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A 3-year clinical follow-up of adult patients with 3243A>G in mitochondrial DNA.

https://arctichealth.org/en/permalink/ahliterature82145
Source
Neurology. 2006 May 23;66(10):1470-5
Publication Type
Article
Date
May-23-2006
Author
Majamaa-Voltti K A M
Winqvist S.
Remes A M
Tolonen U.
Pyhtinen J.
Uimonen S.
Kärppä M.
Sorri M.
Peuhkurinen K.
Majamaa K.
Author Affiliation
Department of Internal Medicine, University of Oulu, Oulu, Finland. kirsi.majamaa-voltti@oulu.fi
Source
Neurology. 2006 May 23;66(10):1470-5
Date
May-23-2006
Language
English
Publication Type
Article
Keywords
Adult
Alleles
Blood Glucose - analysis
Cognition Disorders - genetics
DNA, Mitochondrial - genetics
Diabetes Mellitus - blood - genetics
Disease Progression
Electrocardiography, Ambulatory
Electroencephalography
Female
Finland - epidemiology
Follow-Up Studies
Hearing Loss, Sensorineural - genetics
Humans
Hypertrophy, Left Ventricular - genetics - ultrasonography
Lactates - blood
MELAS Syndrome - genetics - mortality
Male
Middle Aged
Mitochondria, Muscle - metabolism
Mosaicism
Neuropsychological Tests
Point Mutation
Pyruvates - blood
Abstract
OBJECTIVE: To follow the clinical course of patients with the mitochondrial DNA mutation 3243A>G for 3 years. METHODS: Thirty-three adult patients with the 3243A>G mutation entered a 3-year follow-up study. They were clinically evaluated annually, audiometry was performed, and samples were drawn for the analysis of blood chemistry and mutation heteroplasmy in leukocytes. Holter recording was performed three times during the follow-up and echocardiography, neuropsychological assessment, and quantitative EEG and brain imaging conducted at entry and after 3 years. RESULTS: The incidence of new neurologic events was low during the 3-year follow-up. Sensorineural hearing impairment (SNHI) progressed, left ventricular wall thickness increased, mean alpha frequency in the occipital and parietal regions decreased, and the severity of disease index (modified Rankin score) progressed significantly. The rate of SNHI progression correlated with mutation heteroplasmy in muscle. The increase in left ventricular wall thickness was seen almost exclusively in diabetic patients. Seven patients died during the follow-up, and they were generally more severely affected than those who survived. CONCLUSIONS: Significant changes in the severity of disease, sensorineural hearing impairment, left ventricular hypertrophy, and quantitative EEG were seen in adult patients with 3243A>G during the 3-year follow-up.
Notes
Comment In: Neurology. 2007 Jan 9;68(2):163-417210904
PubMed ID
16717204 View in PubMed
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17-year trends in incidence and prognosis of cardiogenic shock in patients with acute myocardial infarction in western Sweden.

https://arctichealth.org/en/permalink/ahliterature269417
Source
Int J Cardiol. 2015 Apr 15;185:256-62
Publication Type
Article
Date
Apr-15-2015
Author
B. Redfors
O. Angerås
T. Råmunddal
C. Dworeck
I. Haraldsson
D. Ioanes
P. Petursson
B. Libungan
J. Odenstedt
J. Stewart
E. Lodin
M. Wahlin
P. Albertsson
G. Matejka
E. Omerovic
Source
Int J Cardiol. 2015 Apr 15;185:256-62
Date
Apr-15-2015
Language
English
Publication Type
Article
Keywords
Aged
Electrocardiography
Female
Forecasting
Humans
Incidence
Male
Myocardial Infarction - complications - epidemiology
Retrospective Studies
Risk factors
Shock, Cardiogenic - epidemiology - etiology
Sweden - epidemiology
Abstract
Cardiogenic shock remains the leading cause of in hospital death in acute myocardial infarction (AMI) and is associated with a mortality rate of approximately 50%. Here we investigated the 17-year trends in incidence and prognosis of AMI-induced cardiogenic shock in Västra Götaland in western Sweden, an area with approximately 1.6 million inhabitants. The study period includes the transition from thrombolysis to primary percutaneous coronary intervention (PCI) as the region-wide therapy of choice for patients with ST-elevation myocardial infarction (STEMI).
Data on patients hospitalized in cardiac care units in Västra Götaland, Sweden between 1995 and 2013 were obtained from the Swedish Websystem for Enhancement of Evidence-based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART). We determined the incidence of cardiogenic shock among patients diagnosed with AMI and the risk of death associated with developing cardiogenic shock. We fitted logistic regression models to study which factors predicted post-AMI cardiogenic shock. Analyses were performed on complete case data as well as after multiple imputation of missing data.
Incidence of cardiogenic shock as a complication of AMI declined in western Sweden in the past decade, from 14% in 1995 to 4% in 2012. The risk of dying once cardiogenic shock had developed increased during the study period (p
PubMed ID
25814213 View in PubMed
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The 2000 Canadian recommendations for the management of hypertension: part two--diagnosis and assessment of people with high blood pressure.

