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Achieving a public health recommendation for preventing neural tube defects with folic acid.

https://arctichealth.org/en/permalink/ahliterature200166
Source
Am J Public Health. 1999 Nov;89(11):1637-40
Publication Type
Article
Date
Nov-1999
Author
M M Werler
C. Louik
A A Mitchell
Author Affiliation
Slone Epidemiology Unit, Boston University School of Public Health, Boston, Mass., USA. mwerler@slone.bu.edu
Source
Am J Public Health. 1999 Nov;89(11):1637-40
Date
Nov-1999
Language
English
Publication Type
Article
Keywords
Adult
Boston - epidemiology
Centers for Disease Control and Prevention (U.S.)
Female
Folic Acid - administration & dosage - therapeutic use
Food, Fortified
Guidelines as Topic
Health Knowledge, Attitudes, Practice
Hematinics - administration & dosage - therapeutic use
Humans
Male
Neural Tube Defects - epidemiology - prevention & control
Ontario - epidemiology
Philadelphia - epidemiology
Population Surveillance
Preconception Care - methods
Public Health
United States
Abstract
This study examined 3 approaches to achieving the public health recommendation that all women of child-bearing age ingest 0.40 mg of folic acid per day to reduce the occurrence of neural tube defects (NTDs).
A total of 1136 mothers of infants with major malformations from the Boston and Philadelphia areas, whose pregnancies began from 1993 to 1995, were interviewed within 6 months of delivery about vitamin supplementation, dietary intakes, and other factors.
Seventy-one percent of the 1136 women in the study did not take folic acid--containing supplements daily before conception, but the proportion decreased over the years of the study. Women not taking supplements consumed an average of 0.25 mg of naturally occurring folates daily. On the basis of dietary intakes reported by women not taking folic acid supplements, a simulation of cereal grain fortification with folic acid at the level required by the US Food and Drug Administration showed that an average of only 0.13 mg of folic acid would be ingested daily.
With consumption of folic acid only through dietary intake, sizeable portions of the childbearing population would receive less than the level of folic acid recommended for preventing NTDs. Even with food fortification, women of childbearing age should be advised to take folic acid--containing supplements on a daily basis.
Notes
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PubMed ID
10553381 View in PubMed
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Adequacy of niacin, folate, and vitamin B12 intakes from foods among Newfoundland and Labrador adults.

https://arctichealth.org/en/permalink/ahliterature113239
Source
Can J Diet Pract Res. 2013;74(2):63-8
Publication Type
Article
Date
2013
Author
Jennifer Colbourne
Natasha Baker
Peter Wang
Lin Liu
Christina Tucker
Barbara Roebothan
Author Affiliation
Division of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada.
Source
Can J Diet Pract Res. 2013;74(2):63-8
Date
2013
Language
English
Publication Type
Article
Keywords
Adult
Aged
Cereals
Female
Folic Acid - administration & dosage - blood
Food, Fortified
Humans
Male
Middle Aged
Newfoundland and Labrador
Niacin - administration & dosage - blood
Nutritional Requirements
Nutritional Status
Pilot Projects
Questionnaires
Recommended dietary allowances
Risk factors
Vitamin B 12 - administration & dosage - blood
Abstract
Adequacy of intake for niacin, folate, and vitamin B12 from food was estimated in an adult population in Newfoundland and Labrador (NL). Also considered was whether study findings support current Canadian food fortification policies.
Four hundred randomly selected adult NL residents were surveyed by telephone. Secondary analysis was performed on two 24-hour food recalls for each participant. Mean daily intakes of niacin, folate, and vitamin B12 were estimated from foods only and compared by sex/age subgroup. Adequacy of intakes was estimated. Contributions of folate by ready-to-eat cereal and bread products were also estimated.
Intakes of all three nutrients were higher in men. In comparison with recommendations, daily niacin intakes were as follows: excessive for 21.9% of all participants (and for 56.8% of men aged 28 to 54), within the recommended range for 73.6%, and less than adequate for 4.5%. In comparison with recommendations, daily folate intakes were as follows: within the recommended range for 18.1% of participants and less than adequate for 81.9%. In comparison with recommendations, daily vitamin B12 intakes were less than adequate for 36.3% of participants.
More than 20% of those surveyed were consuming, from food alone, niacin at levels above the maximum recommended. Food fortification policies pertaining to niacin should be revisited. In addition, despite fortification, NL adults may be consuming inadequate amounts of folate from foods.
PubMed ID
23750977 View in PubMed
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Adverse Pregnancy Outcomes among Adolescents in Northwest Russia: A Population Registry-Based Study.

