This paper draws together the mortality experience for a cohort of some 11000 male Quebec Chrysotile miners and millers, reported at intervals since 1971 and now again updated. Of the 10918 men in the complete cohort, 1138 were lost to view, almost all never traced after employment of only a month or two before 1935; the other 9780 men were traced into 1992. Of these, 8009 (82%) are known to have died: 657 from lung cancer, 38 from mesotheliona, 1205 from other malignant disease, 108 from pneumoconiosis and 561 from other non-malignant respiratory diseases (excluding tuberculosis). After early fluctuations. SMRs (all causes) against Quebec rates have been reasonably steady since about 1945. For men first employed in Asbestos, mine or factory, they were very much what might have been expected for a blue collar population without any hazardous exposure. SMRs in the Thetford Mines area were almost 8% higher, but in line with anecdotal evidence concerning socio-economic status. At exposures below 300 (million particles per cubic foot) x years, (mpcf.y), equivalent to roughly 1000 (fibres/ml) x years-or, say, 10 years in the 1940s at 80 (fibres/ml)-findings were as follows. There were no discernible associations of degree of exposure and SMRs, whether for all causes of death or for all the specific cancer sites examined. The average SMRs were 1.07 (all causes), and 1.16, 0.93, 1.03 and 1.21, respectively, for gastric, other abdominal, laryngeal and lung cancer. Men whose exposures were less then 300 mpcf.y suffered almost one-half of the 146 deaths from pneumoconiosis or mesothelioma; the elimination of these two causes would have reduced these men's SMR (all causes) from 1.07 to approximately 1.06. Thus it is concluded from the viewpoint of mortality that exposure in this industry to less than 300 mpcf.y has been essentially innocuous, although there was a small risk or pneumoconiosis or mesothelioma. Higher exposures have, however, led to excesses, increasing with degree of exposure, of mortality from all causes, and from lung cancer and stomach cancer, but such exposures, of at least 300 mpcf.y, are several orders of magnitude more severe than any that have been seen for many years. The effects of cigarette smoking were much more deleterious than those of dust exposure, not only for lung cancer (the SMR for smokers of 20+ cigarettes a day being 4.6 times higher than that for non-smokers), but also for stomach cancer (2.0 times higher), laryngeal cancer (2.9 times higher), and-most importantly-for all causes (1.6 times higher).
Comment In: Ann Occup Hyg. 1997 Jan;41(1):3-129072948
Comment In: Ann Occup Hyg. 2001 Jun;45(4):329-35; author reply 336-811414250
The article contains results concerning spectral analysis of biologic materials (blood and hair) for heavy metals content. These results helped to reveal health risk factors for workers engaged into chromium ores extraction and for nearby residents.
Otitis media (OM) is one of the most common early childhood infections, resulting in an enormous economic burden to the health care system through unscheduled doctor visits and antibiotic prescriptions.
The objective of this study was to investigate the potential association between ambient air pollution exposure and emergency department (ED) visits for OM.
Ten years of ED data were obtained from Edmonton, Alberta, Canada, and linked to levels of air pollution: carbon monoxide (CO), nitrogen dioxide (NO2), ozone (O3), sulfur dioxide, and particulate matter (PM) of median aerometric diameter
Cites: An Pediatr (Barc). 2004 Feb;60(2):133-814757016
Cites: Vaccine. 2008 Dec 23;26 Suppl 7:G5-1019094935
Ambient exposure to sulphur dioxide (SO2) has been previously associated with emergency department (ED) visits for migraine headaches. In the present study, the objective was to examine the relationship between ED visits for migraine and ambient sulphur dioxide concentrations.
This was a time-series study of 1059 ED visits for migraine (ICD-9: 346) recorded at a Vancouver hospital between 1999 and 2003 (1 520 days). Air pollution levels of SO2 were measured by fixed-site monitoring stations. The generalized linear mixed models technique was applied to regress daily counts of ED visits for migraine on the levels of the pollutant after adjusting for meteorological conditions: temperature and relative humidity. The analysis was stratified by season and gender.
Positive and statistically significant correlations were observed for SO2 exposure and ED visits for migraine for females during colder months (October-March). The percentage increase in daily visits was 16.8% (95% CI: 1.2-34.8) for a 4-day average (of daily mean concentrations) SO2 level, for an interquartile range (IQR) increase of 1.9 ppb.
