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Aberrations in plasma phospholipid fatty acids in lung cancer patients.

https://arctichealth.org/en/permalink/ahliterature128904
Source
Lipids. 2012 Apr;47(4):363-9
Publication Type
Article
Date
Apr-2012
Author
Rachel A Murphy
Taylor F Bureyko
Marina Mourtzakis
Quincy S Chu
M Thomas Clandinin
Tony Reiman
Vera C Mazurak
Author Affiliation
Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-126A Li Ka Shing Centre, Edmonton, AB T6G 2E1, Canada.
Source
Lipids. 2012 Apr;47(4):363-9
Date
Apr-2012
Language
English
Publication Type
Article
Keywords
Adenocarcinoma - drug therapy - metabolism - mortality
Aged
Antineoplastic Agents - administration & dosage - therapeutic use
Body mass index
Canada
Fatty Acids - analysis
Female
Humans
Lipid Metabolism - drug effects
Longitudinal Studies
Lung Neoplasms - drug therapy - metabolism - mortality
Male
Middle Aged
Neoplasm Staging
Phospholipids - analysis
Survival Rate
Weight Loss
Abstract
Abnormalities in lipid metabolism have been frequently observed in cancer and are associated with a poor prognosis. However, a detailed, longitudinal characterization of fatty acid status is lacking. This study aimed to assess plasma phospholipid fatty acids before chemotherapy, immediately after and 1 month following chemotherapy in a group of 50 patients newly diagnosed with lung cancer and explore factors which may contribute to aberrations in fatty acids. Their mean ± SD characteristics: age 64 ± 8.5 years, 75% advanced stage disease, body mass index 27.0 ± 5.4 kg/m², 6 month weight loss -4.6 ± 6.1%. Compared to patients with early stage disease, patients with advanced disease had abnormal fatty acid profiles including significantly lower (P
PubMed ID
22160451 View in PubMed
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Adipose tissue fatty acids as biomarkers of dietary exposure in Danish men and women.

https://arctichealth.org/en/permalink/ahliterature24046
Source
Am J Clin Nutr. 1993 May;57(5):629-33
Publication Type
Article
Date
May-1993
Author
A. Tjønneland
K. Overvad
E. Thorling
M. Ewertz
Author Affiliation
Danish Cancer Registry, Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen.
Source
Am J Clin Nutr. 1993 May;57(5):629-33
Date
May-1993
Language
English
Publication Type
Article
Keywords
Adipose Tissue - metabolism
Adult
Biological Markers - analysis
Denmark - epidemiology
Diet - statistics & numerical data
Dietary Fats - administration & dosage
Fatty Acids - analysis
Female
Humans
Male
Middle Aged
Nutrition Surveys
Research Support, Non-U.S. Gov't
Abstract
Adipose tissue fatty acids, it has been proposed, reflect dietary intake. Using data from a validation study preceding a prospective study on diet, cancer, and health in Denmark, we were able to compare fatty acid profiles in adipose tissue biopsies from 86 individuals (23 men and 63 women) aged 40-64 y and dietary intake of fatty acids (as percentage of total fat) assessed by two 7-d weighed-diet records or by a semi-quantitative food frequency questionnaire. Correlation coefficients (Pearson r) between fatty acid concentrations in adipose tissue biopsies (as percentage of total peak area) and dietary intake of fatty acid (percentage of total fat), determined from the diet records for men and women, respectively, were as follows: polyunsaturated fatty acids r = 0.74 and r = 0.46; n - 3 fatty acids of marine origin: eicosapentaenoic acid r = 0.15 and r = 0.61, and docosahexaenoic acid r = 0.47 and r = 0.57. Correlation coefficients obtained by using the food frequency questionnaire were slightly lower for most fatty acids.
PubMed ID
8480677 View in PubMed
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Adipose tissue fatty acids in men from two populations with different cardiovascular risk: the LiVicordia study.

