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A 4-fold risk of metabolic syndrome in patients with schizophrenia: the Northern Finland 1966 Birth Cohort study.

https://arctichealth.org/en/permalink/ahliterature49604
Source
J Clin Psychiatry. 2005 May;66(5):559-63
Publication Type
Article
Date
May-2005
Author
Kaisa M Saari
Sari M Lindeman
Kaisa M Viilo
Matti K Isohanni
Marjo-Riitta Järvelin
Liisa H Laurén
Markku J Savolainen
Hannu J Koponen
Author Affiliation
Department of Psychiatry, University of Oulu, PO Box 5000, 90014 Oulu, Finland. kaisa.saari@oulu.fi
Source
J Clin Psychiatry. 2005 May;66(5):559-63
Date
May-2005
Language
English
Publication Type
Article
Keywords
Adult
Antipsychotic Agents - adverse effects - therapeutic use
Cohort Studies
Comorbidity
Diet Therapy
Exercise
Female
Finland - epidemiology
Humans
Logistic Models
Male
Metabolic Syndrome X - epidemiology - prevention & control - therapy
Prevalence
Psychiatric Status Rating Scales
Research Support, Non-U.S. Gov't
Risk factors
Schizophrenia - diagnosis - drug therapy - epidemiology
Weight Loss
Abstract
OBJECTIVE: Schizophrenia is associated with a shortened life expectancy and increased somatic comorbidity with, e.g., cardiovascular disorders. One major risk factor for these disorders is the metabolic syndrome, which has been reported to have a higher frequency in schizophrenic patients. Our objective was to study the prevalence of metabolic syndrome in a population-based birth cohort. METHOD: The study sample consisted of 5613 members of the Northern Finland 1966 Birth Cohort who participated in the field study from 1997 to 1998. Subjects were divided into 4 diagnostic categories (DSM-III-R): (1) schizophrenia (N = 31), (2) other functional psychoses (N = 22), (3) nonpsychotic disorders (N = 105), and (4) no psychiatric hospital treatment (N = 5455, comparison group). Subjects were assessed for the presence of metabolic syndrome according to the criteria of the National Cholesterol Education Program. RESULTS: The prevalence of metabolic syndrome was higher in subjects with schizophrenia compared with the comparison group (19% vs. 6%, p = .010). The prevalence of metabolic syndrome in subjects with other psychoses was 5%. After controlling for sex, the results of logistic regression analysis showed that the risk of metabolic syndrome in schizophrenia was 3.7 (95% CI = 1.5 to 9.0). CONCLUSIONS: The high prevalence of metabolic syndrome in schizophrenia even at such a relatively young age underscores the need to select antipsychotic medications with no or little capability to induce metabolic side effects. Also, developing comprehensive efforts directed at controlling weight and diet and improving physical activity are needed.
PubMed ID
15889940 View in PubMed
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A 5-year follow-up of signs and symptoms of TMD and radiographic findings in the elderly.

https://arctichealth.org/en/permalink/ahliterature182090
Source
Int J Prosthodont. 2003 Nov-Dec;16(6):631-4
Publication Type
Article
Author
Kaija Hiltunen
Jaakko S Peltola
Miira M Vehkalahti
Timo Närhi
Anja Ainamo
Author Affiliation
Department of Prosthodontics, Institute of Dentistry, University of Helsinki, Finland. kaija.hiltunen@helsinki.fi
Source
Int J Prosthodont. 2003 Nov-Dec;16(6):631-4
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Chi-Square Distribution
Cohort Studies
Female
Finland
Follow-Up Studies
Humans
Male
Mandibular Condyle - physiopathology - radiography
Radiography, Panoramic
Range of Motion, Articular - physiology
Sex Factors
Temporomandibular Joint - physiopathology - radiography
Temporomandibular Joint Disorders - classification - physiopathology - radiography
Abstract
The aim was to clarify the associations among subjective symptoms, clinical signs of temporomandibular disorders (TMD), and radiographic findings in the mandibular condyles of elderly people during a 5-year follow-up.
As part of a comprehensive medical survey of a random sample born in 1904, 1909, and 1914 (Helsinki Aging Study), 364 subjects living in Helsinki participated in the dental part of the examination during 1990 and 1991; after 5 years, 103 of these were reexamined. Comprehensive data on TMD were available for 94 subjects, and radiographic data were available for 88. TMD were assessed by Helkimo's anamnestic and clinical indices, and radiographic status was assessed by panoramic radiographs.
During the 5-year follow-up, reported anamnestic symptoms of TMD for men changed little (9%); among women, the change from baseline was 42%. When the unchanged indices were compared, the gender difference was obvious. At baseline, 5% of the women, but no men, had severe signs (clinical index III) of TMD. At the end of follow-up, none showed severe signs. Comparison of radiographic findings between baseline and follow-up showed no differences, nor did differences appear in associations between radiographic findings and anamnestic or clinical indices.
During the 5-year follow-up, signs and symptoms of TMD in these elderly individuals became milder or vanished. The radiographic status of the condyles remained stable, and no association appeared between radiographic findings and signs and symptoms of TMD.
PubMed ID
14714843 View in PubMed
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5-year morbidity among very preterm infants in relation to level of hospital care.

