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133 records – page 1 of 14.

11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study).

https://arctichealth.org/en/permalink/ahliterature149701
Source
Lancet. 2009 Aug 22;374(9690):620-7
Publication Type
Article
Date
Aug-22-2009
Author
Jari Tiihonen
Jouko Lönnqvist
Kristian Wahlbeck
Timo Klaukka
Leo Niskanen
Antti Tanskanen
Jari Haukka
Author Affiliation
Department of Forensic Psychiatry, University of Kuopio and Niuvanniemi Hospital, Department of Clinical Physiology, Kuopio University Hospital, Kuopio, Finland. jari.tiihonen@niuva.fi
Source
Lancet. 2009 Aug 22;374(9690):620-7
Date
Aug-22-2009
Language
English
Publication Type
Article
Keywords
Adult
Age Distribution
Aged
Antipsychotic Agents - adverse effects
Case-Control Studies
Cause of Death
Clozapine - adverse effects
Dibenzothiazepines - adverse effects
Drug Utilization - trends
Female
Finland - epidemiology
Follow-Up Studies
Health Status Disparities
Humans
Life expectancy
Male
Middle Aged
Patient Readmission - statistics & numerical data
Perphenazine - adverse effects
Proportional Hazards Models
Registries
Risk factors
Schizophrenia - drug therapy - mortality
Sex Distribution
Time Factors
Abstract
The introduction of second-generation antipsychotic drugs during the 1990s is widely believed to have adversely affected mortality of patients with schizophrenia. Our aim was to establish the long-term contribution of antipsychotic drugs to mortality in such patients.
Nationwide registers in Finland were used to compare the cause-specific mortality in 66 881 patients versus the total population (5.2 million) between 1996, and 2006, and to link these data with the use of antipsychotic drugs. We measured the all-cause mortality of patients with schizophrenia in outpatient care during current and cumulative exposure to any antipsychotic drug versus no use of these drugs, and exposure to the six most frequently used antipsychotic drugs compared with perphenazine use.
Although the proportional use of second-generation antipsychotic drugs rose from 13% to 64% during follow-up, the gap in life expectancy between patients with schizophrenia and the general population did not widen between 1996 (25 years), and 2006 (22.5 years). Compared with current use of perphenazine, the highest risk for overall mortality was recorded for quetiapine (adjusted hazard ratio [HR] 1.41, 95% CI 1.09-1.82), and the lowest risk for clozapine (0.74, 0.60-0.91; p=0.0045 for the difference between clozapine vs perphenazine, and p
Notes
Comment In: Lancet. 2009 Nov 7;374(9701):1591; author reply 1592-319897117
Comment In: Lancet. 2009 Nov 7;374(9701):1591; author reply 1592-319897118
Comment In: Lancet. 2009 Aug 22;374(9690):590-219595448
Comment In: Lancet. 2009 Nov 7;374(9701):1592; author reply 1592-319897121
Comment In: Lancet. 2009 Nov 7;374(9701):1592; author reply 1592-319897120
PubMed ID
19595447 View in PubMed
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Acetazolamide-associated aplastic anaemia.

https://arctichealth.org/en/permalink/ahliterature227880
Source
J Intern Med. 1990 Dec;228(6):627-32
Publication Type
Article
Date
Dec-1990
Author
M. Keisu
B E Wiholm
A. Ost
O. Mortimer
Author Affiliation
Department of Drugs, National Board of Health and Welfare, Uppsala, Sweden.
Source
J Intern Med. 1990 Dec;228(6):627-32
Date
Dec-1990
Language
English
Publication Type
Article
Keywords
Acetazolamide - adverse effects - therapeutic use
Aged
Anemia, Aplastic - chemically induced - epidemiology
Drug Utilization - trends
Female
Glaucoma - drug therapy
Humans
Incidence
Male
Risk
Sweden - epidemiology
Time Factors
Abstract
Eleven cases of acetazolamide-associated aplastic anaemia were reported in Sweden during a 17-year period. There were six women and five men with a median age of 71 years (range 63-85 years). The median dose of acetazolamide was 500 mg, and the median duration of treatment was 3 months (range 2-71 months). Ten of the eleven patients died, all within 8 weeks after detection of their aplastic anaemia. The relative risk of developing aplastic anaemia when taking acetazolamide was 13.3 (95% confidence limits (CL); 6.8-25.3). The estimated incidence of reported acetazolamide-associated aplastic anaemia is approximately one in 18,000 patient years. The results strongly indicate that acetazolamide treatment is associated with a substantial increase in the risk of developing aplastic anaemia.
PubMed ID
2280240 View in PubMed
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[Adverse reactions during therapy with non-steroidal anti-inflammatory preparations in Denmark over a 15-year period].

