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Bone mineral density in femoral neck is positively correlated to circulating insulin-like growth factor (IGF)-I and IGF-binding protein (IGFBP)-3 in Swedish men.

https://arctichealth.org/en/permalink/ahliterature190890
Source
Calcif Tissue Int. 2002 Jan;70(1):22-9
Publication Type
Article
Date
Jan-2002
Author
P. Gillberg
H. Olofsson
H. Mallmin
W F Blum
S. Ljunghall
A G Nilsson
Author Affiliation
Department of Medical Sciences, University Hospital, S-75185 Uppsala, Sweden.
Source
Calcif Tissue Int. 2002 Jan;70(1):22-9
Date
Jan-2002
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon
Adult
Aged
Aged, 80 and over
Aging - physiology
Bone Density
Femur Neck - metabolism - radiography
Gonadal Steroid Hormones - blood
Humans
Insulin-Like Growth Factor Binding Protein 3 - blood
Insulin-Like Growth Factor I - analysis
Lumbar Vertebrae - metabolism - radiography
Male
Middle Aged
Regression Analysis
Sweden
Abstract
Studies on the hormonal regulation of bone metabolism in men have indicated covariation between insulin-like growth factor-I (IGF-I) and sex hormones with bone mineral density (BMD). In this study the relationships between BMD in total body, lumbar spine, femoral neck, distal and ultradistal (UD) radius and circulating levels of IGFs, IGF binding proteins (IGFBPs), and sex steroids were investigated in 55 Swedish men between 22 and 85 (52 +/- 18, mean +/- SD) years of age. BMD in total body, distal and UD radius, and femoral neck was positively correlated with serum IGF-I (r = 0.31 to 0.49), IGF-II (r = 0.32 to 0.48), IGFBP-3 (r = 0.37 to 0.53), and free androgen index (FAI) (r = 0.32 to 0.40), and negatively with IGFBP-1 (r = -0.37 to -0.41) and IGFBP-2 (r = -0.29 to -0.41) levels. A positive correlation was observed between BMD in femoral neck and estradiol/SHBG ratio (r = 0.34, P = 0.01). Age correlated negatively with serum IGF-I, IGF-II, IGFBP-3, FAI, estradiol/SHBG ratio, and BMD in total body, distal and UD radius, and femoral neck, and positively with IGFBP-1, IGFBP-2, and SHBG levels. According to stepwise multiple regression analyses, a combination of weight, IGFBP-3, and testosterone accounted for 43% of the variation in BMD in femoral neck, 34% in ultradistal radius and 48% in total body (P
PubMed ID
11907704 View in PubMed
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Grip strength may facilitate fracture prediction in perimenopausal women with normal BMD: a 15-year population-based study.

https://arctichealth.org/en/permalink/ahliterature156064
Source
Calcif Tissue Int. 2008 Aug;83(2):93-100
Publication Type
Article
Date
Aug-2008
Author
Joonas Sirola
Toni Rikkonen
Marjo Tuppurainen
Jukka S Jurvelin
Esko Alhava
Heikki Kröger
Author Affiliation
Bone and Cartilage Research Unit, University of Kuopio, Kuopio, Finland. joonas.sirola@uku.fi
Source
Calcif Tissue Int. 2008 Aug;83(2):93-100
Date
Aug-2008
Language
English
Publication Type
Article
Keywords
Bone Density - physiology
Cohort Studies
Female
Femur Neck - metabolism - radiography
Finland - epidemiology
Fractures, Bone - epidemiology - etiology
Hand Strength - physiology
Humans
Middle Aged
Perimenopause - physiology
Predictive value of tests
Questionnaires
Risk factors
Spine - metabolism - radiography
Abstract
The aim of the present study was to investigate the ability of grip strength measurements to predict fracture risk in perimenopausal women according to bone mineral density (BMD). A random sample of 971 perimenopausal women from the Kuopio Osteoporosis Risk Factor and Prevention study cohort was measured with dual-energy X-ray absorptiometry (DXA) at the femoral neck and grip strength with a pneumatic squeeze dynamometer in 5-year intervals from baseline (1989-1991). Fractures during the 15-year follow-up were recorded based on self-reports and validated from medical records. In the total sample and in osteopenic or osteoporotic women (T score -1, n = 687) the lowest grip strength quartile had a significantly lower fracture-free survival rate in the Cox proportional hazard model (P = 0.005, hazard ratio [HR] = 2.0). In the multivariate Cox regression model, T score and grip strength were the only significant predictors of 15-year fracture-free survival in the N-BMD group and a risk index (RI) was formed according to HRs of these two variables. High RI (0-5 points) was associated with significantly lower 15-year fracture-free survival rate (P = 0.001, HR = 0.137) in the N-BMD group. In contrast, 5-year T score was no better a predictor of fractures in the baseline N-BMD group (P = 0.04, HR = 0.36). In conclusion, grip strength predicts 15-year fracture-free survival in perimenopausal women with N-BMD, while 5-year DXA does not seem to be any better a predictor of fracture risk. DXA measurements could be coupled with simple and cost-effective grip strength measurements. Controlling BMD in women with N-BMD could be abandoned.
PubMed ID
18641912 View in PubMed
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Interaction of nutritional calcium and HRT in prevention of postmenopausal bone loss: a prospective study.

https://arctichealth.org/en/permalink/ahliterature183255
Source
Calcif Tissue Int. 2003 Jun;72(6):659-65
Publication Type
Article
Date
Jun-2003
Author
J. Sirola
H. Kröger
L. Sandini
M. Tuppurainen
J S Jurvelin
S. Saarikoski
R. Honkanen
Author Affiliation
Research Institute of Public Health, University of Kuopio, Kuopio, Finland. jsirola@hytti.uku.fi
Source
Calcif Tissue Int. 2003 Jun;72(6):659-65
Date
Jun-2003
Language
English
Publication Type
Article
Keywords
Absorptiometry, Photon
Bone Density - physiology
Calcium, Dietary - administration & dosage
Estrogen Replacement Therapy
Female
Femur Neck - metabolism - radiography
Finland - epidemiology
Humans
Lumbar Vertebrae - metabolism - radiography
Middle Aged
Osteoporosis, Postmenopausal - epidemiology - metabolism - prevention & control
Postmenopause
Prospective Studies
Abstract
The aim of this study was to investigate the interactive effects between nutritional calcium (Ca) intake and hormone replacement therapy (HRT) on bone loss. The study population, 937 peri- and postmenopausal women, was selected from a random sample (n = 2025) of the OSTPRE-study cohort (n = 13,100) in Kuopio, Finland. Of them, 545 women had never used HRT and 392 women reported its use during the follow-up period of 6 years. Women were divided in groups according to self-reported daily nutritional Ca intake (mg/day): 927 (3rd). Bone mineral density of the lumbar spine and femoral neck was measured with dual X-ray absorptiometry at baseline in 1989-91 and at the 5-year follow-up in 1994-97. According to analysis of variance, there were no statistically significant differences in annual bone loss rate between Ca intake tertiles in HRT never users. In HRT users the annual bone loss at the femoral neck was significantly lower in the third tertile than in the second and first tertiles. In a linear regression model, Ca intake prevented femoral bone loss in HRT users (P
PubMed ID
14562993 View in PubMed
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