https://arctichealth.org/en/permalink/ahliterature119186
Source
JAMA Pediatr. 2013 Jan;167(1):40-6
Publication Type
Article
Date
Jan-2013
Author
Liisi Rautava
Janne Eskelinen
Unto Häkkinen
Liisa Lehtonen
Author Affiliation
Department of Pediatrics, Turku University Hospital, 20520 Turku, Finland. liisi.rautava@utu.fi
Source
JAMA Pediatr. 2013 Jan;167(1):40-6
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Child, Preschool
Cohort Studies
Female
Finland - epidemiology
Humans
Incidence
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - epidemiology - etiology - therapy
Intensive Care, Neonatal
Logistic Models
Male
Odds Ratio
Outcome and Process Assessment (Health Care)
Patient transfer
Registries
Secondary Care
Tertiary Care Centers
Tertiary Healthcare
Abstract
To determine whether birth and care in the highest-level hospitals (level III) compared with birth in or postnatal transfer to lower-level hospitals (level II) are associated with 5-year morbidity in very preterm children.
A cohort study.
Finland.
All surviving 5-year-old children born very preterm (gestational age
PubMed ID
23128961 View in PubMed
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A 13-year follow-up of a comprehensive program of fissure sealing and resealing in Varkaus, Finland.

https://arctichealth.org/en/permalink/ahliterature189084
Source
Acta Odontol Scand. 2002 Jun;60(3):174-9
Publication Type
Article
Date
Jun-2002
Author
E. Lavonius
E. Kerosuo
S. Kervanto-Seppälä
N. Halttunen
T. Vilkuna
I. Pietilä
Author Affiliation
University of Helsinki, Institute of Dentistry, Finland. e.lavonius@btinternet.com
Source
Acta Odontol Scand. 2002 Jun;60(3):174-9
Date
Jun-2002
Language
English
Publication Type
Article
Keywords
Bicuspid
Child
Cohort Studies
DMF Index
Dental Bonding
Dental Caries - prevention & control
Finland
Follow-Up Studies
Humans
Molar
Pit and Fissure Sealants - therapeutic use
Retreatment
Retrospective Studies
Statistics as Topic
Abstract
The objective of the study was to examine the coverage of the sealing program on first permanent molars (FPMs) and second permanent molars (SPMs) and first and second premolars (FSPMs), as well as to monitor the fate of the sealed teeth over time. All patients born in 1977 who had had regular check-ups in the Varkaus Health Center, Finland (n = 166) were included in the 1996 study. Data on the annual state of each tooth had been collected retrospectively since 1983. The coverage for the sealant program was 95%, 92%, and 6% of the FPMs, SPMs, and FSPMs, respectively. Out of the FPMs sealed at age 6 years, 28% were subjected to resealing, 13% developed occlusal, and 15% proximal caries during a 13-year follow-up period. From the SPMs sealed at age 11 years, 24% were subjected to resealing, 4% developed occlusal caries, and less than 2% proximal caries during the 9-year follow-up. None of the sealed FSPMs and only 1% of the non-sealed ones developed occlusal caries during the 9-year period. The mean DMF in the study population (n = 160) at age 12 years was 0.8 (n = 124), compared to a nation-wide mean value of 1.2. A large percentage of the FPMs and SPMs were sealed and then resealed during the study period. Although the study design lacked a control group for comparison, the lower caries rates of this study compared to the results of other studies with only a single application of sealants suggest a major role for resealing.
PubMed ID
12166912 View in PubMed
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25-Hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort.

