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The -112G>A polymorphism of the secretoglobin 3A2 (SCGB3A2) gene encoding uteroglobin-related protein 1 (UGRP1) increases risk for the development of Graves' disease in subsets of patients with elevated levels of immunoglobulin E.

https://arctichealth.org/en/permalink/ahliterature138513
Source
J Appl Genet. 2011 May;52(2):201-7
Publication Type
Article
Date
May-2011
Author
Dimitry A Chistiakov
Natalia V Voronova
Rust I Turakulov
Kirill V Savost'anov
Author Affiliation
Department of Molecular Diagnostics, National Research Center GosNIIgenetika, 1st Dorozhny Proezd 1, 117545, Moscow, Russia. dimitry.chistiakov@lycos.com
Source
J Appl Genet. 2011 May;52(2):201-7
Date
May-2011
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Asthma - genetics
Case-Control Studies
Female
Genetic Association Studies
Genetic markers
Genetic Predisposition to Disease
Genotype
Graves Disease - epidemiology - genetics
Humans
Hypersensitivity - genetics
Immunoglobulin E - blood
Male
Odds Ratio
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Russia - epidemiology
Secretoglobins
Sequence Analysis, DNA
Uteroglobin - blood - genetics
Young Adult
Abstract
The human secretoglobin 3A2 (SCGB3A2) gene encoding secretory uteroglobin-related protein 1 (UGRP1) resides on the chromosome region 5q31-33 that harbors a susceptibility locus to several autoimmune and inflammatory diseases, including asthma and Graves' disease (GD). Recently, association between the marker rs1368408 (-112G?>A), located in the promoter region of the SCGB3A2 gene, and susceptibility to GD was found in Chinese and UK Caucasians. The study aim was to evaluate whether this polymorphism confers GD susceptibility in a large population cohort comprising 1,474 Russian GD patients and 1,619 controls. The marker rs1368408 was studied using a TaqMan allele discrimination assay. Serum levels of UGRP1 and immunoglobulin E (IgE) were assessed using enzyme-linked immunosorbent assay (ELISA) analyses. Association between the allele A of SCGB3A2 and a higher risk of GD (odds ratio [OR] = 1.33, P = 2.9 × 10(-5)) was shown. Both affected and non-affected carriers of the higher risk genotype A/A had significantly decreased levels of serum UGRP1 compared to the subjects homozygous for G/G (93 ± 37 pg/ml vs. 132 ± 45 pg/ml, P = 0.0011 for GD patients; 77 ± 28 pg/ml vs. 119 ± 33 pg/ml, P = 0.0019 for controls). Serum IgE levels were significantly higher in non-affected subjects homozygous for A/A compared to control individuals homozygous for G/G (153 ± 46 IU/ml vs. 122 ± 40 IU/ml, P = 0.0095). Our data suggest that the carriage of the SCGB3A2 -112A/A variant increases the risk for GD in subsets of patients with elevated levels of IgE, a hallmark of allergic asthma. Therefore, the SCGB3A2 -112G?>A polymorphism may be considered as a likely marker linking susceptibility to allergy/asthma and GD on chromosome 5q31-33.
