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1163 records – page 1 of 117.

Source
Orv Hetil. 1978 Mar 5;119(10):563-72
Publication Type
Article
Date
Mar-5-1978
Author
K. Király
Source
Orv Hetil. 1978 Mar 5;119(10):563-72
Date
Mar-5-1978
Language
Hungarian
Publication Type
Article
Keywords
France
Humans
Hungary
Norway
Sweden
Syphilis - epidemiology
PubMed ID
628552 View in PubMed
Less detail

Estimating the budget impact of orphan drugs in Sweden and France 2013-2020.

https://arctichealth.org/en/permalink/ahliterature258160
Source
Orphanet J Rare Dis. 2014;9:22
Publication Type
Article
Date
2014
Author
Adam Hutchings
Carina Schey
Richard Dutton
Felix Achana
Karolina Antonov
Author Affiliation
Dolon Ltd, 175-185 Gray's Inn Road, London WC1X 8UE, UK. adam.hutchings@dolon.com.
Source
Orphanet J Rare Dis. 2014;9:22
Date
2014
Language
English
Publication Type
Article
Keywords
Budgets
France
Orphan Drug Production - economics
Sweden
Abstract
The growth in expenditure on orphan medicinal products (OMP) across Europe has been identified as a concern. Estimates of future expenditure in Europe have suggested that OMPs could account for a significant proportion of total pharmaceutical expenditure in some countries, but few of these forecasts have been well validated. This analysis aims to establish a robust forecast of the future budget impact of OMPs on the healthcare systems in Sweden and France.
A dynamic forecasting model was created to estimate the budget impact of OMPs in Sweden and France between 2013 and 2020. The model used historical data on OMP designation and approval rates to predict the number of new OMPs coming to the market. Average OMP sales were estimated for each year post-launch by regression analysis of historical sales data. Total forecast sales were compared with expected sales of all pharmaceuticals in each country to quantify the relative budget impact.
The model predicts that by 2020, 152 OMPs will have marketing authorization in Europe. The base case OMP budget impacts are forecast to grow from 2.7% in Sweden and 3.2% in France of total drug expenditure in 2013 to 4.1% in Sweden and 4.9% in France by 2020. The principal driver of expenditure growth is the number of new OMPs obtaining OMP designation. This is tempered by the slowing success rate for new approvals and the loss of intellectual property protection on existing orphan medicines. Given the forward-looking nature of the analysis, uncertainty exists around model parameters and sensitivity analysis found peak year budget impact varying between 2% and 11%.
The budget impact of OMPs in Sweden and France is likely to remain sustainable over time and a relatively small proportion of total pharmaceutical expenditure. This forecast could be affected by changes in the success rate for OMP approvals, average cost of OMPs, and the type of companies developing OMPs.
Notes
Cites: Orphanet J Rare Dis. 2011;6:4221682893
Cites: Orphanet J Rare Dis. 2011;6:6221951518
Cites: BMJ. 2012;345:e546122890124
Cites: J Clin Pharm Ther. 2012 Dec;37(6):664-722731105
Cites: J Med Econ. 2010;13(2):295-30120482245
Cites: Health Policy. 2010 Oct;97(2-3):173-920800761
Cites: Appl Health Econ Health Policy. 2010;8(5):301-1520804223
Cites: BMJ. 2010;341:c647121081598
PubMed ID
24524281 View in PubMed
Less detail

[Acting on environment or individuals: comparisons in health promotion between Quebec and France].

https://arctichealth.org/en/permalink/ahliterature159911
Source
Sante Publique. 2007 Sep-Oct;19(5):439-48
Publication Type
Article
Author
Réal Morin
Author Affiliation
Institut national de santé publique du Québec, 945, avenue Wolfe, Québec (Québec) G1V5B3, Canada. real.morin@inspq.qc.ca
Source
Sante Publique. 2007 Sep-Oct;19(5):439-48
Language
French
Publication Type
Article
Keywords
Environment
France
Health Promotion - methods
Humans
Quebec
PubMed ID
18064845 View in PubMed
Less detail

Cutaneous leishmaniasis in a 3-year-old Finnish visitor to France.

https://arctichealth.org/en/permalink/ahliterature237605
Source
Scand J Infect Dis. 1986;18(6):587-9
Publication Type
Article
Date
1986
Author
H. Kyrönseppä
A L Kariniemi
T. Pitkänen
Source
Scand J Infect Dis. 1986;18(6):587-9
Date
1986
Language
English
Publication Type
Article
Keywords
Child, Preschool
Female
Finland
France
Humans
Leishmaniasis
Travel
Abstract
A child with non-ulcerating cutaneous leishmaniasis after a 3-week visit to Southern France is reported. Diagnosis was histological. The possibility of the patient having had a visceral infection was taken into account when designing the final treatment.
PubMed ID
3810051 View in PubMed
Less detail

[Probable origin of a satellited Y chromosome found in a French-Canadian family].

https://arctichealth.org/en/permalink/ahliterature254135
Source
Union Med Can. 1973 Dec;102(12):2470-2
Publication Type
Article
Date
Dec-1973
Author
P. Genest
Source
Union Med Can. 1973 Dec;102(12):2470-2
Date
Dec-1973
Language
French
Publication Type
Article
Keywords
France
Humans
Pedigree
Quebec
Sex Chromosome Aberrations - genetics
PubMed ID
4772544 View in PubMed
Less detail

[Abusing the young child: a comparison between Canadian and French approaches].