https://arctichealth.org/en/permalink/ahliterature54224
Source
Scand J Clin Lab Invest. 1999 May;59(3):227-32
Publication Type
Article
Date
May-1999
Author
A. Kaminskas
B. Ziedén
B. Elving
M. Kristenson
A. Abaravicius
B. Bergdahl
A G Olsson
Z. Kucinskiene
Author Affiliation
Department of Physiology and Biochemistry, Faculty of Medicine, Vilnius, Lithuania.
Source
Scand J Clin Lab Invest. 1999 May;59(3):227-32
Date
May-1999
Language
English
Publication Type
Article
Keywords
Adipose Tissue - chemistry
Body mass index
Comparative Study
Coronary Disease - epidemiology - metabolism
Diet, Atherogenic
Dietary Fats - analysis
Fatty Acids - analysis
Fatty Acids, Unsaturated - analysis
Humans
Lipid Peroxidation - physiology
Lipoproteins, LDL - metabolism
Lithuania - epidemiology
Male
Middle Aged
Myristic Acid - analysis
Research Support, Non-U.S. Gov't
Risk factors
Sweden - epidemiology
alpha-Linolenic Acid - analysis
Abstract
The LiVicordia study was set up to investigate possible causes for coronary heart disease mortality in middle-aged Lithuanian men being four times higher than in Swedish men. In a previous part of this study we found lower total and low density lipoprotein (LDL) cholesterol in the Lithuanian men in spite of them having a higher fat intake than in the Swedish men. Their LDL was also more susceptible to oxidation in vitro than was that of the Swedish men. Fat quality can influence LDL oxidation. In order to obtain data on long-term fat quality intake we measured the fatty acid composition of abdominal wall adipose tissue by gas chromatography in men aged 50 years from Vilnius, Lithuania (n=50) and Linköping, Sweden (n=50). Men from Vilnius had a significantly higher percentage of adipose tissue long chain polyunsaturated fatty acids (PUFA) (20:4n6, 20:5n3, 22:5n5, 22:6n3) and lower percentage of saturated fatty acids, especially myristic acid (14:0), 3.4+/-0.7 versus 4.6+/-0.8, p
PubMed ID
10400167 View in PubMed
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Alpha-linolenic acid in the treatment of rheumatoid arthritis. A double-blind, placebo-controlled and randomized study: flaxseed vs. safflower seed.

https://arctichealth.org/en/permalink/ahliterature216559
Source
Rheumatol Int. 1995;14(6):231-4
Publication Type
Article
Date
1995
Author
Nordstrom DC
Honkanen VE
Nasu Y
Antila E
Friman C
Konttinen YT
Author Affiliation
Fourth Department of Medicine, Helsinki University Central Hospital, Finland.
Source
Rheumatol Int. 1995;14(6):231-4
Date
1995
Language
English
Publication Type
Article
Keywords
Adult
Aged
Arthritis, Rheumatoid - blood - diet therapy
Double-Blind Method
Fatty Acids - analysis - blood
Female
Finland
Humans
Male
Middle Aged
Trace Elements - analysis - blood
alpha-Linolenic Acid - administration & dosage - blood - therapeutic use
Abstract
In rheumatoid arthritis various pro-inflammatory metabolites of arachidonic acid (AA), such as leukotriene B4 (LTB4) and prostaglandin E2 (PGE2), contribute to tissue destruction and pain. In contrast to AA, which is an omega-6 fatty acid, the omega-3 fatty acids, after having been liberated from the cell membrane phospholipids, are further converted into the non- or anti-inflammatory eicosanoids LTB5 and PGI3. AA concentration is an important regulatory step in the synthesis of both prostanoids and leukotriens. Dietary supplementation with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) has therefore been used to decrease the ratio of AA to EPA or DHA to obtain beneficial clinical effects. EPA and DHA are found in animal fat and are quite expensive compared to their precursor alpha-linolenic acid (alpha-LNA) found in flaxseed oil. We, therefore, performed a placebo-controlled trial with alpha-LNA in 22 patients with rheumatoid arthritis, using a linoleic acid preparation as a placebo. After a 3-month follow-up, the treatment group showed an increased bleeding time, but the clinical, subjective (global assessment, classification of functional status, joint score index, visual analogue scale, pain tenderness score) and laboratory parameters (haemoglobin, erythrocyte sedimentation rate, C-reactive protein) did not show any statistical alterations. AA, EPA and DHA did not change either in spite of a significant increase in alpha-LNA in the treatment group. Thus, 3-month's supplementation with alpha-LNA did not prove to be beneficial in rheumatoid arthritis.
PubMed ID
7597378 View in PubMed
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Altered erythrocyte n-3 fatty acids in Mediterranean patients with coronary artery disease.

