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99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: immune therapies of type 1 diabetes: new opportunities based on the hygiene hypothesis.

https://arctichealth.org/en/permalink/ahliterature144028
Source
Clin Exp Immunol. 2010 Apr;160(1):106-12
Publication Type
Article
Date
Apr-2010
Author
L. Chatenoud
S. You
H. Okada
C. Kuhn
B. Michaud
J-F Bach
Author Affiliation
Université Paris Descarte, Paris, France. lucienne.chatenoud@inserm.fr
Source
Clin Exp Immunol. 2010 Apr;160(1):106-12
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Animals
Autoantigens - immunology
Bacteria - immunology
Canada - epidemiology
Child
Diabetes Mellitus, Type 1 - immunology - therapy
Europe - epidemiology
Humans
Hygiene
Hypersensitivity - immunology
Immunosuppression - methods
Immunotherapy - methods
Infection - immunology - microbiology
Mice
Pancreatitis - immunology - microbiology
Toll-Like Receptors - agonists
Young Adult
Abstract
Insulin-dependent (type 1) diabetes is a prototypic organ-specific autoimmune disease resulting from the selective destruction of insulin-secreting beta cells within pancreatic islets of Langerhans by an immune-mediated inflammation involving autoreactive CD4(+) and CD8(+) T lymphocytes which infiltrate pancreatic islets. Current treatment is substitutive, i.e. chronic use of exogenous insulin which, in spite of significant advances, is still associated with major constraints (multiple daily injections, risks of hypoglycaemia) and lack of effectiveness over the long term in preventing severe degenerative complications. Finding a cure for autoimmune diabetes by establishing effective immune-based therapies is a real medical health challenge, as the disease incidence increases steadily in industrialized countries. As the disease affects mainly children and young adults, any candidate immune therapy must therefore be safe and avoid a sustained depression of immune responses with the attendant problems of recurrent infection and drug toxicity. Thus, inducing or restoring immune tolerance to target autoantigens, controlling the pathogenic response while preserving the host reactivity to exogenous/unrelated antigens, appears to be the ideal approach. Our objective is to review the major progress accomplished over the last 20 years towards that aim. In addition, we would like to present another interesting possibility to access new preventive strategies based on the 'hygiene hypothesis', which proposes a causal link between the increasing incidence of autoimmune diseases, including diabetes, and the decrease of the infectious burden. The underlying rationale is to identify microbial-derived compounds mediating the protective activity of infections which could be developed therapeutically.
Notes
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PubMed ID
20415859 View in PubMed
Less detail

Absence of indigenous specific West Nile virus antibodies in Tyrolean blood donors.

https://arctichealth.org/en/permalink/ahliterature134646
Source
Eur J Clin Microbiol Infect Dis. 2012 Jan;31(1):77-81
Publication Type
Article
Date
Jan-2012
Author
S T Sonnleitner
J. Simeoni
E. Schmutzhard
M. Niedrig
F. Ploner
H. Schennach
M P Dierich
G. Walder
Author Affiliation
Hygiene and Medical Microbiology, Medical University Innsbruck, Fritz Pregl Straße 1-3/III, Innsbruck, Austria. sissyson@gmx.at
Source
Eur J Clin Microbiol Infect Dis. 2012 Jan;31(1):77-81
Date
Jan-2012
Language
English
Publication Type
Article
Keywords
Adult
Antibodies, Viral - blood
Blood Donors
Child, Preschool
Encephalitis Viruses, Tick-Borne - immunology
Enzyme-Linked Immunosorbent Assay
Europe
False Positive Reactions
Female
Humans
Italy
Male
Middle Aged
Neutralization Tests
West Nile Fever - diagnosis - epidemiology - virology
West Nile virus - immunology
Abstract
In the last several years, West Nile virus (WNV) was proven to be present especially in the neighboring countries of Austria, such as Italy, Hungary, and the Czech Republic, as well as in eastern parts of Austria, where it was detected in migratory and domestic birds. In summer 2010, infections with WNV were reported from Romania and northern Greece with about 150 diseased and increasingly fatal cases. We tested the sera of 1,607 blood donors from North Tyrol (Austria) and South Tyrol (Italy) for antibodies against WNV by using IgG enzyme-linked immunosorbent assay (ELISA). Initial results of the ELISA tests showed seroprevalence rates of 46.2% in North Tyrol and 0.5% in South Tyrol, which turned out to be false-positive cross-reactions with antibodies against tick-borne encephalitis virus (TBEV) by adjacent neutralization assays. These results indicate that seropositivity against WNV requires confirmation by neutralization assays, as cross-reactivity with TBEV is frequent and because, currently, WNV is not endemic in the study area.
PubMed ID
21556676 View in PubMed
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Abstracts. Seventh annual meeting. The European Society for Paediatric Haematology and Immunology. Oslo, Norway, June 11-13, 1979.

