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Source
Epidemiol Rev. 2007;29:77-87
Publication Type
Article
Date
2007
Author
M U Jakobsen
T. Berentzen
T I A Sørensen
K. Overvad
Author Affiliation
Institute of Preventive Medicine, Centre for Health And Society, Copenhagen University Hospital, Copenhagen, Denmark. muj@dce.au.dk
Source
Epidemiol Rev. 2007;29:77-87
Date
2007
Language
English
Publication Type
Article
Keywords
Abdominal Fat - metabolism
Denmark
Fatty Liver - metabolism
Humans
Obesity - metabolism
Abstract
It has been hypothesized that visceral fat releases free fatty acids and adipokines and thereby exposes the liver to fat accumulation. The authors aimed to evaluate current epidemiologic evidence for an association between abdominal fat and liver fat content. Clinical and epidemiologic studies with data on abdominal fat and liver fat content were reviewed. Studies using waist circumference to estimate abdominal fat mass suggested a direct association between abdominal fat and liver fat content. Studies using imaging methods suggested a direct association between intraabdominal fat and liver fat content, but not between subcutaneous abdominal fat and liver fat content. In conclusion, clinical and epidemiologic studies of abdominal fat and liver fat content suggest a direct association between abdominal fat and liver fat content which is probably accounted for by visceral fat. However, results from the included studies do not allow strong conclusions regarding the temporal sequence of events. Future longitudinal studies are recommended to obtain additional information on associations and mechanisms. Both abdominal fat depots and other body compartments of interest should be included to further investigate the association between specific fat depots and liver fat content. Biomarkers may provide insight into underlying mechanisms.
PubMed ID
17478441 View in PubMed
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