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Adiponectin is related with carotid artery intima-media thickness and brachial flow-mediated dilatation in young adults--the Cardiovascular Risk in Young Finns Study.

https://arctichealth.org/en/permalink/ahliterature140840
Source
Ann Med. 2010 Dec;42(8):603-11
Publication Type
Article
Date
Dec-2010
Author
Liisa A Saarikoski
Risto K Huupponen
Jorma S A Viikari
Jukka Marniemi
Markus Juonala
Mika Kähönen
Olli T Raitakari
Author Affiliation
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Source
Ann Med. 2010 Dec;42(8):603-11
Date
Dec-2010
Language
English
Publication Type
Article
Keywords
Adiponectin - blood
Adult
Atherosclerosis - epidemiology - pathology - physiopathology
Biological Markers - blood
Brachial Artery - physiopathology - ultrasonography
Carotid Arteries - pathology - physiopathology - ultrasonography
Elasticity Imaging Techniques
Female
Finland - epidemiology
Follow-Up Studies
Humans
Male
Regional Blood Flow
Regression Analysis
Risk factors
Tunica Intima - pathology - ultrasonography
Young Adult
Abstract
Adiponectin may be involved in the pathogenesis of atherosclerosis. We investigated the relation of adiponectin on early functional and structural markers of subclinical atherosclerosis in a large population-based cohort of young men and women.
We measured serum adiponectin using radioimmunoassay in 2,147 young adults (ages 24-39 years) participating in the Cardiovascular Risk in Young Finns Study. The subjects had ultrasound data on carotid intima-media thickness (IMT), carotid artery elasticity (n = 2,139) and brachial flow-mediated dilatation (FMD) (n = 1,996). In univariate analysis, adiponectin was inversely associated with IMT (r = -0.16, P
PubMed ID
20839916 View in PubMed
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Alcohol consumption in patients with primary sclerosing cholangitis.

https://arctichealth.org/en/permalink/ahliterature122648
Source
World J Gastroenterol. 2012 Jun 28;18(24):3105-11
Publication Type
Article
Date
Jun-28-2012
Author
Hannes Hagström
Per Stål
Knut Stokkeland
Annika Bergquist
Author Affiliation
Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, 14186 Stockholm, Sweden. hannes.hagstrom@ki.se
Source
World J Gastroenterol. 2012 Jun 28;18(24):3105-11
Date
Jun-28-2012
Language
English
Publication Type
Article
Keywords
Adult
Aged
Alcohol drinking - epidemiology
Analysis of Variance
Binge Drinking - epidemiology
Chi-Square Distribution
Cholangitis, Sclerosing - diagnosis - epidemiology
Disease Progression
Elasticity Imaging Techniques
Female
Humans
Liver Cirrhosis, Alcoholic - diagnosis - epidemiology
Male
Middle Aged
Predictive value of tests
Questionnaires
Registries
Retrospective Studies
Risk assessment
Risk factors
Sweden - epidemiology
Time Factors
Young Adult
Abstract
To assess the alcohol drinking patterns in a cohort of primary sclerosing cholangitis (PSC) patients and the possible influence on the development of fibrosis.
Ninety-six patients with PSC were evaluated with a validated questionnaire about a patient's lifetime drinking habits: the lifetime drinking history (LDH) questionnaire. In addition, clinical status, transient elastography and biochemistry values were analysed and registered. Patients were defined as having either significant or non-significant fibrosis. Significant fibrosis was defined as either an elastography value of = 17.3 kPa or the presence of clinical signs of cirrhosis. Patients were divided into two groups depending on their alcohol consumption patterns; no/low alcohol consumption (one drink or unit/d) and moderate/high alcohol consumption (= 1 drink or unit/d). LDH data were calculated to estimate lifetime alcohol intake (LAI), current alcohol intake, drinks per year before and after diagnosis of PSC. We also calculated the number of episodes of binge-drinking (defined as consuming = 5 drinks per occasion) in total, before and after the diagnosis of PSC.
The mean LAI was 3882 units of alcohol, giving a mean intake after onset of alcohol consumption of 2.6 units per week. Only 9% of patients consumed alcohol equal to or more than one unit per day. Current alcohol intake in patients with significant fibrosis (n = 26) was less than in patients without significant fibrosis (n = 70), as shown by lower values of phosphatidylethanol (B-PEth) (0.1 ?mol/L vs 0.33 ?mol/L, respectively, P = 0.002) and carbohydrate-deficient transferrin (CDT) (0.88% vs 1.06%, respectively, P = 0.02). Self-reported LAI was similar between the two groups. Patients with significant fibrosis reduced their alcohol intake after diagnosis from 103 to 88 units per year whereas patients without fibrosis increased their alcohol intake after PSC diagnosis from 111 to 151 units/year. There were no correlations between elastography values and intake of alcohol (units/year) (r = -0.036).
PSC patients have low alcohol consumption. The lack of correlation between fibrosis and alcohol intake indicates that a low alcohol intake is safe in these patients.
Notes
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PubMed ID
22791946 View in PubMed
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Cardiovascular risk factors and systolic and diastolic cardiac function: a tissue Doppler and speckle tracking echocardiographic study.

