B27 Antigen - genetics
HLA-DRB1 Chains - genetics
Humans
Inflammatory Bowel Diseases - genetics
Logistic Models
Male
Middle Aged
Norway
Young Adult
Abstract
The strongest genetic risk factors in primary sclerosing cholangitis (PSC) are encoded in the HLA complex. Antineutrophil cytoplasmic antibodies (ANCA) have been reported in up to 94% of PSC patients, but their clinical significance and immunogenetic basis are ill defined. We aimed to characterize clinical and genetic associations of ANCA in PSC.
Antineutrophil cytoplasmic antibodies were analysed with indirect immunofluorescence in 241 Norwegian PSC patients. HLA-B and HLA-DRB1 genotyping was performed in the patients and in 368 healthy controls. Data on perinuclear ANCA (pANCA) and HLA-DRB1 were available from 274 ulcerative colitis (UC) patients without known liver disease.
Antineutrophil cytoplasmic antibodies were found in 193 (80%) of the PSC patients, with pANCA in 169 (70%). ANCA-positive patients were younger than ANCA negative at diagnosis of PSC and had a lower frequency of biliary cancer (9% vs 19%, P=.047). There were no differences between PSC patients with and without inflammatory bowel disease. Genetically, the strong PSC risk factors HLA-B*08 (frequency in healthy 13%) and DRB1*03 (14%) were more prevalent in ANCA-positive than -negative patients (43% vs 25%, P=.0012 and 43% vs 25%, P=.0015 respectively). The results were similar when restricting the analysis to pANCA-positive patients. In UC patients without liver disease, HLA-DRB1*03 was more prevalent in pANCA-positive compared with -negative patients (P=.03).
Antineutrophil cytoplasmic antibodies identified PSC patients with particular clinical and genetic characteristics, suggesting that ANCA may mark a clinically relevant pathogenetic subgroup in the PSC-UC disease spectrum.
PubMed ID
27558072 View in PubMed
Less detail

Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis.

https://arctichealth.org/en/permalink/ahliterature264232
Source
Gastroenterology. 2015 May;148(5):924-927.e2
Publication Type
Article
Date
May-2015
Author
Natalie L Berntsen
Olav Klingenberg
Brian D Juran
Maria Benito de Valle
Björn Lindkvist
Konstantinos N Lazaridis
Kirsten Muri Boberg
Tom H Karlsen
Johannes Roksund Hov
Source
Gastroenterology. 2015 May;148(5):924-927.e2
Date
May-2015
Language
English
Publication Type
Article
Keywords
Biological Markers - blood
Cholangitis, Sclerosing - blood - diagnosis - genetics - immunology
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens - genetics
HLA-B7 Antigen - genetics
HLA-B8 Antigen - genetics
HLA-DRB1 Chains - genetics
Haplotypes
Humans
Immunoglobulin G - blood
Norway
Phenotype
Sweden
United States
Up-Regulation
Abstract
Increased serum levels of IgG4 have been reported in 9%-15% of patients with primary sclerosing cholangitis (PSC); it is not clear whether this increase contributes to pathogenesis. We performed genetic analyses of the HLA complex in patients with PSC from Norway, Sweden, and from the United States. We found an association between levels of IgG4 above the upper reference limit and specific HLA haplotypes. These patients had a significantly lower frequency of the strongest PSC risk factor, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 and HLA-DRB1*15. HLA genotype therefore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.
Notes
Cites: Hepatology. 2013 Jun;57(6):2390-823300096
Cites: Nat Genet. 2013 Jun;45(6):670-523603763
Cites: Hepatology. 2014 May;59(5):1954-6324375491
Cites: Gastroenterology. 2002 May;122(5):1264-911984513
Cites: Lancet. 2013 Nov 9;382(9904):1587-9923810223
Cites: Dig Liver Dis. 2014 Oct;46(10):903-825091876
Cites: Hepatology. 1991 Jan;13(1):129-331988334
Cites: Immunol Rev. 1999 Feb;167:257-7410319267
Cites: Tissue Antigens. 1999 May;53(5):459-6910372541
Cites: Am J Gastroenterol. 2006 Sep;101(9):2070-516879434
Cites: Tissue Antigens. 2007 Feb;69(2):161-917257319
Cites: Gastroenterology. 2008 Mar;134(3):706-1518222442
Cites: J Hepatol. 2010 May;52(5):712-720347497
Cites: J Hepatobiliary Pancreat Sci. 2012 Sep;19(5):536-4222717980
Comment In: Gastroenterology. 2015 May;148(5):886-925805418
PubMed ID
25655558 View in PubMed
Less detail