https://arctichealth.org/en/permalink/ahliterature296661
Source
Int J Environ Res Public Health. 2018 02 03; 15(2):
Publication Type
Journal Article
Date
02-03-2018
Author
Anna A Usynina
Vitaly Postoev
Jon Øyvind Odland
Andrej M Grjibovski
Author Affiliation
Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø 9037, Norway. perinat@mail.ru.
Source
Int J Environ Res Public Health. 2018 02 03; 15(2):
Date
02-03-2018
Language
English
Publication Type
Journal Article
Keywords
Adolescent
Adult
Apgar score
Body Weight
Delivery, Obstetric
Dietary Supplements
Female
Folic Acid - administration & dosage
Humans
Infant, Low Birth Weight
Infant, Newborn
Logistic Models
Pregnancy
Pregnancy Outcome - epidemiology
Pregnancy in Adolescence - statistics & numerical data
Premature Birth - epidemiology
Registries
Reproductive Tract Infections - epidemiology
Russia - epidemiology
Smoking - epidemiology
Stillbirth - epidemiology
Young Adult
Abstract
This study aimed to assess whether adolescents have an increased risk of adverse pregnancy outcomes (APO) compared to adult women. We used data on 43,327 births from the population-based Arkhangelsk County Birth Registry, Northwest Russia, for 2012-2014. The perinatal outcomes included stillbirth, preterm birth (
PubMed ID
29401677 View in PubMed
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Annual trends in use of periconceptional folic acid and birth prevalence of major congenital malformations.

https://arctichealth.org/en/permalink/ahliterature108772
Source
Curr Drug Saf. 2013 Jul;8(3):153-61
Publication Type
Article
Date
Jul-2013
Author
Audrey-Ann Richard-Tremblay
Odile Sheehy
Anick Bérard
Author Affiliation
University of Montreal, Montreal, Quebec, Canada.
Source
Curr Drug Saf. 2013 Jul;8(3):153-61
Date
Jul-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Congenital Abnormalities - epidemiology - physiopathology
Databases, Factual
Female
Folic Acid - administration & dosage - therapeutic use
Heart Defects, Congenital - epidemiology
Humans
Infant, Newborn
Middle Aged
Musculoskeletal Abnormalities - epidemiology
Nervous System Malformations - epidemiology
Pregnancy
Pregnancy outcome
Prevalence
Quebec - epidemiology
Registries
Treatment Outcome
Vitamin B Complex - administration & dosage - therapeutic use
Young Adult
Abstract
Recent evidence suggests that periconceptional folic acid use could not only prevent neural tube defects but also other malformations. The objectives of this study were to assess trends in dispensed high dose periconceptional folic acid (5 mg) and birth prevalence of major congenital malformations.
The Quebec Pregnancy Registry, an administrative database with information on periconceptional prescribed medication and diagnostic codes was used to conduct this study. All pregnant women insured by the Quebec public drug plan between January 1(st) 1998 and December 31(st) 2008 were included. The exposure was defined as the use of high dose periconceptional folic acid 30 days before, and during the first 70 days of pregnancy. The outcome measured was the birth prevalence of major congenital malformations among live births.
We identified 152,392 pregnancies and babies. The annual prevalence of high dose periconceptional folic acid use increased from 0.17% to 0.80% (p
PubMed ID
23845112 View in PubMed
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Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study.

