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99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: immune therapies of type 1 diabetes: new opportunities based on the hygiene hypothesis.

https://arctichealth.org/en/permalink/ahliterature144028
Source
Clin Exp Immunol. 2010 Apr;160(1):106-12
Publication Type
Article
Date
Apr-2010
Author
L. Chatenoud
S. You
H. Okada
C. Kuhn
B. Michaud
J-F Bach
Author Affiliation
Université Paris Descarte, Paris, France. lucienne.chatenoud@inserm.fr
Source
Clin Exp Immunol. 2010 Apr;160(1):106-12
Date
Apr-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Animals
Autoantigens - immunology
Bacteria - immunology
Canada - epidemiology
Child
Diabetes Mellitus, Type 1 - immunology - therapy
Europe - epidemiology
Humans
Hygiene
Hypersensitivity - immunology
Immunosuppression - methods
Immunotherapy - methods
Infection - immunology - microbiology
Mice
Pancreatitis - immunology - microbiology
Toll-Like Receptors - agonists
Young Adult
Abstract
Insulin-dependent (type 1) diabetes is a prototypic organ-specific autoimmune disease resulting from the selective destruction of insulin-secreting beta cells within pancreatic islets of Langerhans by an immune-mediated inflammation involving autoreactive CD4(+) and CD8(+) T lymphocytes which infiltrate pancreatic islets. Current treatment is substitutive, i.e. chronic use of exogenous insulin which, in spite of significant advances, is still associated with major constraints (multiple daily injections, risks of hypoglycaemia) and lack of effectiveness over the long term in preventing severe degenerative complications. Finding a cure for autoimmune diabetes by establishing effective immune-based therapies is a real medical health challenge, as the disease incidence increases steadily in industrialized countries. As the disease affects mainly children and young adults, any candidate immune therapy must therefore be safe and avoid a sustained depression of immune responses with the attendant problems of recurrent infection and drug toxicity. Thus, inducing or restoring immune tolerance to target autoantigens, controlling the pathogenic response while preserving the host reactivity to exogenous/unrelated antigens, appears to be the ideal approach. Our objective is to review the major progress accomplished over the last 20 years towards that aim. In addition, we would like to present another interesting possibility to access new preventive strategies based on the 'hygiene hypothesis', which proposes a causal link between the increasing incidence of autoimmune diseases, including diabetes, and the decrease of the infectious burden. The underlying rationale is to identify microbial-derived compounds mediating the protective activity of infections which could be developed therapeutically.
Notes
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PubMed ID
20415859 View in PubMed
Less detail

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).

https://arctichealth.org/en/permalink/ahliterature95295
Source
Obesity (Silver Spring). 2009 Jul;17(7):1453-7
Publication Type
Article
Date
Jul-2009
Author
Vimaleswaran Karani S
Franks Paul W
Brage Soren
Sardinha Luis B
Andersen Lars B
Wareham Nicholas J
Ekelund Ulf
Loos Ruth J F
Author Affiliation
MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK.
Source
Obesity (Silver Spring). 2009 Jul;17(7):1453-7
Date
Jul-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Child
Cross-Sectional Studies
Denmark
Estonia
Europe
Female
Genetic Predisposition to Disease - genetics
Genotype
Humans
Intracellular Signaling Peptides and Proteins - genetics
Lipids - blood
Male
Membrane Proteins - genetics
Obesity - blood - ethnology - genetics
Polymorphism, Single Nucleotide - genetics
Waist Circumference - genetics
Abstract
The first genome-wide association study for BMI identified a polymorphism, rs7566605, 10 kb upstream of the insulin-induced gene 2 (INSIG2) transcription start site, as the most significantly associated variant in children and adults. Subsequent studies, however, showed inconsistent association of this polymorphism with obesity traits. This polymorphism has been hypothesized to alter INSIG2 expression leading to inhibition of fatty acid and cholesterol synthesis. Hence, we investigated the association of the INSIG2 rs7566605 polymorphism with obesity- and lipid-related traits in Danish and Estonian children (930 boys and 1,073 girls) from the European Youth Heart Study (EYHS), a school-based, cross-sectional study of pre- and early pubertal children. The association between the polymorphism and obesity traits was tested using additive and recessive models adjusted for age, age-group, gender, maturity and country. Interactions were tested by including the interaction terms in the model. Despite having sufficient power (98%) to detect the previously reported effect size for association with BMI, we did not find significant effects of rs7566605 on BMI (additive, P = 0.68; recessive, P = 0.24). Accordingly, the polymorphism was not associated with overweight (P = 0.87) or obesity (P = 0.34). We also did not find association with waist circumference (WC), sum of four skinfolds, or with total cholesterol, triglycerides, low-density lipoprotein, or high-density lipoprotein. There were no gender-specific (P = 0.55), age-group-specific (P = 0.63) or country-specific (P = 0.56) effects. There was also no evidence of interaction between genotype and physical activity (P = 0.95). Despite an adequately powered study, our findings suggest that rs7566605 is not associated with obesity-related traits and lipids in the EYHS.
PubMed ID
19197262 View in PubMed
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Absence of linkage of phonological coding dyslexia to chromosome 6p23-p21.3 in a large family data set.