Association of HLA-DRB1*01 with Dupuytren's disease.

https://arctichealth.org/en/permalink/ahliterature120555
Source
Scand J Rheumatol. 2013;42(1):45-7
Publication Type
Article
Date
2013
Author
T. Jónsson
K G Gudmundsson
K. Bjarnadóttir
I B Hjálmarsdótti
S. Gudmundsson
R. Arngrímsson
Author Affiliation
The Blood Bank, Landspitali University Hospital, Reykjavík, Iceland.
Source
Scand J Rheumatol. 2013;42(1):45-7
Date
2013
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Cohort Studies
Dupuytren Contracture - epidemiology - genetics
European Continental Ancestry Group - genetics
Female
Gene Frequency
Genetic Predisposition to Disease - epidemiology - genetics
Genotype
HLA-DRB1 Chains - genetics
Health Surveys
Humans
Iceland - epidemiology
Male
Sex Distribution
Abstract
To explore the human leucocyte antigen (HLA)-DRB1 allele frequency in Dupuytren's disease (DD).
HLA-DRB1 genotypes were analysed by sequence-specific primers (SSPs) in samples collected from 172 men participating in a nested case-control study on the clinical manifestations and progression of DD. Of those, 121 had signs of DD while 51 did not. Of the 121 men with DD, 49 had contracted fingers or had been operated on, while 72 had nodules or fibrous cords in the palms. Odds ratios (ORs) and 95% confidence interval (CIs) were used to evaluate the results.
The HLA-DRB1*01 allele was observed in 26 of the 121 affected men (23.7%) but in only four of the controls (7.8%) (OR 3.22, 95% CI 1.06-9.75). The HLA-DRB1*01 allele frequency in those affected was 11%, while in the control group it was 4% (OR 3.07, 95% CI 1.05-9.03).
This observation indicates a possible association of HLA-DRB1*01 with DD, but further studies are needed for confirmation.
PubMed ID
22991974 View in PubMed
Less detail

Association of serum 25-hydroxyvitamin D concentration with HLA-B, -DRB1 and -DQB1 genetic polymorphisms.

