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Adherence to a Healthy Nordic Diet and Risk of Stroke: A Danish Cohort Study.

https://arctichealth.org/en/permalink/ahliterature282576
Source
Stroke. 2017 Feb;48(2):259-264
Publication Type
Article
Date
Feb-2017
Author
Camilla Plambeck Hansen
Kim Overvad
Cecilie Kyrø
Anja Olsen
Anne Tjønneland
Søren Paaske Johnsen
Marianne Uhre Jakobsen
Christina Catherine Dahm
Source
Stroke. 2017 Feb;48(2):259-264
Date
Feb-2017
Language
English
Publication Type
Article
Keywords
Animals
Cohort Studies
Denmark - epidemiology
Diet, Mediterranean
Female
Fishes
Fruit
Health Promotion - methods
Healthy Diet - methods
Humans
Male
Middle Aged
Registries
Risk factors
Scandinavian and Nordic Countries - epidemiology
Stroke - diet therapy - epidemiology - prevention & control
Vegetables
Whole Grains
Abstract
Specific dietary patterns, including the Mediterranean diet, have been associated with stroke prevention. Our aim was to investigate whether adherence to a healthy Nordic diet, including fish, apples and pears, cabbages, root vegetables, rye bread, and oatmeal, was associated with risk of stroke.
Incident cases of stroke among 55?338 men and women from the Danish Diet, Cancer and Health cohort were identified from the Danish National Patient Register and verified by review of records. Cases of ischemic stroke were further subclassified based on etiology according to the TOAST classification system (Trial of Org 10172 in Acute Stroke Treatment). Information on diet was collected at baseline (1993-1997) using a semiquantitative food-frequency questionnaire. Cox proportional hazards models were used to estimate hazards ratios of total stroke and subtypes of ischemic and hemorrhagic stroke.
During a median follow-up of 13.5 years, 2283 cases of incident stroke were verified, including 1879 ischemic strokes. Adherence to a healthy Nordic diet, as reflected by a higher Healthy Nordic Food Index score, was associated with a lower risk of stroke. The hazards ratio comparing an index score of 4 to 6 (high adherence) with an index score of 0 to 1 (low adherence) was 0.86 (95% confidence interval 0.76-0.98) for total stroke. Inverse associations were observed for ischemic stroke, including large-artery atherosclerosis. No trend was observed for hemorrhagic stroke; however, a statistically insignificant trend was observed for intracerebral hemorrhage.
Our findings suggest that a healthy Nordic diet may be recommended for the prevention of stroke.
PubMed ID
28049735 View in PubMed
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Adherence to a healthy Nordic food index is associated with a lower incidence of colorectal cancer in women: the Diet, Cancer and Health cohort study.

https://arctichealth.org/en/permalink/ahliterature121827
Source
Br J Nutr. 2013 Mar 14;109(5):920-7
Publication Type
Article
Date
Mar-14-2013
Author
Cecilie Kyrø
Guri Skeie
Steffen Loft
Kim Overvad
Jane Christensen
Anne Tjønneland
Anja Olsen
Author Affiliation
Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark.
Source
Br J Nutr. 2013 Mar 14;109(5):920-7
Date
Mar-14-2013
Language
English
Publication Type
Article
Keywords
Animals
Avena sativa
Brassica
Bread
Cohort Studies
Colonic Neoplasms - epidemiology - prevention & control
Diet
Female
Fishes
Fruit
Health promotion
Humans
Male
Malus
Middle Aged
Norway
Pyrus
Rectal Neoplasms - epidemiology - prevention & control
Secale cereale
Vegetables
Abstract
Colorectal cancer (CRC) is a multi-factorial disease in which diet is believed to play a role. Little is known about the health effects of specific regional diets. The Nordic diet is high in fat and sugar but also includes a range of traditional products with anticipated health-promoting effects. The aim of this cohort study was to determine whether a healthy Nordic food index consisting of fish, cabbage, rye bread, oatmeal, apples, pears and root vegetables was related to CRC incidence. Data were obtained from a prospective cohort study of 57,053 Danish men and women aged 50-64 years, of whom 1025 developed CRC (13 years' follow-up). Incidence rate ratios (IRR) with 95 % CI were calculated from Cox proportional hazard models. Women who strongly adhered to a healthy Nordic food index had a 35 % lower incidence of CRC than women with poor adherence (adjusted IRR, 0·65; 95 % CI 0·46, 0·94); a similar tendency was found for men. Women had a 9 % lower incidence of CRC per point adherence to the healthy Nordic food index, but no significant effect was found for men. A regional diet based on healthy Nordic food items was therefore associated with a lower incidence of CRC in women. The protective effect was of the same magnitude as previously found for the Mediterranean diet, suggesting that healthy regional diets should be promoted in order to ensure health; this will also preserve cultural heredity and the environment.
Notes
Erratum In: Br J Nutr. 2014 Feb;111(4):758-9
PubMed ID
22874538 View in PubMed
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Assessing validity of a short food frequency questionnaire on present dietary intake of elderly Icelanders.