PubMed ID
21170691 View in PubMed
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The ABCB1, rs9282564, AG and TT genotypes and the COMT, rs4680, AA genotype are less frequent in deceased patients with opioid addiction than in living patients with opioid addiction

https://arctichealth.org/en/permalink/ahliterature280048
Source
Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):381-8
Publication Type
Article
Date
Oct-2016
Author
Christoffersen DJ
Damkier P
Feddersen S
Möller S
Thomsen JL
Brasch-Andersen C
Brøsen K
Source
Basic Clin Pharmacol Toxicol. 2016 Oct;119(4):381-8
Date
Oct-2016
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Catechol O-Methyltransferase - genetics - metabolism
Cohort Studies
Death, Sudden - etiology
Denmark
Female
Genetic Association Studies
Heterozygote
Homozygote
Humans
Male
Methadone - blood - toxicity
Middle Aged
Morphine - blood - toxicity
Morphine Dependence - genetics - metabolism - mortality - physiopathology
Narcotics - blood - toxicity
P-Glycoproteins - genetics - metabolism
Polymorphism, Single Nucleotide
Young Adult
Abstract
Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated with this, we examined the frequencies of 29 SNPs located in candidate genes related to opioid pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT, KCNJ6 and SCN9A in 274 deceased patients with OA (DOA), 309 living patients with OA (LOA) and in 394 healthy volunteers (HV). The main hypothesis of the study was that subjects homozygous for the variant 3435T in ABCB1 (rs1045642) occur more frequently in DOA than in LOA and HV because morphine and methadone more readily cross the blood barrier in these subjects due to a lower efflux transporter activity of the ABCB1 (p-glycoprotein) transporter. Our results did not support this hypothesis, because no statistically significant difference (p = 0.506) in the frequency of the TT genotype of rs1045642 was observed between the DOA, LOA and HV cohorts. However, for another ABCB1 variant, rs9282564, we found that the frequencies of the AG and TT genotypes were 13, 21 and 25% in DOA, LOA and HV, respectively, and after correcting for age, sex and multiple testing, the differences between DOA and LOA were statistically significantly different (p = 0.027). The COMT rs4680 AA genotype frequencies were 25%, 35% and 31% in DOA, LOA and HV, respectively, and the difference between DOA and LOA was also statistically significant (p = 0.0028). In conclusion, this study generated two hypotheses suggesting possible associations of a reduced risk of death and carrying, respectively, the ABCB1 rs9282564 AG and TT genotypes and the COMT rs4680 AA genotype among patients with OA. These findings should be confirmed in independent cohorts, and if a causal relationship between these variants and fatal poisoning in OA is confirmed, then it may be possible at least in theory to personalize prevention of sudden death in this patient group.
PubMed ID
27061230 View in PubMed
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Adiponectin receptor 1 gene (ADIPOR1) variant is associated with advanced age-related macular degeneration in Finnish population.

https://arctichealth.org/en/permalink/ahliterature126460
Source
Neurosci Lett. 2012 Apr 4;513(2):233-7
Publication Type
Article
Date
Apr-4-2012
Author
Kai Kaarniranta
Jussi Paananen
Tanja Nevalainen
Iiris Sorri
Sanna Seitsonen
Ilkka Immonen
Antero Salminen
Leena Pulkkinen
Matti Uusitupa
Author Affiliation
Department of Ophthalmology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Department of Ophthalmology, Kuopio University Hospital, Kuopio, Finland.
Source
Neurosci Lett. 2012 Apr 4;513(2):233-7
Date
Apr-4-2012
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Alleles
European Continental Ancestry Group - genetics
Female
Finland
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Macular Degeneration - genetics
Male
Polymorphism, Single Nucleotide
Receptors, Adiponectin - genetics
Abstract
Adiponectin is an adipocyte-expressed protein that regulates the glucose, lipid, and energy metabolism via adiponectin receptors 1 and 2. Obesity is a known risk factor for age-related macular degeneration (AMD). We, therefore, examined associations of single nucleotide polymorphisms in Adiponectin (ADIPOQ) and Adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) genes with the prevalence of advanced AMD in Finnish population. Thirty-seven markers for ADIPOQ, ADIPOR1 and ADIPOR2 were genotyped in a sample collection of 91 men and 177 women having exudative AMD and 18 men and 26 women having severe atrophic AMD. Patients were diagnosed by fundus photographs and fluorescein angiography. The control group (no signs of AMD in fundus photographs) consisted of 55 men and 111 women. Inclusion criteria age was over 65 years old without diabetes diagnosis. Out of the tested SNPs, rs10753929 located in intron of ADIPOR1 gene was significantly associated (p=0.0471) with AMD status when using a permutation procedure that controlled for the number of tested genotypes and genetic models. Odds ratio (OR) for the association was 1.699 (95% CI 1.192-2.423). The SNP consists of C/T alleles and the risk allele T had a minor allele frequency (MAF) of 20.4%. Distribution of proportion of cases/controls between alleles revealed an additive genetic model. Our findings reveal that rs10753929 ADIPOR1 variant is a novel candidate for AMD genetic risk factor in Finnish population.