https://arctichealth.org/en/permalink/ahliterature288176
Source
Eur J Clin Nutr. 2017 Jan;71(1):128-131
Publication Type
Article
Date
Jan-2017
Author
M E Miettinen
L. Kinnunen
V. Harjutsalo
K. Aimonen
H-M Surcel
C. Lamberg-Allardt
J. Tuomilehto
Source
Eur J Clin Nutr. 2017 Jan;71(1):128-131
Date
Jan-2017
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Case-Control Studies
Child
Diabetes Mellitus, Type 1 - genetics
Female
Finland
Genetic Predisposition to Disease
Genotype
HLA-B Antigens - genetics
HLA-DQ beta-Chains - genetics
HLA-DRB1 Chains - genetics
Humans
Polymorphism, Genetic
Pregnancy
Pregnancy Trimester, First - blood
Vitamin D - analogs & derivatives - blood
Abstract
The human leukocyte antigen (HLA) gene region associates with the risk for several autoimmune diseases, including type 1 diabetes. An association between vitamin D deficiency and several autoimmune diseases has been suggested. We tested the association between serum 25-hydroxyvitamin D (25OHD) concentrations and HLA alleles in pregnant Finnish women.
HLA-B (n=395), HLA-DRB1 (n=501) and HLA-DQB1 (n=475) alleles were genotyped in pregnant women (mothers of children who later developed type 1 diabetes and mothers of non-diabetic children). HLA-B alleles were divided into supertypes that share similar peptide-binding specificity. Serum 25OHD concentration had been previously measured in these women from sera collected during the first trimester of pregnancy. Multiple testing was controlled for using the false discovery rate method.
An association was found between 25OHD concentration and HLA-B44 supertype (P=0.009); women with HLA-B44 supertype (B*18, B*37, B*40 and B*44 alleles) had lower 25OHD concentrations. No association was found between HLA-DRB1 or -DQB1 alleles and 25OHD concentration.
In this study we found for the first time an association between HLA genetic polymorphisms and 25OHD concentration. In future studies, the mechanistic background of this association and the role of vitamin D in the regulation of HLA gene expression should be investigated.
Notes
Cites: N Engl J Med. 2007 Jul 19;357(3):266-8117634462
Cites: Diabetologia. 2015 Oct;58(10):2278-8326109216
Cites: PLoS Genet. 2009 Feb;5(2):e100036919197344
Cites: BMC Immunol. 2008 Jan 22;9:118211710
Cites: Diabetologia. 2012 May;55(5):1291-422270224
Cites: Immunogenetics. 2015 Nov;67(11-12):651-6326459025
Cites: Arthritis Res Ther. 2015 Dec 16;17:36326669670
Cites: Joint Bone Spine. 2010 Dec;77(6):552-721067953
Cites: Curr Diab Rep. 2011 Dec;11(6):533-4221912932
Cites: PLoS One. 2012;7(7):e4167822848563
Cites: Diabetes Obes Metab. 2009 Feb;11 Suppl 1:31-4519143813
Cites: Diabetologia. 2000 Sep;43(9):1093-811043854
Cites: Am J Clin Nutr. 2008 Aug;88(2):491S-499S18689389
Cites: Gene. 2015 May 1;561(2):171-8025682935
Cites: J Hum Genet. 2009 Jan;54(1):15-3919158813
Cites: Lancet. 2001 Nov 3;358(9292):1500-311705562
Cites: Diabetologia. 1983 Apr;24(4):224-306407886
Cites: Diabetologia. 2010 Aug;53(8):1599-60720369220
Cites: J Investig Med. 2011 Aug;59(6):881-621527855
Cites: Diabetes. 2008 Apr;57(4):1084-9218252895
Cites: Nutr Cancer. 2010;62(1):51-720043259
Cites: J Hum Genet. 2015 Nov;60(11):665-7326311539
Cites: PLoS One. 2009 Dec 02;4(12):e802319956544
Cites: Diabetes. 2010 Nov;59(11):2972-920798335
Cites: Diabetes. 2012 Jan;61(1):175-822124461
Cites: J Autoimmun. 2015 Nov;64:101-1226272854
PubMed ID
27623983 View in PubMed
Less detail

Bounds on causal interactions for binary outcomes.

https://arctichealth.org/en/permalink/ahliterature270563
Source
Biometrics. 2014 Sep;70(3):500-5
Publication Type
Article
Date
Sep-2014
Author
A. Sjölander
W. Lee
H. Källberg
Y. Pawitan
Source
Biometrics. 2014 Sep;70(3):500-5
Date
Sep-2014
Language
English
Publication Type
Article
Keywords
Age Distribution
Arthritis, Rheumatoid - epidemiology - genetics
Causality
Computer simulation
Female
Genetic Markers - genetics
Genetic Predisposition to Disease - epidemiology - genetics
HLA-DRB1 Chains - genetics
Humans
Logistic Models
Male
Outcome Assessment (Health Care) - methods
Polymorphism, Single Nucleotide - genetics
Prevalence
Protein Tyrosine Phosphatase, Non-Receptor Type 22 - genetics
Reproducibility of Results
Risk assessment
Sensitivity and specificity
Sex Distribution
Sweden - epidemiology
Abstract
A common goal of epidemiologic research is to study how two exposures interact in causing a binary outcome. Causal interaction is defined as the presence of subjects for which the causal effect of one exposure depends on the level of the other exposure. For binary exposures, it has previously been shown that the presence of causal interaction is testable through additive statistical interaction. However, it has also been shown that the magnitude of causal interaction, defined as the proportion of subjects for which there is causal interaction, is generally not identifiable. In this article, we derive bounds on causal interactions, which are applicable to binary outcomes and categorical exposures with arbitrarily many levels. These bounds can be used to assess the magnitude of causal interaction, and serve as an important complement to the statistical test that is frequently employed. The bounds are derived both without and with an assumption about monotone exposure effects. We present an application of the bounds to a study of gene-gene interaction in rheumatoid arthritis.
PubMed ID
24621448 View in PubMed
Less detail