https://arctichealth.org/en/permalink/ahliterature174729
Source
Arch Pediatr. 2005 Jun;12(6):672-3
Publication Type
Article
Date
Jun-2005
Author
G. Picherot
Author Affiliation
Service d'urgence et réanimation pédiatriques, clinique médicale, hôpital Mère-Enfant, CHU de Nantes, 44093 Nantes, France. georges.picherot@chu-nantes.fr
Source
Arch Pediatr. 2005 Jun;12(6):672-3
Date
Jun-2005
Language
French
Publication Type
Article
Keywords
Canada
Child
Child Abuse - prevention & control
France
Humans
PubMed ID
15904765 View in PubMed
Less detail

[Collecting the wounded and transport of the sick; the pilot experience of Malmö and the Midi-Pyrenees region].

https://arctichealth.org/en/permalink/ahliterature111053
Source
Anesth Analg (Paris). 1967 Nov-Dec;24(6):609-22
Publication Type
Article
Author
L. Lareng
J. Daver
Source
Anesth Analg (Paris). 1967 Nov-Dec;24(6):609-22
Language
French
Publication Type
Article
Keywords
Ambulances - utilization
France
Humans
Sweden
Transportation of Patients
PubMed ID
5587729 View in PubMed
Less detail

Temperature-related mortality in France, a comparison between regions with different climates from the perspective of global warming.

https://arctichealth.org/en/permalink/ahliterature95713
Source
Int J Biometeorol. 2006 Nov;51(2):145-53
Publication Type
Article
Date
Nov-2006
Author
Laaidi Mohamed
Laaidi Karine
Besancenot Jean-Pierre
Author Affiliation
Climat et Santé, Faculté de Médecine, Centre Universitaire d'Epidémiologie de Population, BP 87900, Dijon Cedex, France. mohamed.laaidi@u-bourgogne.fr
Source
Int J Biometeorol. 2006 Nov;51(2):145-53
Date
Nov-2006
Language
English
Publication Type
Article
Keywords
Climate
France - epidemiology
Greenhouse Effect
Humans
Mortality - trends
Temperature
Abstract
This paper aims to explain the results of an observational population study that was carried out between 1991 and 1995 in six regions (departments) in France. The study was to assess the relationship between temperature and mortality in a few areas of France that offer widely varying climatic conditions and lifestyles, to determine their thermal optimum, defined as a 3 degrees C temperature band with the lowest mortality rate in each area, and then to compare the mortality rates from this baseline band with temperatures above and below the baseline. The study period was selected because it did not include extreme cold or hot events such as a heatwave. Data on daily deaths from each department were first used to examine the entire population and then to examine men, women, various age groups and various causes of death (respiratory disease, stroke, ischaemic heart disease, other disease of the circulatory system, and all other causes excluding violent deaths). Mean temperatures were provided by the National Weather Service. The results depicted an asymmetrical V- or U-shaped relationship between mortality and temperature, with a thermal optimum lower for the elderly, and generally lower for women than for men except in Paris. The relationship was also different depending on the cause of death. In all cases, more evidence was collected showing that cold weather was more deadly than hot weather, and it would now be interesting to enlarge the study to include years with cold spells and heatwaves. Furthermore, the results obtained could be of great use in estimating weather-related mortality as a consequence of future climate-change scenarios.
PubMed ID
16847688 View in PubMed
Less detail
Source
Sante Publique. 2007 May-Jun;19(3):181-2
Publication Type
Article
Author
Lise Renaud
Hélène Valentini
Source
Sante Publique. 2007 May-Jun;19(3):181-2
Language
French
Publication Type
Article
Keywords
France
Health promotion
Humans
International Cooperation
Public Health
Quebec
PubMed ID
17708482 View in PubMed
Less detail

High-resolution record of climate stability in France during the last interglacial period.

https://arctichealth.org/en/permalink/ahliterature95949
Source
Nature. 2001 Sep 20;413(6853):293-6
Publication Type
Article
Date
Sep-20-2001
Author
Rioual P.
Andrieu-Ponel V.
Rietti-Shati M.
Battarbee R W
de Beaulieu J L
Cheddadi R.
Reille M.
Svobodova H.
Shemesh A.
Author Affiliation
Environmental Change Research Centre, University College London, 26 Bedford Way, London WC1H 0AP, UK. prioual@geog.ucl.ac.uk
Source
Nature. 2001 Sep 20;413(6853):293-6
Date
Sep-20-2001
Language
English
Publication Type
Article
Keywords
Animals
Climate
Diatoms
France
Plankton
Pollen
Silicon Dioxide
Time
Abstract
The last interglacial period (127-110 kyr ago) has been considered to be an analogue to the present interglacial period, the Holocene, which may help us to understand present climate evolution. But whereas Holocene climate has been essentially stable in Europe, variability in climate during the last interglacial period has remained unresolved, because climate reconstructions from ice cores, continental records and marine sediment cores give conflicting results for this period. Here we present a high-resolution multi-proxy lacustrine record of climate change during the last interglacial period, based on oxygen isotopes in diatom silica, diatom assemblages and pollen-climate transfer functions from the Ribains maar in France. Contrary to a previous study, our data do not show a cold event interrupting the warm interglacial climate. Instead, we find an early temperature maximum with a transition to a colder climate about halfway through the sequence. The end of the interglacial period is clearly marked by an abrupt change in all proxy records. Our study confirms that in southwestern Europe the last interglacial period was a time of climatic stability and is therefore still likely to represent a useful analogue for the present climate.
PubMed ID
11565028 View in PubMed
Less detail

1163 records – page 1 of 117.