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Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European White children and adolescents.

https://arctichealth.org/en/permalink/ahliterature289937
Source
BMC Pediatr. 2017 04 28; 17(1):116
Publication Type
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Date
04-28-2017
Author
Tenna Ruest Haarmark Nielsen
Ulrik Lausten-Thomsen
Cilius Esmann Fonvig
Christine Bøjsøe
Lise Pedersen
Palle Skov Bratholm
Torben Hansen
Oluf Pedersen
Jens-Christian Holm
Author Affiliation
The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Smedelundsgade 60, DK 4300, Holbæk, Denmark. ter@regionsjaelland.dk.
Source
BMC Pediatr. 2017 04 28; 17(1):116
Date
04-28-2017
Language
English
Publication Type
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Adolescent
Biomarkers - blood
Case-Control Studies
Child
Cholesterol - blood
Cross-Sectional Studies
Denmark - epidemiology
Dyslipidemias - blood - complications - diagnosis - epidemiology
Europe - epidemiology
European Continental Ancestry Group
Fasting
Female
Humans
Logistic Models
Male
Pediatric Obesity - blood - complications - diagnosis - epidemiology
Prevalence
Reference Values
Triglycerides - blood
Young Adult
Abstract
Dyslipidemia is reported in 27 - 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity. Cut-off values for fasting plasma lipid concentrations are typically set at fixed levels throughout childhood. The objective of this cross-sectional study was to generate fasting plasma lipid references for a Danish/North-European White population-based cohort of children and adolescents, and investigate the prevalence of dyslipidemia in this cohort as well as in a cohort with overweight/obesity.
A population-based cohort of 2141 (1275 girls) children and adolescents aged 6 - 19 (median 11.5) years was recruited from 11 municipalities in Denmark. Additionally, a cohort of children and adolescents of 1421 (774 girls) with overweight/obesity aged 6 - 19 years (median 11.8) was recruited for the study. Height, weight, and fasting plasma lipid concentrations were measured on all participants. Smoothed reference curves and percentiles were generated using the Generalized Additive Models for Location Scale and Shape package in the statistical software R.
In the population-based cohort, plasma concentrations of total cholesterol (TC) (P 
Notes
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PubMed ID
28454530 View in PubMed
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