https://arctichealth.org/en/permalink/ahliterature204108
Source
Am J Hum Genet. 1998 Nov;63(5):1448-56
Publication Type
Article
Date
Nov-1998
Author
L L Field
B J Kaplan
Author Affiliation
Department of Medical Genetics, Faculty of Medicine, Alberta Children's Hospital, University of Calgary, Calgry, Alberta, Canada. field@ucalgary.ca
Source
Am J Hum Genet. 1998 Nov;63(5):1448-56
Date
Nov-1998
Language
English
Publication Type
Article
Keywords
African Continental Ancestry Group - genetics
Alberta
Alleles
Auditory Perception
Child
Chromosome Mapping
Chromosomes, Human, Pair 6
Dyslexia - genetics - physiopathology
Europe - ethnology
European Continental Ancestry Group - genetics
Gene Frequency
Genetic Linkage
Genetic markers
Genotype
Humans
Lod Score
Nuclear Family
Abstract
Previous studies have suggested that a locus predisposing to specific reading disability (dyslexia) resides on chromosome 6p23-p21.3. We investigated 79 families having at least two siblings affected with phonological coding dyslexia, the most common form of reading disability (617 people genotyped, 294 affected), and we tested for linkage with the genetic markers reported to be linked to dyslexia in those studies. No evidence for linkage was found by LOD score analysis or affected-sib-pair methods. However, using the affected-pedigree-member (APM) method, we detected significant evidence for linkage and/or association with some markers when we used published allele frequencies with weighting of rarer alleles. APM results were not significant when we used marker allele frequencies estimated from parents. Furthermore, results were not significant with the more robust SIMIBD method using either published or parental marker frequencies. Finally, family-based association analysis using the AFBAC program showed no evidence for association with any marker. We conclude that the APM method should be used only with extreme caution, because it appears to have generated false-positive results. In summary, using a large data set with high power to detect linkage, we were unable to find evidence for linkage or association between phonological coding dyslexia and chromosome 6p markers.
Notes
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Erratum In: Am J Hum Genet 1999 Jan;64(1):334
PubMed ID
9792873 View in PubMed
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Abstracts. Seventh annual meeting. The European Society for Paediatric Haematology and Immunology. Oslo, Norway, June 11-13, 1979.

https://arctichealth.org/en/permalink/ahliterature41315
Source
Pediatr Res. 1979 Aug;13(8):948-57
Publication Type
Conference/Meeting Material
Date
Aug-1979

Accuracy of actuarial procedures for assessment of sexual offender recidivism risk may vary across ethnicity.

https://arctichealth.org/en/permalink/ahliterature30268
Source
Sex Abuse. 2004 Apr;16(2):107-20
Publication Type
Article
Date
Apr-2004
Author
Niklas Långström
Author Affiliation
Centre for Violence Prevention, Karolinska Institutet, P.O. Box 23000, S-104 35 Stockholm, Sweden. niklas.langstrom@cns.ki.se
Source
Sex Abuse. 2004 Apr;16(2):107-20
Date
Apr-2004
Language
English
Publication Type
Article
Keywords
Actuarial Analysis
Adult
Africa - ethnology
Analysis of Variance
Asia - ethnology
Child
Child Abuse, Sexual - ethnology - statistics & numerical data
Cross-Sectional Studies
Europe - ethnology
Humans
Male
Middle Aged
Predictive value of tests
Questionnaires - standards
Recurrence - prevention & control
Reproducibility of Results
Research Design
Research Support, Non-U.S. Gov't
Retrospective Studies
Risk Assessment - statistics & numerical data
Risk factors
Sex Offenses - ethnology - statistics & numerical data
Sexual Behavior - ethnology - statistics & numerical data
Sweden - epidemiology
Abstract
Little is known about whether the accuracy of tools for assessment of sexual offender recidivism risk holds across ethnic minority offenders. I investigated the predictive validity across ethnicity for the RRASOR and the Static-99 actuarial risk assessment procedures in a national cohort of all adult male sex offenders released from prison in Sweden 1993-1997. Subjects ordered out of Sweden upon release from prison were excluded and remaining subjects (N = 1303) divided into three subgroups based on citizenship. Eighty-three percent of the subjects were of Nordic ethnicity, and non-Nordic citizens were either of non-Nordic European (n = 49, hereafter called European) or African Asian descent (n = 128). The two tools were equally accurate among Nordic and European sexual offenders for the prediction of any sexual and any violent nonsexual recidivism. In contrast, neither measure could differentiate African Asian sexual or violent recidivists from nonrecidivists. Compared to European offenders, AfricanAsian offenders had more often sexually victimized a nonrelative or stranger, had higher Static-99 scores, were younger, more often single, and more often homeless. The results require replication, but suggest that the promising predictive validity seen with some risk assessment tools may not generalize across offender ethnicity or migration status. More speculatively, different risk factors or causal chains might be involved in the development or persistence of offending among minority or immigrant sexual abusers.
PubMed ID
15208896 View in PubMed
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Across six nations: stressful events in the lives of children.