https://arctichealth.org/en/permalink/ahliterature286504
Source
Neurology. 2017 Oct 10;89(15):1578-1583
Publication Type
Article
Date
Oct-10-2017
Author
Kassandra L Munger
Kira Hongell
Julia Åivo
Merja Soilu-Hänninen
Heljä-Marja Surcel
Alberto Ascherio
Source
Neurology. 2017 Oct 10;89(15):1578-1583
Date
Oct-10-2017
Language
English
Publication Type
Article
Keywords
Adult
Age Factors
Case-Control Studies
Cohort Studies
Female
Finland - epidemiology
Humans
Middle Aged
Multiple Sclerosis - blood - epidemiology
Pregnancy - blood
Severity of Illness Index
Vitamin D - analogs & derivatives - blood
Vitamin D Deficiency - blood - epidemiology
Young Adult
Abstract
To determine whether and to what extent vitamin D deficiency is associated with multiple sclerosis (MS) risk.
We conducted a prospective nested case-control study among women in the Finnish Maternity Cohort (FMC). The FMC had 1.8 million stored serum samples taken during the pregnancies of over 800,000 women at the time of this study. Through linkages with hospital and prescription registries, we identified 1,092 women with MS diagnosed between 1983 and 2009 with at least 1 serum sample collected prior to date of MS diagnosis; =2 serum samples were available for 511 cases. Cases were matched to up to 3 controls (n = 2,123) on date of birth (±2 years) and area of residence. 25-Hydroxyvitamin D (25[OH]D) levels were measured using a chemiluminescence assay. We used conditional logistic regression adjusted for year of sample collection, gravidity, and parity to estimate relative risks (RRs) and 95% confidence intervals (CIs).
A 50 nmol/L increase in 25(OH)D was associated with a 39% reduced risk of MS (RR 0.61, 95% CI 0.44-0.85), p = 0.003. Women with 25(OH)D levels
Notes
Cites: J Steroid Biochem Mol Biol. 2017 Oct;173:117-12127979577
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Cites: Eur J Obstet Gynecol Reprod Biol. 2003 Feb 10;106(2):209-1312551794
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Cites: Semin Neurol. 2016 Apr;36(2):103-1427116717
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Cites: PLoS Med. 2015 Aug 25;12(8):e100186626305103
Cites: Neurology. 2017 Jan 3;88(1):44-5127903815
Cites: Neurology. 2012 Nov 20;79(21):2140-523170011
Cites: Ann Neurol. 1983 Mar;13(3):227-316847134
Cites: Neurol Genet. 2016 Sep 13;2(5):e9727652346
PubMed ID
28904091 View in PubMed
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A 25-year follow-up of a population screened with faecal occult blood test in Finland.

https://arctichealth.org/en/permalink/ahliterature161415
Source
Acta Oncol. 2007;46(8):1103-6
Publication Type
Article
Date
2007
Author
Nea Malila
Matti Hakama
Eero Pukkala
Author Affiliation
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Liisankatu 21 B, FI-001 70 Helsinki, Finland. nea.malila@cancer.fi
Source
Acta Oncol. 2007;46(8):1103-6
Date
2007
Language
English
Publication Type
Article
Keywords
Cohort Studies
Colorectal Neoplasms - diagnosis - epidemiology - mortality
Feasibility Studies
Female
Finland
Follow-Up Studies
Humans
Incidence
Male
Mass Screening - methods
Occult Blood
Patient compliance
Reagent kits, diagnostic
Sensitivity and specificity
Abstract
The aim of the study was to assess the feasibility of and possible selection to attend in colorectal cancer screening.
During the years 1979-1980, 1 785 men and women (born in 1917-1929) were invited to a pilot screening project for colorectal cancer. The screening method used was a guaiac-based faecal occult blood test repeated once if the initial test was positive.
Compliance was 69% and the test was positive in 19% of those attending. In a record linkage with the Finnish Cancer Registry, 47 colorectal cancer cases and 24 deaths from colorectal cancer were observed by the end of 2004. In all, the particular test method was not regarded specific enough for population screening. There was, however, no difference in cancer incidence between those who complied and those who did not when compared to the general population of same age and gender.
Compliance was found high enough to make screening feasible and there was no self selection of persons with low cancer risk to attend screening.
PubMed ID
17851857 View in PubMed
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30-Day Mortality after Cardiovascular Events in Persons with or without Alzheimer's Disease.

