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Dyslipidemia and reference values for fasting plasma lipid concentrations in Danish/North-European White children and adolescents.
BMC Pediatr. 2017 04 28; 17(1):116
Publication Type
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Tenna Ruest Haarmark Nielsen
Ulrik Lausten-Thomsen
Cilius Esmann Fonvig
Christine Bøjsøe
Lise Pedersen
Palle Skov Bratholm
Torben Hansen
Oluf Pedersen
Jens-Christian Holm
Author Affiliation
The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Smedelundsgade 60, DK 4300, Holbæk, Denmark.
BMC Pediatr. 2017 04 28; 17(1):116
Publication Type
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Biomarkers - blood
Case-Control Studies
Cholesterol - blood
Cross-Sectional Studies
Denmark - epidemiology
Dyslipidemias - blood - complications - diagnosis - epidemiology
Europe - epidemiology
European Continental Ancestry Group
Logistic Models
Pediatric Obesity - blood - complications - diagnosis - epidemiology
Reference Values
Triglycerides - blood
Young Adult
Dyslipidemia is reported in 27 - 43% of children and adolescents with overweight/obesity and tracks into adulthood, increasing the risk of cardiovascular morbidity. Cut-off values for fasting plasma lipid concentrations are typically set at fixed levels throughout childhood. The objective of this cross-sectional study was to generate fasting plasma lipid references for a Danish/North-European White population-based cohort of children and adolescents, and investigate the prevalence of dyslipidemia in this cohort as well as in a cohort with overweight/obesity.
A population-based cohort of 2141 (1275 girls) children and adolescents aged 6 - 19 (median 11.5) years was recruited from 11 municipalities in Denmark. Additionally, a cohort of children and adolescents of 1421 (774 girls) with overweight/obesity aged 6 - 19 years (median 11.8) was recruited for the study. Height, weight, and fasting plasma lipid concentrations were measured on all participants. Smoothed reference curves and percentiles were generated using the Generalized Additive Models for Location Scale and Shape package in the statistical software R.
In the population-based cohort, plasma concentrations of total cholesterol (TC) (P 
Cites: Pediatrics. 2008 Jul;122(1):198-208 PMID 18596007
Cites: JAMA Pediatr. 2015 Mar;169(3):272-9 PMID 25599372
Cites: Obesity (Silver Spring). 2011 May;19(5):1069-76 PMID 20948517
Cites: Int J Pediatr Obes. 2010 Apr;5(2):122-9 PMID 19593726
Cites: Pediatrics. 1988 Sep;82(3):309-18 PMID 3405659
Cites: N Engl J Med. 1998 Jun 4;338(23):1650-6 PMID 9614255
Cites: Obesity (Silver Spring). 2008 Jul;16(7):1672-9 PMID 18451769
Cites: Lipids Health Dis. 2015 Sep 15;14:108 PMID 26370413
Cites: JAMA. 2016 Jun 7;315(21):2292-9 PMID 27272581
Cites: Eur J Clin Nutr. 1990 Jan;44(1):45-60 PMID 2354692
Cites: MMWR Morb Mortal Wkly Rep. 2010 Jan 22;59(2):29-33 PMID 20094024
Cites: BMJ. 2012 Sep 25;345:e4759 PMID 23015032
Cites: Clin Chem. 1997 Nov;43(11):2183-4 PMID 9365406
Cites: Int J Pediatr Obes. 2011 Oct;6(5-6):342-60 PMID 21838570
Cites: Arch Dis Child. 1969 Jun;44(235):291-303 PMID 5785179
Cites: Acta Paediatr. 2010 Nov;99(11):1675-8 PMID 20528793
Cites: Pediatrics. 2012 Apr;129(4):e1020-9 PMID 22451707
Cites: Coll Antropol. 2009 Dec;33(4):1015-22 PMID 20102043
Cites: Lancet. 2012 Dec 15;380(9859):2095-128 PMID 23245604
Cites: Int J Cardiol. 2014 Jul 15;175(1):176-8 PMID 24874906
Cites: Eur Heart J. 2012 Jul;33(13):1635-701 PMID 22555213
Cites: J Pediatr. 2011 Oct;159(4):584-90 PMID 21514597
Cites: Arch Dis Child. 1970 Feb;45(239):13-23 PMID 5440182
Cites: Clin Biochem. 2016 Jul;49(10-11):740-9 PMID 26948098
Cites: Circulation. 2003 Mar 25;107(11):1562-6 PMID 12654618
Cites: Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2007 May-Jun;50(5-6):736-43 PMID 17514458
Cites: Int J Obes Relat Metab Disord. 2001 Feb;25(2):177-84 PMID 11410817
Cites: Obesity (Silver Spring). 2016 May;24(5):1116-23 PMID 27112068
Cites: Pediatrics. 2015 Jan;135(1):86-93 PMID 25535262
Cites: Pediatrics. 2011 Dec;128 Suppl 5:S213-56 PMID 22084329
Cites: Circ Cardiovasc Qual Outcomes. 2011 May;4(3):337-45 PMID 21487090
Cites: Child Obes. 2012 Dec;8(6):533-41 PMID 23181919
Cites: PLoS One. 2013 Jul 24;8(7):e69860 PMID 23894553
PubMed ID
28454530 View in PubMed
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