PubMed ID
22387454 View in PubMed
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ALK fusion and its association with other driver gene mutations in Finnish non-small cell lung cancer patients.

https://arctichealth.org/en/permalink/ahliterature264912
Source
Genes Chromosomes Cancer. 2014 Nov;53(11):895-901
Publication Type
Article
Date
Nov-2014
Author
Katja Tuononen
Mia Kero
Satu Mäki-Nevala
Virinder Kaur Sarhadi
Milja Tikkanen
Tiina Wirtanen
Mikko Rönty
Aija Knuuttila
Sakari Knuutila
Source
Genes Chromosomes Cancer. 2014 Nov;53(11):895-901
Date
Nov-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - genetics
Cohort Studies
Female
Finland
Gene Fusion
Genetic Association Studies
Humans
Lung Neoplasms - genetics
Male
Middle Aged
Mutation
Phosphatidylinositol 3-Kinases - genetics
Proto-Oncogene Proteins c-met - genetics
Receptor Protein-Tyrosine Kinases - genetics
Tumor Suppressor Protein p53 - genetics
beta Catenin - genetics
Abstract
Screening of anaplastic lymphoma tyrosine kinase (ALK) gene fusions in non-small cell lung cancer (NSCLC) patients enables the identification of the patients likely to benefit from ALK-targeted therapy. Our aim was to assess the prevalence of ALK fusion in Finnish NSCLC patients, which has not been reported earlier, and to study the presence of ALK fusion in relation to clinicopathological characteristics and other driver gene mutations. A total of 469 formalin-fixed paraffin-embedded tumor tissue specimens from Finnish NSCLC patients were screened for ALK fusion by immunohistochemistry (IHC). For confirmation of IHC results, fluorescence in situ hybridization (FISH) was conducted for 171 specimens. Next-generation sequencing was performed for all ALK-positive specimens to characterize the association of ALK fusion with mutations in targeted regions of 22 driver genes. Of the 469 tumors screened, 11 (2.3%) harbored an ALK fusion, including nine adenocarcinomas and two large cell carcinomas. The IHC results for all 11 ALK-positive and 160 random ALK-negative specimens were confirmed by FISH. ALK fusion was significantly associated with never/ex-light smoking history (P
PubMed ID
24942490 View in PubMed
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Allele rs2010963 C of the VEGFA gene is associated with the decreased risk of primary varicose veins in ethnic Russians.