https://arctichealth.org/en/permalink/ahliterature126210
Source
Nutr J. 2012;11:12
Publication Type
Article
Date
2012
Author
Tinna Eysteinsdottir
Inga Thorsdottir
Ingibjorg Gunnarsdottir
Laufey Steingrimsdottir
Author Affiliation
Unit for Nutrition Research, University of Iceland and Landspitali National-University Hospital, Reykjavik, Iceland. tinnaey@landspitali.is
Source
Nutr J. 2012;11:12
Date
2012
Language
English
Publication Type
Article
Keywords
Aged
Animals
Cod Liver Oil
Coffee
Dairy Products
Diet - statistics & numerical data
Diet Records
Diet Surveys
Energy intake
Female
Food Habits
Fruit
Geriatric Assessment
Humans
Iceland
Interviews as Topic
Male
Meat
Nutrition Assessment
Questionnaires - standards
Sex Factors
Tea
Vegetables
Abstract
Few studies exist on the validity of food frequency questionnaires (FFQs) administered to elderly people. The aim of this study was to assess the validity of a short FFQ on present dietary intake, developed specially for the AGES-Reykjavik Study, which includes 5,764 elderly individuals. Assessing the validity of FFQs is essential before they are used in studies on diet-related disease risk and health outcomes.
128 healthy elderly participants (74 y ± 5.7; 58.6% female) answered the AGES-FFQ, and subsequently filled out a 3-day weighed food record. Validity of the AGES-FFQ was assessed by comparing its answers to the dietary data obtained from the weighed food records, using Spearman's rank correlation, Chi-Square/Kendall's tau, and a Jonckheere-Terpstra test for trend.
For men a correlation = 0.4 was found for potatoes, fresh fruits, oatmeal/muesli, cakes/cookies, candy, dairy products, milk, pure fruit juice, cod liver oil, coffee, tea and sugar in coffee/tea (r = 0.40-0.71). A lower, but acceptable, correlation was also found for raw vegetables (r = 0.33). The highest correlation for women was found for consumption of rye bread, oatmeal/muesli, raw vegetables, candy, dairy products, milk, pure fruit juice, cod liver oil, coffee and tea (r = 0.40-0.61). An acceptable correlation was also found for fish topping/salad, fresh fruit, blood/liver sausage, whole-wheat bread, and sugar in coffee/tea (r = 0.28-0.37). Questions on meat/fish meals, cooked vegetables and soft drinks did not show a significant correlation to the reference method. Pearson Chi-Square and Kendall's tau showed similar results, as did the Jonckheere-Terpstra trend test.
A majority of the questions in the AGES-FFQ had an acceptable correlation and may be used to rank individuals according to their level of intake of several important foods/food groups. The AGES-FFQ on present diet may therefore be used to study the relationship between consumption of several specific foods/food groups and various health-related endpoints gathered in the AGES-Reykjavik Study.
Notes
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PubMed ID
22413931 View in PubMed
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Associations between adherence to the Danish Food-Based Dietary Guidelines and cardiometabolic risk factors in a Danish adult population: the DIPI study.