https://arctichealth.org/en/permalink/ahliterature5155
Source
Int J Cardiol. 2001 Mar;78(1):27-32
Publication Type
Article
Date
Mar-2001
Author
F. Paganelli
J M Maixent
M J Duran
R. Parhizgar
G. Pieroni
S. Sennoune
Author Affiliation
Division of Cardiology, Hôpital Nord, School of Medicine, Marseille, France.
Source
Int J Cardiol. 2001 Mar;78(1):27-32
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Adult
Aged
Coronary Disease - blood
Erythrocyte Membrane - chemistry
Fatty Acids - analysis
Fatty Acids, Omega-3 - analysis
Female
France
Humans
Male
Middle Aged
Research Support, Non-U.S. Gov't
Abstract
A low frequency of ischaemic heart diseases in Eskimos has been related to polyunsaturated fatty acids. We therefore studied fatty acid patterns associated with coronary artery disease (CAD) for a possible relationship between fatty acid profile and CAD diagnosis in Mediterranean patients. The gas chromatography method was used to analyze the membranes of patients' erythrocytes. The patients without coronary stenosis were used as controls. Patients with CAD showed increased percentages of saturated fatty acids (35.8 vs. 34.2%, P
PubMed ID
11259810 View in PubMed
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Analysis of the core components of Alzheimer paired helical filaments. A gas chromatography/mass spectrometry characterization of fatty acids, carbohydrates and long-chain bases.

https://arctichealth.org/en/permalink/ahliterature214948
Source
FEBS Lett. 1995 Jun 5;366(1):81-5
Publication Type
Article
Date
Jun-5-1995
Author
W J Goux
S. Rodriguez
D R Sparkman
Author Affiliation
Department of Chemistry, University of Texas at Dallas, Richardson 75083-0688, USA.
Source
FEBS Lett. 1995 Jun 5;366(1):81-5
Date
Jun-5-1995
Language
English
Publication Type
Article
Keywords
Aged
Aged, 80 and over
Alzheimer Disease - metabolism
Brain Chemistry
Carbohydrates - analysis - chemistry
Fatty Acids - analysis - chemistry
Female
Gas Chromatography-Mass Spectrometry
Humans
Male
Neurofibrillary Tangles - chemistry
Abstract
We have carried out a fatty acid and carbohydrate compositional analysis of the protease-resistant core of paired helical filaments (prcPHF) isolated from six Alzheimer's diseased brains. Fatty acids, long-chain bases and monosaccharides were characterized by gas chromatography/mass spectrometry (GC/MS) of fatty acid methyl esters, trimethylsilylated long-chain bases, peracetylated alditol acetates and trimethylsilyl methyl glycosides. Glucose and mannose were found to be the only carbohydrate components. Four of the six prcPHF samples contained only glucose while the remaining two samples contained between 30-40% mannose in addition to glucose. None of the samples were found to contain either hydroxylated fatty acids or long-chain bases. The average fatty acid profile of prcPHF was highest in stearic (C18:0) and palmitic acids (C16:0) with less than 10% unsaturated fatty acids. By comparing the carbohydrate and lipid composition of prcPHF to similar data for other brain glycolipids, it was determined that prcPHF is a unique glycolipid, distinct from cerebrosides, gangliosides or brain phospholipids. The fatty acid and carbohydrate composition of a glycolipid isolated from a population of normal brains according to the prcPHF protocol was found to be identical to that of prcPHF glycolipid. It is possible that subtle differences in structure or indigenous factors are responsible for the initiation of PHF formation in vivo.
Notes
Erratum In: FEBS Lett 1995 Nov 13;375(1-2):168
PubMed ID
7789523 View in PubMed
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An infrared spectroscopic method for quantitative analysis of fatty alcohols and fatty acid esters in machinery oils.