https://arctichealth.org/en/permalink/ahliterature274270
Source
J Alzheimers Dis. 2015;48(1):241-9
Publication Type
Article
Date
2015
Author
Jari Heiskanen
Sirpa Hartikainen
Risto P Roine
Anna-Maija Tolppanen
Source
J Alzheimers Dis. 2015;48(1):241-9
Date
2015
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Alzheimer Disease - epidemiology - mortality
Cardiovascular Diseases - epidemiology - mortality
Cohort Studies
Female
Finland - epidemiology
Hemorrhagic Disorders
Humans
Male
Morbidity
Myocardial Infarction
Outcome Assessment (Health Care)
Proportional Hazards Models
Residence Characteristics
Stroke
Abstract
Persons with Alzheimer's disease (AD) have been suggested to receive suboptimal treatment. We studied the 30-day mortality after ischemic stroke, hemorrhagic stroke, or myocardial infarction in individuals with or without AD.
An exposure matched cohort of all Finnish community-dwellers diagnosed with clinically verified AD in 2005-2012 (n?=?73,005) and 1-4 matched comparison persons/AD-affected person (n?=?215,449). Data on 30-day mortality after ischemic stroke (n?=?16,419; deaths: n?=?2,748), hemorrhagic stroke (n?=?3,570; deaths: n?=?1,224), and myocardial infarction (n?=?15,304; deaths: n?=?3,804) were obtained from the National Hospital Discharge register. The main analyses were restricted to first-ever events.
Persons with AD had slightly higher 30-day mortality after ischemic stroke (adjusted HR 1.36, 95% Confidence interval (CI) 1.24,1.49), hemorrhagic stroke (adjusted HR 1.11, 95% CI 0.98,1.25), or myocardial infarction (adjusted HR, 1.40, 9% CI 1.30,1.51). The associations were not affected by age, gender, or co-morbidities and remained similar when patients with previous ischemic strokes or infarctions were included. The absolute risk increase in 30-day mortality after ischemic or hemorrhagic stroke and myocardial infarction were 4.9% (95% CI 3.3,6.5), 3.3% (95% CI - 1.6,8.2), and 7.5% (95% CI 5.0,10.0), respectively.
Although the 30-day mortality was somewhat higher in the AD cohort, the absolute differences were small indicating that acute treatment was not notably inferior in AD patients. The slightly higher mortality was not explained by co-morbidities but may reflect the higher mortality of AD persons in general, or treatment practice of patients with severe cognitive impairment.
PubMed ID
26401944 View in PubMed
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[50-60 Hz electromagnetic fields and cancer risk].

https://arctichealth.org/en/permalink/ahliterature209111
Source
Rev Epidemiol Sante Publique. 1997 Mar;45(1):93-5
Publication Type
Article
Date
Mar-1997
Author
P. Guénel
Author Affiliation
INSERM U88, Saint-Maurice.
Source
Rev Epidemiol Sante Publique. 1997 Mar;45(1):93-5
Date
Mar-1997
Language
French
Publication Type
Article
Keywords
Cohort Studies
Electromagnetic fields - adverse effects
Epidemiologic Methods
Finland
Humans
Neoplasms, Radiation-Induced - etiology
PubMed ID
9173465 View in PubMed
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Abnormally invasive placenta-prevalence, risk factors and antenatal suspicion: results from a large population-based pregnancy cohort study in the Nordic countries.