https://arctichealth.org/en/permalink/ahliterature294742
Source
Phlebology. 2018 Feb; 33(1):27-35
Publication Type
Journal Article
Date
Feb-2018
Author
Alexandra S Shadrina
Mariya A Smetanina
Ekaterina A Sokolova
Darya V Shamovskaya
Kseniya S Sevost'ianova
Andrey I Shevela
Evgenii Y Soldatsky
Evgenii I Seliverstov
Marina Y Demekhova
Oleg A Shonov
Evgeny A Ilyukhin
Elena N Voronina
Ilya V Pikalov
Igor A Zolotukhin
Alexander I Kirienko
Maxim L Filipenko
Author Affiliation
1 Institute of Chemical Biology and Fundamental Medicine, Russia.
Source
Phlebology. 2018 Feb; 33(1):27-35
Date
Feb-2018
Language
English
Publication Type
Journal Article
Keywords
5' Untranslated Regions
Adolescent
Adult
Aged
Case-Control Studies
Chi-Square Distribution
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes
Humans
Linkage Disequilibrium
Logistic Models
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Protective factors
Risk factors
Russia - epidemiology
Varicose Veins - diagnosis - ethnology - genetics
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor Receptor-2 - genetics
Young Adult
Abstract
Objective To study the association of polymorphisms rs699947, rs2010963, rs3025039 in the VEGFA gene region and rs1870377, rs2305949, rs2071559 in the VEGFR2 gene region with the risk of primary varicose veins in ethnic Russians. Methods Genotypes were determined by real-time PCR allelic discrimination. The case group consisted of 448 patients with primary varicose veins and the control group comprised 609 individuals without a history of chronic venous disease. Association was studied by logistic regression analysis. Results Allele rs2010963 C was associated with the decreased risk of varicose veins (additive model of inheritance: odds ratio?=?0.73, 95% confidence interval?=?0.59-0.91, P?=?0.004). Conclusions Our results provide evidence that polymorphism rs2010963 located in the 5' untranslated region of the VEGFA gene can influence genetic susceptibility to primary varicose veins in Russians. Otherwise, it can be in linkage disequilibrium with another functional single nucleotide polymorphism that can alter the level of vascular endothelial growth factor A protein.
PubMed ID
27932624 View in PubMed
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[Analysis association of acute ischemic stroke and DNA markers in Russian and Moldavian populations].

https://arctichealth.org/en/permalink/ahliterature128118
Source
Genetika. 2011 Oct;47(10):1393-401
Publication Type
Article
Date
Oct-2011
Author
E A Bondarenko
I M Shetova
N A Shamalov
E I Mokan
N I Barbakar
G S Kurochkin
S S Protopop
L T Lysyi
P A SlominskIi
S A Limborskaia
V I Skvortsova
Source
Genetika. 2011 Oct;47(10):1393-401
Date
Oct-2011
Language
Russian
Publication Type
Article
Keywords
Adult
Brain Ischemia - genetics - pathology
Case-Control Studies
Factor V - genetics
Female
Gene Frequency
Genetic Association Studies
Genetic markers
Humans
Male
Membrane Glycoproteins - genetics
Moldova
Plasminogen Activator Inhibitor 1 - genetics
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prothrombin - genetics
Russia
Stroke - genetics - pathology
Abstract
Polymorphisms c.202G > A of prothrombin F2 gene, c.1691G > A of coagulation factor V F5 gene, c.675delinsG of plasminogen activator1 gene, and (-5)T > C Kozak gene of thrombocytic receptor were studied in the Russian and Moldavian ethnic groups. We have found no association between these polymorphisms and the risk of ischemic stroke development in both ethnic groups. No association was revealed between the risk of stroke development and various combinations of the single nucleotide polymorphisms examined in the sample of ischemic stroke patients from Russia.
PubMed ID
22232928 View in PubMed
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Analysis of genetic variants of class II cytokine and their receptor genes in psoriasis patients of two ethnic groups from the Volga-Ural region of Russia.

https://arctichealth.org/en/permalink/ahliterature122173
Source
J Dermatol Sci. 2012 Oct;68(1):9-18
Publication Type
Article
Date
Oct-2012
Author
Elvira Galimova
Vita Akhmetova
Boris Latipov
Külli Kingo
Ranno Rätsep
Tanel Traks
Sulev Kõks
Elza Khusnutdinova
Author Affiliation
Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia. elya-4@yandex.ru
Source
J Dermatol Sci. 2012 Oct;68(1):9-18
Date
Oct-2012
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Chi-Square Distribution
Child
Child, Preschool
Female
Genetic Association Studies
Genetic Loci
Genetic Predisposition to Disease
Haplotypes
Humans
Interleukins - genetics
Male
Middle Aged
Odds Ratio
Phenotype
Polymorphism, Single Nucleotide
Psoriasis - ethnology - genetics - immunology
Receptors, Interleukin - genetics
Risk assessment
Risk factors
Russia - epidemiology
Young Adult
Abstract
The molecular basis of pathogenesis of psoriasis remains unclear, but one unifying hypothesis of disease aetiology is the cytokine network model. The class II cytokines (CF2) and their receptors (CRF2) are all involved in the inflammatory processes and single nucleotide polymorphisms (SNPs) in respective genes have been associated with psoriasis in a previous study of the Estonian population.