https://arctichealth.org/en/permalink/ahliterature35027
Source
Child Psychiatry Hum Dev. 1996;26(3):139-50
Publication Type
Article
Date
1996
Author
K. Yamamoto
O L Davis
S. Dylak
J. Whittaker
C. Marsh
P C van der Westhuizen
Author Affiliation
University of Colorado at Denver 80217, USA.
Source
Child Psychiatry Hum Dev. 1996;26(3):139-50
Date
1996
Language
English
Publication Type
Article
Keywords
Adolescent
Australia
Chi-Square Distribution
Child
Child Psychology
Cross-Cultural Comparison
Europe
Female
Humans
Life Change Events
Male
Reference Values
Stress, Psychological
United States
Abstract
A total of 1,729 children (2nd-9th grades) in South Africa, Iceland, Poland, Australia, the U.K., and the U.S.A. rated 20 events in terms of how upsetting they are. Save in Poland, the ratings were in close agreement (r, .85-.97), placing the loss of parent at the top and a new baby sibling at the bottom. In Poland, the baby's arrival led the list. Even so, what was seen as quite upsetting fell everywhere in the same two categories--experiences that threaten one's sense of security and those that occasion personal denigration and embarrassment.
PubMed ID
8819876 View in PubMed
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ADHD symptoms and associated psychopathology in a community sample of adolescents from the European north of Russia.

https://arctichealth.org/en/permalink/ahliterature161796
Source
J Atten Disord. 2008 Jul;12(1):54-63
Publication Type
Article
Date
Jul-2008
Author
Vladislav Ruchkin
Boris Lorberg
Roman Koposov
Mary Schwab-Stone
Denis G Sukhodolsky
Author Affiliation
Child Study Center, Yale University School of Medicine, New Haven, CT 06520-7900, USA. vladislav.ruchkin@yale.edu
Source
J Atten Disord. 2008 Jul;12(1):54-63
Date
Jul-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Attention Deficit Disorder with Hyperactivity - diagnosis - epidemiology - psychology
Catchment Area (Health)
Child
Comorbidity
Europe - epidemiology
Faculty
Female
Humans
Male
Mental Disorders - epidemiology
Observer Variation
Residence Characteristics
Russia - epidemiology
Severity of Illness Index
Violence - statistics & numerical data
Abstract
To assess the prevalence of ADHD symptoms and their relationship to psychopathology in adolescents from the European North of Russia.
The prevalence of ADHD symptoms is assessed by teacher reports in 536 adolescents. Internalizing and externalizing problems are assessed by teacher ratings and student self-reports.
Prevalence of individual ADHD symptoms ranges between 3.3% and 35%. Only 8.9% of boys and 3.6% of girls have positive ratings on six items in either inattention or hyperactivity subtype. These adolescents fare significantly worse regarding externalizing but not internalizing problems. Compared to girls with ADHD, boys with ADHD report higher levels of violent and nonviolent delinquency and are described by teachers as having more conduct problems. Possible ADHD status is associated with depressive symptoms in boys but not in girls.
The estimates of ADHD prevalence rates obtained in this study are similar to those of other countries, suggesting the need for identification and treatment of the disorder. Evaluation of associated disruptive behavior disorders and depression, particularly in boys, is warranted.
PubMed ID
17712166 View in PubMed
Less detail

