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Adipose tissue arachidonic acid content is associated with the risk of myocardial infarction: a Danish case-cohort study.

https://arctichealth.org/en/permalink/ahliterature116504
Source
Atherosclerosis. 2013 Apr;227(2):386-90
Publication Type
Article
Date
Apr-2013
Author
Nielsen MS
Schmidt EB
Stegger J
Gorst-Rasmussen A
Tjonneland A
Overvad K
Author Affiliation
Department of Cardiology, Center for Cardiovascular Research, Aalborg Hospital, Aarhus University Hospital, Soendre Skovvej 15, 9000 Aalborg, Denmark. mrsn@rn.dk
Source
Atherosclerosis. 2013 Apr;227(2):386-90
Date
Apr-2013
Language
English
Publication Type
Article
Keywords
Adipose Tissue - metabolism - pathology
Arachidonic Acid - metabolism
Denmark - epidemiology
Diet
Fatty Acids - metabolism
Female
Humans
Life Style
Male
Middle Aged
Myocardial Infarction - epidemiology - metabolism
Proportional Hazards Models
Prospective Studies
Questionnaires
Regression Analysis
Risk factors
Abstract
The primary aim of the study was to evaluate the association between adipose tissue arachidonic acid (AA) content and the risk of myocardial infarction (MI). The secondary aim was to assess the correlation between adipose tissue AA and dietary intake of AA and linoleic acid (LA).
We conducted a case-cohort study nested within the Danish prospective Diet, Cancer and Health (DCH) study. After appropriate exclusions, the study included 2134 incident MI cases. Gluteal adipose tissue biopsies were collected at recruitment, and the fatty acid composition was determined by gas chromatography. A weighted Cox proportional hazards model was used to evaluate the association between adipose tissue AA content and the risk of MI.
After adjusting for confounders we found a positive association between adipose tissue AA content and the risk of MI. Hazard ratios (HR) of MI relative to the lowest quintile of adipose tissue AA content, increased across quintiles; second quintile (HR 1.19 95%CI: 0.97-1.45), third (HR 1.24 95%CI: 1.02-1.52), fourth (HR 1.28 95%CI: 1.03-1.60), and fifth quintile (HR 1.39 95%CI: 1.10-1.77). Adipose tissue AA levels were not correlated with dietary intake of AA (r=0.03, 95%CI: -0.01, 0.06) and weakly negatively correlated with dietary intake of LA (r=-0.12, 95%CI: -0.15, -0.08).
The adipose tissue content of AA was positively associated with the risk of MI but did not correlate with dietary intake of neither AA nor LA.
PubMed ID
23390891 View in PubMed
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An outbreak of Bacillus cereus food-poisoning in Finland associated with boiled rice.

https://arctichealth.org/en/permalink/ahliterature251027
Source
J Hyg (Lond). 1976 Jun;76(3):319-27
Publication Type
Article
Date
Jun-1976
Author
M. Raevuori
T. Kiutamo
A. Niskanen
K. Salminen
Source
J Hyg (Lond). 1976 Jun;76(3):319-27
Date
Jun-1976
Language
English
Publication Type
Article
Keywords
Abdomen
Bacillus cereus - metabolism
Condiments
Fatty Acids - metabolism
Female
Finland
Food Microbiology
Food Services
Foodborne Diseases - diagnosis - etiology
Humans
Male
Nausea - etiology
Oryza sativa
Pain - etiology
Species Specificity
Temperature
Vomiting - etiology
Abstract
A food-poisoning outbreak caused by Bacillus cereus occurred in a Finnish industrial plant in January 1975. Eighteen of the 36 persons who ate a lunch including boiled rice, meat and vegetables became ill. The disease pattern was similar to previously reported short incubation time B. cereus food-poisonings associated with cooked rice. The median incubation time was two hours, the main symptoms being nausea, abdominal pain and vomiting. Rice and certain seasonings were the contaminated raw materials. Gas chromatographic fatty acid analysis of a bacterial cell was used as a diagnostic method as well as to identify a certain strain of B. cereus.
Notes
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Cites: J Med Microbiol. 1975 Nov;8(4):543-50813000
Cites: Lancet. 1974 May 25;1(7865):1043-54133716
Cites: Infect Immun. 1973 Jul;8(1):25-94198101
Cites: Can J Public Health. 1974 Mar-Apr;65(2):109-134207768
Cites: J Hyg (Lond). 1974 Dec;73(3):433-444216605
Cites: Appl Microbiol. 1972 Sep;24(3):341-84627964
Cites: Appl Microbiol. 1974 Jan;27(1):83-54809910
Cites: Health Lab Sci. 1969 Oct;6(4):185-984981479
Cites: Health Lab Sci. 1967 Oct;4(4):199-2066061371
PubMed ID
819571 View in PubMed
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Arctic-adapted dogs emerged at the Pleistocene-Holocene transition.