https://arctichealth.org/en/permalink/ahliterature137790
Source
J Am Soc Echocardiogr. 2011 Mar;24(3):322-32.e6
Publication Type
Article
Date
Mar-2011
Author
Havard Dalen
Anders Thorstensen
Pal R Romundstad
Svein A Aase
Asbjorn Stoylen
Lars J Vatten
Author Affiliation
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. havard.dalen@ntnu.no
Source
J Am Soc Echocardiogr. 2011 Mar;24(3):322-32.e6
Date
Mar-2011
Language
English
Publication Type
Article
Keywords
Adult
Aged
Aged, 80 and over
Blood Glucose - analysis
Body mass index
Elasticity Imaging Techniques - statistics & numerical data
Female
Humans
Kidney Function Tests - statistics & numerical data
Lipids - blood
Male
Middle Aged
Norway - epidemiology
Prevalence
Risk assessment
Risk factors
Stroke Volume
Ventricular Dysfunction - blood - diagnosis - epidemiology
Young Adult
Abstract
The aim of this study was to determine whether blood pressure, body mass index (BMI), serum lipids, glucose, and renal function are associated with left ventricular (LV) and right ventricular function in a low-risk population.
The associations of common risk factors with cardiac function were assessed, using multiple linear regression, in a random sample of 1,266 individuals free from hypertension, diabetes, and cardiovascular disease. A combination of conventional echocardiographic, speckle-tracking, and tissue Doppler methods was used to assess cardiac function.
Older age and higher BMI, systolic and diastolic blood pressure, and non-high-density lipoprotein (HDL) cholesterol were associated with lower LV function. Thus, LV strain was reduced by approximately 5% per 5 kg/m(2) increase in BMI and by 4% per 10 mm Hg increase in diastolic blood pressure. Corresponding reductions in peak early diastolic mitral annular velocity were 7% for both BMI and diastolic blood pressure. Higher HDL cholesterol was associated with better LV function. In women, smoking was also associated with reduced LV function. LV function was lower also at low levels of diastolic pressure and BMI. Reduced right ventricular function was related to older age, smoking, higher diastolic blood pressure and non-HDL cholesterol, and lower HDL cholesterol.
These findings suggest that conventional risk factors may predict cardiac function many years before clinical disease. The J-shaped associations related to diastolic blood pressure and BMI may suggest that in some individuals, low levels of these factors may indicate underlying but unknown disease.
PubMed ID
21247733 View in PubMed
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Combination of real-time elastography and urine prostate cancer gene 3 (PCA3) detects more than 97% of significant prostate cancers.

https://arctichealth.org/en/permalink/ahliterature120140
Source
Scand J Urol. 2013 Jun;47(3):211-6
Publication Type
Article
Date
Jun-2013
Author
Yngve Nygård
Svein A Haukaas
Jo E R Waage
Ole J Halvorsen
Karsten Gravdal
Jannicke Frugård
Lars A Akslen
Christian Beisland
Author Affiliation
Department of Urology, Haukeland University Hospital, Norway.
Source
Scand J Urol. 2013 Jun;47(3):211-6
Date
Jun-2013
Language
English
Publication Type
Article
Keywords
Aged
Antigens, Neoplasm - urine
Elasticity - physiology
Elasticity Imaging Techniques - methods
False Positive Reactions
Humans
Male
Middle Aged
Norway
Prostate - pathology - physiopathology
Prostatic Neoplasms - diagnosis - physiopathology - urine
Sensitivity and specificity
Tumor Markers, Biological - urine
Abstract
The prostate cancer gene 3 (PCA3) score in urine is a promising biomarker for prostate cancer. Real-time elastography (RTE) is a well-documented ultrasound modality. The objective of this study was to evaluate the ability to detect significant cancer foci in the prostate with these methods alone and in combination.
From September 2009 to September 2010, 40 patients planned for radical prostatectomy underwent a PCA3 urine test and RTE before operation. A Hitachi EUB-8500 with prostate end-fire transrectal probe was used. The PCA3 score was evaluated with a standard cut-off value of 35. RTE was evaluated in correlation with whole-mount section pathology. Three patients fulfilled the criteria for insignificant prostate cancer and were excluded from the study.
The PCA3 score was increased in 26 patients (70%). RTE identified at least one tumour in 33 out of 37 patients (89%). RTE detected the largest tumour in 27 out of 37 patients (73%). More than one cancer was present in 29 patients and RTE identified more than one tumour in 13 of these. The RTE was false positive in four patients. The PCA3 score was increased in three out of four false-negative RTE patients. By combining both methods, 36 out of 37 patients (97%) with significant prostate cancer were detected.
The combination of PCA3 score and RTE detected 97% of significant prostate cancers. The combinative use of RTE and PCA3 will be further investigated in an unselected series of men with suspected prostate cancer.
PubMed ID
23035756 View in PubMed
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Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography.

