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9 records – page 1 of 1.

A controlled five-year follow-up study of laser trabeculoplasty as primary therapy for open-angle glaucoma.

https://arctichealth.org/en/permalink/ahliterature51366
Source
Am J Ophthalmol. 1987 Oct 15;104(4):334-8
Publication Type
Article
Date
Oct-15-1987
Author
A. Tuulonen
A K Niva
H I Alanko
Author Affiliation
Department of Ophthalmology, University of Oulu, Finland.
Source
Am J Ophthalmol. 1987 Oct 15;104(4):334-8
Date
Oct-15-1987
Language
English
Publication Type
Article
Keywords
Aged
Cataract Extraction
Comparative Study
Female
Follow-Up Studies
Glaucoma, Open-Angle - pathology - physiopathology - surgery
Humans
Intraocular Pressure - radiation effects
Laser Surgery - standards
Male
Middle Aged
Research Support, Non-U.S. Gov't
Trabeculectomy - standards
Visual Fields
Abstract
We followed up 32 eyes of 32 patients with early glaucoma (22 with capsular glaucoma and ten with simple glaucoma) who received laser trabeculoplasty as a primary therapy. These eyes were compared with a matched control group of 32 eyes treated with medication initially. The success rate (intraocular pressure below 22 mm Hg with laser alone or medication alone) at five years was 50% (16 of 32 eyes) in the laser-treated group and 22% (seven of 32 eyes) in the control group (P less than .02). The control group required more modifications of their therapy to control intraocular pressure. The neuroretinal rim area in the control eyes decreased 2.5 times as much as in the laser group (P = .017). Changes in the Friedmann visual fields did not differ significantly between the two groups.
PubMed ID
3661640 View in PubMed
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[Exfoliation syndrome in a non-selected Finnish population group].

https://arctichealth.org/en/permalink/ahliterature233893
Source
Fortschr Ophthalmol. 1988;85(1):59-60
Publication Type
Article
Date
1988

Hemifield association between blue-on-yellow visual field and optic nerve head topographic measurements.

https://arctichealth.org/en/permalink/ahliterature50989
Source
Graefes Arch Clin Exp Ophthalmol. 1998 May;236(5):339-45
Publication Type
Article
Date
May-1998
Author
P. Teesalu
K. Vihanninjoki
P J Airaksinen
A. Tuulonen
Author Affiliation
Department of Ophthalmology, University of Oulu, Finland.
Source
Graefes Arch Clin Exp Ophthalmol. 1998 May;236(5):339-45
Date
May-1998
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Glaucoma, Open-Angle - pathology
Humans
Middle Aged
Nerve Fibers - pathology
Ocular Hypertension - pathology
Optic Disk - pathology
Optic Nerve - pathology
Perimetry - methods
Research Support, Non-U.S. Gov't
Tomography - methods
Vision Disorders - diagnosis
Visual Fields
Abstract
BACKGROUND: Blue-on-yellow (B/Y) perimetry can reveal visual field defects earlier and larger in extent than white-on-white (W/W) perimetry. The Heidelberg Retina Tomograph (HRT) produces a three-dimensional image of the optic disc. The aim of this study was to compare the strength of the association of the B/Y and W/W visual hemifield mean deviation (HMD) variables with the optic nerve head (ONH) morphological variables of the respective area. METHODS: We evaluated one randomly chosen eye of 40 normal subjects and 37 patients with ocular hypertension and different stages of glaucoma. The B/Y and W/W visual fields (program 30-2) were obtained with a Humphrey perimeter. Results of both visual fields were adjusted for the patient's age and lens transmission index measured with a lens fluorometer. HMD was calculated as the difference between the measured and expected hemifield mean sensitivity values, predicted by the regression model fitted in our nonglaucomatous subject data. The HRT with the software version 1.11 was used to acquire and evaluate the topographic measurements of the optic disc. RESULTS: The B/Y and W/W visual field HMDs showed statistically significant correlation with ONH parameters such as cup shape measure (CSM), rim volume, rim area, mean retinal nerve fiber layer (RNFL) thickness and RNFL cross-sectional area. With forward stepwise logistic regression analysis using B/Y hemifield data 38% of the glaucoma patient's normal W/W hemifields were classified abnormal. With the CSM alone in the model 52% of the cases were classified abnormal. CONCLUSIONS: B/Y visual field hemifield mean deviation values correlate well with ONH parameters examined with the HRT.
PubMed ID
9602317 View in PubMed
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Optical coherence tomography and localized defects of the retinal nerve fiber layer.

