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167 records – page 1 of 17.

Abnormal adherence junctions in the heart and reduced angiogenesis in transgenic mice overexpressing mutant type XIII collagen.

https://arctichealth.org/en/permalink/ahliterature53860
Source
EMBO J. 2001 Sep 17;20(18):5153-64
Publication Type
Article
Date
Sep-17-2001
Author
M. Sund
R. Ylönen
A. Tuomisto
R. Sormunen
J. Tahkola
A P Kvist
S. Kontusaari
H. Autio-Harmainen
T. Pihlajaniemi
Author Affiliation
Collagen Research Unit, Biocenter Oulu, Department of Medical Biochemistry, University of Oulu, PL 5000, 90014 Oulu, Finland.
Source
EMBO J. 2001 Sep 17;20(18):5153-64
Date
Sep-17-2001
Language
English
Publication Type
Article
Keywords
Adherens Junctions - ultrastructure
Animals
Collagen - genetics - metabolism - physiology
Embryonic and Fetal Development
Fetus - abnormalities - blood supply
Heart - embryology
Heart Defects, Congenital - pathology
Mice
Mice, Transgenic
Mutation
Myocardium - ultrastructure
Neovascularization, Physiologic
Phenotype
Placenta - abnormalities - blood supply
RNA, Messenger - biosynthesis
Research Support, Non-U.S. Gov't
Survival Analysis
Abstract
Type XIII collagen is a type II transmembrane protein found at sites of cell adhesion. Transgenic mouse lines were generated by microinjection of a DNA construct directing the synthesis of truncated alpha1(XIII) chains. Shortened alpha 1(XIII) chains were synthesized by fibroblasts from mutant mice, and the lack of intracellular accumulation in immunofluorescent staining of tissues suggested that the mutant molecules were expressed on the cell surface. Transgene expression led to fetal lethality in offspring from heterozygous mating with two distinct phenotypes. The early phenotype fetuses were aborted by day 10.5 of development due to a lack of fusion of the chorionic and allantoic membranes. The late phenotype fetuses were aborted by day 13.5 of development and displayed a weak heartbeat, defects of the adherence junctions in the heart with detachment of myofilaments and abnormal staining for the adherence junction component cadherin. Decreased microvessel formation was observed in certain regions of the fetus and the placenta. These results indicate that type XIII collagen has an important role in certain adhesive interactions that are necessary for normal development.
PubMed ID
11566879 View in PubMed
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Accuracy in estimating fetal urinary bladder volume using a modified ultrasound technique.

https://arctichealth.org/en/permalink/ahliterature63687
Source
Ultrasound Obstet Gynecol. 2002 Apr;19(4):371-9
Publication Type
Article
Date
Apr-2002
Author
M. Fägerquist
U. Fägerquist
H. Steyskal
A. Odén
S G Blomberg
Author Affiliation
Department of Obstetrics and Gynaecology, North Elfsborg County Hospital, Trollhättan, Sweden. mats.fagerquist@vgregion.se
Source
Ultrasound Obstet Gynecol. 2002 Apr;19(4):371-9
Date
Apr-2002
Language
English
Publication Type
Article
Keywords
Adult
Bladder - embryology - ultrasonography
Comparative Study
Computer simulation
Embryonic and Fetal Development
Female
Gestational Age
Humans
Pregnancy
Research Support, Non-U.S. Gov't
Sweden
Ultrasonography, Prenatal - methods
Abstract
OBJECTIVE: Fetal urine production at different gestational ages has been evaluated using ultrasound in several previous studies. In a recent study, we investigated the accuracy when estimating the bladder volume using the conventional ultrasound technique and found a total variability of 17.3-10.9% for bladder volumes of 5-40 mL. The variability is mainly caused by: (i) inappropriate image selection (the 'freezing error') and (ii) limitations when measuring on the frozen image (the 'frozen error'). The aim of this study was to reduce the total error by reducing the 'freezing' and the 'frozen error'. To this end, we used a modified manual ultrasound technique (adding a 'rocking' motion to the conventional method) and digitized the selected image. METHODS: Two patients for each gestational week from 24 to 40 weeks were selected. The fetal urinary bladder was examined with ultrasound three times within 1 min and documented on videotape. The volume, as assessed by the longitudinal section of the recorded bladder images, stored in digitized form, was evaluated on three occasions with > 24 h in between. The mean and variability (standard deviation, SD) were estimated. RESULTS: For fetal bladder volumes between 5 and 40 mL, the 'freezing error' (SD), the 'frozen error' and the 'total error' were 11.7-5.1%, 8.0-3.0% and 14.2-5.9%, respectively. Comparing the present with a previous study, when selecting images and assessing bladder volumes repeatedly within 1 min, SD was 12.9-5.5% vs. 17.3-10.9%. CONCLUSIONS: Using a modified ultrasound technique, the variability in fetal bladder volume estimation can be reduced.
PubMed ID
11952967 View in PubMed
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Adult major affective disorder after prenatal exposure to an influenza epidemic.