https://arctichealth.org/en/permalink/ahliterature299378
Source
Br J Nutr. 2018 03; 119(6):664-673
Publication Type
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Date
03-2018
Author
Johanne L Arentoft
Camilla Hoppe
Elisabeth W Andersen
Kim Overvad
Inge Tetens
Author Affiliation
1Division of Diet, Disease Prevention and Toxicology,National Food Institute,Technical University of Denmark,2800 Kgs. Lyngby,Denmark.
Source
Br J Nutr. 2018 03; 119(6):664-673
Date
03-2018
Language
English
Publication Type
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Keywords
Adult
Aged
Cardiovascular Diseases - epidemiology
Cross-Sectional Studies
Denmark
Diet
Dietary Sugars - administration & dosage
Exercise
Fatty Acids - administration & dosage
Female
Follow-Up Studies
Food Quality
Fruit
Health Behavior
Humans
Life Style
Male
Metabolic Syndrome - epidemiology
Middle Aged
Nutrition Assessment
Nutrition Policy
Patient compliance
Risk factors
Single-Blind Method
Surveys and Questionnaires
Vegetables
Waist Circumference
Whole Grains
Abstract
Diet is recognised as one modifiable lifestyle factor for ischaemic heart disease (IHD). We aimed at investigating the associations between adherence to the Danish Food-Based Dietary Guidelines (FBDG) indicated by a Dietary Quality Index (DQI) and selected cardiometabolic risk factors in a cross-sectional study with 219 Danish adult participants (59 %women; age 31-65years) with a minimum of one self-rated risk marker of IHD. Information regarding diet was obtained using web-based dietary assessment software and adherence to the Danish FBDG was expressed by a DQI calculated from 5 food and nutrient indicators (whole grain, fish, fruit and vegetables, energy from saturated fat and from added sugar). Background information, blood samples and anthropometrics were collected and blood pressure was measured. Linear regression analyses were used to evaluate the association between DQI and cardiometabolic risk factors. DQI was inversely associated with LDL:HDL ratio and TAG (-0·089 per unit; 95 % CI -0·177, -0·002 and -5 % per unit; 95 % CI -9, 0, respectively) and positively associated with HDL-cholesterol (0·047 mmol/l per unit; 95 % CI 0·007, 0·088). For men, DQI was inversely associated with BMI (-3 %per unit; 95 % CI -5, -1), trunk fat (-1 % per unit; 95 % CI -2, -1), high-sensitivity C-reactive protein (-30 % per unit; 95 % CI -41, -16 %), HbA1c (-0·09 % per unit; 95 % CI -0·14, -0·04), insulin (-13 % per unit; 95 % CI -19, -7) and homoeostatic model assessment-insulin resistance (-14 % per unit; 95 % CI -21, -7). In women, DQI was positively associated with systolic blood pressure (2·6 mmHg per unit; 95 % CI 0·6, 4·6). In conclusion, higher adherence to the current Danish FBDG was associated with a more beneficial cardiometabolic risk profile in a Danish adult population with a minimum of one self-rated risk factor for IHD.
PubMed ID
29352831 View in PubMed
Less detail

[Diet of six-year-old Icelandic children - National dietary survey 2011-2012].

