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27 records – page 1 of 3.

[A case of death of a newborn infant delivered by a mother sensitized to antibiotics]

https://arctichealth.org/en/permalink/ahliterature61061
Source
Pediatr Akus Ginekol. 1972 May-Jun;3:27-8
Publication Type
Article

[Acute hepatorenal failure occurring after taking rifampicin]

https://arctichealth.org/en/permalink/ahliterature69605
Source
Lik Sprava. 1993 Jul;(7):124-6
Publication Type
Article
Date
Jul-1993
Author
V H M'iasnykov
Source
Lik Sprava. 1993 Jul;(7):124-6
Date
Jul-1993
Language
Ukrainian
Publication Type
Article
Keywords
Acute Disease
Aged
Drug Hypersensitivity - etiology - pathology
Drug Therapy, Combination
English Abstract
Fatal Outcome
Female
Hepatorenal Syndrome - chemically induced - pathology
Humans
Rifampin - adverse effects
Tuberculosis, Pulmonary - complications - drug therapy
Abstract
A case of acute hepato-renal failure which developed after the oral intake of rifampicin is reported. Allergic reaction on the drug was accompanied by chill, weakness, paraesthesia, skin itch and facial swelling. The case described in the article appears to be all the more interesting due to the fact that severe lethal complication has developed in patient who had a history of allergic reactions on rifampicin.
PubMed ID
8209524 View in PubMed
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Adverse experiences during treatment with zimeldine on special licence in Sweden.

https://arctichealth.org/en/permalink/ahliterature46553
Source
Int Clin Psychopharmacol. 1994;9(1):55-61
Publication Type
Article
Date
1994
Author
B O Bengtsson
B E Wiholm
M. Myrhed
J. Wålinder
Author Affiliation
Department of Psychiatry, Faculty of Health Sciences, University Hospital, Linköping, Sweden.
Source
Int Clin Psychopharmacol. 1994;9(1):55-61
Date
1994
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Aged
Aged, 80 and over
Depressive Disorder - drug therapy - psychology
Drug Approval - legislation & jurisprudence
Drug Hypersensitivity - etiology
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neurologic Examination - drug effects
Zimeldine - adverse effects - therapeutic use
Abstract
Adverse experiences during licensed treatment with the antidepressant serotonin (5-HT) reuptake inhibitor zimeldine in Sweden are presented. Data were obtained from a written inquiry of 694 patients and 67 reports to the Medical Products Agency. The spectrum of adverse symptoms was in agreement with those reported in previous studies on zimeldine. The most frequent adverse experiences were headache, nausea, myalgia, signs of liver function disturbance, arthralgia, neurological symptoms, fever and insomnia. No new case of the Guillain-Barré syndrome was found. The estimated frequency of the zimeldine-induced hypersensitivity syndrome (HSS), comprising fever, myalgia and/or arthralgia and signs of liver function disturbance, ranged from 1.4% to 13% in the inquiry and from 0.63% to 3.4% in the report part of the study. Adverse experiences usually had a considerably higher incidence during the first 6 weeks of zimeldine treatment than thereafter. This is in agreement with the clinical experience that most of the adverse reactions occur early during zimeldine treatment. However, a number of adverse experiences did occur with a later onset. This may justify a prolongation of the compulsory 4 weeks' testing of liver function that is required during licensed treatment. There were significantly fewer patients who developed fever among the patients who had experienced previous zimeldine treatment than among those who had not. Otherwise there was no statistically significant difference in frequency of adverse symptoms between these two groups. Consequently zimeldine treatment per se does not seem to predispose to development of an HSS or other types of adverse reactions during subsequent therapy.
PubMed ID
8195584 View in PubMed
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Adverse reactions in connection with zimeldine treatment--a review.

https://arctichealth.org/en/permalink/ahliterature242565
Source
Acta Psychiatr Scand Suppl. 1983;308:115-9
Publication Type
Article
Date
1983
Author
B S Nilsson
Source
Acta Psychiatr Scand Suppl. 1983;308:115-9
Date
1983
Language
English
Publication Type
Article
Keywords
Clinical Trials as Topic
Drug Hypersensitivity - etiology
Great Britain
Humans
Sweden
Zimeldine - adverse effects
Abstract
The results of clinical trials have shown that the general level of side-effects is substantially lower with zimeldine than with tricyclic antidepressants. Data from ordinary clinical usage in Sweden and the U.K. (as opposed to clinical research experience) shows a similar picture. Hypersensitivity reactions, characterized by fever, myalgia and/or arthralgia, and transient increases in transaminases, occur in approximately 1.5% of patients. In rare cases potentially serious neuropathies have been reported.
PubMed ID
6230884 View in PubMed
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Automatic leukocyte differentiation in bronchoalveolar lavage fluids of guinea pigs and brown-Norway rats.

