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577 records – page 1 of 58.

A 1-year, placebo-controlled, double-blind house-dust-mite immunotherapy study in asthmatic adults.

https://arctichealth.org/en/permalink/ahliterature15782
Source
Allergy. 1997 Aug;52(8):853-9
Publication Type
Article
Date
Aug-1997
Author
O T Olsen
K R Larsen
L. Jacobsan
U G Svendsen
Author Affiliation
Department of Pulmonery Medicine and Allergology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Source
Allergy. 1997 Aug;52(8):853-9
Date
Aug-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adrenergic beta-Agonists - therapeutic use
Adult
Antigens, Dermatophagoides
Asthma - diagnosis - drug therapy - therapy
Bronchial Provocation Tests
Double-Blind Method
Female
Forced expiratory volume
Glycoproteins - administration & dosage - adverse effects - immunology
Humans
Immunoglobulin E - analysis - blood - immunology
Immunotherapy
Male
Middle Aged
Peak Expiratory Flow Rate
Severity of Illness Index
Skin Tests
Steroids - therapeutic use
Vital Capacity
Abstract
Thirty-one adult patients with asthma caused by house-dust mites (HDM) were included in this placebo-controlled, double-blind study to evaluate the efficacy and safety of specific immunotherapy (SIT) with biologically standardized extracts of HDM. The specific diagnosis was confirmed by skin prick tests, specific IgE, and bronchial provocation tests with HDM allergens. The patients were randomized to receive active treatment with extracts of either Dermatophagoides pteronyssinus (Dpt) or D. farinae (Dfa) (Alutard SQ, ALK, Denmark) or placebo injections. Twenty-three patients completed the study. After 1 year of treatment, we found a clinically important and significant reduction in both asthma medicine consumption (inhaled steroids 38% and beta 2-agonists 46%) and symptom score (57%) in the actively treated group, but not the placebo group. These findings were confirmed by a significant decrease in skin and bronchial sensitivity to HDM in the active group. Additionally, there was a significant difference in the patients' scores for effect in favor of the actively treated group. Total IgE and specific IgE to HDM showed no significant changes before and after treatment for either group. Spirometric lung-function measurements showed a significant increase in forced expiratory volume in 1 s (FEV1) from 85% before to 89% of predicted values after treatment for the actively treated group. Peak-flow measurements at home showed no significant changes during the study. It is concluded that allergen SIT is an effective treatment in adult patients suffering from asthma due to HDM.
PubMed ID
9284985 View in PubMed
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Absence of relationship between tuberculin reactivity and asthmatic symptoms, level of FEV1 and bronchial hyperresponsiveness in BCG vaccinated young adults.

https://arctichealth.org/en/permalink/ahliterature15399
Source
Allergy. 2002 Apr;57(4):336-40
Publication Type
Article
Date
Apr-2002
Author
H F Jentoft
E. Omenaas
G E Eide
A. Gulsvik
Author Affiliation
Department of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway.
Source
Allergy. 2002 Apr;57(4):336-40
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Asthma - drug therapy - physiopathology
BCG Vaccine - therapeutic use
Bronchial Hyperreactivity - drug therapy - physiopathology
Comparative Study
Cross-Sectional Studies
Female
Forced Expiratory Volume - physiology
Humans
Logistic Models
Male
Norway - epidemiology
Predictive value of tests
Prevalence
Questionnaires
Random Allocation
Research Support, Non-U.S. Gov't
Sex Factors
Smoking
Treatment Outcome
Tuberculin - drug effects - physiology
Abstract
BACKGROUND: Some recent studies have suggested that bacillus Calmette-Guérin (BCG) vaccination or mycobacterial infection early in life is inversely related to asthma. We wondered if an increase in tuberculin reactivity was inversely related to commonly used indices of asthma in a population of young adults who were BCG vaccinated at age 14. METHODS: Men and women aged 20-44 years, randomly selected from the general population, were tuberculin tested with the epinephrine-Pirquet method with Norwegian-produced synthetic medium tuberculin (n = 588). In addition they were interviewed using eight questions on asthma symptoms and medication. Lung function and bronchial responsiveness were also tested. RESULTS: Altogether 95% of those studied had been BCG vaccinated at age 14 (n = 558). In the 386 subjects with complete examinations, there was no relationship between a positive tuberculin reaction (> or = 4 mm) and asthma symptoms or use of asthma medication. Furthermore we did not observe any relationship between a positive tuberculin reaction and the level of forced expiratory volume (FEV1) or a positive bronchial responsiveness test, assessed as the percent of predicted of FEV1 and PD20
PubMed ID
11906365 View in PubMed
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Acculturation and the growth of lung function: three cross-sectional surveys of an Inuit community.