https://arctichealth.org/en/permalink/ahliterature192030
Source
Can J Cardiol. 2001 Dec;17(12):1249-63
Publication Type
Conference/Meeting Material
Article
Date
Dec-2001
Author
K B Zarnke
M. Levine
F A McAlister
N R Campbell
M G Myers
D W McKay
P. Bolli
G. Honos
M. Lebel
K. Mann
T W Wilson
C. Abbott
S. Tobe
E. Burgess
S. Rabkin
Author Affiliation
Department of Medicine, London Health Sciences Centre, University of Western Ontario, 339 Windermere Road, London, Ontario N6A 5A5, Canada. Kelly.Zarnke@lhsc.on.ca
Source
Can J Cardiol. 2001 Dec;17(12):1249-63
Date
Dec-2001
Language
English
French
Publication Type
Conference/Meeting Material
Article
Keywords
Adrenal Gland Neoplasms - complications
Adult
Blood Pressure Determination - methods - psychology - standards
Blood Pressure Monitoring, Ambulatory - methods - standards
Canada
Cardiovascular Diseases - etiology - prevention & control
Clinical Laboratory Techniques - standards
Diabetes Complications
Diabetic Nephropathies - complications - diagnosis
Echocardiography - standards
Electrocardiography
Evidence-Based Medicine - methods
Humans
Hypertension - complications - diagnosis - etiology - psychology
Hypertension, Renovascular - diagnosis
Hypertrophy, Left Ventricular - complications - ultrasonography
Office Visits
Patient compliance
Pheochromocytoma - complications - diagnosis
Risk factors
Self Care - methods - standards
Abstract
To provide updated, evidence-based recommendations for the diagnosis and assessment of high blood pressure in adults.
For people with high blood pressure, the assignment of a diagnosis of hypertension depends on the appropriate measurement of blood pressure, the level of the blood pressure elevation, the duration of follow-up and the presence of concomitant vascular risk factors, target organ damage and established atherosclerotic diseases. For people diagnosed with hypertension, defining the overall risk of adverse cardiovascular outcomes requires laboratory testing, a search for target organ damage and an assessment of the modifiable causes of hypertension. Out-of-clinic blood pressure assessment and echocardiography are options for selected patients.
People at increased risk of adverse cardiovascular outcomes and were identified and quantified.
Medline searches were conducted from the period of the last revision of the Canadian recommendations for the management of hypertension (May 1998 to October 2000). Reference lists were scanned, experts were polled, and the personal files of the subgroup members and authors were used to identify other studies. All relevant articles were reviewed and appraised, using prespecified levels of evidence, by content experts and methodological experts.
A high value was placed on the identification of people at increased risk of cardiovascular morbidity and mortality.
The identification of people at higher risk of cardiovascular disease will permit counselling for lifestyle manoeuvres and the introduction of antihypertensive drugs to reduce blood pressure for patients with sustained hypertension. In certain settings, and for specific classes of drugs, blood pressure lowering has been associated with reduced cardiovascular morbidity and/or mortality.
The present document contains detailed recommendations pertaining to aspects of the diagnosis and assessment of patients with hypertension, including the accurate measurement of blood pressure, criteria for the diagnosis of hypertension and recommendations for follow-up, routine and optional laboratory testing, assessment for renovascular hypertension, home and ambulatory blood pressure monitoring, and the role of echocardiography in hypertension.
All recommendations were graded according to strength of the evidence and voted on by the Canadian Hypertension Recommendations Working Group. Only the recommendations achieving high levels of consensus are reported here. These guidelines will be updated annually.
These recommendations are endorsed by the Canadian Hypertension Society, The Canadian Coalition for High Blood Pressure Prevention and Control, The College of Family Physicians of Canada, The Heart and Stroke Foundation of Canada, The Adult Disease Division and Bureau of Cardio-Respiratory Diseases and Diabetes at the Centre for Chronic Disease Prevention and Control of Health Canada.
PubMed ID
11773936 View in PubMed
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The 2004 ACC/AHA Guidelines: a perspective and adaptation for Canada by the Canadian Cardiovascular Society Working Group.