https://arctichealth.org/en/permalink/ahliterature125972
Source
Liver Int. 2012 Jul;32(6):902-10
Publication Type
Article
Date
Jul-2012
Author
Robert P Myers
Aaron Pollett
Richard Kirsch
Gilles Pomier-Layrargues
Melanie Beaton
Mark Levstik
Andres Duarte-Rojo
David Wong
Pam Crotty
Magdy Elkashab
Author Affiliation
Liver Unit, Division of Gastroenterology and Hepatology, Department of Medicine, University of Calgary, Calgary, Alberta, Canada. rpmyers@ucalgary.ca
Source
Liver Int. 2012 Jul;32(6):902-10
Date
Jul-2012
Language
English
Publication Type
Article
Keywords
Adult
Biopsy
Body mass index
Chi-Square Distribution
Chronic Disease
Elasticity Imaging Techniques
Fatty Liver - diagnosis - pathology - ultrasonography
Female
Humans
Liver - pathology - ultrasonography
Liver Cirrhosis - diagnosis - pathology - ultrasonography
Male
Middle Aged
Multivariate Analysis
Ontario
Predictive value of tests
Prospective Studies
ROC Curve
Reproducibility of Results
Sensitivity and specificity
Severity of Illness Index
Abstract
Accurate tools for the noninvasive detection of hepatic steatosis are needed. The Controlled Attenuation Parameter (CAP) specifically targets liver steatosis using a process based on transient elastography.
Patients with chronic liver disease and body mass index (BMI) =28 kg/m(2) underwent biopsy and liver stiffness measurement (LSM) with simultaneous CAP determination using the FibroScan(®) M probe. The performance of the CAP for diagnosing steatosis compared with biopsy was assessed using areas under receiver operating characteristic curves (AUROC).
A total of 153 patients were included: 69% were male, median BMI was 32 kg/m(2); 47% had nonalcoholic fatty liver disease (NAFLD); and 65% had significant (=10%) steatosis. The CAP was significantly correlated with the percentage of steatosis (? = 0.47) and steatosis grade (? = 0.51; both P 33% and >66% steatosis were 0.79, 0.76 and 0.70, respectively.
The CAP is a promising tool for the noninvasive detection of hepatic steatosis. Advantages of CAP include its ease of measurement, operator-independence and simultaneous availability with LSM for fibrosis assessment.
Notes
Comment In: Liver Int. 2012 Jul;32(6):875-722672640
PubMed ID
22435761 View in PubMed
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Doppler tissue imaging is an independent predictor of outcome in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention.