https://arctichealth.org/en/permalink/ahliterature117006
Source
Laeknabladid. 2013 Jan;99(1):17-23
Publication Type
Article
Date
Jan-2013
Author
Ingibjorg Gunnarsdottir
Hafdis Helgadottir
Birna Thorisdottir
Inga Thorsdottir
Author Affiliation
University of Iceland, Iceland. ingigun@hi.is
Source
Laeknabladid. 2013 Jan;99(1):17-23
Date
Jan-2013
Language
Icelandic
Geographic Location
Iceland
Publication Type
Article
Keywords
Age Factors
Child
Child Behavior
Child Nutritional Physiological Phenomena
Dairy Products
Diet
Dietary Fats
Dietary Fiber
Dietary Sucrose
Energy intake
Food Habits
Fruit
Humans
Iceland
Minerals
Nutrition Assessment
Nutrition Policy
Nutrition Surveys
Nutritional Status
Seafood
Vegetables
Vitamins
Abstract
Knowledge of dietary habits makes the basis for public nutrition policy. The aim of this study was to assess dietary intake of Icelandic six-year-olds.
Subjects were randomly selected six-year-old children (n=162). Dietary intake was assessed by three-day-weighed food records. Food and nutrient intake was compared with the Icelandic food based dietary guidelines (FBDG) and recommended intake of vitamins and minerals.
Fruit and vegetable intake was on average 275±164 g/d, and less than 20% of the subjects consumed =400 g/day. Fish and cod liver oil intake was in line with the FBDG among approximately 25% of subjects. Most subjects (87%) consumed at least two portions of dairy products daily. Food with relatively low nutrient density (cakes, cookies, sugar sweetened drinks, sweets and ice-cream) provided up to 25% of total energy intake. The contribution of saturated fatty acids to total energy intake was 14.1%. Less than 20% of the children consumed dietary fibers in line with recommendations, and for saturated fat and salt only 5% consumed less than the recommended upper limits. Average intake of most vitamins and minerals, apart from vitamin-D, was higher than the recommended intake.
Although the vitamin and mineral density of the diet seems adequate, with the exception of vitamin-D, the contribution of low energy density food to total energy intake is high. Intake of vegetables, fruits, fish and cod liver oil is not in line with public recommendations. Strategies aiming at improving diet of young children are needed.
PubMed ID
23341402 View in PubMed
Less detail

Do descriptive norms related to parents and friends predict fruit and vegetable intake similarly among 11-year-old girls and boys?

https://arctichealth.org/en/permalink/ahliterature271271
Source
Br J Nutr. 2016 Jan 14;115(1):168-75
Publication Type
Article
Date
Jan-14-2016
Author
Elviira Lehto
Carola Ray
Ari Haukkala
Agneta Yngve
Inga Thorsdottir
Eva Roos
Source
Br J Nutr. 2016 Jan 14;115(1):168-75
Date
Jan-14-2016
Language
English
Publication Type
Article
Keywords
Attitude
Child
Diet - standards
Eating
Energy intake
Female
Finland
Food Habits
Food Preferences
Friends
Fruit
Humans
Male
Parents
Sex Factors
Social Environment
Surveys and Questionnaires
Vegetables
Abstract
We examined whether there are sex differences in children's fruit and vegetable (FV) intake and in descriptive norms (i.e. perceived FV intake) related to parents and friends. We also studied whether friends' impact is as important as that of parents on children's FV intake. Data from the PRO GREENS project in Finland were obtained from 424 children at the age 11 years at baseline. At baseline, 2009 children filled in a questionnaire about descriptive norms conceptualised as perceived FV intake of their parents and friends. They also filled in a validated FFQ that assessed their FV intake both at baseline and in the follow-up in 2010. The associations were examined with multi-level regression analyses with multi-group comparisons. Girls reported higher perceived FV intake of friends and higher own fruit intake at baseline, compared with boys, and higher vegetable intake both at baseline and in the follow-up. Perceived FV intake of parents and friends was positively associated with both girls' and boys' FV intake in both study years. The impact of perceived fruit intake of the mother was stronger among boys. The change in children's FV intake was affected only by perceived FV intake of father and friends. No large sex differences in descriptive norms were found, but the impact of friends on children's FV intake can generally be considered as important as that of parents. Future interventions could benefit from taking into account friends' impact as role models on children's FV intake.
PubMed ID
26450715 View in PubMed
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Does insufficient adjustment for smoking explain the preventive effects of fruit and vegetables on lung cancer?

