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Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe.
BMC Genet. 2017 12 28; 18(Suppl 1):110
Publication Type
Historical Article
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Petr Triska
Nikolay Chekanov
Vadim Stepanov
Elza K Khusnutdinova
Ganesh Prasad Arun Kumar
Vita Akhmetova
Konstantin Babalyan
Eugenia Boulygina
Vladimir Kharkov
Marina Gubina
Irina Khidiyatova
Irina Khitrinskaya
Ekaterina E Khrameeva
Rita Khusainova
Natalia Konovalova
Sergey Litvinov
Andrey Marusin
Alexandr M Mazur
Valery Puzyrev
Dinara Ivanoshchuk
Maria Spiridonova
Anton Teslyuk
Svetlana Tsygankova
Martin Triska
Natalya Trofimova
Edward Vajda
Oleg Balanovsky
Ancha Baranova
Konstantin Skryabin
Tatiana V Tatarinova
Egor Prokhortchouk
Author Affiliation
Children's Hospital Los Angeles, Los Angeles, CA, USA.
BMC Genet. 2017 12 28; 18(Suppl 1):110
Publication Type
Historical Article
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Datasets as Topic
Emigration and Immigration - history
Ethnic Groups - genetics
Genetic Variation
Genetics, Population
Genotyping Techniques
History, 15th Century
History, 16th Century
History, 17th Century
History, 18th Century
History, 19th Century
History, 20th Century
History, 21st Century
History, Ancient
History, Medieval
The history of human populations occupying the plains and mountain ridges separating Europe from Asia has been eventful, as these natural obstacles were crossed westward by multiple waves of Turkic and Uralic-speaking migrants as well as eastward by Europeans. Unfortunately, the material records of history of this region are not dense enough to reconstruct details of population history. These considerations stimulate growing interest to obtain a genetic picture of the demographic history of migrations and admixture in Northern Eurasia.
We genotyped and analyzed 1076 individuals from 30 populations with geographical coverage spanning from Baltic Sea to Baikal Lake. Our dense sampling allowed us to describe in detail the population structure, provide insight into genomic history of numerous European and Asian populations, and significantly increase quantity of genetic data available for modern populations in region of North Eurasia. Our study doubles the amount of genome-wide profiles available for this region. We detected unusually high amount of shared identical-by-descent (IBD) genomic segments between several Siberian populations, such as Khanty and Ket, providing evidence of genetic relatedness across vast geographic distances and between speakers of different language families. Additionally, we observed excessive IBD sharing between Khanty and Bashkir, a group of Turkic speakers from Southern Urals region. While adding some weight to the "Finno-Ugric" origin of Bashkir, our studies highlighted that the Bashkir genepool lacks the main "core", being a multi-layered amalgamation of Turkic, Ugric, Finnish and Indo-European contributions, which points at intricacy of genetic interface between Turkic and Uralic populations. Comparison of the genetic structure of Siberian ethnicities and the geography of the region they inhabit point at existence of the "Great Siberian Vortex" directing genetic exchanges in populations across the Siberian part of Asia. Slavic speakers of Eastern Europe are, in general, very similar in their genetic composition. Ukrainians, Belarusians and Russians have almost identical proportions of Caucasus and Northern European components and have virtually no Asian influence. We capitalized on wide geographic span of our sampling to address intriguing question about the place of origin of Russian Starovers, an enigmatic Eastern Orthodox Old Believers religious group relocated to Siberia in seventeenth century. A comparative reAdmix analysis, complemented by IBD sharing, placed their roots in the region of the Northern European Plain, occupied by North Russians and Finno-Ugric Komi and Karelian people. Russians from Novosibirsk and Russian Starover exhibit ancestral proportions close to that of European Eastern Slavs, however, they also include between five to 10 % of Central Siberian ancestry, not present at this level in their European counterparts.
Our project has patched the hole in the genetic map of Eurasia: we demonstrated complexity of genetic structure of Northern Eurasians, existence of East-West and North-South genetic gradients, and assessed different inputs of ancient populations into modern populations.
PubMed ID
29297395 View in PubMed
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