https://arctichealth.org/en/permalink/ahliterature15858
Source
J Pharmacol Toxicol Methods. 1996 Apr;35(2):91-9
Publication Type
Article
Date
Apr-1996
Author
A. Hatzelmann
D. Haefner
R. Beume
C. Schudt
Author Affiliation
Department of Biochemistry, Byk Gulden, Konstanz, Germany.
Source
J Pharmacol Toxicol Methods. 1996 Apr;35(2):91-9
Date
Apr-1996
Language
English
Publication Type
Article
Keywords
Animals
Bronchoalveolar Lavage Fluid - cytology
Coloring Agents
Drug Hypersensitivity - etiology
Guinea Pigs
Leukocyte Count - methods
Male
Ovalbumin - administration & dosage
Rats
Serine Proteinase Inhibitors - administration & dosage
Abstract
Asthma is considered to be a chronic inflammatory response of the airways characterized by a leukocyte infiltration into the lungs. Whereas lymphocytes and macrophages are involved in the initiation and propagation of inflammation, both neutrophils and in particular eosinophils are considered to play major effector roles. Therefore, allergic animal models in various species have been established to assess leukocyte infiltration by bronchoalveolar lavage (BAL) of antigen-sensitized and antigen-challenged animals as an inflammatory parameter in asthma pharmacology. Differential leukocyte counts in BAL fluids are routinely assessed by visual microscopic analysis of stained slides after cytocentrifugation. This procedure is very time-consuming, and the underlying standard morphological criteria may vary between different observers. In the present paper, we propose an alternative automatic method for leukocyte differentiation in BAL fluids from ovalbumin-treated guinea pigs and Brown-Norway rats using Cobas Helios 5Diff from Hoffmann-La Roche. BAL samples are directly applied to the analyzer and are automatically mixed with "Eosinofix," which stabilizes leukocyte membranes and specifically stains eosinophils. By a combination of electric (resistance) and optical (light scatter) analysis, the lymphocytes, monocytes/macrophages, neutrophils, and eosinophils are discriminated and the total leukocyte numbers are obtained. For both animal species we found high correlations for all leukocyte populations by comparing the results obtained with Cobas Helios 5Diff and conventional microscopic analysis. The major advantage of the automatic method is the much lower (about one-third) time requirement.
PubMed ID
8729435 View in PubMed
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Carboplatin hypersensitivity reaction in pediatric patients with low-grade glioma: a Canadian Pediatric Brain Tumor Consortium experience.

https://arctichealth.org/en/permalink/ahliterature159693
Source
Cancer. 2008 Feb 15;112(4):892-9
Publication Type
Article
Date
Feb-15-2008
Author
Lucie Lafay-Cousin
Lillian Sung
Anne-Sophie Carret
Juliette Hukin
Beverly Wilson
Donna L Johnston
Shayna Zelcer
Mariana Silva
Isaac Odame
Chris Mpofu
Douglas Strother
Eric Bouffet
Author Affiliation
Pediatric Brain Tumor Program, Hospital for Sick Children, Toronto, Ontario, Canada. lucie.lafay-cousin@calgaryhealthregion.ca
Source
Cancer. 2008 Feb 15;112(4):892-9
Date
Feb-15-2008
Language
English
Publication Type
Article
Keywords
Adolescent
Antineoplastic Agents - administration & dosage - adverse effects - therapeutic use
Brain Neoplasms - drug therapy - pathology
Canada
Carboplatin - administration & dosage - adverse effects - therapeutic use
Child
Child, Preschool
Disease Progression
Drug Administration Schedule
Drug Hypersensitivity - etiology
Exanthema - chemically induced
Female
Glioma - drug therapy - pathology
Humans
Infant
Infusions, Intravenous
Male
Retrospective Studies
Survival Analysis
Treatment Outcome
Abstract
Carboplatin-based regimens have demonstrated activity in pediatric patients with low-grade glioma (LGG). However, carboplatin hypersensitivity reaction (Cb HSR) represents a common and limiting factor for the continuation of therapy.
The objectives of this study were to describe the prevalence, characteristics, and management of Cb HSR and to detail their impact on outcome. The authors conducted a comprehensive, national, retrospective review of children who were diagnosed with LGG between 1985 and 2004 and received treatment with carboplatin.
One hundred five patients from 10 Canadian centers were included. The median patient age at diagnosis was 3.5 years (range, 0.3-16.8 years), and 33 patients (31.4%) had neurofibromatosis type 1. Carboplatin was administered monthly in 46 children and weekly in 59 children. Forty-four patients (41.9%) developed Cb HSR after a median of 10.5 infusions (range, 3-39 infusions). Cb HSR occurred significantly earlier among children on the weekly schedule (4.4 months vs 9.1 months; P = .02). The first allergic reaction was grade I or II in 36 patients (82%). The cumulative incidence of Cb HSR increased with the number of infusions, and there was no evidence of a plateau. The only predictive factor was being a girl rather than a boy (P = .02). Thirty-four of 44 patients with Cb HSR were re-exposed to carboplatin, and 24 of 34 patients (70.5%) had recurrent Cb HSR. A desensitization approach did not provide any advantage compared with premedication alone for altering Cb HSR. The median number of additional Cb infusions delivered was 4 (range, 0.5-34 infusions). The effect of Cb HSR on the 5-year progression-free survival rate was not statistically significant (P = .1).
Forty-two percent of children with LGG who received carboplatin regimens experienced Cb HSR. Most rechallenged children had recurrent Cb HSR despite Cb HSR-altering regimens. Cb HSR did not have an impact on progression-free survival.
PubMed ID
18098210 View in PubMed
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Comparative safety of tetracycline, minocycline, and doxycycline.