https://arctichealth.org/en/permalink/ahliterature237378
Source
Ugeskr Laeger. 1986 Feb 17;148(8):462-8
Publication Type
Article
Date
Feb-17-1986

Aging and heavy drug use: a prescription survey in Manitoba.

https://arctichealth.org/en/permalink/ahliterature242344
Source
J Chronic Dis. 1983;36(1):75-84
Publication Type
Article
Date
1983
Author
F Y Aoki
V K Hildahl
G W Large
P A Mitenko
D S Sitar
Source
J Chronic Dis. 1983;36(1):75-84
Date
1983
Language
English
Publication Type
Article
Keywords
Aged
Costs and Cost Analysis
Drug Prescriptions
Drug Therapy
Drug Utilization - trends
Drug-Related Side Effects and Adverse Reactions
Fees, Pharmaceutical - trends
Female
Humans
Male
Manitoba
Middle Aged
Pharmaceutical Preparations - administration & dosage
Risk
Abstract
A random sample of claimants under Manitoba's Pharmacare plan provided information on the drugs prescribed for those individuals who spent more than $50 for drugs in 1978. More women than men were represented among the 412 claimants aged 50 to 64 (58% females), and more drugs were prescribed for women than men (8.38 +/- 3.4 vs. 7.17 +/- .33, mean +/- S.E.M., p less than 0.02). For the 403 claimants aged 65 and older, the sex distribution matched that of the general population (55%), and the difference in number of drugs prescribed was not statistically significant (8.49 +/- .36 vs 7.98 +/- .35). For the claimants aged 65 and older, the five most heavily prescribed drug categories were thiazide-type diuretics (prescribed for 51.6% of older claimants in 1978), benzodiazepines (40.0%), salicylates (26.8%), digoxin (22.6%) and codeine (20.8%). There were few differences in prescription frequencies between younger and older claimants, and these data indicate that drugs prescribed for heavy drug users do not change markedly as a function of age.
PubMed ID
6848551 View in PubMed
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[Alarming increase in the number of abortions. Does fear of thrombosis limit the use of oral contraceptives?]

https://arctichealth.org/en/permalink/ahliterature64267
Source
Lakartidningen. 1997 Dec 10;94(50):4731-2, 4735-6
Publication Type
Article
Date
Dec-10-1997
Author
I. Milsom
V. Odlind
C. Hedberg
O. Lidegaard
Author Affiliation
Kvinnokliniken, Sahlgrenska Universitetssjukhuset, Göteborg.
Source
Lakartidningen. 1997 Dec 10;94(50):4731-2, 4735-6
Date
Dec-10-1997
Language
Swedish
Publication Type
Article
Keywords
Abortion, Induced - statistics & numerical data - trends
Adolescent
Adult
Contraceptives, Oral - administration & dosage - adverse effects
Drug Utilization - trends
Europe
Female
Humans
Pregnancy
Risk factors
Sweden
Thrombosis - chemically induced - prevention & control
Abstract
According to official Swedish epidemiological figures, during 1996 the number of abortions increased for the first time in the 1990s, breaking a declining trend, especially among women under 24 years of age. In several European countries a similar increase was reported. The number of induced abortions declined by 16.1% during 1990-95, whereas it increased by 2.3% in 1996 compared to the previous year. The corresponding increase was 4.1% for teenagers and 2.5% for women in the 20-24 age group. In Norway, a 7.2% increase was reported in the first half of 1996 compared to the first half of 1995, although there, too, there had been a declining trend during the 1990s. Preliminary figures from Denmark indicate an increase of abortions to 18,022 for 1996 vs. 17,720 for 1995. Similarly, in Great Britain, in the first half of 1996, the figure increased by 10% compared with the same period in 1995. More than 90% of women in Sweden use or have used oral contraceptives (OCs); about 50% of women up to age 24 use them, and for women up to age 29 OCs also continue to be the most frequently used contraceptive. In October 1995, the World Health Organization published an extensive epidemiological study, which showed that low-dose OCs containing third-generation gestagens pose double the risk of deep venous thrombosis compared to low-dose OCs containing second-generation gestagens. Immediately after this alarming report the trend of declining abortions stopped and the users of OCs dropped from 440,000 before the report to 370,000 in 1996 in Sweden.
PubMed ID
9445952 View in PubMed
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Antibiotic consumption in Sweden 1975 to 1987: changes in prescription patterns.