https://arctichealth.org/en/permalink/ahliterature305477
Source
Science. 2020 06 26; 368(6498):1495-1499
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Date
06-26-2020
Author
Mikkel-Holger S Sinding
Shyam Gopalakrishnan
Jazmín Ramos-Madrigal
Marc de Manuel
Vladimir V Pitulko
Lukas Kuderna
Tatiana R Feuerborn
Laurent A F Frantz
Filipe G Vieira
Jonas Niemann
Jose A Samaniego Castruita
Christian Carøe
Emilie U Andersen-Ranberg
Peter D Jordan
Elena Y Pavlova
Pavel A Nikolskiy
Aleksei K Kasparov
Varvara V Ivanova
Eske Willerslev
Pontus Skoglund
Merete Fredholm
Sanne Eline Wennerberg
Mads Peter Heide-Jørgensen
Rune Dietz
Christian Sonne
Morten Meldgaard
Love Dalén
Greger Larson
Bent Petersen
Thomas Sicheritz-Pontén
Lutz Bachmann
Øystein Wiig
Tomas Marques-Bonet
Anders J Hansen
M Thomas P Gilbert
Author Affiliation
The GLOBE Institute, University of Copenhagen, Copenhagen, Denmark. mhssinding@gmail.com tomas.marques@upf.edu ajhansen@sund.ku.dk tgilbert@sund.ku.dk.
Source
Science. 2020 06 26; 368(6498):1495-1499
Date
06-26-2020
Language
English
Publication Type
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adaptation, Physiological - genetics
Animals
Apolipoproteins - genetics
Arctic Regions
Dogs - genetics
Fatty Acids - metabolism
Genome
Greenland
Haplotypes
Mitochondrial Membrane Transport Proteins - genetics
Selective Breeding
Sequence Analysis, DNA
Siberia
Triglycerides - metabolism
Wolves - genetics
Abstract
Although sled dogs are one of the most specialized groups of dogs, their origin and evolution has received much less attention than many other dog groups. We applied a genomic approach to investigate their spatiotemporal emergence by sequencing the genomes of 10 modern Greenland sled dogs, an ~9500-year-old Siberian dog associated with archaeological evidence for sled technology, and an ~33,000-year-old Siberian wolf. We found noteworthy genetic similarity between the ancient dog and modern sled dogs. We detected gene flow from Pleistocene Siberian wolves, but not modern American wolves, to present-day sled dogs. The results indicate that the major ancestry of modern sled dogs traces back to Siberia, where sled dog-specific haplotypes of genes that potentially relate to Arctic adaptation were established by 9500 years ago.
PubMed ID
32587022 View in PubMed
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Arctic permafrost active layer detachments stimulate microbial activity and degradation of soil organic matter.

https://arctichealth.org/en/permalink/ahliterature97020
Source
Environ Sci Technol. 2010 Jun 1;44(11):4076-82
Publication Type
Article
Date
Jun-1-2010
Author
Brent G Pautler
André J Simpson
David J McNally
Scott F Lamoureux
Myrna J Simpson
Author Affiliation
Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Source
Environ Sci Technol. 2010 Jun 1;44(11):4076-82
Date
Jun-1-2010
Language
English
Publication Type
Article
Keywords
Arctic Regions
Bacteria - metabolism
Fatty Acids - metabolism
Magnetic Resonance Spectroscopy
Nunavut
Soil Microbiology
Abstract
Large quantities of soil organic carbon in Arctic permafrost zones are becoming increasingly unstable due to a warming climate. High temperatures and substantial rainfall in July 2007 in the Canadian High Arctic resulted in permafrost active layer detachments (ALDs) that redistributed soils throughout a small watershed in Nunavut, Canada. Molecular biomarkers and NMR spectroscopy were used to measure how ALDs may lead to microbial activity and decomposition of previously unavailable soil organic matter (SOM). Increased concentrations of extracted bacterial phospholipid fatty acids (PLFAs) and large contributions from bacterial protein/peptides in the NMR spectra at recent ALDs suggest increased microbial activity. PLFAs were appreciably depleted in a soil sample where ALDs occurred prior to 2003. However an enrichment of bacterial derived peptidoglycan was observed by (1)H-(13)C heteronuclear multiple quantum coherence (HMQC) and (1)H diffusion edited (DE) NMR and enhanced SOM degradation was observed by (13)C solid-state NMR. These data suggest that a previous rise in microbial activity, as is currently underway at the recent ALD site, led to degradation and depletion of labile SOM components. Therefore, this study indicates that ALDs may amplify climate change due to the release of labile SOM substrates from thawing High Arctic permafrost.
PubMed ID
20459054 View in PubMed
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Associations between polymorphisms in genes involved in fatty acid metabolism and dietary fat intakes.