We performed a replication study of 47 SNPs in CF2 and CRF2 genes in independent cohorts of psoriasis patients of two ethnic groups (Russians and Bashkirs) from the Volga-Ural region of Russia.
DNA was obtained from 395 psoriasis patients of two ethnic groups from the Volga-Ural region of Russia and 476 ethnically matched controls. 47 SNPs in the loci of the genes encoding Class II cytokines and their receptors were selected by SNPbrowser version 3.5. Genotyping was performed using the SNPlexâ„¢ (Applied Biosystems) platform.
The genetic variant rs30461 previously associated in original case-control study in Estonians, was also associated in Russians (corrected P-value (Pc=0.008, OR=0.44), but did not reach statistical significance in the Bashkir population. Additionally, the haplotype analysis provided that CC haplotype formed by the SNPs rs30461 and rs955155 had a protective effect in Russians (Pc=0.0024, OR=0.44), supporting the involvement of this locus in the protection against psoriasis. Combined meta-analysis of three populations, including 943 psoriasis patients and 812 healthy controls, showed that the IL29 rs30461 C-allele was not associated with decreased risk of psoriasis (P=0.165, OR=0.68). Moreover, stratification of studies by ethnicity revealed a significant association in the European cohort (P=9.506E-006, OR=0.53).
Therefore, there is no overall evidence of association between psoriasis and SNP rs30461 of the IL29 gene, but there is some evidence to suggest that an association exists in Europeans. However, this current concept should be considered as preliminary and the results need to be confirmed in future independent studies.
PubMed ID
22840887 View in PubMed
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[Analysis of the MTHFR gene linkage disequilibrium structure and association of polymorphic gene variants with coronary atherosclerosis].

https://arctichealth.org/en/permalink/ahliterature117795
Source
Genetika. 2012 Oct;48(10):1207-20
Publication Type
Article
Date
Oct-2012
Author
E A Trifonova
M G Spiridonova
T V Gabidulina
F D Urnov
V P Puzyrev
V A Stepanov
Author Affiliation
Research Institute of Medical Genetics, Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, 634050 Russia.
Source
Genetika. 2012 Oct;48(10):1207-20
Date
Oct-2012
Language
Russian
Publication Type
Article
Keywords
Adult
Alleles
Coronary Artery Disease - genetics - metabolism - pathology
Female
Genetic Association Studies
Genetic Drift
Genetic Predisposition to Disease
Genome, Human
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Lipid Metabolism - genetics
Male
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Mutation
Polymorphism, Single Nucleotide
Russia
Abstract
Analysis of the genome-specific linkage disequilibrium patterns in certain populations is a highly promising approach to the identification of functional variants that underlie susceptibility to complex diseases. In the present study, the linkage disequilibrium patterns of the methylenetetrahydrofolate reductase gene (MTHFR) were examined in a group of patients with coronary atherosclerosis (coronary artery disease, CAD) and in a control sample from the Russian population. It was demonstrated that in the samples from one population, which were differentiated by the presence or absence of CAD, the MTHFR linkage disequilibrium patterns had similar features. Association of the MTHFR rs7533315 and rs2066462 polymorphisms with CAD was demonstrated. In addition, the evolution of the haplotypes and their role in the formation of CAD in the Russian population was reconstructed. The data on the association between genetic variability in the MTHFR locus and pathogenetically important indices of lipid metabolism were obtained. The high informativeness of the haplotype approach in case-control tests for associations with CAD was demonstrated.
PubMed ID
23270270 View in PubMed
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An association study of 21 potential Alzheimer's disease risk genes in a Finnish population.