[Comparative characteristics of HLA system gene distribution in patients with lung tuberculosis of the Russian population of Chelyabinsk region].

https://arctichealth.org/en/permalink/ahliterature258703
Source
Zh Mikrobiol Epidemiol Immunobiol. 2014 May-Jun;(3):35-41
Publication Type
Article
Author
A L Burmistrova
S V Beliaeva
T A Suslova
O V Bukharin
Source
Zh Mikrobiol Epidemiol Immunobiol. 2014 May-Jun;(3):35-41
Language
Russian
Publication Type
Article
Keywords
Alleles
Female
Genetic Predisposition to Disease - genetics
Genetics, Population
HLA-DR Antigens - genetics
HLA-DRB1 Chains - genetics
Haplotypes
Humans
Male
Russia
Tuberculosis, Pulmonary - genetics - pathology
Abstract
Study of distribution of genes and HLA system haplotypes A, B, DRB1, DQA1, DQB1 in healthy individuals and patients with lung tuberculosis, members of the Russian population of Chelyabinsk region for isolation of risk markers for the development of various forms of tuberculosis.
The study group consisted of 86 patients with lung tuberculosis of the Tuberculosis Dispensary No. 3 of Chelyabinsk of Russian nationality. 239 healthy donors of Chelyabinsk Hemotransfusion Station of Russian nationality composed the comparison group. HLA-typing was carried out by multi-primer polymerase chain reaction--PCR SSP, HLA II genotyping--by DNA technology (Russia) kits, HLA class I--by methods described in the article by Downing J.M.G. et al. (2004). Result detection was carried out by electrophoresis.
In lung tuberculosis patients high frequency of detection of HLA haplotype DRB1*16-DQA1*01:02-DQB1*05:02/4 was established. In patients with fibrous-cavernous form B*08 and DRB1*03 gene frequency of detection increased and DRB1*07 and DQA1*02:01 genes did not occur. During focal form high frequency of HLA B*15 and HLA DRB1*15 alleles was determined compared with infiltrative form. HLA A*01-B*08-DRB1*03-DQA1*05:01-DQB1*02:01 haplotype only occurred ingroups of patients with more severe forms of tuberculosis.
Markers of sensitivity to clinical phenotypes of tuberculosis were isolated.
PubMed ID
25286510 View in PubMed
Less detail

Disease marker combination enhances patient characterization in the Finnish sarcoidosis patients.