https://arctichealth.org/en/permalink/ahliterature41315
Source
Pediatr Res. 1979 Aug;13(8):948-57
Publication Type
Conference/Meeting Material
Date
Aug-1979

The aetiology of nasopharyngeal carcinoma.

https://arctichealth.org/en/permalink/ahliterature3952
Source
Clin Otolaryngol Allied Sci. 2001 Apr;26(2):82-92
Publication Type
Article
Date
Apr-2001
Author
A L McDermott
S N Dutt
J C Watkinson
Author Affiliation
Department of Otolaryngology/Head and Neck Surgery, Queen Elizabeth Hospital, Birmingham University, Birmingham, UK.
Source
Clin Otolaryngol Allied Sci. 2001 Apr;26(2):82-92
Date
Apr-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Africa - epidemiology
Aged
Aged, 80 and over
Asia - epidemiology
Carcinoma - classification - epidemiology - etiology
Child
Child, Preschool
Europe - epidemiology
Female
Humans
Incidence
Male
Middle Aged
Nasopharyngeal Neoplasms - epidemiology - ethnology - etiology
Retrospective Studies
Risk factors
Socioeconomic Factors
Abstract
Nasopharyngeal carcinoma is a disease with a remarkable racial and geographical distribution. In most parts of the world it is a rare condition and in only a handful of places does this low risk profile alter. These include the Southern Chinese, Eskimos and other Arctic natives, inhabitants of South-East Asia and also the populations of North Africa and Kuwait.
PubMed ID
11309046 View in PubMed
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Age at onset of multiple sclerosis may be influenced by place of residence during childhood rather than ancestry.

https://arctichealth.org/en/permalink/ahliterature170585
Source
Neuroepidemiology. 2006;26(3):162-7
Publication Type
Article
Date
2006
Author
J. Kennedy
P. O'Connor
A D Sadovnick
M. Perara
I. Yee
B. Banwell
Author Affiliation
The Hospital for Sick Children, University of Toronto, Toronto, Ont. L5M 4A7, Canada.
Source
Neuroepidemiology. 2006;26(3):162-7
Date
2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Aged
Asia - ethnology
Caribbean Region - ethnology
Child
Child, Preschool
Cohort Studies
Emigration and Immigration
Europe - ethnology
Humans
Middle Aged
Multiple Sclerosis - epidemiology
Ontario - epidemiology
Residence Characteristics
Risk factors
Abstract
Multiple sclerosis (MS) most commonly affects individuals of Northern European descent who live in countries at high latitude. The relative contributions of ancestry, country of birth and residence as determinants of MS risk have been studied in adult MS, but have not been explored in the pediatric MS population. In this study, we compare the demographics of pediatric- and adult-onset MS patients cared for in Toronto, Ontario, Canada, a multicultural region. The country of birth, residence during childhood, and ancestry were compared for 44 children and 573 adults. Our results demonstrate that although both the pediatric and adult cohorts were essentially born and raised in the same region of Ontario, Canada, children with MS were more likely to report Caribbean, Asian or Middle Eastern ancestry, and were less likely to have European heritage compared with individuals with adult-onset MS. The difference in ancestry between the pediatric and adult MS cohorts can be explained by two hypotheses: (1) individuals raised in a region of high MS prevalence, but whose ancestors originate from regions in which MS is rare, have an earlier age of MS onset, and (2) the place of residence during childhood, irrespective of ancestry, determines lifetime MS risk -- a fact that will be reflected in a change in the demographics of the adult MS cohort in our region as Canadian-raised children of recent immigrants reach the typical age of adult-onset MS.
PubMed ID
16493204 View in PubMed
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Age-standardisation of relative survival ratios of cancer patients in a comparison between countries, genders and time periods.