https://arctichealth.org/en/permalink/ahliterature50888
Source
Acta Ophthalmol Scand. 2000 Feb;78(1):49-52
Publication Type
Article
Date
Feb-2000
Author
P. Teesalu
A. Tuulonen
P J Airaksinen
Author Affiliation
Department of Ophthalmology, University of Oulu, Finland.
Source
Acta Ophthalmol Scand. 2000 Feb;78(1):49-52
Date
Feb-2000
Language
English
Publication Type
Article
Keywords
Axons - pathology
Chronic Disease
Glaucoma, Open-Angle - pathology
Humans
Interferometry
Light
Middle Aged
Nerve Fibers - pathology
Observer Variation
Retinal Ganglion Cells - pathology
Tomography - methods
Visual Fields
Abstract
PURPOSE: To test the capability of the optical coherence tomography (OCT) to demonstrate and quantitate retinal nerve fiber layer (RNFL) defects. METHODS: The authors examined 6 eyes of 6 chronic open angle glaucoma patients with the OCT. The patients had abnormal Humphrey 30-2 visual fields which corresponded to RNFL defects visible in monochromatic fundus images taken with a digital imaging system. The RNFL images were used for directing the OCT scans to areas where most information was believed to be obtainable. Several linear scans of different lengths across healthy and abnormal RNFL regions were made. RESULTS: When the OCT images were compared to RNFL photographs, the defective areas showed reduced backscattering with the OCT, being distinctly different from the adjacent normal RNFL. Except for one case the RNFL thickness values were smaller in the areas of abnormal appearance compared to areas of normal appearance. CONCLUSION: This preliminary study suggests that the OCT examination results of the RNFL are in good agreement with the RNFL appearance in monochromatic fundus images.
PubMed ID
10726789 View in PubMed
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Optic disc size in exfoliative, primary open angle, and low-tension glaucoma.

https://arctichealth.org/en/permalink/ahliterature51242
Source
Arch Ophthalmol. 1992 Feb;110(2):211-3
Publication Type
Article
Date
Feb-1992
Author
A. Tuulonen
P J Airaksinen
Author Affiliation
Department of Ophthalmology, University of Oulu, Finland.
Source
Arch Ophthalmol. 1992 Feb;110(2):211-3
Date
Feb-1992
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Anterior Eye Segment
Comparative Study
Female
Glaucoma - pathology
Glaucoma, Open-Angle - pathology
Humans
Image Processing, Computer-Assisted
Intraocular Pressure
Male
Middle Aged
Optic Disk - pathology
Photography
Research Support, Non-U.S. Gov't
Retrospective Studies
Abstract
We examined the magnification-corrected optic disc size in 54 patients with exfoliative glaucoma, 61 patients with primary open angle glaucoma, and 50 patients with low-tension glaucoma. The mean optic disc area in low-tension glaucoma was statistically significantly larger than that in primary open angle and exfoliative glaucoma. The mean values of eyes with primary open angle and exfoliative glaucoma did not differ significantly from each other. Frequency distribution of the optic disc size showed, however, that all three diagnostic groups differed significantly from each other. Small discs were more frequent in eyes with exfoliative glaucoma, and large discs were more frequent in eyes with low-tension glaucoma. In primary open angle glaucoma, small and large optic discs were found equally frequently. It is possible that in some eyes large optic discs are vulnerable to even low intraocular pressures due to qualitative properties of the extracellular matrix.
PubMed ID
1736870 View in PubMed
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Presence of pseudoexfoliation on clear and opacified crystalline lenses in an aged population.

https://arctichealth.org/en/permalink/ahliterature224648
Source
Ophthalmologica. 1992;204(2):67-70
Publication Type
Article
Date
1992
Author
H. Rouhiainen
M. Teräsvirta
Author Affiliation
Department of Ophthalmology, University of Kuopio, Finland.
Source
Ophthalmologica. 1992;204(2):67-70
Date
1992
Language
English
Publication Type
Article
Keywords
Aged
Cataract - pathology
Finland
Glaucoma, Open-Angle - pathology
Humans
Lens Capsule, Crystalline - pathology
Risk factors
Abstract
Pseudoexfoliation (PEX) of the lens capsule is a well-known risk factor for open-angle glaucoma. Its prevalence is known to increase by age in the same way as prevalence of age-dependent cataract. In the present paper the prevalence of PEX varied from 8.5 to 13.2% increasing by age. Lens opacities were statistically significantly more common in PEX-positive than PEX-negative eyes. The importance of detecting exfoliation from the lens surface is discussed.
PubMed ID
1594183 View in PubMed
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Rate and pattern of neuroretinal rim area decrease in ocular hypertension and glaucoma.

