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399 records – page 1 of 40.

The 6th Klaas Breur memorial lecture, 1987. The Chernobyl accident--impact Western Europe.

https://arctichealth.org/en/permalink/ahliterature25858
Source
Radiother Oncol. 1988 May;12(1):1-13
Publication Type
Article
Date
May-1988

902 MHz mobile phone does not affect short term memory in humans.

https://arctichealth.org/en/permalink/ahliterature51972
Source
Bioelectromagnetics. 2004 Sep;25(6):452-6
Publication Type
Article
Date
Sep-2004
Author
Christian Haarala
Maria Ek
Linda Björnberg
Matti Laine
Antti Revonsuo
Mika Koivisto
Heikki Hämäläinen
Author Affiliation
Centre for Cognitive Neuroscience, University of Turku, Turku, Finland. christian.haarala@utu.fi
Source
Bioelectromagnetics. 2004 Sep;25(6):452-6
Date
Sep-2004
Language
English
Publication Type
Article
Keywords
Adult
Cellular Phone
Dose-Response Relationship, Radiation
Female
Finland
Humans
Male
Memory, Short-Term - physiology - radiation effects
Microwaves
Middle Aged
Radiation Dosage
Reaction Time - physiology - radiation effects
Research Support, Non-U.S. Gov't
Sweden
Abstract
We studied the effects of an electromagnetic field (EMF) as emitted by a 902 MHz mobile phone on human short term memory. This study was a replication with methodological improvements to our previous study. The improvements included multi-centre testing and a double blind design. A total of 64 subjects (32 men) in two independent laboratories performed a short term memory task (n-back) which poses a varying memory load (0-3 items) on the subjects' memory. They performed the task twice, once each under EMF and sham exposure. Reaction times (RTs) and accuracy of the responses were recorded. The order of exposure and memory load conditions were counterbalanced across subjects and gender. There were no statistically significant differences in performance between the two laboratories. We could not replicate our previous results: the EMF had no effect on RTs or on the accuracy of the subjects' answers. The inability to replicate previous findings could have been caused by lack of actual EMF effects or the magnitude of effects being at the sensitivity threshold of the test used.
PubMed ID
15300731 View in PubMed
Less detail

Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms.

https://arctichealth.org/en/permalink/ahliterature162439
Source
J Neurosci. 2007 Jul 18;27(29):7648-53
Publication Type
Article
Date
Jul-18-2007
Author
Marlen Knobloch
Mélissa Farinelli
Uwe Konietzko
Roger M Nitsch
Isabelle M Mansuy
Author Affiliation
Division of Psychiatry Research, University of Zurich, 8008 Zurich, Switzerland.
Source
J Neurosci. 2007 Jul 18;27(29):7648-53
Date
Jul-18-2007
Language
English
Publication Type
Article
Keywords
Age Factors
Amyloid Precursor Protein Secretases - genetics
Amyloid beta-Peptides - chemistry - metabolism - ultrastructure
Analysis of Variance
Animals
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases - genetics
Dose-Response Relationship, Radiation
Electric Stimulation - methods
Excitatory Postsynaptic Potentials - drug effects - physiology
Gene Expression Regulation - genetics
Hippocampus - cytology
Humans
Long-Term Potentiation - genetics - physiology - radiation effects
Mice
Mice, Transgenic
Microscopy, Electron, Transmission - methods
Neurons - drug effects - physiology
Patch-Clamp Techniques
Phosphoprotein Phosphatases - physiology
Presenilin-1 - genetics
Protein Phosphatase 1
Reverse Transcriptase Polymerase Chain Reaction - methods
Abstract
Amyloid beta (Abeta) oligomers are derived from proteolytic cleavage of amyloid precursor protein (APP) and can impair memory and hippocampal long-term potentiation (LTP) in vivo and in vitro. They are recognized as the primary neurotoxic agents in Alzheimer's disease. The mechanisms underlying such toxicity on synaptic functions are complex and not fully understood. Here, we provide the first evidence that these mechanisms involve protein phosphatase 1 (PP1). Using a novel transgenic mouse model expressing human APP with the Swedish and Arctic mutations that render Abeta more prone to form oligomers (arcAbeta mice), we show that the LTP impairment induced by Abeta oligomers can be fully reversed by PP1 inhibition in vitro. We further demonstrate that the genetic inhibition of endogenous PP1 in vivo confers resistance to Abeta oligomer-mediated toxicity and preserves LTP. Overall, these results reveal that PP1 is a key player in the mechanisms of AD pathology.
PubMed ID
17634359 View in PubMed
Less detail

Accommodative function of eyes in persons exposed to ionizing radiation.