https://arctichealth.org/en/permalink/ahliterature126193
Source
J Nutrigenet Nutrigenomics. 2012;5(1):1-12
Publication Type
Article
Date
2012
Author
Annie Bouchard-Mercier
Ann-Marie Paradis
Louis Pérusse
Marie-Claude Vohl
Author Affiliation
Institute of Nutraceuticals and Functional Foods-INAF, Quebec, Que., Canada.
Source
J Nutrigenet Nutrigenomics. 2012;5(1):1-12
Date
2012
Language
English
Publication Type
Article
Keywords
Adult
Dietary Fats - administration & dosage
Fatty Acids - metabolism
Female
Humans
Male
Middle Aged
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide
Quebec
Questionnaires
Reverse Transcriptase Polymerase Chain Reaction
Abstract
Obesity prevalence is growing in our population. Twin studies have estimated the heritability of dietary intakes to about 30%. The objective of this study was to verify whether polymorphisms in genes involved in fatty acid metabolism are associated with dietary fat intakes.
Seven hundred participants were recruited. A validated food frequency questionnaire was used to assess dietary intakes. PCR-RFLP and TAQMAN methodology were used to genotype PPARa Leu162Val, PPAR? Pro12Ala, PPARd -87T>C, PPARGC1a Gly482Ser, FASN Val1483Ile and SREBF1 c.*619C>G. Statistical analyses were executed with SAS statistical package.
Carriers of the Ala12 allele of PPAR? Pro12Ala polymorphism had higher intakes of total fat (p = 0.04). For FASN Val1483Ile polymorphism, significant gene-sex interaction effects were found for total fat and saturated fat intakes (p = 0.02 and p = 0.002, respectively). No significant difference in fat intakes was observed for PPARa Leu162Val, PPARd -87T>C, PPARGC1a Gly482Ser and SREBF1 c.*619C>G polymorphisms.
Polymorphisms in PPAR? and FASN seem to be associated with dietary fat intakes. Genetic variants are important to take into account when studying dietary intakes.
PubMed ID
22414759 View in PubMed
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Carcinogenicity study of the emulsifier TOSOM and the release agent TOS in Wistar rats.

https://arctichealth.org/en/permalink/ahliterature23884
Source
Food Chem Toxicol. 1993 Nov;31(11):825-33
Publication Type
Article
Date
Nov-1993
Author
O. Meyer
E. Kristiansen
J. Gry
C. Madsen
P. Olsen
I. Thorup
Author Affiliation
Institute of Toxicology, National Food Agency, Søborg, Denmark.
Source
Food Chem Toxicol. 1993 Nov;31(11):825-33
Date
Nov-1993
Language
English
Publication Type
Article
Keywords
Animals
Emulsions
Excipients - metabolism - toxicity
Fatty Acids - metabolism - toxicity
Female
Incidence
Male
Margarine
Neoplasms - chemically induced - epidemiology
Oxidation-Reduction
Random Allocation
Rats
Rats, Wistar
Soybean Oil - metabolism - toxicity
Survival Rate
Abstract
Groups of 60 Wistar rats of each sex were fed diets containing 3, 6 or 12% of the margarine emulsifier TOSOM (thermally oxidized soybean oil interacted with mono- and diglycerides of fatty acids) for 2.5 yr. In addition, three groups of 60 rats of each sex were fed two products of the release agent TOS (thermally oxidized soybean oil) in dietary levels of 1.2% TOS(G) (TOS from Grindsted Product A/S, Denmark) and 0.3 and 1.2% TOS(N) (TOS from Nexus Aps, Denmark), respectively for 2.5 yr. 120 rats of each sex fed a diet containing mono- and diglycerides served as controls. The diets given to all groups were isocaloric. Clinical appearance, food consumption, body weight and weight gain, survival, haematology, and clinical chemistry parameters were examined. Gross and histopathological examinations, including neoplastic and non-neoplastic lesions, were performed on all groups. Time to occurrence of tumours was recorded. No substance-related effect, including carcinogenicity, was found.
PubMed ID
8258411 View in PubMed
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Changes in Dietary Fat Intake and Projections for Coronary Heart Disease Mortality in Sweden: A Simulation Study.