https://arctichealth.org/en/permalink/ahliterature153684
Source
Eur J Cancer. 2009 Mar;45(4):642-7
Publication Type
Article
Date
Mar-2009
Author
Arun Pokhrel
Timo Hakulinen
Author Affiliation
Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Pieni Roobertinkatu 9, FI-00130 Helsinki, Finland. arun.pokhrel@cancer.fi
Source
Eur J Cancer. 2009 Mar;45(4):642-7
Date
Mar-2009
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Aged, 80 and over
Child
Child, Preschool
Epidemiologic Methods
Europe - epidemiology
Female
Finland - epidemiology
Humans
Infant
Infant, Newborn
Male
Middle Aged
Neoplasms - mortality
Prognosis
Sex Distribution
United States - epidemiology
Young Adult
Abstract
A recent method of age-standardisation of relative survival ratios for cancer patients does not require calculation of age-specific relative survival ratios, as ratios of age-specific proportions between the standard population and study group at the beginning of the follow-up are used to substitute the original individual observations. This method, however, leads to direct age-standardisation with weights that are different for each patient group if the general population mortality patterns for the groups are different. This is the case in international comparisons, and in comparisons between genders and time periods. The magnitude of the bias caused by the differences in general population mortality is investigated for comparisons involving European countries and the USA. Patients in each country are assumed to have exactly the same age-specific relative survival ratios as those diagnosed in Finland in 1985-2004. An application of a properly functioning age-standardisation method should then give exactly equal age-standardised relative survival ratios for each country. However, the recent method shows substantial differences between countries, with highest relative survival for populations, where the general population mortality in the oldest ages is the highest. This source of error can thus be a serious limitation for the use of the method, and other methods that are available should then be employed.
PubMed ID
19081246 View in PubMed
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AIDS--dramatic surge in ex-Soviet Union, no respite worldwide, new data show.

https://arctichealth.org/en/permalink/ahliterature195656
Source
Bull World Health Organ. 2001;79(1):78
Publication Type
Article
Date
2001
Author
R. Dobson
Source
Bull World Health Organ. 2001;79(1):78
Date
2001
Language
English
Publication Type
Article
Keywords
Acquired Immunodeficiency Syndrome - epidemiology - mortality
Adolescent
Adult
Child
Child, Preschool
Europe, Eastern - epidemiology
Female
Humans
Infant
Infant, Newborn
Russia - epidemiology
Notes
Comment In: Bull World Health Organ. 2001;79(3):26911285679
PubMed ID
11217673 View in PubMed
Less detail
Source
Tidsskr Nor Laegeforen. 1996 Feb 10;116(4):471
Publication Type
Article
Date
Feb-10-1996

Alcohol advertising bans and alcohol abuse: an international perspective.

https://arctichealth.org/en/permalink/ahliterature226519
Source
J Health Econ. 1991 May;10(1):65-79
Publication Type
Article
Date
May-1991
Author
H. Saffer
Author Affiliation
National Bureau of Economic Research, New York University, NY 10003.
Source
J Health Econ. 1991 May;10(1):65-79
Date
May-1991
Language
English
Publication Type
Article
Keywords
Accidents, Traffic - statistics & numerical data
Advertising as Topic - legislation & jurisprudence
Alcohol Drinking - legislation & jurisprudence
Alcoholic Beverages - utilization
Canada - epidemiology
Cross-Sectional Studies
Europe - epidemiology
Health Behavior
Humans
Liver Cirrhosis - mortality
Models, Statistical
Public Policy
United States - epidemiology
World Health
Abstract
This paper examines the effect of banning broadcast advertising of alcoholic beverages. The data used in this study are a pooled time series from 17 countries for the period 1970 to 1983. The empirical results show that countries with bans on spirits advertising have about 16% lower alcohol consumption than countries with no bans and that countries with bans on beer and wine advertising have about 11% lower alcohol consumption than countries with bans only on spirits advertising.
Notes
Comment In: J Health Econ. 1993 Jul;12(2):213-2810127781
PubMed ID
10112150 View in PubMed
Less detail

448 records – page 1 of 45.