https://arctichealth.org/en/permalink/ahliterature3566
Source
Respiration. 1994;61(4):187-94
Publication Type
Article
Date
1994
Author
A. Rode
R J Shephard
Author Affiliation
School of Physical and Health Education, University of Toronto, Ont., Canada.
Source
Respiration. 1994;61(4):187-94
Date
1994
Language
English
Publication Type
Article
Keywords
Acculturation
Adolescent
Adult
Body Composition - physiology
Body Height
Canada
Child
Cross-Sectional Studies
Female
Forced Expiratory Volume - physiology
Humans
Inuits
Lung - growth & development - physiology
Male
Maximal Midexpiratory Flow Rate - physiology
Pulmonary Ventilation - physiology
Research Support, Non-U.S. Gov't
Respiration - physiology
Smoking - physiopathology
Somatotypes
Vital Capacity - physiology
Abstract
The influence of acculturation to a sedentary lifestyle upon the growth and development of lung volumes has been studied in Inuit children aged 9-19 years. Surveys were conducted in the circumpolar community of Igloolik (69 degrees 40'N, 81 degrees W) in 1969/70, 1979/80 and 1989/90. Over this period, the children showed little change of height or body mass at any given age, but a progressive loss of what initially had been a high level of health-related fitness. The sample for each survey comprised about 70% of children in the chosen age range: in the most recent study 87 males and 65 females. Respiratory data included forced vital capacity, one-second forced expiratory volume, maximal mid-expiratory flow rate (second and third surveys only), smoking habits and respiratory health. In each of the 3 surveys, many of the older children in the community were regular smokers. The average cigarette consumption currently rises progressively to 13 +/- 8 cigarettes/day in 87% of males and 11 +/- 7 cigarettes/day in 95% of females over 17 years of age. Nevertheless, lung volumes show the anticipated increase as a logarithmic function of stature. Furthermore, statistically fitted curves show only minor inter-survey differences in volumes for a given standing height. We thus conclude that the deterioration in other aspects of health-related fitness has not yet influenced the growth and development of respiratory function within this Inuit population.
PubMed ID
7973102 View in PubMed
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Acute asthma: emergency department management and prospective evaluation of outcome.

https://arctichealth.org/en/permalink/ahliterature229449
Source
CMAJ. 1990 Mar 15;142(6):591-5
Publication Type
Article
Date
Mar-15-1990
Author
J M Fitzgerald
F E Hargreave
Author Affiliation
Firestone Regional Chest and Allergy Unit, St. Joseph's Hospital, Hamilton, Ont.
Source
CMAJ. 1990 Mar 15;142(6):591-5
Date
Mar-15-1990
Language
English
Publication Type
Article
Keywords
Acute Disease
Adolescent
Adrenal Cortex Hormones - administration & dosage - therapeutic use
Adrenergic beta-Agonists - administration & dosage - therapeutic use
Adult
Asthma - diagnosis - drug therapy - physiopathology
Emergencies
Emergency Service, Hospital - utilization
Evaluation Studies as Topic
Female
Follow-Up Studies
Forced expiratory volume
Humans
Male
Medical History Taking
Middle Aged
Ontario
Prednisone - therapeutic use
Prognosis
Questionnaires
Recurrence
Retrospective Studies
Spirometry
Abstract
To determine the current management of acute asthma in the emergency department and to evaluate outcome we reviewed the charts of 99 patients aged 15 to 55 years who presented to the emergency department of a tertiary referral, university-affiliated hospital and were subsequently discharged with a diagnosis of acute asthma. Outcome was evaluated prospectively, with a structured questionnaire, by telephone. During the visit pulsus paradoxus was documented in four patients. Spirometry was done in 63 patients; postbronchodilator values ranged from 0.9 to 4.1 L. A total of 92 patients received inhaled bronchodilator therapy, most by wet nebulization. Sixteen patients received anticholinergic agents and three received theophylline. Ingested corticosteroids were given to 27 patients. Of the 71 patients contacted, a mean of 12 days after the visit, 26 (37%) had sought further medical attention, 19 at the emergency department; 9 had required admission. Forty-six patients reported that their condition had improved, but over 60% continued to have cough, sputum production, nocturnal waking and early-morning chest tightness. The results indicate that asthma continues to be undertreated in the emergency department and highlight the importance of routine spirometry in all patients and the need for systemic corticosteroid therapy.
Notes
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Comment In: CMAJ. 1990 Jun 1;142(11):1183, 1186-72344573
PubMed ID
1968778 View in PubMed
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Acute effects of ambient inhalable particles in asthmatic and nonasthmatic children.

