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6-Locus HLA allele and haplotype frequencies in a population of 1075 Russians from Karelia.

https://arctichealth.org/en/permalink/ahliterature301335
Source
Hum Immunol. 2019 Feb; 80(2):95-96
Publication Type
Journal Article
Date
Feb-2019
Author
Yvonne Hagenlocher
Beatrix Willburger
Geoffrey A Behrens
Alexander H Schmidt
Yuri Ioffe
Jürgen Sauter
Author Affiliation
DKMS German Bone Marrow Donor Center, Tübingen, Germany.
Source
Hum Immunol. 2019 Feb; 80(2):95-96
Date
Feb-2019
Language
English
Publication Type
Journal Article
Keywords
Alleles
Gene Frequency
Genetic Loci
Genetics, Population
Genotype
HLA Antigens - genetics
Haplotypes
Humans
Population Groups
Russia - ethnology
Abstract
A total of 1075 Russians from the Russian part of Karelia were genotyped at high-resolution for the human leukocyte antigen loci HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next generation sequencing methods. The haplotypic and allelic profiles as well as Hardy-Weinberg proportions of this population sample were evaluated. As the most frequent 6-locus haplotype, A*03:01?g?~?B*07:02?g?~?C*07:02?g?~?DRB1*15:01?g?~?DQB1*06:02?g?~?DPB1*04:01?g was identified with an estimated frequency of 3.5%. No deviation from Hardy-Weinberg Equilibrium was detected at any of the loci studied. The HLA genotypic data of the population sample reported here are available publicly in the Allele Frequencies Net Database under the population name "Russia Karelia" and the identifier AFN3430.
PubMed ID
30391501 View in PubMed
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Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada.

https://arctichealth.org/en/permalink/ahliterature123483
Source
PLoS One. 2012;7(5):e36933
Publication Type
Article
Date
2012
Author
Manon Ragonnet-Cronin
Stéphane Aris-Brosou
Isabelle Joanisse
Harriet Merks
Dominic Vallee
Kyna Caminiti
Paul Sandstrom
James Brooks
Author Affiliation
National HIV and Retrovirology Laboratories, Public Health Agency of Canada, Ottawa, Canada.
Source
PLoS One. 2012;7(5):e36933
Date
2012
Language
English
Publication Type
Article
Keywords
Adaptation, Physiological - genetics
Adult
Alleles
Canada - ethnology
Epitopes - immunology
Evolution, Molecular
Female
HIV Infections - ethnology - immunology - virology
HIV-1 - genetics - pathogenicity
HLA Antigens - genetics - immunology
Humans
Male
Middle Aged
Selection, Genetic
Young Adult
Abstract
Host immune selection pressure influences the development of mutations that allow for HIV escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA-allele specific. As ethnic groups have distinct and characteristic HLA allele frequencies, we can expect divergent viral evolution within ethnicities. Here, we have sequenced and analyzed the HIV pol gene from 1248 subtype B infected, treatment-na?ve individuals in Canada. Phylogenetic analysis showed no separation between pol sequences from five self-identified ethnic groups, yet fixation index (F(ST)) values showed significant divergence between ethnicities. A total of 17 amino acid sites showed an ethnic-specific fixation pattern (0.015
Notes
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PubMed ID
22693560 View in PubMed
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[A genetic pool study of the population of the Republic of Tyva using genetic markers for the search for associations with tuberculosis]

https://arctichealth.org/en/permalink/ahliterature69550
Source
Probl Tuberk. 1996;(4):38-41
Publication Type
Article
Date
1996
Author
L E Pospelov
A G Matrakshin
K N Tsoi
L S Erdynieva
B K Kuderek
Source
Probl Tuberk. 1996;(4):38-41
Date
1996
Language
Russian
Publication Type
Article
Keywords
Blood Donors
Blood Proteins - genetics
Chi-Square Distribution
Comparative Study
Electrophoresis, Polyacrylamide Gel - statistics & numerical data
English Abstract
Gene Pool
Genetic markers
Genotype
HLA Antigens - genetics
Humans
Reference Values
Risk factors
Siberia
Tuberculosis, Pulmonary - genetics
Abstract
Eighty three Tyvin patients with local pulmonary tuberculosis and 295 healthy donors of the same nationality were examined. They are resided in the central area of Tyva (in Kyzyl and its vicinities). In addition, 132 healthy Tyvin-Todjins were examined. Tuberculosis mortality was found to be associated with the antigen HLA-B15 in the Tyvins living in the central area of the Republic of Tyva (Kyzyl). The incidence of HLA antigens and polymorphic protein locus genotypes varies in different areas of the Republic of Tyva.
PubMed ID
9026803 View in PubMed
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Allelic association with SNPs: metrics, populations, and the linkage disequilibrium map.