https://arctichealth.org/en/permalink/ahliterature9130
Source
Anal Bioanal Chem. 2005 Sep;383(2):305-11
Publication Type
Article
Date
Sep-2005
Author
Pekka Vähäoja
Jani Närhi
Toivo Kuokkanen
Outi Naatus
Jorma Jalonen
Sulo Lahdelma
Author Affiliation
Department of Chemistry, University of Oulu, P.O. Box 3000, 90014, Oulu, Finland. Pekka.Vahaoja@oulu.fi
Source
Anal Bioanal Chem. 2005 Sep;383(2):305-11
Date
Sep-2005
Language
English
Publication Type
Article
Keywords
Carbon Disulfide - chemistry
Carbon Tetrachloride - chemistry
Comparative Study
Dodecanol - analysis
Esters - analysis
Fatty Acids - analysis
Fatty Alcohols - analysis
Palmitates - analysis
Plant Oils - chemistry
Research Support, Non-U.S. Gov't
Solvents - chemistry
Spectrophotometry, Infrared - methods
Stearates - analysis
Volatilization
Abstract
A new infrared spectroscopic method suitable for determining total fatty alcohol and fatty acid ester concentrations in industrial oils has been developed. Oil samples were diluted with toluene (1:3 w/w), the toxicity and volatility of which are relatively low compared with more commonly used IR solvents, like carbon tetrachloride or carbon disulfide. Mixture standards were prepared from dodecanol, tetradecanol, octadecanol, methyl stearate and methyl palmitate. Some analytical and statistical tests were performed on the developed method. The recoveries and the repeatability of the method proved to be sufficient for the quantitative determination of fatty alcohol and fatty acid ester additives in industrial oils. Reproducibility testing in another laboratory also produced satisfactory results. The developed method also proved to be relatively quick and simple. This method was developed to satisfy industry's need to determine the concentrations of these oil additives, and it has already been applied successfully in machinery oil analysis.
PubMed ID
16132128 View in PubMed
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Association of Adipose Tissue Fatty Acids With Cardiovascular and All-Cause Mortality in Elderly Men.

https://arctichealth.org/en/permalink/ahliterature295101
Source
JAMA Cardiol. 2016 10 01; 1(7):745-753
Publication Type
Journal Article
Date
10-01-2016
Author
David Iggman
Johan Ärnlöv
Tommy Cederholm
Ulf Risérus
Author Affiliation
Unit for Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden2Center for Clinical Research Dalarna, Falun, Sweden.
Source
JAMA Cardiol. 2016 10 01; 1(7):745-753
Date
10-01-2016
Language
English
Publication Type
Journal Article
Keywords
Adipose Tissue - chemistry
Aged
Aged, 80 and over
Cardiovascular Diseases - mortality
Cause of Death
Cohort Studies
Fatty Acids - analysis
Fatty Acids, Unsaturated - analysis
Humans
Male
Middle Aged
Sweden
Abstract
The major polyunsaturated fatty acids in adipose tissue objectively reflect long-term dietary intake, and may provide more reliable information than would self-reported intake. Whether adipose tissue fatty acids predict cardiovascular and all-cause mortality needs investigation.
To investigate associations between adipose tissue fatty acids and cardiovascular and overall mortality in a cohort of elderly men.
We hypothesized that polyunsaturated fatty acids reflecting dietary intake, are inversely associated with cardiovascular and all-cause mortality. In the Swedish cohort study Uppsala Longitudinal Cohort of Adult Men, buttock fatty acid composition was analyzed by gas-liquid chromatography in 1992 to 1993 and 2008. The study participants were followed during 11?311 person-years, between 1991 and 2011 (median follow-up, 14.8 years). In this community-based study that took place from 1970 to 1973, all men born in 1920 to 1924 in Uppsala, Sweden, were invited and 2322 (82%) were included (at age 50 years). At the reinvestigation at age 71 years, 1221 (73%) of the 1681 invited men participated. Adipose tissue biopsy specimens were taken in a subsample of 853 men. There was no loss to follow-up.
Adipose tissue proportions of 4 polyunsaturated fatty acids that were considered to mainly reflect dietary intake (linoleic acid, 18:2n-6; a-linolenic acid, 18:3n-3; eicosapentaenoic acid, 20:5n-3; and docosahexaenoic acid, 22:6n-3) comprised primary analyses, and all other available fatty acids were secondary analyses.
Hazard ratios (HRs) for cardiovascular and all-cause mortality using Cox proportional hazards regression analyses, performed in 2015.
Among the 853 Swedish men, there were 605 deaths, of which 251 were cardiovascular deaths. After adjusting for risk factors, none of the 4 primary fatty acids were associated with cardiovascular mortality (HR, 0.92-1.05 for each standard deviation increase; P?=?.27). Linoleic acid was inversely associated with all-cause mortality (HR,?0.90; 95% CI, 0.82-0.98; P?=?.02) and directly associated with intake (P?
PubMed ID
27541681 View in PubMed
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Atherosclerosis and biochemical composition of coronary arteries in Finnish men. Comparison of two populations with different incidences of coronary heart disease.

