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Adverse drug events in children during hospitalization and after discharge in a Norwegian university hospital.

https://arctichealth.org/en/permalink/ahliterature19260
Source
Acta Paediatr. 2002;91(1):88-94
Publication Type
Article
Date
2002
Author
I. Buajordet
F. Wesenberg
O. Brørs
A. Langslet
Author Affiliation
Department of Paediatrics, Ullevaal University Hospital, Oslo, Norway. ingebjorg.buajordet@legemiddelverket.no
Source
Acta Paediatr. 2002;91(1):88-94
Date
2002
Language
English
Publication Type
Article
Keywords
Adolescent
Adverse Drug Reaction Reporting Systems
Age Distribution
Child
Child, Preschool
Data Collection
Drug Interactions
Drug Therapy - adverse effects
Female
Hospitalization - statistics & numerical data
Humans
Infant
Male
Norway - epidemiology
Pharmaceutical Preparations - adverse effects
Research Support, Non-U.S. Gov't
Risk assessment
Risk factors
Severity of Illness Index
Sex Distribution
Abstract
The frequency and characteristics of adverse drug events (ADEs) in children hospitalized in the paediatric department of Ullevaal University Hospital, Norway, were determined using intensive monitoring. Of 579 children treated with drugs, 28% experienced ADEs; 7% at the time of admission, 18% during hospitalization and 9% after discharge. All children treated for cancer, 19% treated with anti-infective drugs, 15% treated with antiasthmatics and 10% treated with drugs affecting the nervous system experienced ADEs. The most frequent events were gastrointestinal, CNS- and skin reactions and 19% were considered as serious. ADEs caused 6% of the admissions and 44% required interventions. Most ADEs were found by screening patient records, where physicians mostly described adverse drug events requiring interventions and nurses described less serious events. Parents reported 14% of the events, of which a majority were CNS reactions. CNS reactions may be more common than expected and observations by parents are important when investigating such reactions in children. Conclusions: ADEs, mainly gastrointestinal, CNS and skin reactions related to drugs affecting the nervous system, anti-infectives and antiasthmatics, were seen in 28% of the patients. The reporting of events by parents was a useful supplement to the screening of patient records.
PubMed ID
11883826 View in PubMed
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Adverse drug reactions causing hospitalization can be monitored from computerized medical records and thereby indicate the quality of drug utilization.

https://arctichealth.org/en/permalink/ahliterature83234
Source
Pharmacoepidemiol Drug Saf. 2006 Mar;15(3):179-84
Publication Type
Article
Date
Mar-2006
Author
von Euler Mia
Eliasson Erik
Ohlén Gunnar
Bergman Ulf
Author Affiliation
Department of Clinical Pharmacology, Karolinska University Hospital, Huddinge, Karolinska Institutet, Stockholm, Sweden. Mia.voneuler@karolinska.se
Source
Pharmacoepidemiol Drug Saf. 2006 Mar;15(3):179-84
Date
Mar-2006
Language
English
Publication Type
Article
Keywords
Adverse Drug Reaction Reporting Systems
Aged
Drug Therapy - adverse effects
Drug Toxicity - epidemiology
Drug Utilization - standards
Hospitalization - statistics & numerical data
Hospitals, University - utilization
Humans
Internal Medicine
Medical Records Systems, Computerized
Middle Aged
Pharmacoepidemiology - methods
Pilot Projects
Prescriptions, Drug - standards
Sweden - epidemiology
Abstract
PURPOSE: To use computerized medical records to study the frequency of adverse drug reactions (ADR) as a cause for acute admission to a university hospital. METHODS: Computerized medical records in 168 consecutively acutely admitted cases to a short-term internal medicine ward at a university hospital were retrospectively evaluated to see if an ADR could have caused the admission. RESULTS: In 18 cases (11%), an ADR was judged to be the reason for acute admission to the hospital. Augmented pharmacological effects (type A reactions) accounted for 89% of the cases. An additional eight cases (5%) were intentional intoxications with prescription drugs. ADR-associated hospital admissions were age-related (average age 72 compared to 65 in patients admitted for other reasons) and also associated with poly-pharmacy (8.3 drugs compared to 5.2). The ADR was considered to arise from a drug-drug interaction in four cases (22%). Although all ADRs fulfilled the criteria for mandatory reporting, none of them were reported to the Swedish Adverse Drug Reactions Advisory Committee (SADRAC). CONCLUSIONS: The observed frequency of ADR-related acute hospital admissions in this pilot study is similar to earlier reported data from Sweden and abroad. Almost all of these reactions were known pharmacological (type A) reactions and many therefore theoretically preventable. In contrast to many prospective and costly studies, this retrospective analysis of computerized medical records offered a simple method that can be used in routine health care and also serve as an indicator of the quality of drug use.
PubMed ID
16184621 View in PubMed
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[Children and health. 1. Current general conditions affecting conception, pregnancy and the newborn infant]

https://arctichealth.org/en/permalink/ahliterature41393
Source
Sygeplejersken. 1979 Apr 11;79(15):4-7, 20
Publication Type
Article
Date
Apr-11-1979

[Clinical pharmacology (17): experiences from pediatric patient care]

https://arctichealth.org/en/permalink/ahliterature44108
Source
Lakartidningen. 1970 Apr 29;67(18):2057-9
Publication Type
Article
Date
Apr-29-1970
Author
J. Lind
Source
Lakartidningen. 1970 Apr 29;67(18):2057-9
Date
Apr-29-1970
Language
Swedish
Publication Type
Article
Keywords
Child
Drug Therapy - adverse effects
Humans
Sweden
PubMed ID
5460327 View in PubMed
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[Conservative treatment of lung cancer]

https://arctichealth.org/en/permalink/ahliterature28032
Source
Vopr Onkol. 1975;21(3):11-5
Publication Type
Article
Date
1975
Author
I V Kas'ianenko
Source
Vopr Onkol. 1975;21(3):11-5
Date
1975
Language
Russian
Publication Type
Article
Keywords
Adenocarcinoma - therapy
Carcinoma, Squamous Cell - therapy
Cyclophosphamide - therapeutic use
Drug Therapy - adverse effects
Drug Therapy, Combination
English Abstract
Female
Fluorouracil - therapeutic use
Humans
Lung Neoplasms - drug therapy - mortality - radiotherapy - therapy
Male
Methotrexate - therapeutic use
Radioisotope Teletherapy - adverse effects
Radiotherapy Dosage
Ukraine
Vinblastine - therapeutic use
Abstract
393 inoperable patients with lung cancer of stage III and IV were given two or three chemical substances according to the schemes applied or one of cytostatics with telegamma therapy. Control patients were administered only cyclophosphan or subjected to telegamma therapy. The best immediate and late results were noted in objects receiving either three substances or gamma-radiation with antimetabolites, 5-fluoruracil in particular, An efficacy of the treatment was estimated depending on the morphological structure of a tumor. A toxic effect of the therapy employed on the gastrointestinal tract, hemopoiesis was studied.
PubMed ID
1130013 View in PubMed
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71 records – page 1 of 8.