https://arctichealth.org/en/permalink/ahliterature195078
Source
Hum Mutat. 2001 Apr;17(4):255-62
Publication Type
Article
Date
Apr-2001
Author
A. Collins
S. Ennis
P. Taillon-Miller
P Y Kwok
N E Morton
Author Affiliation
Human Genetics Research Division, University of Southampton, Southampton, UK.
Source
Hum Mutat. 2001 Apr;17(4):255-62
Date
Apr-2001
Language
English
Publication Type
Article
Keywords
Alleles
Chromosome Mapping
Finland
Gene Frequency - genetics
HLA Antigens - genetics
Haplotypes - genetics
Histocompatibility Antigens Class I - genetics
Humans
Likelihood Functions
Linkage Disequilibrium - genetics
Membrane Proteins
Models, Genetic
Molecular Sequence Data
Polymorphism, Single Nucleotide - genetics
Recombination, Genetic - genetics
X Chromosome - genetics
Abstract
Comparison of different metrics, using three large samples of haplotypes from different populations, demonstrates that rho is the most efficient measure of association between pairs of single nucleotide polymorphisms (SNPs). Pairwise data can be modeled, using composite likelihood, to describe the decline in linkage disequilibrium with distance (the Malecot model). The evidence from more isolated populations (Finland, Sardinia) suggests that linkage disequilibrium extends to 427-893 kb but, even in samples representative of large heterogeneous populations, such as CEPH, the extent is 385 kb or greater. This suggests that isolated populations are not essential for linkage disequilibrium mapping of common diseases with SNPs. The in parameter of the Malecot model (recombination and time), evaluated at each SNP, indicates regions of the genome with extensive and less extensive disequilibrium (low and high values of in respectively). When plotted against the physical map, the regions with extensive and less extensive linkage disequilibrium may correspond to recombination cold and hot spots. This is discussed in relation to the Xq25 cytogenetic band and the HFE gene region.
PubMed ID
11295822 View in PubMed
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Analysis of the Toronto-Rochester Depression Study follow-up data confirms an HLA-region gene contribution to susceptibility to affective disorder.

https://arctichealth.org/en/permalink/ahliterature231953
Source
Genet Epidemiol. 1989;6(1):305-10
Publication Type
Article
Date
1989
Author
L R Weitkamp
H C Stancer
Author Affiliation
Department of Psychiatry, University of Rochester Medical Center, New York 14642.
Source
Genet Epidemiol. 1989;6(1):305-10
Date
1989
Language
English
Publication Type
Article
Keywords
Affective Disorders, Psychotic - diagnosis - genetics
Canada
Disease Susceptibility
Follow-Up Studies
Gene Frequency
Genes, MHC Class II
HLA Antigens - genetics
Haplotypes
Humans
New York
Abstract
Analysis of HLA haplotype distributions in relation to major affective disorder in affected sibling pairs and affected aunt or uncle and niece or nephew pairs confirmed that HLA-region genes do contribute to susceptibility to affective disorder. The data indicated that this effect may be greater in unipolar than in bipolar disorder, and more apparent in families with few affected members than in heavily loaded families. Nonrandom assortment of HLA haplotypes to affected and unaffected offspring in "low load" families occurred principally for the haplotype transmitted from the side of the family without affective disorder. We conclude that HLA-region genes contribute to but are not the only factor in susceptibility to major depression.
PubMed ID
2499504 View in PubMed
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Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q.

https://arctichealth.org/en/permalink/ahliterature203590
Source
Hum Hered. 1999 Jan;49(1):2-8
Publication Type
Article
Date
Jan-1999
Author
F. Enlund
L. Samuelsson
C. Enerbäck
A. Inerot
J. Wahlström
M. Yhr
A. Torinsson
T. Martinsson
G. Swanbeck
Author Affiliation
Department of Clinical Genetics, Gothenburg University, Sahlgrenska University Hospital, Gothenburg, Sweden.
Source
Hum Hered. 1999 Jan;49(1):2-8
Date
Jan-1999
Language
English
Publication Type
Article
Keywords
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Family Health
Genetic Linkage - genetics
Genetic Predisposition to Disease
HLA Antigens - genetics
Humans
Linkage Disequilibrium
Lod Score
Psoriasis - genetics
Sweden
Abstract
Psoriasis is known to be a heterogeneous disease with so far three reported major psoriasis susceptibility loci on chromosome 4q, 6p and 17q. In this study we investigated three reported gene locations by nonparametric and parametric linkage analysis in a large family set consisting of 104 families (153 sib pairs) from Sweden. We could confirm linkage to chromosome 6p. A maximum heterogeneous lod score of 2.78 was reached at locus D6S276 (alpha = 0.60). Allelic association studies within the HLA region indicated linkage disequilibrium at locus TNFbeta with a significant p value of 0.0009. Furthermore, we obtained weak evidence of linkage to the locus on chromosome 17q while no evidence of linkage could be found to the chromosome 4q region.
PubMed ID
9858851 View in PubMed
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An association between the common hereditary hemochromatosis mutation and the factor V Leiden allele in a population with thrombosis.