https://arctichealth.org/en/permalink/ahliterature285263
Source
PLoS One. 2016;11(8):e0160474
Publication Type
Article
Date
2016
Author
Lena Björck
Annika Rosengren
Anna Winkvist
Simon Capewell
Martin Adiels
Piotr Bandosz
Julia Critchley
Kurt Boman
Maria Guzman-Castillo
Martin O'Flaherty
Ingegerd Johansson
Source
PLoS One. 2016;11(8):e0160474
Date
2016
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Cholesterol - blood
Coronary Disease - epidemiology - mortality - prevention & control
Dietary Fats - metabolism
Fatty Acids - metabolism
Feeding Behavior
Female
Humans
Life Style
Male
Middle Aged
Models, Theoretical
Mortality - trends
Risk factors
Smoking
Sodium Chloride, Dietary - metabolism
Sweden - epidemiology
Abstract
In Sweden, previous favourable trends in blood cholesterol levels have recently levelled off or even increased in some age groups since 2003, potentially reflecting changing fashions and attitudes towards dietary saturated fatty acids (SFA). We aimed to examine the potential effect of different SFA intake on future coronary heart disease (CHD) mortality in 2025.
We compared the effect on future CHD mortality of two different scenarios for fat intake a) daily SFA intake decreasing to 10 energy percent (E%), and b) daily SFA intake rising to 20 E%. We assumed that there would be moderate improvements in smoking (5%), salt intake (1g/day) and physical inactivity (5% decrease) to continue recent, positive trends.
In the baseline scenario which assumed that recent mortality declines continue, approximately 5,975 CHD deaths might occur in year 2025. Anticipated improvements in smoking, dietary salt intake and physical activity, would result in some 380 (-6.4%) fewer deaths (235 in men and 145 in women). In combination with a mean SFA daily intake of 10 E%, a total of 810 (-14%) fewer deaths would occur in 2025 (535 in men and 275 in women). If the overall consumption of SFA rose to 20 E%, the expected mortality decline would be wiped out and approximately 20 (0.3%) additional deaths might occur.
CHD mortality may increase as a result of unfavourable trends in diets rich in saturated fats resulting in increases in blood cholesterol levels. These could cancel out the favourable trends in salt intake, smoking and physical activity.
Notes
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PubMed ID
27490257 View in PubMed
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Changes in freezing tolerance, plasma membrane H+-ATPase activity and fatty acid composition in Pinus resinosa needles during cold acclimation and de-acclimation.

https://arctichealth.org/en/permalink/ahliterature82700
Source
Tree Physiol. 2006 Jun;26(6):783-90
Publication Type
Article
Date
Jun-2006
Author
Martz Françoise
Sutinen Marja-Liisa
Kiviniemi Sari
Palta Jiwan P
Author Affiliation
The Finnish Forest Research Institute, Rovaniemi Research Station, P.O. Box 16, FIN-96301 Rovaniemi, Finland.
Source
Tree Physiol. 2006 Jun;26(6):783-90
Date
Jun-2006
Language
English
Publication Type
Article
Keywords
Acclimatization
Adenosine Triphosphatases - metabolism
Cell Membrane - metabolism
Fatty Acids - metabolism
Freezing
Pinus - metabolism - physiology
Plant Proteins - metabolism
Proton-Translocating ATPases - metabolism
Seasons
Abstract
It has previously been suggested that plasma membrane ATPase (PM H+-ATPase, EC 3.6.1.3.) is a site of incipient freezing injury because activity increases following cold acclimation and there are published data indicating that activity of PM H+-ATPase is modulated by changes in lipids associated with the enzyme. To test and extend these findings in a tree species, we analyzed PM H+-ATPase activity and the fatty acid (FA) composition of glycerolipids in purified plasma membranes (PMs) prepared by the two-phase partition method from current-year needles of adult red pine (Pinus resinosa Ait.) trees. Freezing tolerance of the needles decreased from -56 degrees C in March to -9 degrees C in May, and increased from -15 degrees C in September to -148 degrees C in January. Specific activity of vanadate-sensitive PM H+-ATPase increased more than two-fold following cold acclimation, despite a concurrent increase in protein concentration. During de-acclimation, decreases in PM H+-ATPase activity and freezing tolerance were accompanied by decreases in the proportions of oleic (18:1) and linoleic (18:2) acids and increases in the proportions of palmitic (16:0) and linolenic (18:3) acids in total glycerolipids extracted from the plasma membrane fraction. This pattern of changes in PM H+-ATPase activity and the 18:1, 18:2 and 18:3 fatty acids was reversed during cold acclimation. In the PM fractions, changes in FA unsaturation, expressed as the double bond index (1 x 18:1 + 2 x 18:2 + 3 x 18:3), were closely correlated with changes in H+-ATPase specific activity (r2 = 0.995). Changes in freezing tolerance were well correlated with DBI (r2 = 0.877) and ATPase specific activity (r2 = 0.833) in the PM fraction. Total ATPase activity in microsomal fractions also closely followed changes in freezing tolerance (r2 = 0.969). We conclude that, as in herbaceous plants, simultaneous seasonal changes in PM H+-ATPase activity and fatty acid composition occur during cold acclimation and de-acclimation in an extremely winter hardy tree species under natural conditions, lending support to the hypothesis that FA-regulated PM H+-ATPase activity is involved in the cellular response underlying cold acclimation and de-acclimation.
PubMed ID
16510394 View in PubMed
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Changes in lipid composition of neuroblastoma C1300 N18 cell during differentiation.