https://arctichealth.org/en/permalink/ahliterature17658
Source
Lung Cancer. 2004 Jul;45(1):1-10
Publication Type
Article
Date
Jul-2004
Author
Halla Skuladottir
Anne Tjoenneland
Kim Overvad
Connie Stripp
Jane Christensen
Ole Raaschou-Nielsen
Jørgen H Olsen
Author Affiliation
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100 Copenhagen, Denmark. halla@cancer.dk
Source
Lung Cancer. 2004 Jul;45(1):1-10
Date
Jul-2004
Language
English
Publication Type
Article
Keywords
Aged
Cohort Studies
Confounding Factors (Epidemiology)
Denmark - epidemiology
Diet
Female
Fruit
Humans
Incidence
Lung Neoplasms - epidemiology - prevention & control
Male
Middle Aged
Reproducibility of Results
Smoking - adverse effects
Vegetables
Abstract
Recent reports have raised the question, whether the previously observed protective effects of high intake of fruit and vegetables on the risk of lung cancer were due to insufficient adjustment for smoking leading to residual confounding. Association of intake of fruit and vegetables on lung cancer risk was examined, using the Danish prospective cohort study, "Diet, Cancer and Health". Participants completed a food-frequency and lifestyle questionnaire, and age-standardized incidence rates and rate ratios were estimated for quartiles of dietary exposure. In 1993-2001, 247 out of the 54158 participants were diagnosed with lung cancer. The incidence rate of lung cancer was highest in the lowest quartile of intake of plant food (fruit, vegetables, legumes and potatoes) and the age-standardized rate ratio of lung cancer decreased significantly with increasing intake of plant food to 0.35 (95% CI, 0.27-0.45) but after control for smoking it was attenuated to 0.65 (95% CI, 0.45-0.93). The incidence rate differences of current smokers with high (> or = 400 g per day) and low (
PubMed ID
15196728 View in PubMed
Less detail

Food composition of the diet in relation to changes in waist circumference adjusted for body mass index.

https://arctichealth.org/en/permalink/ahliterature131961
Source
PLoS One. 2011;6(8):e23384
Publication Type
Article
Date
2011
Author
Dora Romaguera
Lars Ã?ngquist
Huaidong Du
Marianne Uhre Jakobsen
Nita G Forouhi
Jytte Halkjær
Edith J M Feskens
Daphne L van der A
Giovanna Masala
Annika Steffen
Domenico Palli
Nicholas J Wareham
Kim Overvad
Anne Tjønneland
Heiner Boeing
Elio Riboli
Thorkild I Sørensen
Author Affiliation
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, United Kingdom. d.romaguera-bosch@imperial.ac.uk
Source
PLoS One. 2011;6(8):e23384
Date
2011
Language
English
Publication Type
Article
Keywords
Abdominal Fat - metabolism
Adiposity - physiology
Adult
Aged
Body Composition - physiology
Body mass index
Dairy Products
Denmark
Diet
Female
Food
Fruit
Germany
Glycemic Index
Great Britain
Humans
Italy
Linear Models
Male
Meat
Middle Aged
Netherlands
Waist Circumference - physiology
Abstract
Dietary factors such as low energy density and low glycemic index were associated with a lower gain in abdominal adiposity. A better understanding of which food groups/items contribute to these associations is necessary.
To ascertain the association of food groups/items consumption on prospective annual changes in "waist circumference for a given BMI" (WC(BMI)), a proxy for abdominal adiposity.
We analyzed data from 48,631 men and women from 5 countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Anthropometric measurements were obtained at baseline and after a median follow-up time of 5.5 years. WC(BMI) was defined as the residuals of waist circumference regressed on BMI, and annual change in WC(BMI) (?WC(BMI), cm/y) was defined as the difference between residuals at follow-up and baseline, divided by follow-up time. The association between food groups/items and ?WC(BMI) was modelled using centre-specific adjusted linear regression, and random-effects meta-analyses to obtain pooled estimates.
Higher fruit and dairy products consumption was associated with a lower gain in WC(BMI) whereas the consumption of white bread, processed meat, margarine, and soft drinks was positively associated with ?WC(BMI). When these six food groups/items were analyzed in combination using a summary score, those in the highest quartile of the score--indicating a more favourable dietary pattern--showed a ?WC(BMI) of -0.11 (95% CI -0.09 to -0.14) cm/y compared to those in the lowest quartile.
A dietary pattern high in fruit and dairy and low in white bread, processed meat, margarine, and soft drinks may help to prevent abdominal fat accumulation.
Notes
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PubMed ID
21858094 View in PubMed
Less detail