https://arctichealth.org/en/permalink/ahliterature258008
Source
J Am Soc Echocardiogr. 2014 Mar;27(3):258-67
Publication Type
Article
Date
Mar-2014
Author
Tor Biering-Sørensen
Jan Skov Jensen
Sune Pedersen
Søren Galatius
Soren Hoffmann
Magnus Thorsten Jensen
Rasmus Mogelvang
Author Affiliation
Department of Cardiology, Gentofte University Hospital, Copenhagen, Denmark; Institute of Clinical Medicine Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: tor.biering@gmail.com.
Source
J Am Soc Echocardiogr. 2014 Mar;27(3):258-67
Date
Mar-2014
Language
English
Publication Type
Article
Keywords
Aged
Coronary Artery Disease - mortality - surgery - ultrasonography
Denmark - epidemiology
Echocardiography - statistics & numerical data
Elasticity Imaging Techniques - statistics & numerical data
Female
Humans
Male
Middle Aged
Myocardial Infarction - mortality - surgery - ultrasonography
Percutaneous Coronary Intervention - mortality
Prevalence
Prognosis
Reproducibility of Results
Risk assessment
Sensitivity and specificity
Survival Rate
Treatment Outcome
Ventricular Dysfunction, Left - mortality - surgery - ultrasonography
Abstract
Doppler tissue imaging (DTI) detects early signs of left ventricular (LV) dysfunction; however, the prognostic significance of DTI after ST-segment elevation myocardial infarction (STEMI) is unknown. The aim of this study was to evaluate the prognostic value of DTI after STEMI in patients treated with primary percutaneous coronary intervention.
In total, 391 patients who were admitted with STEMIs and treated with primary percutaneous coronary intervention were prospectively included. All participants were examined by echocardiography 2 days (interquartile range, 1-3 days) after STEMI. Longitudinal systolic (s'), early diastolic (e'), and late diastolic (a') myocardial velocities were measured using color DTI at six mitral annular sites and averaged to provide global estimates.
The median follow-up period was 25 months (interquartile range, 19-32 months). The primary end point was a composite of death, heart failure, or a new myocardial infarction. Patients with low global systolic function (s') or low global diastolic function (e') had >2 times greater risk for the combined end point compared with patients with high global s' (hazard ratio, 2.60; 95% confidence interval, 1.64-4.13; P
PubMed ID
24325959 View in PubMed
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Global left ventricular longitudinal systolic strain for early risk assessment in patients with acute myocardial infarction treated with primary percutaneous intervention.

https://arctichealth.org/en/permalink/ahliterature126261
Source
J Am Soc Echocardiogr. 2012 Jun;25(6):644-51
Publication Type
Article
Date
Jun-2012
Author
Kim Munk
Niels H Andersen
Christian J Terkelsen
Bo M Bibby
Søren P Johnsen
Hans E Bøtker
Torsten T Nielsen
Steen H Poulsen
Author Affiliation
Department of Cardiology, Aarhus University Hospital Skejby, Aarhus, Denmark. kim.munk@ki.au.dk
Source
J Am Soc Echocardiogr. 2012 Jun;25(6):644-51
Date
Jun-2012
Language
English
Publication Type
Article
Keywords
Aged
Angioplasty, Balloon, Coronary - statistics & numerical data
Comorbidity
Denmark
Elastic Modulus
Elasticity Imaging Techniques - statistics & numerical data
Female
Humans
Male
Middle Aged
Myocardial Infarction - physiopathology - surgery - ultrasonography
Prevalence
Risk Assessment - methods
Risk factors
Stroke Volume
Ventricular Dysfunction, Left - physiopathology - surgery - ultrasonography
Abstract
Left ventricular systolic function is a key determinant of outcome after ST-segment elevation myocardial infarction (STEMI). The aim of this study was to study speckle-tracking global longitudinal strain (GLS) for early risk evaluation in STEMI and compare it with left ventricular ejection fraction (LVEF), wall motion score index (WMSI), and end-systolic volume index (ESVI).
Five-hundred seventy-six patients underwent echocardiography =24 hours after primary percutaneous coronary intervention for STEMI. The end point was the composite of death, hospitalization with reinfarction, congestive heart failure, or stroke. Associations with outcome were assessed by multivariate Cox regression with adjustment for clinical parameters. Hazard ratios (HRs) for events within the first year are reported per absolute percentage GLS increase.
During a median follow-up period of 24 months, 162 patients experienced at least one event. GLS was associated with the composite end point (adjusted HR, 1.20; 95% confidence interval [CI], 1.12-1.29) and also when controlling for LVEF (adjusted HR, 1.17; 95% CI, 1.07-1.29) and ESVI (adjusted HR, 1.18; 95% CI, 1.08-1.28). Although WMSI was significantly associated with outcome beyond any association accounted for by GLS, a borderline significant association was found after controlling for WMSI (adjusted HR for GLS, 1.10; 95% CI, 1.00-1.21). When GLS or WMSI was known, there was no significant association between LVEF or ESVI and outcome.
In a large population of patients with STEMI, GLS and WMSI were comparable and both superior for early risk assessment compared with volume-based left ventricular function indicators such as LVEF and ESVI. Compared with WMSI, the advantage of GLS is the provision of a semiautomated quantitative measure.
PubMed ID
22406163 View in PubMed
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Lower liver stiffness in patients with sustained virological response 4 years after treatment for chronic hepatitis C.

