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Contemporary predictors of death and sustained ventricular tachycardia in patients with repaired tetralogy of Fallot enrolled in the INDICATOR cohort.

https://arctichealth.org/en/permalink/ahliterature106389
Source
Heart. 2014 Feb;100(3):247-53
Publication Type
Article
Date
Feb-2014
Author
Anne Marie Valente
Kimberlee Gauvreau
Gabriele Egidy Assenza
Sonya V Babu-Narayan
Jenna Schreier
Michael A Gatzoulis
Maarten Groenink
Ryo Inuzuka
Philip J Kilner
Zeliha Koyak
Michael J Landzberg
Barbara Mulder
Andrew J Powell
Rachel Wald
Tal Geva
Author Affiliation
Departments of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, , Boston, Massachusetts, USA.
Source
Heart. 2014 Feb;100(3):247-53
Date
Feb-2014
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Canada
Child
Child, Preschool
Cohort Studies
Electrocardiography
Europe
Exercise Test
Humans
Infant
Magnetic Resonance Imaging
Middle Aged
Predictive value of tests
Prognosis
Registries
Risk factors
Tachycardia, Ventricular - diagnosis - epidemiology
Tetralogy of Fallot - complications - mortality - surgery
United States
Young Adult
Abstract
Patients with repaired tetralogy of Fallot (TOF) experience increased rates of mortality and morbidity in adulthood. This study was designed to identify risk factors for death and ventricular tachycardia (VT) in a large contemporary cohort of patients with repaired TOF.
Subjects with repaired TOF from four large congenital heart centres in the USA, Canada and Europe were enrolled. Clinical, ECG, exercise, cardiac magnetic resonance (CMR) and outcome data were analysed.
Of the 873 patients (median age 24.4 years), 32 (3.7%) reached the primary outcome (28 deaths, 4 sustained VT; median age at outcome 38 years; median time from CMR to outcome 1.9 years). Cox proportional-hazards regression identified RV mass-to-volume ratio = 0.3 g/mL (HR, 5.04; 95% CI 2.3 to 11.0; p
Notes
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Comment In: Heart. 2014 Feb;100(3):185-724293521
PubMed ID
24179163 View in PubMed
Less detail

Rationale and design of an International Multicenter Registry of patients with repaired tetralogy of Fallot to define risk factors for late adverse outcomes: the INDICATOR cohort.

https://arctichealth.org/en/permalink/ahliterature123755
Source
Pediatr Cardiol. 2013 Jan;34(1):95-104
Publication Type
Article
Date
Jan-2013
Author
Anne Marie Valente
Kimberlee Gauvreau
Gabriele Egidy Assenza
Sonya V Babu-Narayan
Sarah P Evans
Michael Gatzoulis
Maarten Groenink
Ryo Inuzuka
Philip J Kilner
Zeliha Koyak
Michael J Landzberg
Barbara Mulder
Andrew J Powell
Rachel Wald
Tal Geva
Author Affiliation
Department of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Source
Pediatr Cardiol. 2013 Jan;34(1):95-104
Date
Jan-2013
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Canada
Child
Child, Preschool
Cohort Studies
Electrocardiography
Europe
Exercise Test
Female
Humans
Infant
Infant, Newborn
Magnetic Resonance Imaging
Male
Middle Aged
Prognosis
Registries - statistics & numerical data
Research Design
Risk factors
Tetralogy of Fallot - complications - mortality - surgery
Treatment Outcome
United States
Young Adult
Abstract
Although early survival after tetralogy of Fallot (TOF) repair in the modern era is excellent, studies on late outcomes have shown increasing rates of mortality and morbidity. Despite multiple publications on factors associated with late complications, risk factors for major outcomes (death and sustained ventricular tachycardia [VT]) remain poorly defined. Consequently, the International Multicenter TOF Registry (INDICATOR) was established. This article describes the development, structure, and goals of this registry and characterizes the initial cohort derived from four large congenital heart centers in the United States, Canada, and Europe. A data coordinating center with a core cardiac magnetic resonance (CMR) laboratory and statistical core was established. Subjects with repaired TOF who had CMR imaging performed between 1997 and 2010 and = 1 year follow-up were included. Clinical end points were death and sustained VT. Demographic, electrophysiologic, exercise, and outcome data were collected. A total of 873 subjects fulfilled inclusion criteria (median age at repair 2.9 years and at CMR imaging 22.8 years). Of these, 9 % had QRS duration >180 ms on electrocardiogram (ECG). On CMR imaging, 38 % had severe right-ventricular (RV) dilatation (= 160 mL/m(2)), and 6 % had severe RV dysfunction (ejection fraction
PubMed ID
22669402 View in PubMed
Less detail