https://arctichealth.org/en/permalink/ahliterature290863
Source
BMJ Open. 2017 06 10; 7(6):e016154
Publication Type
Journal Article
Date
06-10-2017
Author
Cecilia Lourdudoss
Alicja Wolk
Lena Nise
Lars Alfredsson
Ronald van Vollenhoven
Author Affiliation
Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Source
BMJ Open. 2017 06 10; 7(6):e016154
Date
06-10-2017
Language
English
Publication Type
Journal Article
Keywords
Adult
Aged
Antirheumatic Agents - therapeutic use
Arthritis, Rheumatoid - drug therapy
Dietary Supplements
Fatty Acids, Omega-3 - administration & dosage
Female
Folic Acid - administration & dosage
Humans
Male
Middle Aged
Prospective Studies
Sweden
Vitamin D - administration & dosage
Vitamins - therapeutic use
Abstract
Dietary intake of vitamin D and omega-3 fatty acids (FA) may be associated with superior response to antirheumatic treatments. In addition, dietary folate intake may be associated with worse response to methotrexate (MTX). The aim of this study was to investigate the association between dietary vitamin D, omega-3 FA, folate and treatment results of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA).
This prospective study was based on data from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, and included 727 patients with early RA from 10 hospitals in Sweden. Data on dietary vitamin D, omega-3 FA and folate intake based on food frequency questionnaires were linked with data on European League Against Rheumatism (EULAR) response after 3?months of DMARD treatment. Associations between vitamin D, omega-3 FA, folate and EULAR response were analysed with logistic regression adjusted for potential confounders.
The majority of patients (89.9%) were initially treated with MTX monotherapy and more than half (56.9%) with glucocorticoids. Vitamin D and omega-3 FA were associated with good EULAR response (OR 1.80 (95% CI 1.14 to 2.83) and OR 1.60 (95% CI 1.02 to 2.53), respectively). Folate was not significantly associated with EULAR response (OR 1.20 (95% CI 0.75 to 1.91)). Similar results were seen in a subgroup of patients who were initially treated with MTX monotherapy at baseline.
Higher intake of dietary vitamin D and omega-3 FA during the year preceding DMARD initiation may be associated with better treatment results in patients with early RA. Dietary folate intake was not associated with worse or better response to treatment, especially to MTX. Our results suggest that some nutrients may be associated with enhanced treatment results of DMARDs.
Notes
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PubMed ID
28601838 View in PubMed
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The association between atopy and factors influencing folate metabolism: is low folate status causally related to the development of atopy?

https://arctichealth.org/en/permalink/ahliterature81891
Source
Int J Epidemiol. 2006 Aug;35(4):954-61
Publication Type
Article
Date
Aug-2006
Author
Husemoen Lise Lotte N
Toft Ulla
Fenger Mogens
Jørgensen Torben
Johansen Niels
Linneberg Allan
Author Affiliation
Copenhagen County Research Centre for Prevention and Health, Glostrup, Denmark. lloh@glostruphosp.kbhamt.dk
Source
Int J Epidemiol. 2006 Aug;35(4):954-61
Date
Aug-2006
Language
English
Publication Type
Article
Keywords
Adult
Cross-Sectional Studies
Diet
Female
Folic Acid - administration & dosage - metabolism
Genotype
Homocysteine - blood
Humans
Hypersensitivity - diagnosis - etiology - metabolism
Male
Methionine - administration & dosage
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
Middle Aged
Multivariate Analysis
Polymorphism, Genetic
Questionnaires
Riboflavin - administration & dosage
Risk Assessment - methods
Vitamin B 12 - administration & dosage
Vitamin B 6 - administration & dosage
Abstract
BACKGROUND: Deficiency of folate has been associated with several disorders characterized by enhanced activation of the cellular immune system (non-allergic th1 type immune response). Whether folate status is also associated with atopic disease (allergic th2 type immune response) is unknown. We aimed at examining the association between atopy and markers of impaired folate metabolism, i.e. MTHFR(C677T) genotype, plasma total homocysteine, and dietary intakes of methionine, folates, and vitamins B12, B6, and B2. METHODS: Cross-sectional population-based study of 1,671 male and female residents of Copenhagen County, Denmark, aged 30-60 years participating in a health examination during 1999-2001. Atopy was defined as positive levels of specific IgE against a panel of inhalant allergens. MTHFR(C677T) genotype was determined by PCR followed by restriction fragment length polymorphism analyses. Total homocysteine was measured by fluorescent polarization immunoassay. Dietary vitamin intakes were estimated from a semi-quantitative food frequency questionnaire. RESULTS: The prevalence of atopy was associated with MTHFR(C677T) genotype. TT individuals had a significantly higher risk of atopy compared with CC/CT individuals [odds ratio 1.76, 95% confidence interval (95% CI) 1.19-2.60]. Additionally, gene-diet interaction effects were identified. Dietary markers were negatively associated with risk of atopy in persons with the TT genotype. Total homocysteine was not related to atopy (odds ratio per 5 mumol/l = 1.12, 95% CI 0.98-1.29). CONCLUSIONS: The results suggest that an impaired folate metabolism may be causally related to the development of atopy.
PubMed ID
16766537 View in PubMed
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Association between folic acid food fortification and congenital orofacial clefts.