https://arctichealth.org/en/permalink/ahliterature178142
Source
Can J Cardiol. 2004 Sep;20(11):1075-9
Publication Type
Article
Date
Sep-2004
Author
Paul W Armstrong
Peter Bogaty
Christopher E Buller
Paul Dorian
Blair J O'Neill
Author Affiliation
VIGOUR Centre, University of Alberta, Edmonton. paul.armstrong@ualberta.ca
Source
Can J Cardiol. 2004 Sep;20(11):1075-9
Date
Sep-2004
Language
English
Publication Type
Article
Keywords
Canada
Defibrillators, Implantable - standards
Electrocardiography
Emergency Medical Services - standards
Emergency Service, Hospital - standards
Female
Guideline Adherence
Humans
Male
Myocardial Infarction - diagnosis - therapy
Myocardial Reperfusion - standards
Severity of Illness Index
Survival Analysis
Treatment Outcome
Abstract
Major changes in acute ST elevation myocardial infarction (STEMI) management prompted a comprehensive rewriting of the American College of Cardiology/American Heart Association Guidelines. The Canadian Cardiovascular Society (CCS) participated in both the writing process and the external review. Subsequently, a Canadian Working Group (CWG), formed under the auspices of the CCS, developed a perspective and adaptation for Canada. Herein, accounting for specific realities of the Canadian cardiovascular health system, is a discussion of the implications for prehospital care and transport, optimal reperfusion therapy and an approach to decision making regarding reperfusion options and invasive therapy following fibrinolytic therapy. Major recent developments regarding indications for implantable cardioverter defibrillator(s) (ICDs) also prompted a review of indications for ICDs and the optimal timing of implantation given the potential for recovery of left ventricular function. At least a 40-day, preferably a 12-week, waiting period was judged to be optimal to evaluate left ventricular function post-STEMI. A recommended algorithm for the insertion of an ICD is provided. Implementation of the new STEMI guidelines has substantial implications for resources, organization and priorities of the Canadian health care system. While on the one hand, the necessary incremental funding to provide tertiary and quaternary care and to support revascularization and device implantation capability is desirable, it is equally or more important to develop enhanced prehospital care, including the capacity for early recognition, risk assessment, fibrinolytic therapy and/or triage to a tertiary care centre as part of an enlightened approach to improving cardiac care.
PubMed ID
15457302 View in PubMed
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The ability of an electrocardiogram to predict fatal and non-fatal cardiac events in asymptomatic middle-aged subjects.

https://arctichealth.org/en/permalink/ahliterature283977
Source
Ann Med. 2016 Nov;48(7):525-531
Publication Type
Article
Date
Nov-2016
Author
Henri K Terho
Jani T Tikkanen
Tuomas V Kenttä
M Juhani Junttila
Aapo L Aro
Olli Anttonen
Tuomas Kerola
Harri A Rissanen
Paul Knekt
Antti Reunanen
Heikki V Huikuri
Source
Ann Med. 2016 Nov;48(7):525-531
Date
Nov-2016
Language
English
Publication Type
Article
Keywords
Adult
Cardiovascular Diseases - mortality - physiopathology
Electrocardiography - methods
Female
Finland
Humans
Male
Middle Aged
Predictive value of tests
Prognosis
Registries
Risk factors
Abstract
The long-term prognostic value of a standard 12-lead electrocardiogram (ECG) for predicting cardiac events in apparently healthy middle-aged subjects is not well defined.
A total of 9511 middle-aged subjects (mean age 43?±?8.2 years, 52% males) without a known cardiac disease and with a follow-up 40 years were included in the study. Fatal and non-fatal cardiac events were collected from the national registries. The predictive value of ECG was separately analyzed for 10 and 30 years. Major ECG abnormalities were classified according to the Minnesota code.
Subjects with major ECG abnormalities (N?=?1131) had an increased risk of cardiac death after 10-years (adjusted hazard ratio [HR] 1.7; 95% confidence interval [95% CI], 1.1-2.5, p?=?0.009) and 30-years of follow-up (HR 1.3, 95% CI, 1.1-1.5, p?
PubMed ID
27684209 View in PubMed
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Ablation for atrial fibrillation during mitral valve surgery: 1-year results through continuous subcutaneous monitoring.