https://arctichealth.org/en/permalink/ahliterature141682
Source
J Alzheimers Dis. 2010;21(3):763-7
Publication Type
Article
Date
2010
Author
Timo Sarajärvi
Seppo Helisalmi
Leila Antikainen
Petra Mäkinen
Anne Maria Koivisto
Sanna-Kaisa Herukka
Annakaisa Haapasalo
Hilkka Soininen
Mikko Hiltunen
Author Affiliation
Institute of Clinical Medicine-Neurology, University of Eastern Finland, Department of Neurology, Kuopio University Hospital, Kuopio, Finland.
Source
J Alzheimers Dis. 2010;21(3):763-7
Date
2010
Language
English
Publication Type
Article
Keywords
Alleles
Alzheimer Disease - genetics
Databases, Factual
European Continental Ancestry Group - genetics
Finland
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Genetic
Risk
Tumor Necrosis Factor-alpha - genetics
Abstract
Alzheimer's disease (AD) is a genetically complex disorder encompassing several individual susceptibility genes with low risk effects. To assess the risk gene effects in a cohort consisting of ~ 1300 Finnish AD patients and controls, 21 candidate gene polymorphisms were selected for genotyping on the basis of the meta-analyses retrieved from the AlzGene database. A significant genotype and allele association with AD was observed with rs1800629 in the tumor necrosis factor a (TNF). Risk analysis revealed a protective effect for the minor allele carriers of rs1800629. This suggests that genetic alteration in TNF gene may play a role in AD.
PubMed ID
20693638 View in PubMed
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ANGPTL3 serum concentration and rare genetic variants in Finnish population.

https://arctichealth.org/en/permalink/ahliterature293055
Source
Scand J Clin Lab Invest. 2017 Dec; 77(8):601-609
Publication Type
Journal Article
Date
Dec-2017
Author
Anna Tikka
Jari Metso
Matti Jauhiainen
Author Affiliation
a Genomics and Biomarkers Unit , National Institute for Health and Welfare , Helsinki , Finland.
Source
Scand J Clin Lab Invest. 2017 Dec; 77(8):601-609
Date
Dec-2017
Language
English
Publication Type
Journal Article
Keywords
Adult
Aged
Angiopoietin-like Proteins - blood - genetics
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cross-Sectional Studies
DNA Mutational Analysis
Female
Finland
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Hypercholesterolemia - blood - genetics
Male
Middle Aged
Mutation
Polymorphism, Single Nucleotide
Risk factors
Abstract
Genetic variants of angiopoietin-like protein 3 (ANGPTL3) are associated with serum triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) concentration in GWASs. ANGPTL3 deficiency causes declined TG, total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) serum concentration, a phenotype defined as familial combined hypolipidaemia (FHBL2). Our aim is to establish whether ANGPTL3 serum protein concentration correlates with lipoproteins and lipids in hyper- or hypolipidaemic subjects, and whether ANGPTL3 sequence variants are associated with untypical lipid profiles. Additionally, 10 subjects with very low lipoprotein concentrations were sequenced for ANGPTL3 for possible loss-of-function (LOF) variants. Study subjects were selected from Finnish FINRISK and Health 2000 surveys. ANGPTL protein concentrations were measured by ELISA method. As a result, ANGPTL3 serum concentration correlated positively with age, phospholipid transfer protein (PLTP) and cholesteryl ester transfer protein (CETP) activities, but not with any of the lipid or lifestyle attributes. No ANGPTL3 variants were found among sequenced samples. Subjects who carried ANGPTL3 sequence variants rs12563308 (n?=?4) and rs199772471 (n?=?1) had abnormally high TC and LDL-C concentrations. Whole exome sequencing data of these five subjects were further analyzed for rare and deleterious missense variants in genes associated with cholesterol metabolism. In conclusion, ANGPTL3 serum protein concentration did not predict lipid concentrations, unlike apolipoprotein C-III (apoC-III) which positively correlated with most of the lipid attributes. ANGPTL3 variant screen yielded five carriers with abnormally high TC concentration; the actual genetic causality, however, could not be verified.
PubMed ID
28972399 View in PubMed
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336 records – page 1 of 34.