https://arctichealth.org/en/permalink/ahliterature182537
Source
J Pediatr. 2003 Dec;143(6):805-7
Publication Type
Article
Date
Dec-2003
Author
Joel G Ray
Chris Meier
Marian J Vermeulen
Philip R Wyatt
David E c Cole
Author Affiliation
Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada. jray515445@aol.com
Source
J Pediatr. 2003 Dec;143(6):805-7
Date
Dec-2003
Language
English
Publication Type
Article
Keywords
Canada - epidemiology
Cleft Lip - epidemiology - prevention & control
Cleft Palate - epidemiology - prevention & control
Female
Folic Acid - administration & dosage
Food, Fortified
Hematinics - administration & dosage
Humans
Infant, Newborn
Pregnancy
Program Evaluation
Retrospective Studies
Abstract
By January 1998, most of Canada's cereal grain products were being fortified with folic acid. Among 336963 women who underwent antenatal maternal serum screening, the prevalence of orofacial clefts did not change from before (1.15 per 1000) to after (1.21 per 1000) food fortification (prevalence ratio, 1.06; 95% confidence interval, 0.86-1.30).
PubMed ID
14657833 View in PubMed
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Association of neural tube defects and folic acid food fortification in Canada.

https://arctichealth.org/en/permalink/ahliterature187217
Source
Lancet. 2002 Dec 21-28;360(9350):2047-8
Publication Type
Article
Author
Joel G Ray
Chris Meier
Marian J Vermeulen
Sheila Boss
Philip R Wyatt
David E C Cole
Author Affiliation
Department of Medicine, Sunnybrook and Women's College Health Sciences Center, Toronto, Ontario, Canada. Jray515445@aol.com
Source
Lancet. 2002 Dec 21-28;360(9350):2047-8
Language
English
Publication Type
Article
Keywords
Adult
Female
Folic Acid - administration & dosage - blood - therapeutic use
Food, Fortified
Humans
Infant, Newborn
Neural Tube Defects - epidemiology - prevention & control
Ontario - epidemiology
Poisson Distribution
Pregnancy
Prevalence
Spinal Dysraphism - epidemiology - prevention & control
Abstract
Many women do not receive folic acid supplements before conception. In response, most of Canada's cereal grain products were being fortified with folic acid by January, 1998, thereby providing an additional 0.1-0.2 mg per day of dietary folate to the Canadian population. We assessed the effect of supplementation on prevalence of open neural tube defects in the province of Ontario. Among 336 963 women who underwent maternal serum screening over 77 months, the prevalence of open neural tube defects declined from 1.13 per 1000 pregnancies before fortification to 0.58 per 1000 pregnancies thereafter (prevalence ratio 0.52, 95% CI 0.40-0.67, p
PubMed ID
12504403 View in PubMed
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Association of periconceptional multivitamin use with reduced risk of preeclampsia among normal-weight women in the Danish National Birth Cohort.