Our findings provide additional support for a consistent correlation between migraine headache and air pollution (SO2).
To analyze prevalence and variability of Legionella strains isolated in town Verkhnaya Pyshma located in Sverdlovsk region during prophylactic surveillance of potentially dangerous water objects in 2007 - 2008.
Sequencing of mip gene was conducted for identification of species of Legionella. Multi-locus sequence typing was used for describing of allelic profiles of Legionella pneumophila strains.
Five firstly identified on Russian territory strains of Legionella species were deposited in institute's collection. Sixty-three strains of L. pneumophila belonging to 28 sequence types were characterized. Relation between strains isolated in industrial building and from water supply system was demonstrated.
Observations made on the basis of study of L. pneumophila strains isolated from cooling stacks of industrial plants confirmed potential danger of these objects as a source of dissemination of Legionella infection.
To account for use of hearing protection devices (HPDs) in retrospective noise exposure assessment, adjust noise exposure estimates accordingly, and validate the adjusted estimates.
A previous study in the same working population showed a stronger relation for noise and acute myocardial infarction among those who did not wear HPD. Because accurate noise exposure assessment is complicated by the use of HPD, we previously developed a multilevel model of the likelihood of HPD use for British Columbia (Canada) lumber mill workers. Historical estimates of noise exposure can be adjusted according to models predictions and a reduction in misclassifying workers, exposure is expected.
Work history and exposure information were obtained for 13,147 lumber mill workers followed from 1909 until 1998. Audiometric data for the cohort, including hearing threshold levels at several pure tone frequencies, were obtained from the local regulatory agency for the period from 1978 to 2003. Following the modeling of HPD use, noise estimates were adjusted according to models predictions and attenuation factors based on existing research and standards. Adjusted and unadjusted noise metrics were compared by investigating their ability to predict noise-induced hearing loss.
We showed a 4-fold increase in the noise exposure and hearing loss slope, after adjusting for HPD use, while controlling for gender, age, race, as well as medical and non-occupational confounding variables.
While the relative difference before and after adjustment for use of HPD is considerable, we observed a subtle absolute magnitude of the effect. Using noise-induced hearing loss as a 'gold standard' for testing the assessment of retrospective noise exposure estimates should continue to be investigated.
At the period of 1982 - 2003, morbidity rate in pseudotuberculosis and the Yersinia pseudotuberculosis culture rates in groups of servicemen (from different abiotic objects, from humans and small rodents) in different geographic zones were studied. The cases of the isolation of Y. pseudotuberculosis were most frequently registered in groups of servicemen in the Far East and the Kola Peninsula. In these regions the highest morbidity rate in pseudotuberculosis was registered among servicemen. The contamination rate of vegetables during the year was always greater than in other objects under study, including small rodents. The study demonstrated that in the Armed Forces could appear, temporary and relatively constant anthropurgic foci of pseudotuberculosis even in non endemic regions. They were formed in the objects of the food supply service due to the supply of contaminated vegetables. Synanthropic rodents played a secondary role, though they too facilitated the formation of new anthropurgic foci. Under definite conditions anthropurgic foci could exist autonomously, independently of natural foci.
Analysis of the antibioticograms of 22 strains of Vibrio cholerae non O1/non O139 serogroups (ctxA- tepA-) isolated from the environment in the Rostov Region in 2011 showed that all the cultures were susceptible to ciprofloxacin, aminoglycosides, ceftriaxone, trimetoprime/sulfamethoxazole and resistant to levomycetin and furazolidone. 32%, 18% and 9% of the isolates were resistant to tetracycline, rifampicin and nalidixic acid respectively. No strains of V. cholerae susceptible to all the tested antimicrobials were detected. 37% of the V. cholerae isolates was resistant to two antibacterials and the others showed multiple resistance and contained 3-6 r-determinants of antibiotic resistance. Since the antibiotic resistance genes in Vibrio cholerae non O1/non O139 serogroups are often located on mobile genetic elements (plasmids, interferons, SXT elements), many strains of such organisms, the same as the natural environment, could serve as reservoirs of antibiotic resistance. The presence of antibiotic resistance r-determinants in the investigated strains in various combinations, the antibiotic resistance variability in the isolates collected on the same territory within a relatively short period of time require monitoring of antibiotic susceptibility in them and the use of the antibiotic for the etiotropic therapy only in strict accordance with the antibioticogram of the culture isolated from the concrete patient.