https://arctichealth.org/en/permalink/ahliterature231555
Source
Scand J Infect Dis Suppl. 1989;60:9-15
Publication Type
Article
Date
1989
Author
S R Norrby
H. Johansson
Author Affiliation
Department of Infectious Diseases, University of Lund, Sweden.
Source
Scand J Infect Dis Suppl. 1989;60:9-15
Date
1989
Language
English
Publication Type
Article
Keywords
Anti-Bacterial Agents - administration & dosage
Drug Prescriptions
Drug Utilization - trends
Humans
Sweden
Abstract
The antibiotic consumption in Sweden was evaluated during the period 1975 to 1987. Consumption was measured in terms of defined daily doses (DDDs), that is, the normally prescribed daily adult doses. During the study period the total consumption varied between 49 and 51 million DDD, indicating a considerable over-use of antibiotics in Sweden. In the various groups of antibiotics, considerable fluctuations were seen. The cephalosporin use increased from 477000 DDDs 1975 to 1795000 DDDs in 1987, which can be explained by an increased use of cefaclor for treatment of respiratory tract infections and by the fact that cefuroxime is the dominant injectable antibiotic in Sweden. Markedly increased usage during the study period was also seen for erythromycin and penicillinase resistant penicillins. There were no obvious medical reasons for those increases. Among the folate inhibitors, sulphonamide usage has been almost completely abandoned during the period and the sulphonamides have been replaced by pivmecillinam, trimethoprim and, lately, norfloxacin for the treatment of urinary tract infections. Reduced usage was also seen for sulphonamide/trimethoprim combinations, probably due to an increased awareness of the risk for side effects to these antibiotics. During the entire period the use of tetracyclines, and especially doxycycline, was extensive--almost 10 million DDDs in 1987. The reason for that remains unclear but there are reasons to assume that these antibiotics are prescribed too frequently.
PubMed ID
2756355 View in PubMed
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Antibiotics prescription in primary care: a 5-year follow-up of an educational programme.

https://arctichealth.org/en/permalink/ahliterature217447
Source
Fam Pract. 1994 Sep;11(3):282-6
Publication Type
Article
Date
Sep-1994
Author
S. Mölstad
A. Ekedahl
B. Hovelius
H. Thimansson
Author Affiliation
Community Health Centre, Höör, Sweden.
Source
Fam Pract. 1994 Sep;11(3):282-6
Date
Sep-1994
Language
English
Publication Type
Article
Keywords
Anti-Bacterial Agents - contraindications - therapeutic use
Curriculum
Drug Prescriptions - statistics & numerical data
Drug Utilization - trends
Education, Medical, Continuing
Family Practice - education
Follow-Up Studies
Humans
Registries - statistics & numerical data
Respiratory Tract Infections - drug therapy - etiology
Rural Health
Sweden
Abstract
An educational programme on the use of antibiotics for respiratory tract infections (RTIs) in primary care, initiated among district physicians at the Community Health Centre of Höör, Sweden in 1985, resulted in an overall reduction in prescriptions for antibiotics, particularly broad-spectrum antibiotics. The aim of the present study was to evaluate the long-term effects of the programme on antibiotic prescription patterns at the centre. Since 1985, computerized records have been kept of every consultation at the centre, including details of the attending physician, the patient, diagnosis and type of antibiotic prescribed. Moreover, during a 3-month period in 1991, each pharmacy in the region recorded details of all prescriptions for antibiotics dispensed. Estimated immediately after the programme, the proportion of RTI patients prescribed antibiotics had fallen to 44%, a figure virtually unchanged 5 years later. During the subsequent five-year period, antibiotics dispensed at the pharmacy in Höör were further reduced from 14.1 to 13.2 defined daily doses 1000 inhabitants-1 day-1. As compared with district physicians at other community health centres in the region, those at Höör prescribed more penicillin V (80% of all antibiotic prescriptions) and less broad-spectrum antibiotics. The educational programme, combined with an active interest among district physicians at Höör in current research into antibiotic usage, has thus wrought enduring changes in the pattern of antibiotic prescription. A probable contributory factor was the district physicians' awareness that the computerized registration of diagnosis and treatment enables prescription patterns to be audited at an individual level.
PubMed ID
7843518 View in PubMed
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Are the monamine oxidase inhibitors facing extinction?