Fruit and vegetable intake and risk of acute coronary syndrome.

https://arctichealth.org/en/permalink/ahliterature99436
Source
Br J Nutr. 2010 Jul;104(2):248-55
Publication Type
Article
Date
Jul-2010
Author
Louise Hansen
Lars O Dragsted
Anja Olsen
Jane Christensen
Anne Tjønneland
Erik B Schmidt
Kim Overvad
Author Affiliation
Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. louhan@cancer.dk
Source
Br J Nutr. 2010 Jul;104(2):248-55
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Acute Coronary Syndrome - epidemiology - prevention & control
Cohort Studies
Denmark - epidemiology
Diet
Female
Fruit
Humans
Male
Malus
Middle Aged
Questionnaires
Risk factors
Vegetables
Abstract
Prospective epidemiological studies have reported that a higher fruit and vegetable intake is associated with a lower risk of CHD. The aim of the present study was to examine associations between fruit and vegetable consumption, in particular the subgroupings citrus fruits, apples and cruciferous vegetables, and the risk of acute coronary syndrome (ACS). During a median follow-up of 7.7 years, 1075 incident ACS cases were identified among 53 383 men and women, aged 50-64 years at recruitment into the Diet, Cancer and Health cohort study in 1993-7. Fruit and vegetable intake was estimated from a validated FFQ, and ACS incidence rate ratios (IRR) were estimated using Cox proportional hazards models. Overall, a tendency towards a lower risk of ACS was observed for both men and women with higher fruit and vegetable consumption. For men, we found an inverse association for apple intake (IRR per 25 g/d: 0.97; 95 % CI 0.94, 0.99). This association was also seen among women, albeit borderline significant. However, a higher risk was seen among women with higher fruit juice intake (IRR per 25 g/d: 1.04; 95 % CI 1.00, 1.08). The present results provide some support for previously observed inverse associations between fresh fruit intake, particularly apples, and ACS risk.
PubMed ID
20178672 View in PubMed
Less detail

Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort.

https://arctichealth.org/en/permalink/ahliterature131882
Source
Int J Cancer. 2012 Jul 15;131(2):469-78
Publication Type
Article
Date
Jul-15-2012
Author
Louise Hansen
Guri Skeie
Rikard Landberg
Eiliv Lund
Richard Palmqvist
Ingegerd Johansson
Lars O Dragsted
Rikke Egeberg
Nina F Johnsen
Jane Christensen
Kim Overvad
Anne Tjønneland
Anja Olsen
Author Affiliation
Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark. louhan@cancer.dk
Source
Int J Cancer. 2012 Jul 15;131(2):469-78
Date
Jul-15-2012
Language
English
Publication Type
Article
Keywords
Adult
Cereals
Cohort Studies
Colonic Neoplasms - epidemiology - etiology - prevention & control
Dietary Fiber - administration & dosage
Eating
Female
Food Habits
Fruit
Humans
Incidence
Male
Middle Aged
Rectal Neoplasms - epidemiology
Risk factors
Scandinavia - epidemiology
Vegetables
Abstract
The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (= 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.
PubMed ID
21866547 View in PubMed
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