https://arctichealth.org/en/permalink/ahliterature208905
Source
Arch Gen Psychiatry. 1997 Apr;54(4):322-8
Publication Type
Article
Date
Apr-1997
Author
R A Machón
S A Mednick
M O Huttunen
Author Affiliation
Department of Psychology, Loyola Marymount University, Los Angeles, Calif., USA.
Source
Arch Gen Psychiatry. 1997 Apr;54(4):322-8
Date
Apr-1997
Language
English
Publication Type
Article
Keywords
Adult
Bipolar Disorder - epidemiology - etiology
Brain - embryology
Depressive Disorder - epidemiology - etiology
Disease Outbreaks - statistics & numerical data
Embryonic and Fetal Development - physiology
Female
Finland - epidemiology
Humans
Influenza, Human - epidemiology
Male
Pregnancy
Pregnancy Complications, Infectious - epidemiology - physiopathology
Pregnancy Trimester, Second
Prenatal Exposure Delayed Effects
Psychotic Disorders - epidemiology - etiology
Risk factors
Abstract
We have previously reported an increase in schizophrenia diagnoses in a population exposed during the second trimester to the 1957 influenza epidemic. These basic findings together with a fair number of replications have been interpreted as supporting a neurodevelopmental contribution to the origins of schizophrenia. Recent neuroimaging findings suggest that affective illness may also have a neurodevelopmental origin. We examined the hypothesis that exposure to an influenza epidemic during the second trimester would increase the risk for adult major affective disorder.
The subjects had been exposed as fetuses to the type A2/Singapore influenza epidemic in greater Helsinki, Finland. Control subjects were born in the 6 years before the epidemic.
We found a significant (P .05) were similar. The second-trimester effect remained when we estimated population-based rates (2.1 vs 0.6 per 1000) (P .05) elevation was observed for the bipolar forms of major affective disorder.
These data are consistent with the hypothesis concerning the possible neurodevelopmental contribution to the origins of some forms of major affective disorder, especially unipolar depressive disorder. These encouraging findings, if replicated, may suggest that some mental disorders may stem, in part, from a disturbance in the development of the fetal brain during the second trimester.
PubMed ID
9107148 View in PubMed
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The association of indicators of fetal growth with visual acuity and hearing among conscripts.

https://arctichealth.org/en/permalink/ahliterature50835
Source
Epidemiology. 2001 Mar;12(2):235-8
Publication Type
Article
Date
Mar-2001
Author
J. Olsen
H T Sørensen
F H Steffensen
S. Sabroe
M W Gillman
P. Fischer
K J Rothman
Author Affiliation
Danish Epidemiology Science Centre at the Institute of Epidemiology and Social Medicine, University of Aarhus.
Source
Epidemiology. 2001 Mar;12(2):235-8
Date
Mar-2001
Language
English
Publication Type
Article
Keywords
Adult
Birth weight
Body constitution
Cohort Studies
Denmark
Embryonic and Fetal Development - physiology
Fetal Growth Retardation - complications
Gestational Age
Hearing - physiology
Hearing Disorders - etiology
Humans
Infant, Low Birth Weight
Infant, Newborn
Male
Military Personnel
Registries
Research Support, Non-U.S. Gov't
Vision Disorders - etiology
Visual Acuity - physiology
Abstract
Impaired fetal growth is associated with increased susceptibility to several chronic diseases. We studied the association between birth weight, indicators of disproportional fetal growth, and impaired visual acuity and hearing in 4,300 conscripts from a well-defined region in Denmark from August 1, 1993, to July 31, 1994. From the standard health examination for conscripts, we obtained data on sight based on the Snellen's chart and data on hearing acuity based on audiometry. By means of record linkage, we obtained data on outcomes for the conscripts at birth from the Medical Birth Registry. From this registry, we have data on birth weight, gestational age, and birth length that were recorded from existing computerized registers based on the records of midwives. A birth weight of less than 3,000 gm and a body mass index at birth of less than 3.4 were associated with reduced visual acuity and impaired hearing. The results could be due to fetal brain programming or due to confounding, by early birth trauma or other factors.
PubMed ID
11246586 View in PubMed
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Attitudes towards abortion in the Danish population.

https://arctichealth.org/en/permalink/ahliterature63765
Source
Bioethics. 1997 Oct;11(5):439-49
Publication Type
Article
Date
Oct-1997
Author
Michael Norup
Source
Bioethics. 1997 Oct;11(5):439-49
Date
Oct-1997
Language
English
Publication Type
Article
Keywords
Abortion, Eugenic
Abortion, Induced
Abortion, Legal
Age Factors
Attitude
Chromosome Aberrations
Chromosome Disorders
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Cystic Fibrosis
Data Collection
Denmark
Down Syndrome
Embryonic and Fetal Development
Female
Fetus
Humans
Kidney Diseases
Men
Morals
Pregnancy Trimesters
Public Opinion
Religion
Socioeconomic Factors
Value of Life
Women
Abstract
This article reports the results of a survey, by mailed questionnaire, of the attitudes among a sample of the Danish population towards abortion for social and genetic reasons. Of 1080 questionnaires sent to a random sample of persons between 18 and 45 years, 731 (68%) were completed and returned. A great majority of the respondents were liberal towards early abortion both for social reasons and in case of minor disease. In contrast, there was controversy about late abortions for social reasons and in the case of Down syndrome. Further there was strong reluctance to accept late abortion in case of minor disease. An analysis of the response patterns showed that most of the respondents had gradualist views on abortion, i.e. they would allow all early abortions, but only abortions for some reasons later in pregnancy. It was also found that the number who would find an early abortion acceptable in general was much higher than the number who would accept it in their own case. These findings suggest that a great part of the resistance towards abortion does not rest on a concern for the rights and interests for the fetus. Instead it may be explained on a view according to which fetal life is ascribed intrinsic moral value.
PubMed ID
11655122 View in PubMed
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167 records – page 1 of 17.