https://arctichealth.org/en/permalink/ahliterature207511
Source
Arch Dermatol. 1997 Oct;133(10):1224-30
Publication Type
Article
Date
Oct-1997
Author
L E Shapiro
S R Knowles
N H Shear
Author Affiliation
Department of Medicine, Sunnybrook Hospital, University of Toronto Medical School, Ontario, Canada.
Source
Arch Dermatol. 1997 Oct;133(10):1224-30
Date
Oct-1997
Language
English
Publication Type
Article
Keywords
Adolescent
Adult
Adverse Drug Reaction Reporting Systems
Anti-Bacterial Agents - adverse effects - metabolism
Arthralgia - chemically induced
Canada - epidemiology
Databases as Topic
Doxycycline - adverse effects
Drug Eruptions - etiology
Drug Hypersensitivity - etiology
Drug Prescriptions - statistics & numerical data
Female
Fever - chemically induced
Follow-Up Studies
Humans
Liver - drug effects - enzymology
Lupus Erythematosus, Systemic - chemically induced
Male
Middle Aged
Minocycline - adverse effects - metabolism
Retrospective Studies
Safety
Serum Sickness - chemically induced
Syndrome
Tetracycline - adverse effects
Time Factors
Abstract
Because minocycline can cause serious adverse events including hypersensitivity syndrome reaction (HSR), serum sicknesslike reaction (SSLR), and drug-induced lupus, a follow-up study based on a retrospective review of our Drug Safety Clinic and the Health Protection Branch databases and a literature review was conducted to determine if similar rare events are associated with tetracycline and doxycycline. Cases of isolated single organ dysfunction (SOD) attributable to the use of these antibiotics also were identified.
Nineteen cases of HSR due to minocycline, 2 due to tetracycline, and 1 due to doxycycline were identified. Eleven cases of SSLR due to minocycline, 3 due to tetracycline, and 2 due to doxycycline were identified. All 33 cases of drug-induced lupus were attributable to minocycline. Forty cases of SOD from minocycline, 37 cases from tetracycline, and 6 from doxycycline were detected. Hypersensitivity syndrome reaction, SSLR, and SOD occur on average within 4 weeks of therapy, whereas minocycline-induced lupus occurs on average 2 years after the initiation of therapy.
Early serious events occurring during the course of tetracycline antibiotic treatment include HSR, SSLR, and SOD. Drug-induced lupus, which occurs late in the course of therapy, is reported only with minocycline. We theorize that minocycline metabolism may account for the increased frequency of serious adverse events with this drug.
PubMed ID
9382560 View in PubMed
Less detail
Source
Ecol Dis. 1982;1(4):201-12
Publication Type
Article
Date
1982
Author
J. Steensberg
Source
Ecol Dis. 1982;1(4):201-12
Date
1982
Language
English
Publication Type
Article
Keywords
Accidents, Occupational
Child
Child, Preschool
Cosmetics - poisoning
Denmark
Dermatitis, Contact - epidemiology
Dermatitis, Occupational - epidemiology
Drug Hypersensitivity - etiology
Environmental pollution
Humans
Infant
Neoplasms - chemically induced - epidemiology - mortality
Nickel - poisoning
Parathion - poisoning
Poisoning - epidemiology - mortality
Population Surveillance
Skin Diseases - chemically induced
Abstract
An outline is given of the data on human health effects that are needed as a foundation for the administration of legislation on chemical substances and products. Danish data on mortality and morbidity from acute poisoning and some published clinical studies are presented. Serious problems may persist in subgroups of the population and the prevention of acute poisoning is still a basic aim of this legislation. Allergic reactions to chemicals are discussed. Not all sensitized individuals can be protected but steps should be taken to prevent contact with the sensitizing agents that are of the greatest public health importance. Chronic health effects following exposure to chemicals have influenced the recent strengthening of regulations but carcinogenic risks especially are extremely difficult for administrative and political systems to handle in an approximately rational way. While we are reducing the use of suspected carcinogenic chemicals our populations must, however, be given a greater appreciation of the cancer risk problem, particularly the fact that we cannot eliminate all cancer risks. Biological monitoring of human populations is a necessary supplement to the traditional registration of diseases as part of our health surveillance systems. Fortunately our societies have been able to pay increasing attention to the long-term public health consequences of exposures to chemical factors in our environment.
PubMed ID
6236969 View in PubMed
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27 records – page 1 of 3.