https://arctichealth.org/en/permalink/ahliterature205834
Source
Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1034-43
Publication Type
Article
Date
Apr-1998
Author
S. Vedal
J. Petkau
R. White
J. Blair
Author Affiliation
Department of Medicine, University of British Columbia, Vancouver, Canada.
Source
Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1034-43
Date
Apr-1998
Language
English
Publication Type
Article
Keywords
Adolescent
Air Pollutants, Occupational - adverse effects - analysis
Asthma - physiopathology
British Columbia
Child
Cross-Sectional Studies
Female
Forced expiratory volume
Humans
Lung Diseases, Obstructive - physiopathology
Male
Meteorological Concepts
Particle Size
Peak Expiratory Flow Rate
Respiratory Mechanics
Vital Capacity
Wood
Abstract
Although increases in inhalable particle (PM10) concentrations have been associated with acute reductions in the level of lung function and increased symptom reporting in children, including children with asthma, it is not clear whether these effects occur largely in asthmatic children, or even whether asthmatic children are more likely to experience these effects than children without asthma. To address these points, the following subgroups of children were selected from a survey population of all 2,200 elementary school children (6 to 13 yr of age) in a pulp mill community on the west coast of Vancouver Island: (1) all children with physician-diagnosed asthma (n = 75 participated), (2) all children with an exercise-induced fall in FEV1 without diagnosed asthma (n = 57), (3) all children with airway obstruction (FEV1/FVC
PubMed ID
9563716 View in PubMed
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Acute effects on forced expiratory volume in one second and longitudinal change in pulmonary function among wood trimmers.

https://arctichealth.org/en/permalink/ahliterature218525
Source
Am J Ind Med. 1994 Apr;25(4):551-8
Publication Type
Article
Date
Apr-1994
Author
M. Dahlqvist
U. Ulfvarson
Author Affiliation
Department of Work Science, Royal Institute of Technology, Stockholm, Sweden.
Source
Am J Ind Med. 1994 Apr;25(4):551-8
Date
Apr-1994
Language
English
Publication Type
Article
Keywords
Air Pollutants, Occupational - adverse effects
Dust - adverse effects
Follow-Up Studies
Forced Expiratory Volume - physiology
Humans
Lung - physiopathology
Lung Diseases, Fungal - physiopathology
Occupational Exposure - adverse effects
Pneumoconiosis - physiopathology
Risk factors
Sweden
Vital Capacity - physiology
Wood
Abstract
Wood trimmers are exposed to molds that periodically grow on timber, and may develop acute as well as chronic pulmonary function impairment. This study examined whether these acute changes in pulmonary function are predictors for a longitudinal deterioration in pulmonary function, beyond normal aging and exposure. Across-shift changes in pulmonary function, measured during a working week, were evaluated in 15 wood trimmers with a follow-up time of 27 months. Twenty-six sawmill workers, employed at the same plants as the wood trimmers, served as control subjects. The highest concentration of viable mold spores for the wood trimmers was 10(6) colony-forming units (cfu)/m3, i.e., several times higher than the corresponding value for the sawmill workers. At the follow-up, wood trimmers had a lower forced vital capacity (FVC) on average, after adjustment for age and height, compared to the sawmill workers. In addition, a correlation was found between the across-week change in forced expiratory volume in 1 second (FEV1) and the decline in FEV1 between the first and the second occasion, after adjusting for normal aging in nonsmoking wood trimmers (r2 = 84%, p
PubMed ID
8010297 View in PubMed
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Adjustments in cardiorespiratory function after pneumonectomy: results of the pneumonectomy project.