https://arctichealth.org/en/permalink/ahliterature294555
Source
Respir Med. 2017 Nov; 132:92-94
Publication Type
Letter
Date
Nov-2017
Author
E Lahtela
A Wolin
A Pietinalho
M-L Lokki
O Selroos
Author Affiliation
Transplantation Laboratory, Medicum, University of Helsinki, Finland. Electronic address: Laura.lahtela@helsinki.fi.
Source
Respir Med. 2017 Nov; 132:92-94
Date
Nov-2017
Language
English
Publication Type
Letter
Keywords
Alleles
Finland
Genotype
HLA-DP beta-Chains - genetics
HLA-DRB1 Chains - genetics
Humans
Logistic Models
Peptidyl-Dipeptidase A - genetics
Phenotype
Polymorphism, Single Nucleotide
Prognosis
Sarcoidosis - genetics - physiopathology
Abstract
Sarcoidosis is an inflammatory disease of unknown etiology and multiple clinical phenotypes. Clinical manifestations range from asymptomatic disease to severe loss-of-function leading to the hypothesis that sarcoidosis might not be just one disease, but consists of several distinct disease entities each with potentially distinct genetic associations. We have previously demonstrated that in our series HLADRB1* 03:01 and haplotype HLA-DRB1*04:01-DPB1*04:01 are associated with good prognosis sarcoidosis. In our recent work, we found a novel SNP (rs9905945) in the 5'upstream region of the ACE gene to be associated with favorable disease prognosis as well. The main objective of this study was to expand the previous results and analyse combined influence of the found ACE SNP rs9905945 with the protective HLA markers HLADRB1* 03:01 and HLA-DRB1*04:01-DPB1*04:01 in 188 Finnish sarcoidosis patients (resolved disease, n = 90; persistent disease, n = 98). When combining the frequencies of the rs9905945 and of the HLA markers, the strongest association was found for a combination of either/or both HLA markers and rs9905945 for good disease prognosis (37.1% in resolved vs. 11.3% in persistent, p 
PubMed ID
29229112 View in PubMed
Less detail

The DQB1 *03:02 HLA haplotype is associated with increased risk of chronic pain after inguinal hernia surgery and lumbar disc herniation.

https://arctichealth.org/en/permalink/ahliterature117263
Source
Pain. 2013 Mar;154(3):427-33
Publication Type
Article
Date
Mar-2013
Author
Cecilia A Dominguez
Maija Kalliomäki
Ulf Gunnarsson
Aurora Moen
Gabriel Sandblom
Ingrid Kockum
Ewa Lavant
Tomas Olsson
Fred Nyberg
Lars Jørgen Rygh
Cecilie Røe
Johannes Gjerstad
Torsten Gordh
Fredrik Piehl
Author Affiliation
Neuroimmunology Unit, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. cecilia.dominguez@ki.se
Source
Pain. 2013 Mar;154(3):427-33
Date
Mar-2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Alleles
Chronic Pain - etiology - genetics
Diskectomy
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
HLA-DQ beta-Chains - genetics
HLA-DRB1 Chains - genetics
Haplotypes - genetics
Hernia, Inguinal - physiopathology - surgery
Herniorrhaphy
Humans
Intervertebral Disc Displacement - physiopathology - surgery
Lumbar Vertebrae - surgery
Male
Middle Aged
Neuralgia - etiology - genetics
Pain, Postoperative - etiology - genetics
Peripheral Nerve Injuries - etiology - genetics
Risk
Sweden - epidemiology
Young Adult
Abstract
Neuropathic pain conditions are common after nerve injuries and are suggested to be regulated in part by genetic factors. We have previously demonstrated a strong genetic influence of the rat major histocompatibility complex on development of neuropathic pain behavior after peripheral nerve injury. In order to study if the corresponding human leukocyte antigen complex (HLA) also influences susceptibility to pain, we performed an association study in patients that had undergone surgery for inguinal hernia (n=189). One group had developed a chronic pain state following the surgical procedure, while the control group had undergone the same type of operation, without any persistent pain. HLA DRB1genotyping revealed a significantly increased proportion of patients in the pain group carrying DRB1*04 compared to patients in the pain-free group. Additional typing of the DQB1 gene further strengthened the association; carriers of the DQB1*03:02 allele together with DRB1*04 displayed an increased risk of postsurgery pain with an odds risk of 3.16 (1.61-6.22) compared to noncarriers. This finding was subsequently replicated in the clinical material of patients with lumbar disc herniation (n=258), where carriers of the DQB1*03:02 allele displayed a slower recovery and increased pain. In conclusion, we here for the first time demonstrate that there is an HLA-dependent risk of developing pain after surgery or lumbar disc herniation; mediated by the DRB1*04 - DQB1*03:02 haplotype. Further experimental and clinical studies are needed to fine-map the HLA effect and to address underlying mechanisms.
PubMed ID
23318129 View in PubMed
Less detail

48 records – page 1 of 5.