Skip header and navigation

3 records – page 1 of 1.

Accuracy of GFR estimating equations in a large Swedish cohort: implications for radiologists in daily routine and research.

https://arctichealth.org/en/permalink/ahliterature280255
Source
Acta Radiol. 2017 Mar;58(3):367-375
Publication Type
Article
Date
Mar-2017
Author
Ulf Nyman
Anders Grubb
Veronica Lindström
Jonas Björk
Source
Acta Radiol. 2017 Mar;58(3):367-375
Date
Mar-2017
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cohort Studies
Contrast Media - pharmacokinetics
Female
Glomerular Filtration Rate - physiology
Humans
Iohexol - pharmacokinetics
Kidney Function Tests - methods - statistics & numerical data
Male
Middle Aged
Radiologists
Radiology
Reproducibility of Results
Research
Sweden
Young Adult
Abstract
Background Guidelines recommend estimation of glomerular filtration rate (eGFR) prior to iodine contrast media (CM) examinations. It is also recommended that absolute eGFR in mL/min, not commonly used relative GFR (adjusted to body surface area; mL/min/1.73?m(2)), should be preferred when dosing and evaluating toxicity of renally excreted drugs. Purpose To validate the absolute Lund-Malmö equation (LM-ABS) in comparison with the absolute Cockcroft-Gault (CG) equation and the relative equations, revised Lund-Malmö (LM-REV), MDRD, and CKD-EPI, after converting relative estimates to absolute values, and to analyze change in eGFR classification when absolute instead of relative eGFR was used. Material and Methods A total of 3495 plasma clearance of iohexol to measure GFR (mGFR) served as reference test. Bias, precision, and accuracy (percentage of estimates ±30% of mGFR; P30) were compared overall and after stratification for various mGFR, eGFR, age, and BMI subgroups. Results The overall P30 results of CG/LM-ABS/LM-REV/MDRD/CKD-EPI were 62.8%/84.9%/83.7%/75.3%/75.6%, respectively. LM-ABS was the most stable equations across subgroups and the only equation that did not exhibit marked overestimation in underweight patients. For patients with relative eGFR 30-44 and 45-59?mL/min/1.73?m(2), 36% and 58% of men, respectively, and 24% and 32% of women, respectively, will have absolute eGFR values outside these relative eGFR intervals. Conclusion Choosing one equation to estimate GFR prior to contrast medium examinations, LM-ABS may be preferable. Unless absolute instead of relative eGFR are used, systematic inaccuracies in assessment of renal function may occur in daily routine and research on CM nephrotoxicity may be flawed.
PubMed ID
27166345 View in PubMed
Less detail

Decentralized glomerular filtration rate (GFR) estimates in healthy kidney donors show poor correlation and demonstrate the need for improvement in quality and standardization of GFR measurements in Sweden.

https://arctichealth.org/en/permalink/ahliterature78410
Source
Scand J Clin Lab Invest. 2007;67(2):227-35
Publication Type
Article
Date
2007
Author
Biglarnia A-R
Wadström J.
Larsson A.
Author Affiliation
Department of Surgery, Uppsala University Hoplital, Uppsala, Sweden.
Source
Scand J Clin Lab Invest. 2007;67(2):227-35
Date
2007
Language
English
Publication Type
Article
Keywords
Creatinine - diagnostic use - urine
Edetic Acid - diagnostic use - urine
Female
Glomerular Filtration Rate - physiology
Humans
Iohexol - analysis - diagnostic use
Kidney - physiology
Kidney Transplantation - standards
Male
Middle Aged
Quality Assurance, Health Care
Reference Standards
Reproducibility of Results
Retrospective Studies
Sweden
Tissue Donors
Abstract
OBJECTIVE: Glomerular filtration rate (GFR) is generally accepted as the best overall index of renal function. Thus, all potential live kidney donors are tested to ensure that they have a normal GFR before they are eligible for kidney transplantation. The choice of GFR test is very much dependent on local traditions and may include iohexol, 51Cr-EDTA, inulin, or creatinine clearance based on urine collection, and creatinine clearance calculated from the Cockcroft-Gault or Modification of Diet in Renal Disease (MDRD) equation as well as cystatin C. The aim of this study was to compare the results of GFR measurements performed in all actual live kidney donors who have undergone live donor nephrectomy at the University Hospital in Uppsala, Sweden, between the years 2000 and 2004. MATERIAL AND METHODS: The patients were selected from all parts of Sweden and the measurements were performed at their local hospital. RESULTS: We found large discrepancies between repeated iohexol measurements in these presumably healthy individuals. There was also a poor correlation between iohexol clearance and calculated creatinine clearance using the Cockcroft-Gault (R2=0.046) or MDRD formula (R2=0.045). CONCLUSIONS: The study shows that the standardization and quality of GFR measurements in Sweden have to be improved.
PubMed ID
17366002 View in PubMed
Less detail

Relationship between body composition and glomerular filtration rate estimates in the general population.

https://arctichealth.org/en/permalink/ahliterature113222
Source
Nephron Clin Pract. 2013;123(1-2):22-7
Publication Type
Article
Date
2013
Author
Sverrir I Gunnarsson
Runolfur Palsson
Gunnar Sigurdsson
Olafur S Indridason
Author Affiliation
Division of Nephrology, Internal Medicine Services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.
Source
Nephron Clin Pract. 2013;123(1-2):22-7
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Aged, 80 and over
Algorithms
Body Composition - physiology
Computer simulation
Creatinine - blood
Female
Glomerular Filtration Rate - physiology
Hand Strength - physiology
Humans
Iceland - epidemiology
Male
Middle Aged
Models, Biological
Reference Values
Reproducibility of Results
Sensitivity and specificity
Sex Distribution
Statistics as Topic
Abstract
Differences in body composition may lead to imprecision in estimates of glomerular filtration rate (eGFR) derived from serum creatinine. Our aims were to examine the relationship between eGFR and anthropometric and body composition measures and handgrip strength.
We analyzed data from a cross-sectional study comprising 1,630 randomly selected community-dwelling adults. The Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were used to calculate eGFR from IMDS-standardized serum creatinine. Body mass index and body surface area were calculated from measured height and weight. Body composition was determined by dual-energy x-ray absorptiometry, handgrip strength measured by a hand-held dynamometer. Regression analysis was used to examine the association between eGFR and other factors.
In women, eGFR determined by the MDRD equation was inversely associated with height (ß = -0.08; p = 0.012), lean mass percentage (ß = -0.06; p = 0.047) and handgrip strength (ß = -0.15; p
PubMed ID
23752061 View in PubMed
Less detail