https://arctichealth.org/en/permalink/ahliterature25714
Source
Neuroscience. 1989;30(1):153-64
Publication Type
Article
Date
1989
Author
N M Gulaya
G L Volkov
V M Klimashevsky
N N Govseeva
A A Melnik
Author Affiliation
A.V. Palladine Institute of Biochemistry, Academy of Sciences, Ukrainian SSR, Kiev.
Source
Neuroscience. 1989;30(1):153-64
Date
1989
Language
English
Publication Type
Article
Keywords
Animals
Arachidonic Acid
Arachidonic Acids - metabolism
Cell Differentiation
Cell Line
Fatty Acids - metabolism
Membrane Lipids - metabolism
Mice
Neuroblastoma
Phospholipids - metabolism
Tumor Cells, Cultured - cytology - metabolism
Abstract
Phospholipids and cholesterol were found to be the main lipids in mature and immature neuroblastoma cells. The ratios for the total cholesterol/phospholipids in these undifferentiated and differentiated cells were 0.33 and 0.52, respectively. The ratios of 0.45 and 0.62 were obtained with corresponding plasma membrane fractions. Individual fatty acid contents in the loosely bound lipid fraction were higher than in tightly bound lipids. The total levels of saturated fatty acids increased in both of these fractions. While arachidonic acid content significantly decreased, it increased simultaneously (600%) in the free fatty acid fraction during differentiation. The amount of cholesterol esters increased three-fold as a result of maturation. For the first time it was possible to detect, in neuroblastoma cells, several lipids, namely N-acylphosphatidylethanolamine, N-acylethanolamine and semilysobisphosphatidic acid. They all changed during maturation. Total N-acylphosphatidylethanolamine content decreased by 50%, disappearing completely from membrane fractions. N-Acylethanolamine disappeared from the cell as well as from membrane fractions. On the other hand the total cellular content of semilysobisphosphatidic acid increased without any alterations in its membrane content. Functional implications of our investigations are discussed.
PubMed ID
2501710 View in PubMed
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[Changes of fatty acid spectrum of thrombocyte lipids in patients with a stable and unstable angina]

https://arctichealth.org/en/permalink/ahliterature97039
Source
Lik Sprava. 2009 Oct-Dec;(7-8):30-2
Publication Type
Article
Author
V H Lyzohub
T V Zaval's'ka
Kh A Kh Abu Sara
T S Briuzhina
O V Savchenko
Source
Lik Sprava. 2009 Oct-Dec;(7-8):30-2
Language
Ukrainian
Publication Type
Article
Keywords
Adult
Aged
Angina Pectoris - blood - metabolism
Angina, Unstable - blood - metabolism
Blood Platelets - metabolism
Case-Control Studies
Fatty Acids - metabolism
Humans
Middle Aged
Phospholipids - metabolism
Abstract
Ischemic heart desease (IHD) remains actual issue of the current clinical medicine, because, IHD takes a leading position among reasons of death rate of population. Purpose of the study was to find diagnostic features of fat-acid composition of lipid of thrombocytes in patients with stable and unstable course of ischemic heart disease (IHD). 52 patients with an unstable angina pectoris aged 42-65 years and 31 patients with stable angina aged 41-66 years have been observed. Reliable changes in relation of the sum of saturated, unsaturated and poli-unsaturated of fat acids of phosphotides of thrombocytes in patients with unstable course of ischemic heart disease (IHD) have been detected. It improves knowledge about the mechanisms of destabilization of coronal circulation of blood.
PubMed ID
20455444 View in PubMed
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67 records – page 1 of 7.