https://arctichealth.org/en/permalink/ahliterature294473
Source
BJOG. 2016 Jul; 123(8):1348-55
Publication Type
Journal Article
Video-Audio Media
Date
Jul-2016
Author
L Thurn
P G Lindqvist
M Jakobsson
L B Colmorn
K Klungsoyr
R I Bjarnadóttir
A M Tapper
P E Børdahl
K Gottvall
K B Petersen
L Krebs
M Gissler
J Langhoff-Roos
K Källen
Author Affiliation
Department of Obstetrics and Gynaecology, Blekinge Hospital, Karlskrona, Sweden.
Source
BJOG. 2016 Jul; 123(8):1348-55
Date
Jul-2016
Language
English
Publication Type
Journal Article
Video-Audio Media
Keywords
Adult
Cesarean Section - statistics & numerical data
Cohort Studies
Denmark - epidemiology
Female
Finland - epidemiology
Humans
Hysterectomy - statistics & numerical data
Iceland - epidemiology
Incidence
Norway - epidemiology
Peripartum Period
Placenta Accreta - diagnostic imaging - epidemiology
Postpartum Hemorrhage - epidemiology
Pregnancy
Prevalence
Risk factors
Sweden - epidemiology
Ultrasonography
Ultrasonography, Prenatal
Uterine Rupture - epidemiology
Young Adult
Abstract
The objective was to investigate prevalence, estimate risk factors, and antenatal suspicion of abnormally invasive placenta (AIP) associated with laparotomy in women in the Nordic countries.
Population-based cohort study.
A 3-year Nordic collaboration among obstetricians to identify and report on uterine rupture, peripartum hysterectomy, excessive blood loss, and AIP from 2009 to 2012 The Nordic Obstetric Surveillance Study (NOSS).
In the NOSS study, clinicians reported AIP cases from maternity wards and the data were validated against National health registries.
Prevalence, risk factors, antenatal suspicion, birth complications, and risk estimations using aggregated national data.
A total of 205 cases of AIP in association with laparotomy were identified, representing 3.4 per 10 000 deliveries. The single most important risk factor, which was reported in 49% of all cases of AIP, was placenta praevia. The risk of AIP increased seven-fold after one prior caesarean section (CS) to 56-fold after three or more CS. Prior postpartum haemorrhage was associated with six-fold increased risk of AIP (95% confidence interval 3.7-10.9). Approximately 70% of all cases were not diagnosed antepartum. Of these, 39% had prior CS and 33% had placenta praevia.
Our findings indicate that a lower CS rate in the population may be the most effective way to lower the incidence of AIP. Focused ultrasound assessment of women at high risk will likely strengthen antenatal suspicion. Prior PPH is a novel risk factor associated with an increased prevalence of AIP.
An ultrasound assessment in women with placenta praevia or prior CS may double the awareness for AIP.
Notes
CommentIn: BJOG. 2016 May;123(6):1032 PMID 27101265
CommentIn: BJOG. 2016 May;123(6):1031-2 PMID 27101264
CommentIn: BJOG. 2017 Jan;124(1):164-165 PMID 28009121
PubMed ID
26227006 View in PubMed
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Accidental hypothermia: factors related to long-term hospitalization. A retrospective study from northern Finland.

https://arctichealth.org/en/permalink/ahliterature290758
Source
Intern Emerg Med. 2017 Dec; 12(8):1225-1233
Publication Type
Journal Article
Date
Dec-2017
Author
Jari Pirnes
Tero Ala-Kokko
Author Affiliation
Division of Intensive Care Medicine, and Medical Research Center Oulu, Department of Anaesthesiology, Oulu University Hospital and Research Group of Surgery, Anaesthesiology and Intensive Care, Medical Faculty, University of Oulu, Box 21, OUH, 90029, Oulu, Finland. jari.pirnes@fimnet.fi.
Source
Intern Emerg Med. 2017 Dec; 12(8):1225-1233
Date
Dec-2017
Language
English
Publication Type
Journal Article
Keywords
Acidosis, Lactic - etiology - mortality
Adolescent
Adult
Aged
Chi-Square Distribution
Cohort Studies
Female
Finland
Hospitalization - statistics & numerical data
Humans
Hypothermia - mortality
Intensive Care Units - organization & administration - statistics & numerical data
Male
Middle Aged
Prognosis
Renal Insufficiency - complications - mortality
Retrospective Studies
Rhabdomyolysis - complications - mortality
Statistics, nonparametric
Abstract
Accidental hypothermia has a low incidence, but is associated with a high mortality rate. Knowledge about concomitant factors, complications, and length of hospital stay is limited. A retrospective cohort study on patients with accidental hypothermia admitted to Oulu University Hospital in Finland, over a 5-year period. Patients were categorized as short-stay patients (7 days or less) and long-stay patients (more than 7 days) according to their length of stay in hospital. From a total of 105 patients, 67 patients were included in the analyses. Alcohol abuse was the most common concomitant factor (54 %). Median length of hospital stay was 4 days, and 16 patients (24 %) stayed in hospital over 7 days (median 15 days). Thirty-day mortality was low (14/105, 13 %). Patients with long-term hospitalization had a lower initial temperature (28.4 versus 31.2 °C, p = 0.011), a lower level of consciousness (GCS score 8.4 versus 12.8, p = 0.003), more severe acidosis (pH 7.08 versus 7.28, p = 0.005, and lactate 7.2 versus 3.9, p = 0.043), and a lower level of platelets (183 versus 242, p = 0.041) on admission compared with short-stay patients. Thirty-six patients (54 %) had at least one complication, and this prolonged median hospital treatment for 2.5 days (p 
Notes
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PubMed ID
27677616 View in PubMed
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2424 records – page 1 of 243.