https://arctichealth.org/en/permalink/ahliterature139287
Source
Eur J Gastroenterol Hepatol. 2011 Jan;23(1):41-4
Publication Type
Article
Date
Jan-2011
Author
Ellen Sloth Andersen
Belinda Klemmensen Moessner
Peer Brehm Christensen
Mette Kjær
Henrik Krarup
Søren Lillevang
Nina Weis
Author Affiliation
Departments of Infectious Diseases, Hvidovre, Copenhagen University Hospital, Rigshospitalet, Denmark. ellensloth@dadlnet.dk
Source
Eur J Gastroenterol Hepatol. 2011 Jan;23(1):41-4
Date
Jan-2011
Language
English
Publication Type
Article
Keywords
Alanine Transaminase - blood
Antiviral agents - therapeutic use
Cohort Studies
Denmark
Elasticity Imaging Techniques
Female
Hepacivirus - drug effects - isolation & purification
Hepatitis C, Chronic - drug therapy - pathology - ultrasonography
Humans
Hyaluronic Acid - blood
Interferon-alpha - therapeutic use
Liver - pathology - ultrasonography
Liver Cirrhosis - pathology - ultrasonography
Male
Middle Aged
Platelet Count
Polyethylene Glycols - therapeutic use
Recombinant Proteins
Ribavirin - therapeutic use
Treatment Outcome
Abstract
Transient elastography (TE) is a noninvasive and well validated method for measurement of liver stiffness. The aim of this study was to use TE to evaluate whether patients with sustained virological response (SVR) have lower liver stiffness than patients with non-SVR after treatment for chronic hepatitis C (CHC).
Patients with CHC, who had undergone liver biopsy before treatment with pegylated interferon and ribavirin, were included from four clinical centres in Denmark. All patients were examined with TE and had a blood test taken for hepatitis C virus-virus detection and analysis of alanine aminotransferase, platelet counts and hyaluronic acid.
For 110 (92%) of the 120 patients included, it was possible to obtain a successful measurement of liver stiffness. Of these, 71 (64.5%) had achieved SVR. Median follow-up time was 47 months. Patients with pretreatment minimal fibrosis (F0/F1) in their liver biopsy had median liver stiffness of 5.3 kPa for SVR versus 6.1 kPa for non-SVR (P=0.56). Patients with pretreatment moderate fibrosis (F2/F3) had median liver stiffness of 5.4 kPa for SVR versus 9.4 kPa for non-SVR (P
PubMed ID
21079513 View in PubMed
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Mitral annular displacement by Doppler tissue imaging may identify coronary occlusion and predict mortality in patients with non-ST-elevation myocardial infarction.

https://arctichealth.org/en/permalink/ahliterature112850
Source
J Am Soc Echocardiogr. 2013 Aug;26(8):875-84
Publication Type
Article
Date
Aug-2013
Author
Wasim Zahid
Jonas Johnson
Carl Westholm
Christian H Eek
Kristina H Haugaa
Marit Kristine Smedsrud
Helge Skulstad
Erik Fosse
Reidar Winter
Thor Edvardsen
Author Affiliation
Department of Cardiology and Center for Cardiological Innovation, Oslo University Hospital, Oslo, Norway.
Source
J Am Soc Echocardiogr. 2013 Aug;26(8):875-84
Date
Aug-2013
Language
English
Publication Type
Article
Keywords
Comorbidity
Coronary Stenosis - mortality - ultrasonography
Elasticity Imaging Techniques - statistics & numerical data
Female
Humans
Incidence
Male
Middle Aged
Mitral Valve - ultrasonography
Myocardial Infarction - mortality - ultrasonography
Norway - epidemiology
Reproducibility of Results
Risk assessment
Sensitivity and specificity
Survival Analysis
Sweden - epidemiology
Abstract
Mitral annular displacement (MAD) is a simple marker of left ventricular (LV) systolic function. The aim of this study was to test the hypothesis that MAD can distinguish patients with non-ST-segment elevation myocardial infarctions (NSTEMIs) from those with significant coronary artery disease without infarctions, identify coronary occlusion, and predict mortality in patients with NSTEMIs. MAD was compared with established indices of LV function.
In this retrospective study, 167 patients with confirmed NSTEMIs were included at two Scandinavian centers. Forty patients with significant coronary artery disease but without myocardial infarctions were included as controls. Doppler tissue imaging was performed at the mitral level of the left ventricle in the three apical planes, and velocities were integrated over time to acquire MAD. LV ejection fraction, global longitudinal strain (GLS), and wall motion score index were assessed according to guidelines.
MAD and GLS could accurately distinguish patients with NSTEMIs from controls. During 48.6 ± 12.1 months of follow-up, 22 of 167 died (13%). MAD, LV ejection fraction, and GLS were reduced and wall motion score index was increased among those who died compared with those who survived (P
PubMed ID
23791116 View in PubMed
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21 records – page 1 of 3.