https://arctichealth.org/en/permalink/ahliterature204897
Source
Blood. 1998 Aug 15;92(4):1461-2
Publication Type
Article
Date
Aug-15-1998

Anti-tissue antibodies and immunoglobulin levels in relation to HLA and other markers in Icelandic families.

https://arctichealth.org/en/permalink/ahliterature246983
Source
J Immunogenet. 1979 Aug;6(4):223-44
Publication Type
Article
Date
Aug-1979
Author
N. Williamson
J H Edwards
K. Monk
P. McLaughlan
D R Stanworth
A. Arnasan
O. Jensson
T. Helgason
F. Kissmeyer-Nielsen
L U Lamm
E. van Loghem
G. de Lange
Source
J Immunogenet. 1979 Aug;6(4):223-44
Date
Aug-1979
Language
English
Publication Type
Article
Keywords
Aged
Blood Group Antigens - genetics
Gene Frequency
Genes, MHC Class II
Genetic markers
Genotype
HLA Antigens - genetics
Humans
Iceland
Immunoglobulins - genetics
Isoantibodies - genetics
Phenotype
Abstract
Studies of 521 sera from the Icelandic cousin marriage project were made to assess the incidence of various anti-tissue antibodies and the levels of immunoglobulins, as these were considered to be useful markers of the humoral immune response. Comparisons were made between these parameters and the HLA-A and B antigens, the blood groups, the immunoglobulin allotypes (Gm, Km and Am), the properdin factor (Bf), and other markers. These investigations offered another approach to the study of the sites of action of immune response genes in man. Because the immune response may be expected to differ for each individual and depend at least in part, on the degree of exposure to different antigens, no absolute correlation was expected. There was, however, a marked association between certain IgG anti-tissue antibodies and HLA antigens. This was most marked for HLA-A10, B18 and b27, but not for HLA-A1 or B8. The comparison of immunoglobulin levels with HLA antigens, was less striking, although HLA-A2 appeared to be associated with low levels of IgE. There were also some associations between immunoglobulin levels and ABO blood groups.
PubMed ID
118221 View in PubMed
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The association between coeliac disease, dermatitis herpetiformis and certain HLA-antigens in Icelanders.

https://arctichealth.org/en/permalink/ahliterature35562
Source
Eur J Immunogenet. 1994 Dec;21(6):457-60
Publication Type
Article
Date
Dec-1994
Author
A. Arnason
I. Skaftadóttir
J. Sigmundsson
E. Mooney
J. Björnsson
N. Cariglia
G. Pálsson
H. Gudjónsson
Author Affiliation
Department of Pathology, University of Iceland, Rekjavík, Iceland.
Source
Eur J Immunogenet. 1994 Dec;21(6):457-60
Date
Dec-1994
Language
English
Publication Type
Article
Keywords
Adult
Celiac Disease - genetics - immunology
Child
Dermatitis Herpetiformis - genetics - immunology
Female
Genotype
HLA Antigens - genetics
HLA-B8 Antigen - genetics
HLA-DQ Antigens - genetics
HLA-DR3 Antigen - genetics
Histocompatibility testing
Homozygote
Humans
Iceland
Male
Abstract
Twenty-eight cases of coeliac disease (CD) and seven of dermatitis herpetiformis (DH) have been verified in Iceland. Standard serological techniques were used for HLA typing. Twenty-five individuals with CD were typed, 21 (84%) of whom carried DR3,DQ2. Twelve of these 25 (48%) had DR3,DR7, DQ2, which makes them possibly homozygous for DQ2, and suggests that homozygosity of DQ2 increases the risk for CD. The four DH patients that were typed all had HLA-B8,DR3,DQ2. It is concluded that CD and DH are associated with DR3, DQZ in Icelanders.
PubMed ID
9098455 View in PubMed
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153 records – page 1 of 16.