https://arctichealth.org/en/permalink/ahliterature89309
Source
Am J Epidemiol. 2009 Jun 1;169(11):1304-11
Publication Type
Article
Date
Jun-1-2009
Author
Catov Janet M
Nohr Ellen A
Bodnar Lisa M
Knudson Vibeke K
Olsen Sjurdur F
Olsen Jorn
Author Affiliation
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. catovjm@upmc.edu
Source
Am J Epidemiol. 2009 Jun 1;169(11):1304-11
Date
Jun-1-2009
Language
English
Publication Type
Article
Keywords
Adult
Body mass index
Body Weight
Confounding Factors (Epidemiology)
Denmark
Female
Folic Acid - administration & dosage
Humans
Longitudinal Studies
Pre-Eclampsia - epidemiology - prevention & control
Preconception Care
Pregnancy
Proportional Hazards Models
Risk
Vitamins - administration & dosage
Abstract
The timing and frequency of periconceptional multivitamin use may be related to the risk of preeclampsia. Women in the Danish National Birth Cohort (1997-2003) reported multivitamin or folate-only supplement use during a 12-week periconceptional period (from 4 weeks prior to 8 weeks after the last menstrual period). Preeclampsia cases were identified by using International Classification of Diseases, Tenth Revision, codes. Cox regression was used to estimate the association of frequency (weeks of use) and timing (preconception and postconception) of use with preeclampsia risk. Overall, there were 668 cases of preeclampsia (2.3%), and 18,551 women (65%) reported periconceptional multivitamin use. After adjustment, regular use (12 of 12 weeks) was related to a reduced risk of preeclampsia among normal-weight women. Compared with nonusers with a body mass index of 22 kg/m(2), regular multivitamin users with the same body mass index had a 20% reduced risk of preeclampisa (hazard ratio = 0.78, 95% confidence interval: 0.60, 0.99). In addition, regular use in the postconception period only was associated with reduced risk, a relation that also appeared to be limited to women with a body mass index of
PubMed ID
19372217 View in PubMed
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Association of the B-vitamins pyridoxal 5'-phosphate (B(6)), B(12), and folate with lung cancer risk in older men.

https://arctichealth.org/en/permalink/ahliterature195150
Source
Am J Epidemiol. 2001 Apr 1;153(7):688-94
Publication Type
Article
Date
Apr-1-2001
Author
T J Hartman
K. Woodson
R. Stolzenberg-Solomon
J. Virtamo
J. Selhub
M J Barrett
D. Albanes
Author Affiliation
Department of Nutrition, The Pennsylvania State University, University Park, PA, USA.
Source
Am J Epidemiol. 2001 Apr 1;153(7):688-94
Date
Apr-1-2001
Language
English
Publication Type
Article
Keywords
Age Distribution
Aged
Case-Control Studies
Cohort Studies
Confidence Intervals
Finland - epidemiology
Folic Acid - administration & dosage - blood
Homocysteine - blood
Humans
Incidence
Lung Neoplasms - epidemiology - prevention & control - therapy
Male
Middle Aged
Odds Ratio
Pyridoxine - administration & dosage - blood
Reference Values
Risk factors
Sampling Studies
Sensitivity and specificity
Vitamin B 12 - administration & dosage - blood
Abstract
A nested case-control study was conducted within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort to test for associations between selected B-vitamins (folate, vitamin B(6), vitamin B(12)) and incident lung cancer. This trial was conducted in Finland between 1985 and 1993. Serum was analyzed for these nutrients and homocysteine among 300 lung cancer cases and matched controls (1:1). Odds ratios and 95% confidence intervals were determined in conditional and unconditional (controlling for the matching factors) logistic regression models, after adjusting for body mass index, years of smoking, and number of cigarettes smoked per day. No significant associations were seen between serum folate, vitamin B(12), or homocysteine and lung cancer risk. The authors found significantly lower risk of lung cancer among men who had higher serum vitamin B(6) levels. Compared with men with the lowest vitamin B(6) concentration, men in the fifth quintile had about one half of the risk of lung cancer (odds ratio = 0.51; 95% confidence interval: 0.23, 0.93; p-trend = 0.02). Adjusting for any of the other serum factors (folate, B(12), and homocysteine) either alone or jointly did not significantly alter these estimates. This is the first report from a prospectively conducted study to suggest a role for vitamin B(6) in lung cancer.
PubMed ID
11282797 View in PubMed
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164 records – page 1 of 17.