https://arctichealth.org/en/permalink/ahliterature226551
Source
Can J Psychiatry. 1991 Apr;36(3):186-9
Publication Type
Article
Date
Apr-1991
Author
R L O'Reilly
Author Affiliation
St. Thomas Psychiatric Hospital, Ontario.
Source
Can J Psychiatry. 1991 Apr;36(3):186-9
Date
Apr-1991
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Antidepressive Agents - therapeutic use
Antidepressive Agents, Tricyclic - therapeutic use
Child
Depressive Disorder - drug therapy - psychology
Drug Prescriptions - statistics & numerical data
Drug Utilization - trends
Humans
Longitudinal Studies
Middle Aged
Monoamine Oxidase Inhibitors - therapeutic use
Saskatchewan
Abstract
The use of monoamine oxidase inhibitors (MAOIs) in the province of Saskatchewan was compared for two years, 1978 and 1986, using the Saskatchewan Prescription Drug Plan data base. The percentage of the adult population receiving an MAOI decreased from 0.17% in 1978 to 0.07% in 1986. The use of both tricyclic antidepressants and the new generation antidepressants increased during the same period. Physicians appear to have selectively avoided using MAOIs for the elderly. Physicians who are not psychiatrists showed the greatest reduction in their use of the MAOIs. The data indicate an increasing reluctance to prescribe the MAOIs despite the recent resurgence of interest in these agents and the positive literature concerning their safety and efficacy.
PubMed ID
2059937 View in PubMed
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Are too many children being treated with methylphenidate?

https://arctichealth.org/en/permalink/ahliterature222995
Source
Can J Psychiatry. 1992 Oct;37(8):570-2
Publication Type
Article
Date
Oct-1992
Author
J M Ruel
C P Hickey
Author Affiliation
Bureau of Dangerous Drugs, Health and Welfare Canada, Ottawa, Ontario.
Source
Can J Psychiatry. 1992 Oct;37(8):570-2
Date
Oct-1992
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity - diagnosis - drug therapy - epidemiology - psychology
British Columbia - epidemiology
Child
Cross-Sectional Studies
Depressive Disorder - drug therapy - epidemiology - psychology
Drug Utilization - trends
Female
Humans
Incidence
Male
Methylphenidate - adverse effects - therapeutic use
Narcolepsy - diagnosis - drug therapy - epidemiology - psychology
Abstract
A survey was conducted of the use of methylphenidate in British Columbia during a six month period to determine if a disproportionate number of children are being treated with methylphenidate for hyperactivity. The data obtained do not indicate a problem regarding the diagnosis of attention deficit hyperactivity disorder in children. However, the data pertaining to adults indicate that the reasons stated for prescribing methylphenidate are controversial in a significant number of cases.
PubMed ID
1423160 View in PubMed
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Association between fluoroquinolone usage and a dramatic rise in ciprofloxacin-resistant Streptococcus pneumoniae in Canada, 1997-2006.

https://arctichealth.org/en/permalink/ahliterature151713
Source
Int J Antimicrob Agents. 2009 Jul;34(1):82-5
Publication Type
Article
Date
Jul-2009
Author
Heather J Adam
Daryl J Hoban
Alfred S Gin
George G Zhanel
Author Affiliation
Department of Medical Microbiology and Infectious Diseases, Faculty of Medicine, University of Manitoba, 730 William Ave., Winnipeg, Manitoba R3E0W3, Canada. hjadam@gmail.com
Source
Int J Antimicrob Agents. 2009 Jul;34(1):82-5
Date
Jul-2009
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - pharmacology - therapeutic use
Canada
Child
Child, Preschool
Ciprofloxacin - pharmacology
Drug Resistance, Bacterial
Drug Utilization - trends
Female
Fluoroquinolones - pharmacology - therapeutic use
Humans
Infant
Male
Microbial Sensitivity Tests
Middle Aged
Pneumococcal Infections - microbiology
Streptococcus pneumoniae - drug effects - isolation & purification
Young Adult
Abstract
This study evaluated the prevalence of fluoroquinolone usage and investigated the association between usage and resistance in respiratory isolates of Streptococcus pneumoniae in Canada. Fluoroquinolone susceptibility testing was conducted on S. pneumoniae collected from 25 medical centres across Canada over nine study years. Fluoroquinolone prescriptions and consumption figures were derived from data in the IMS Health, Canada CompuScript Audit. Between 1997 and 2006, 11825 S. pneumoniae isolates were collected. Ciprofloxacin resistance rates increased significantly (P or = 65 years). Outpatient ciprofloxacin and respiratory fluoroquinolone prescriptions increased by 55.6% (38.2 prescriptions/1000 population to 59.4 prescriptions/1000 population; P
PubMed ID
19342204 View in PubMed
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133 records – page 1 of 14.