https://arctichealth.org/en/permalink/ahliterature51243
Source
Arch Ophthalmol. 1992 Feb;110(2):206-10
Publication Type
Article
Date
Feb-1992
Author
P J Airaksinen
A. Tuulonen
H I Alanko
Author Affiliation
Department of Ophthalmology, University of Oulu, Finland.
Source
Arch Ophthalmol. 1992 Feb;110(2):206-10
Date
Feb-1992
Language
English
Publication Type
Article
Keywords
Adult
Aged
Comparative Study
Female
Follow-Up Studies
Glaucoma, Open-Angle - pathology
Humans
Longitudinal Studies
Male
Middle Aged
Ocular Hypertension - pathology
Optic Disk - pathology
Photography
Regression Analysis
Research Support, Non-U.S. Gov't
Retina - pathology
Risk factors
Abstract
The neuroretinal rim areas of 123 eyes (from five normal subjects, 75 patients with ocular hypertension, and 43 patients with glaucoma) were measured to determine the rate and pattern of rim area change during 5 to 15 years (mean, 10 years) of follow-up. Fifty-seven percent of the patients with ocular hypertension and 79% of those with glaucoma showed a statistically significant slope of rim area decrease, a high rate of loss being associated with a high initial rim area. Ninety percent of the variation of rim area loss was accounted for by variables other than the ones measured herein, however (age, disc area, initial rim area, and intraocular pressure). The yearly loss of rim area was 0.23% of the initial area in normal subjects, 0.47% and 2.75% in the patients with stable and deteriorating ocular hypertension, respectively, and 3.47% in the patients with deteriorating glaucoma. The pattern of rim area change was linear in 49% of the patients with a statistically significant rim area decrease, episodic in 22%, and curvilinear in 29%.
PubMed ID
1736869 View in PubMed
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Ultrastructure of connective tissue of eye drainage system in ophthalmic hypertension associated with primary juvenile glaucoma.

https://arctichealth.org/en/permalink/ahliterature91041
Source
Bull Exp Biol Med. 2008 Mar;145(3):374-6
Publication Type
Article
Date
Mar-2008
Author
Kuleshova O N
Nepomnyashchikh G I
Aidagulova S V
Author Affiliation
Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. pathol@soramn.ru
Source
Bull Exp Biol Med. 2008 Mar;145(3):374-6
Date
Mar-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Connective Tissue - ultrastructure
Female
Glaucoma - pathology
Glaucoma, Open-Angle - pathology
Humans
Male
Middle Aged
Ocular Hypertension - pathology
Sclera - pathology - ultrastructure
Abstract
In primary juvenile glaucoma, the connective tissue of the juxtacanalicular zone and sclera undergo constant reorganization because of incessant synthesis and degradation of extracellular matrix components with pronounced fluctuations of electron density of collagen fibrils. Destructive changes in the perivascular nerve trunks were detected at all stages of the glaucoma process, including the initial stages: numerous large foci of cytoplasmic organelle destruction with the formation of autophagosomes and residual bodies predominated in the cytoplasm of myelinated axons of nerve cells.
PubMed ID
19039948 View in PubMed
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Ultrastructure of the endothelium of the drainage system of the eye.

https://arctichealth.org/en/permalink/ahliterature90425
Source
Bull Exp Biol Med. 2008 May;145(5):634-7
Publication Type
Article
Date
May-2008
Author
Kuleshova O N
Nepomnyashchikh G I
Aidagulova S V
Shvedova E V
Author Affiliation
Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Source
Bull Exp Biol Med. 2008 May;145(5):634-7
Date
May-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Child
Endothelium - ultrastructure
Eye - ultrastructure
Female
Glaucoma - pathology
Glaucoma, Open-Angle - pathology
Humans
Male
Microscopy, Electron, Transmission
Middle Aged
Trabecular Meshwork - ultrastructure
Young Adult
Abstract
The endothelium of the ocular drainage system (Schlemm's canal, collector tubules, and aqueous veins) in primary juvenile glaucoma undergoes degenerative dystrophic changes with compensatory hypertrophy and proliferation at the initial stages of the glaucomatous process and atrophy and desquamation at advanced and terminal stages. Progressive decrease in the pinocytous function of endotheliocytes, reduction of the protein-synthesizing and mitochondrial compartments of the cytoplasm, and formation of autophagosomes reflect the process of endotheliocyte degeneration in general.
PubMed ID
19145301 View in PubMed
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9 records – page 1 of 1.