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Altered behavior and alcohol tolerance in transgenic mice lacking MAO A: a comparison with effects of MAO A inhibitor clorgyline.

https://arctichealth.org/en/permalink/ahliterature10300
Source
Pharmacol Biochem Behav. 2000 Dec;67(4):719-27
Publication Type
Article
Date
Dec-2000
Author
N K Popova
G B Vishnivetskaya
E A Ivanova
J A Skrinskaya
I. Seif
Author Affiliation
Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Lavrentieva 10, 630090 Novosibirsk 90, Russia. npopova@bionet.nsc.ru
Source
Pharmacol Biochem Behav. 2000 Dec;67(4):719-27
Date
Dec-2000
Language
English
Publication Type
Article
Keywords
Alcohol Drinking - genetics
Animals
Anxiety - genetics
Central Nervous System Depressants - pharmacology
Clorgyline - pharmacology
Drug Tolerance - genetics
Ethanol - pharmacology
Exploratory Behavior - drug effects - physiology
Hypothermia - chemically induced - genetics
Male
Mice
Mice, Inbred C3H
Mice, Transgenic
Monoamine Oxidase - deficiency - genetics
Monoamine Oxidase Inhibitors - pharmacology
Motor Activity - drug effects - genetics
Research Support, Non-U.S. Gov't
Sleep - drug effects - genetics
Startle Reaction - drug effects - genetics
Abstract
The influence of deficiency of monoamine oxidase A (MAO A) gene and the lack of enzyme MAO A on the behavior of transgenic mouse strain (Tg8) was studied. It was shown that MAO-A-lacking mice differed from mice of the wild-type strain C3H/HeJ (C3H) by an attenuated acoustic startle response, prepulse inhibition (PPI) was unchanged. In Tg 8 mice, the exploratory nose-poking in the holeboard test as well as exploratory line crossing in the "light-dark" test were decreased. No effect of MAO A deficiency on locomotor activity was found. No alcohol preference or difference between Tg8 and C3H in ethanol consumption in the free-choice test has been found, although an increase in alcohol tolerance has been demonstrated. Ethanol-induced (0.3 g/100 g ip) sleep latency was longer, duration of sleep was shorter and ethanol hypothermia was reduced in MAO-A-lacking mice. Comparison of effects of MAO A knockout with those of irreversible MAO A inhibitor clorgyline (5 and 10 mg/kg ip) on C3H mice showed a similar reducing effect on ethanol-induced sleep, but potentiated ethanol-induced hypothermia. Clorgyline administration provoked a tendency to decrease of exploratory activity in the nose-poking test and decreased the frequency of exploratory rearings in the light-dark test. Clorgyline (5 and 10 mg/kg) did not affect the acoustic startle response, but a dose of 5 mg/kg diminished PPI. Therefore, Tg8 mice exhibited a decreased startle response and exploratory activity and an increased tolerance to ethanol. A similar increase in tolerance to ethanol-induced sleep and a tendency to decrease exploratory behavior were displayed by clorgyline. Other effects on behavior were different, suggesting the influence of long-lasting action of MAO A knockout and the involvement of a compensatory mechanism in Tg8 mice.
PubMed ID
11166062 View in PubMed
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[Data on the standardization of a lubricant F-11 in the air of the work area].

https://arctichealth.org/en/permalink/ahliterature224847
Source
Gig Tr Prof Zabol. 1992;(6):26-8
Publication Type
Article
Date
1992
Author
N G Shubenkin
T V Suchkova
V V Zhukova
G A Volchkova
I V Nikiforova
G A Smirnova
Source
Gig Tr Prof Zabol. 1992;(6):26-8
Date
1992
Language
Russian
Publication Type
Article
Keywords
Air Pollutants, Occupational - toxicity
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Combinations
Exploratory Behavior - drug effects - physiology
Guinea Pigs
Humans
Male
Maximum Allowable Concentration
Models, Neurological
Models, Psychological
Nylons
Oleic Acids - administration & dosage - toxicity
Polyethylene Glycols - administration & dosage - toxicity
Rabbits
Rats
Reflex, Abnormal - drug effects - physiology
Russia
Textile Industry - standards
Abstract
F-11 lubricant is used in synthetic fibers industry for the polyamide fibers processing. LD50 in intragastric administration is over 11,000 mg/kg. Acute action threshold (limac) is 180 mg/m3 (as evidenced by changes of the investigatory reflex). Chronic action threshold (limch) is 100 mg/m3. MAC in the air is 5 mg/m3, hazard class III. F-11 lubricant is a moderately hazardous chemical compound.
PubMed ID
1478520 View in PubMed
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[Efficacy of the lithium compound with prolonged action during "reserpine depression"]