[Aerobic capacity in children and adolescents--Nordic results over the past 45 years]

https://arctichealth.org/en/permalink/ahliterature33698
Source
Tidsskr Nor Laegeforen. 1998 Aug 30;118(20):3106-10
Publication Type
Article
Date
Aug-30-1998
Author
P M Fredriksen
E. Thaulow
W. Nystad
F. Ingjer
Author Affiliation
Barnehjerteseksionen Rikshospitalet, Oslo.
Source
Tidsskr Nor Laegeforen. 1998 Aug 30;118(20):3106-10
Date
Aug-30-1998
Language
Norwegian
Publication Type
Article
Keywords
Adolescent
Adult
Child
Comparative Study
English Abstract
Europe
Exercise - physiology
Female
History, 20th Century
Humans
Infant, Newborn
Male
Oxygen consumption
Scandinavia
Abstract
The aim of this study was to reveal whether today's children and adolescents have lower aerobic capacity compared with earlier studies. Aerobic capacity may be defined as the highest amount of oxygen a subject is able to consume per unit of time. Peak oxygen uptake (VO2peak) is often used as a measure of aerobic capacity in children. VO2peak in 196 healthy children and adolescents of both sexes, aged 8-16 years, was measured on a graded treadmill test. The mean results of VO2peak (l.min-1) showed only small differences compared with previous studies in Scandinavia. There was, however, greater dispersion in the present study when the VO2peak-values were corrected for weight (ml.kg-1.min-1) than in the earlier studies. When compared to other countries in Europe, Norwegian subjects achieved higher values. The reason may be due to either genetic differences or to a higher level of physical activity among the Norwegian subjects.
PubMed ID
9760851 View in PubMed
Less detail

The aetiology of nasopharyngeal carcinoma.

https://arctichealth.org/en/permalink/ahliterature3952
Source
Clin Otolaryngol Allied Sci. 2001 Apr;26(2):82-92
Publication Type
Article
Date
Apr-2001
Author
A L McDermott
S N Dutt
J C Watkinson
Author Affiliation
Department of Otolaryngology/Head and Neck Surgery, Queen Elizabeth Hospital, Birmingham University, Birmingham, UK.
Source
Clin Otolaryngol Allied Sci. 2001 Apr;26(2):82-92
Date
Apr-2001
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Africa - epidemiology
Aged
Aged, 80 and over
Asia - epidemiology
Carcinoma - classification - epidemiology - etiology
Child
Child, Preschool
Europe - epidemiology
Female
Humans
Incidence
Male
Middle Aged
Nasopharyngeal Neoplasms - epidemiology - ethnology - etiology
Retrospective Studies
Risk factors
Socioeconomic Factors
Abstract
Nasopharyngeal carcinoma is a disease with a remarkable racial and geographical distribution. In most parts of the world it is a rare condition and in only a handful of places does this low risk profile alter. These include the Southern Chinese, Eskimos and other Arctic natives, inhabitants of South-East Asia and also the populations of North Africa and Kuwait.
PubMed ID
11309046 View in PubMed
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Age at onset of multiple sclerosis may be influenced by place of residence during childhood rather than ancestry.

https://arctichealth.org/en/permalink/ahliterature170585
Source
Neuroepidemiology. 2006;26(3):162-7
Publication Type
Article
Date
2006
Author
J. Kennedy
P. O'Connor
A D Sadovnick
M. Perara
I. Yee
B. Banwell
Author Affiliation
The Hospital for Sick Children, University of Toronto, Toronto, Ont. L5M 4A7, Canada.
Source
Neuroepidemiology. 2006;26(3):162-7
Date
2006
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Age of Onset
Aged
Asia - ethnology
Caribbean Region - ethnology
Child
Child, Preschool
Cohort Studies
Emigration and Immigration
Europe - ethnology
Humans
Middle Aged
Multiple Sclerosis - epidemiology
Ontario - epidemiology
Residence Characteristics
Risk factors
Abstract
Multiple sclerosis (MS) most commonly affects individuals of Northern European descent who live in countries at high latitude. The relative contributions of ancestry, country of birth and residence as determinants of MS risk have been studied in adult MS, but have not been explored in the pediatric MS population. In this study, we compare the demographics of pediatric- and adult-onset MS patients cared for in Toronto, Ontario, Canada, a multicultural region. The country of birth, residence during childhood, and ancestry were compared for 44 children and 573 adults. Our results demonstrate that although both the pediatric and adult cohorts were essentially born and raised in the same region of Ontario, Canada, children with MS were more likely to report Caribbean, Asian or Middle Eastern ancestry, and were less likely to have European heritage compared with individuals with adult-onset MS. The difference in ancestry between the pediatric and adult MS cohorts can be explained by two hypotheses: (1) individuals raised in a region of high MS prevalence, but whose ancestors originate from regions in which MS is rare, have an earlier age of MS onset, and (2) the place of residence during childhood, irrespective of ancestry, determines lifetime MS risk -- a fact that will be reflected in a change in the demographics of the adult MS cohort in our region as Canadian-raised children of recent immigrants reach the typical age of adult-onset MS.
PubMed ID
16493204 View in PubMed
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455 records – page 1 of 46.