https://arctichealth.org/en/permalink/ahliterature125117
Source
Interact Cardiovasc Thorac Surg. 2012 Jul;15(1):37-41
Publication Type
Article
Date
Jul-2012
Author
Alexandr Bogachev-Prokophiev
Sergey Zheleznev
Alexander Romanov
Evgeny Pokushalov
Alexey Pivkin
Giorgio Corbucci
Alexander Karaskov
Author Affiliation
Department of Heart Valves Surgery, State Research Institute of Circulation Pathology, Novosibirsk, Russian Federation. b-pav@rambler.ru
Source
Interact Cardiovasc Thorac Surg. 2012 Jul;15(1):37-41
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Atrial Fibrillation - complications - diagnosis - mortality - surgery
Atrial Flutter - diagnosis - etiology - mortality
Catheter Ablation - adverse effects - mortality
Chi-Square Distribution
Disease-Free Survival
Electrocardiography, Ambulatory
Female
Heart Valve Diseases - complications - mortality - surgery
Heart Valve Prosthesis Implantation - adverse effects - mortality
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mitral Valve - surgery
Predictive value of tests
Prospective Studies
Recurrence
Risk assessment
Risk factors
Russia
Time Factors
Treatment Outcome
Abstract
Continuous monitoring of cardiac rhythm may play an important role in measuring the true symptomatic/asymptomatic atrial fibrillation (AF) burden and improve the management of anti-arrhythmic and anti-thrombotic therapies. Forty-seven patients with mitral valve disease and longstanding persistent AF (LSPAF) underwent a left atrial maze procedure with bipolar radiofrequency and valve surgery. The follow-up data recorded by an implanted loop recorder were analysed after 3, 6 and 12 months. On discharge, 40 (85.1%) patients were in stable sinus rhythm, as documented by in-office electrocardiography (ECG), 4 (8.5%) were in pacemaker rhythm and 3 (6.4%) were in AF. One (2.1%) patient died after 7 months. On 12-month follow-up examination, 30 (65.2%) patients had an AF burden 0.5%. Two (4.3%) patients with AF recurrences were completely asymptomatic. Among the symptomatic events stored by the patients, only 27.6% was confirmed as genuine AF recurrences according to the concomitant ECG recorded by the implanted loop recorder. A concomitant bipolar maze procedure during mitral valve surgery is effective in treating AF, as proved by detailed 1-year continuous monitoring.
Notes
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Cites: Asian Cardiovasc Thorac Ann. 2008 Aug;16(4):292-718670021
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Cites: Ann Thorac Surg. 2009 Jul;88(1):101-519559203
Cites: J Thorac Cardiovasc Surg. 2007 Apr;133(4):1037-4417382650
Cites: Circ Arrhythm Electrophysiol. 2010 Apr;3(2):141-720160169
Cites: Eur J Cardiothorac Surg. 2011 Aug;40(2):405-1121601472
Cites: J Am Coll Cardiol. 2000 Jan;35(1):183-710636278
Cites: Ann Thorac Surg. 2007 Mar;83(3):1225-3017307507
Cites: Ann Thorac Surg. 2007 Apr;83(4):1319-2417383333
Cites: Circulation. 2009 Sep 15;120(11 Suppl):S177-8419752365
PubMed ID
22514258 View in PubMed
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Source
Duodecim. 2000;116(18):2007-9
Publication Type
Article
Date
2000
Author
S. Mustajoki
Author Affiliation
Jorvin sairaala Turuntie 150, 02740 Espoo. sami.mustajoki@iki.fi
Source
Duodecim. 2000;116(18):2007-9
Date
2000
Language
Finnish
Publication Type
Article
Keywords
Aged
Antipsychotic Agents - therapeutic use
Diabetic Neuropathies - complications
Electrocardiography - instrumentation
Equipment Failure
Haloperidol - therapeutic use
Hiccup - drug therapy - etiology
Humans
Male
PubMed ID
12017615 View in PubMed
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Abnormal echocardiography in patients with type 2 diabetes and relation to symptoms and clinical characteristics.

https://arctichealth.org/en/permalink/ahliterature286353
Source
Diab Vasc Dis Res. 2016 Sep;13(5):321-30
Publication Type
Article
Date
Sep-2016
Author
Peter Godsk Jørgensen
Magnus T Jensen
Rasmus Mogelvang
Bernt Johan von Scholten
Jan Bech
Thomas Fritz-Hansen
Søren Galatius
Tor Biering-Sørensen
Henrik U Andersen
Tina Vilsbøll
Peter Rossing
Jan S Jensen
Source
Diab Vasc Dis Res. 2016 Sep;13(5):321-30
Date
Sep-2016
Language
English
Publication Type
Article
Keywords
Aged
Denmark - epidemiology
Diabetes Mellitus, Type 2 - diagnosis - epidemiology
Diastole
Echocardiography, Doppler
Electrocardiography
Female
Humans
Hypertrophy, Left Ventricular - diagnostic imaging - epidemiology - physiopathology
Male
Middle Aged
Outpatients
Predictive value of tests
Prevalence
Risk factors
Ventricular Dysfunction, Left - diagnostic imaging - epidemiology - physiopathology
Ventricular Function, Left
Abstract
We aimed to determine the prevalence of echocardiographic abnormalities and their relation to clinical characteristics and cardiac symptoms in a large, contemporary cohort of patients with type 2 diabetes.
A total of 1030 patients with type 2 diabetes participated. Echocardiographic abnormalities were present in 513 (49.8%) patients, mainly driven by a high prevalence of diastolic dysfunction 178 (19.4%), left ventricular hypertrophy 213 (21.0%) and left atrial enlargement, 200 (19.6%). The prevalence increased markedly with age from 31.1% in the youngest group (75?years) (p?
PubMed ID
27208801 View in PubMed
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1678 records – page 1 of 168.