https://arctichealth.org/en/permalink/ahliterature138536
Source
J Thorac Cardiovasc Surg. 2011 Jan;141(1):7-15
Publication Type
Article
Date
Jan-2011
Author
Jean Deslauriers
Paula Ugalde
Santiago Miro
Sylvie Ferland
Sébastien Bergeron
Yves Lacasse
Steve Provencher
Author Affiliation
Department of Thoracic Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. jean.deslauriers@chg.ulaval.ca
Source
J Thorac Cardiovasc Surg. 2011 Jan;141(1):7-15
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Adaptation, Physiological
Aged
Atrial Function, Right
Blood pressure
Chi-Square Distribution
Dyspnea - etiology - physiopathology
Echocardiography, Doppler
Exercise Test
Exercise Tolerance
Female
Forced expiratory volume
Heart - physiopathology
Humans
Hypertension, Pulmonary - etiology - physiopathology
Kaplan-Meier Estimate
Lung - physiopathology - surgery
Lung Neoplasms - mortality - physiopathology - surgery
Male
Middle Aged
Pneumonectomy - adverse effects - mortality
Pulmonary Artery - physiopathology
Pulmonary Diffusing Capacity
Pulmonary Gas Exchange
Quebec
Recovery of Function
Risk assessment
Risk factors
Survival Rate
Time Factors
Treatment Outcome
Ventricular Function, Left
Ventricular Function, Right
Vital Capacity
Abstract
To assess lung function, gas exchange, exercise capacity, and right-sided heart hemodynamics, including pulmonary artery pressure, in patients long term after pneumonectomy.
Among 523 consecutive patients who underwent pneumonectomy for lung cancer between January 1992 and September 2001, 117 were alive in 2006 and 100 were included in the study. During a 1-day period, each patient had complete medical history, chest radiographs, pulmonary function studies, resting arterial blood gas analysis, 6-minute walk test, and Doppler echocardiography.
Most patients (N = 73) had no or only minimal dyspnea. On the basis of predicted values, functional losses in forced expiratory volume in 1 second and forced vital capacity were 38% ± 18% and 31% ± 24%, respectively, and carbon monoxide diffusing capacity decreased by 31% ± 18%. There was a significant correlation between preoperative and postoperative forced expiratory volume in 1 second (P
PubMed ID
21168011 View in PubMed
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Adult respiratory outcomes of extreme preterm birth. A regional cohort study.

https://arctichealth.org/en/permalink/ahliterature268379
Source
Ann Am Thorac Soc. 2015 Mar;12(3):313-22
Publication Type
Article
Date
Mar-2015
Author
Maria Vollsæter
Hege H Clemm
Emma Satrell
Geir E Eide
Ola D Røksund
Trond Markestad
Thomas Halvorsen
Source
Ann Am Thorac Soc. 2015 Mar;12(3):313-22
Date
Mar-2015
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Bronchopulmonary Dysplasia - epidemiology - physiopathology
Female
Follow-Up Studies
Forced expiratory volume
Forecasting
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature, Diseases - epidemiology - physiopathology
Lung
Male
Norway - epidemiology
Prognosis
Pulmonary Disease, Chronic Obstructive - epidemiology - etiology - physiopathology
Retrospective Studies
Spirometry
Total lung capacity
Young Adult
Abstract
Lifetime respiratory function after extremely preterm birth (gestational age=28 wk or birth weight=1,000 g) is unknown.
To compare changes from 18-25 years of age in respiratory health, lung function, and airway responsiveness in young adults born extremely prematurely to that of term-born control subjects.
Comprehensive lung function investigations and interviews were conducted in a population-based sample of 25-year-old subjects born extremely prematurely in western Norway in 1982-1985, and in matched term-born control subjects. Comparison was made to similar data collected at 18 years of age.
At 25 years of age, 46/51 (90%) eligible subjects born extremely prematurely and 39/46 (85%) control subjects participated. z-Scores for FEV1, forced expiratory flow at 25-75% of vital capacity, and FEV1/FVC were significantly reduced in subjects born extremely prematurely by 1.02, 1.26, and 0.88, respectively, and airway resistance (kPa/L/s) was increased (0.23 versus 0.18). Residual volume to total lung capacity increased with severity of neonatal bronchopulmonary dysplasia. Responsiveness to methacholine (dose-response slope; 3.16 versus 0.85) and bronchial lability index (7.5 versus 4.8%) were increased in subjects born extremely prematurely. Lung function changes from 18 to 25 years and respiratory symptoms were similar in the prematurely born and term-born groups.
Lung function in early adult life was in the normal range in the majority of subjects born extremely prematurely, but methacholine responsiveness was more pronounced than in term-born young adults, suggesting a need for ongoing pulmonary monitoring in this population.
PubMed ID
25616079 View in PubMed
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Aging of lung function. Cross-sectional and longitudinal trends in an Inuit community