https://arctichealth.org/en/permalink/ahliterature46357
Source
Eksp Klin Farmakol. 1997 Sep-Oct;60(5):27-30
Publication Type
Article
Author
T A Zamoshchina
A S Saratikov
Author Affiliation
Siberian State Medical University, Tomsk, Russia.
Source
Eksp Klin Farmakol. 1997 Sep-Oct;60(5):27-30
Language
Russian
Publication Type
Article
Keywords
Animals
Antidepressive Agents - pharmacology
Blepharoptosis - chemically induced - prevention & control
Body Temperature - drug effects
Circadian Rhythm
Comparative Study
Delayed-Action Preparations
Depression - chemically induced - physiopathology - prevention & control
English Abstract
Exploratory Behavior - drug effects
Hydroxybutyrates - pharmacology
Lithium Carbonate - pharmacology
Male
Organometallic Compounds - pharmacology
Rats
Abstract
A single administration of the new lithium compound with prolonged action formed on the basis of lithium oxyburate produces an antiblepharoptosis effect in rats with reserpine depression for 24 to 48 h. It optimally prevents the development of "reserpine-desynchronization" in rats when prescribed in the morning at intervals of 48 h.
PubMed ID
9483401 View in PubMed
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Social model of depression in mice of C57BL/6J strain.

https://arctichealth.org/en/permalink/ahliterature46649
Source
Pharmacol Biochem Behav. 1991 Feb;38(2):315-20
Publication Type
Article
Date
Feb-1991
Author
N N Kudryavtseva
I V Bakshtanovskaya
L A Koryakina
Author Affiliation
Institute of Cytology and Genetics, Siberian Department of USSR Academy of Sciences, Novosibirsk.
Source
Pharmacol Biochem Behav. 1991 Feb;38(2):315-20
Date
Feb-1991
Language
English
Publication Type
Article
Keywords
Aggression
Animals
Depression - pathology - psychology
Disease Models, Animal
Exploratory Behavior - drug effects
Gastric Mucosa - pathology
Gastrointestinal Hemorrhage - pathology
Imipramine - pharmacology
Mice
Mice, Inbred C57BL
Reaction Time - drug effects
Social Behavior
Social Dominance
Abstract
Long experience of defeat in daily social intermale confrontations and permanent living with aggressive males under sensory contact conditions [Kudryavtseva (8)] has been shown to produce changes in the patterns of submissive behavior of male mice of C57BL/6J strain. The submissive males after 20 defeats demonstrated passive defense postures instead of active defense and withdrawal which they had displayed in first encounters. Moreover, new immobile postures appeared, which were very rare in the first confrontations. Submissive animals displayed a decrease of ambulation in the open-field test and increase the immobility time in the Porsolt's test. Chronic treatment with imipramine prevented the increase of "depressiveness" estimated by means of the Porsolt's test. There was a loss of weight and some disturbances in gastrointestinal functions. The data are discussed in terms of the development of depression in submissive male C57BL/6J mice as a result of chronic unavoidable social stress.
PubMed ID
2057501 View in PubMed
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Stimulation of cell component of the immune response activates exploratory behavior in senescence accelerated OXYS rats.

https://arctichealth.org/en/permalink/ahliterature83074
Source
Bull Exp Biol Med. 2005 Sep;140(3):345-7
Publication Type
Article
Date
Sep-2005
Author
Markova E V
Kozlov V A
Trofimova N A
Kolosova N G
Author Affiliation
Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. evgeniya_markova@mail.ru
Source
Bull Exp Biol Med. 2005 Sep;140(3):345-7
Date
Sep-2005
Language
English
Publication Type
Article
Keywords
Aging - physiology
Animals
BCG Vaccine - pharmacology
Exploratory Behavior - drug effects
Hypersensitivity, Delayed - immunology
Immune System - drug effects - physiology
Male
Motor Activity
Rats
Rats, Inbred Strains
Rats, Wistar
Abstract
Suppression of the cell component of the immune system and open-field behavior developing in OXYS rats by the age of 3 months are regarded as manifestations of accelerated aging. Stimulation of cell-mediated immune response with BCG vaccine caused a dose-dependent increase of orientation and exploratory activity of OXYS rats in the open field test to virtually the same level as in Wistar rats.
PubMed ID
16307055 View in PubMed
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6 records – page 1 of 1.