https://arctichealth.org/en/permalink/ahliterature235241
Source
Atherosclerosis. 1987 May;65(1-2):109-15
Publication Type
Article
Date
May-1987
Author
S. Ylä-Herttuala
H. Sumuvuori
K. Karkola
M. Möttönen
T. Nikkari
Source
Atherosclerosis. 1987 May;65(1-2):109-15
Date
May-1987
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Arteries - analysis
Cholesterol - analysis
Coronary Artery Disease - metabolism
Coronary Disease - epidemiology
Coronary Vessels - analysis - pathology
Fatty Acids - analysis
Finland
Glycosaminoglycans - analysis
Humans
Male
Middle Aged
Phospholipids - analysis
Abstract
Men in Eastern Finland show a substantially higher rate of coronary heart disease (CHD) than men in the Western part of the country. To study possible differences in the biochemical composition and atherosclerotic involvement of coronary arteries between these two populations, we analyzed major lipid and non-lipid components of coronary arteries from 15- to 60-year-old Finnish men after accidental death. The material consisted of 59 age-matched pairs from East and West Finland, respectively, collected at successive autopsies during 1979-1983. The coronary arteries from East Finland contained significantly more esterified cholesterol and a higher percentage of oleate in cholesteryl esters. The findings were most conspicuous under the age of 40 years, and imply a higher degree of atherosclerosis together with an increased rate of intracellular cholesterol esterification in coronary arteries in Eastern as compared with Western Finland. The vessels from East Finland also tended to contain more free cholesterol and raised lesions, but the differences were not statistically significant. No major regional differences were seen in total phospholipids, phospholipid subfractions, DNA, calcium, collagen, total protein, or glycosaminoglycans.
PubMed ID
3606727 View in PubMed
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Baseline patterns of adipose tissue fatty acids and long-term risk of breast cancer: a case-cohort study in the Danish cohort Diet, Cancer and Health.

https://arctichealth.org/en/permalink/ahliterature264936
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Publication Type
Article
Date
Oct-2014
Author
J A Schmidt
A. Gorst-Rasmussen
P W Nyström
J H Christensen
E B Schmidt
C. Dethlefsen
A. Tjønneland
K. Overvad
C C Dahm
Source
Eur J Clin Nutr. 2014 Oct;68(10):1088-94
Date
Oct-2014
Language
English
Publication Type
Article
Keywords
Adult
Aged
Breast Neoplasms - epidemiology - pathology
Cohort Studies
Denmark - epidemiology
Fatty Acids - analysis
Female
Humans
Incidence
Male
Middle Aged
Prospective Studies
Risk
Risk factors
Subcutaneous Fat - chemistry
Abstract
The evidence regarding fatty acids and breast cancer risk is inconclusive. Adipose tissue fatty acids can be used as biomarkers of fatty acid intake and of endogenous fatty acid exposure. Fatty acids in adipose tissue are correlated owing to common dietary sources and shared metabolic pathways, which group fatty acids into naturally occurring patterns. We aimed to prospectively investigate associations between adipose tissue fatty acid patterns and long-term risk of total breast cancer and breast cancer subtypes characterised by oestrogen and progesterone receptor status (ER and PR).
This case-cohort study was based on data from the Danish cohort Diet, Cancer and Health. At baseline, a fat biopsy and information on lifestyle and reproductive factors were collected. From the 31 original fatty acids measured, patterns of fatty acids were identified using the treelet transform. During a median follow-up of 5.3 years, 474 breast cancer cases were identified. Hazard ratios and 95% confidence intervals of risk of total breast cancer and of subtypes according to quintiles of factor score were determined by weighted Cox proportional hazards regression.
After adjustment for potential confounders, factor scores for the seven patterns identified by the treelet transform were not associated with risk of total breast cancer, nor with risk of ER+, ER-, PR+ or PR- tumours.
No clear associations between the patterns of fatty acids at baseline and long-term risk of total breast cancer or ER+, ER-, PR+ or PR- tumours were observed.
PubMed ID
24642780 View in PubMed
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135 records – page 1 of 14.