https://arctichealth.org/en/permalink/ahliterature102159
Source
Pages 233-237 in G. Pétursdóttir et al., eds. Circumpolar Health 93. Proceedings of the 9th International Congress on Circumpolar Health, Reykjavík, Iceland, June 20-25, 1993. Arctic Medical Research. 1994;53(Suppl.2)
Publication Type
Article
Date
1994
, smoking habits, forced vital capacity, one-second forced expiratory volume, and maximal mid-expiratory flow rate have been examined in all willing Inuit aged 9-79 years living in the Arctic community oflgloolik, NWT, Canada (69"N, 8'W) in 1969fi0(1970),1979/80 (1980),and 1989/ 90 (1990). The sample
  1 document  
Author
Rode, A
Shephard, R.J
Author Affiliation
School of Physical and Health Education, University of Toronto, Ontario, Canada
Source
Pages 233-237 in G. Pétursdóttir et al., eds. Circumpolar Health 93. Proceedings of the 9th International Congress on Circumpolar Health, Reykjavík, Iceland, June 20-25, 1993. Arctic Medical Research. 1994;53(Suppl.2)
Date
1994
Language
English
Geographic Location
Canada
Publication Type
Article
Digital File Format
Text - PDF
Keywords
Age
Cigarette addiction
Females
Forced expiratory volume
Forced vital capacity
Igloolik
Inuit
Lung function
Lung volumes
Males
Pulmonary function
Respiratory health
Smoking
Abstract
Respiratory health, smoking habits, forced vital capacity, one-second forced expiratory volume, and maximal mid-expiratory flow rate have been examined in all willing Inuit aged 9-79 years living in the Arctic community of Igloolik, NWT, Canada (69 degrees N, 81 degrees W) in 1969/70 (1970), 1979/80 (1980), and 1989/90 (1990). The sample comprises about 70% of the children and more than 50% of the adults; in the more recent survey, 219 males and 160 females. Almost all of the adults and many of the children smoke, the current average consumption in those over 17 years of age being 13 plus/minus 7 cigarettes/day in the men and 11 plus/minus 7 cigarettes/day in the women. About a third of the community have radiographically visible chest disease, but with a few exceptions this has had only a minor effect upon pulmonary function. During adolescence, long volumes increase as a logarithmic function of stature; statistically fitted curves predict only minor inter-survey differences for a given height. In adults, multiple regressions on age and height show an increase of cross-sectional aging coefficients from 1970 to 1990, with parallel trends in longitudinal data. Radiographic chest disease and domestic air pollution do not seem the sole cause of the secular trend to accelerated aging. Other possible factors include greater pack-years of cigarette exposure, nonspecific respiratory disease, increased inspiration of cold air, altered chest mechanics due to operation of high-speed snowmobiles, and more general consequences of the secular trend to a loss of physical fitness.
Documents
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Air pollution and health in three urban communities.

https://arctichealth.org/en/permalink/ahliterature246878
Source
Arch Environ Health. 1979 Sep-Oct;34(5):360-8
Publication Type
Article
Author
F. Aubry
G W Gibbs
M R Becklake
Source
Arch Environ Health. 1979 Sep-Oct;34(5):360-8
Language
English
Publication Type
Article
Keywords
Air Pollutants - analysis
Air Pollutants, Occupational - analysis
Closing Volume
Female
Forced expiratory volume
Health
Humans
Male
Maximal Expiratory Flow Rate
Middle Aged
Quebec
Respiratory Function Tests
Respiratory Tract Diseases - epidemiology
Smoking
Sulfur Dioxide - analysis
Total lung capacity
Urban health
Vital Capacity
Abstract
A health study was conducted in three communities in the greater Montreal region; the first two were characterized by relatively high particulate and sulfur dioxide levels, respectively, and a third community without major industrial pollution. In each community, 300 men and women 45 to 64 yr of age were studied. Residents of the two more polluted communities exhibited a higher prevalence of respiratory symptoms and mean lung function evaluated by various tests was lower than in residents of the less polluted community. When intercity differences in age and smoking were accounted for, no statistically significant intercity differences in health status could be shown. Given the limitations of this study, the results provide no evidence to suggest that current Canadian standards for sulfur dioxide adequately protect human health as measured by the indices used in the study, for adults in the age range of 45 to 64 yr.
PubMed ID
496434 View in PubMed
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577 records – page 1 of 58.