https://arctichealth.org/en/permalink/ahliterature50741
Source
Ophthalmic Res. 2002 Jul-Aug;34(4):192-4
Publication Type
Article
Author
N M Sergienko
P. Fedirko
Author Affiliation
Department of Ophthalmology, Ukrainian Medical Academy of Post-Diploma Education, Kiev, Ukraine. NMS@micro.kiev.ua
Source
Ophthalmic Res. 2002 Jul-Aug;34(4):192-4
Language
English
Publication Type
Article
Keywords
Accidents, Radiation
Accommodation, Ocular - radiation effects
Adult
Aging - physiology
Control Groups
Dose-Response Relationship, Radiation
Eye - radiation effects
Humans
Male
Middle Aged
Ukraine
Abstract
Results of a comparative study of accommodative capability of eyes in individuals exposed to various doses of ionizing radiation and in a control group are presented. The mean values for ranges of accommodation in the control group were consonant with previous data. However, the range of accommodation was found to be reduced in exposed patients from younger age groups. It has been established that the ranges of accommodation depended, besides the age, on the absorbed dose of ionizing radiation: the greater the dose absorbed, the lesser the range of accommodation in the same age group. The effect of ionizing radiation seems to be additive to that of age.
PubMed ID
12297690 View in PubMed
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[A comparative analysis of the existing standards for exposure to ultraviolet radiation].

https://arctichealth.org/en/permalink/ahliterature208776
Source
Usp Fiziol Nauk. 1997 Apr-Jun;28(2):94-106
Publication Type
Article
Author
A D Strzhizhovskii
Source
Usp Fiziol Nauk. 1997 Apr-Jun;28(2):94-106
Language
Russian
Publication Type
Article
Keywords
Animals
Dose-Response Relationship, Radiation
Humans
Maximum Allowable Concentration
Neoplasms, Radiation-Induced - etiology
Netherlands
Occupational Exposure - adverse effects - standards - statistics & numerical data
Russia
Time Factors
Ultraviolet Rays - adverse effects
United States
Abstract
Quantitative analysis of threshold limit levels of UV-irradiation in the workroom environment established in USA, Netherlands and Russia was made. Comparison of its results with modern information about effective doses and action spectra of UV-radiation biological action allowed to reveal essential differences in the approach to rate setting and in some cases presence of internal contradictions and exceeding of threshold limit levels of UV irradiation above biologically effective values. The possibility of workroom UV standards utilisation for regulation of nature UV-radiation exposures was considered.
PubMed ID
9235809 View in PubMed
Less detail

[Activity of glutathione-S-transferase in the blood plasma, liver and crystalline lens tissues as affected by low doses of ionizing radiation and polychromatic light]

https://arctichealth.org/en/permalink/ahliterature51029
Source
Ukr Biokhim Zh. 1997 May-Jun;69(3):54-9
Publication Type
Article
Author
N F Leus
S G Kolomiichuk
V B Lishchenko
Author Affiliation
V.P. Filatov Institute of Eye Diseases and Tissue Therapy, Academy of Medical Sciences of Ukraine, Odessa.
Source
Ukr Biokhim Zh. 1997 May-Jun;69(3):54-9
Language
Russian
Publication Type
Article
Keywords
Animals
Dose-Response Relationship, Radiation
English Abstract
Glutathione Transferase - blood - metabolism - radiation effects
Lens, Crystalline - enzymology - radiation effects
Light
Liver - enzymology - radiation effects
Male
Rabbits
Abstract
The developmental dynamics of pathologic changes in the lenses and activity of glutathione-S-transferase in the blood plasma, liver and lens tissues of rabbits under chronic influence (2 months) of small doses of X-ray radiation (total dose 2 Gy) and polychromatic light have been researched. It was shown, that polychromatic light and X-ray irradiation of rabbits significantly affected the lens nativity and increased the developmental frequency and the intensity of lens opacities. It was determined, that activity of glutathione-S-transferase in blood plasma increased for 1 month after the beginning of X-ray effects. The same effect on the enzymatic activity was shown by the summary influence of polychromatic light and X-ray irradiation. Glutathione-S-transferase activity decreased during 2 months as compared with the initial values, before irradiation of the animals. The enzymatic activity was increased in rabbit-liver cytoplasm by X-ray irradiation in 2 months. A decrease of glutathione-S-transferase activity in the liver, cortex and lens nucleus was determined under the influence of both X-ray radiation and polychromatic light.
PubMed ID
9505362 View in PubMed
Less detail

[Adaptive response of blood lymphocytes as a marker of hemopoiesis status in exposed persons].

https://arctichealth.org/en/permalink/ahliterature126505
Source
Radiats Biol Radioecol. 2011 Nov-Dec;51(6):645-50
Publication Type
Article
Author
A V Akleev
A V Aleshchenko
O V Kudriashova
L P Semenova
A M Serebrianyi
O I Khudiakova
I I Pelevina
Source
Radiats Biol Radioecol. 2011 Nov-Dec;51(6):645-50
Language
Russian
Publication Type
Article
Keywords
Adaptation, Physiological
Adult
Aged
Bone Marrow Cells - radiation effects
Dose-Response Relationship, Radiation
Female
Hematopoiesis - radiation effects
Hematopoietic Stem Cells - radiation effects
Humans
Industrial Waste - adverse effects
Lymphocyte Count
Lymphocytes - cytology - physiology - radiation effects
Male
Middle Aged
Radiation, Ionizing
Rivers
Russia
Strontium Radioisotopes - adverse effects
Water Pollution, Radioactive - adverse effects
Abstract
An obvious correlation between the type of reaction manifested by peripheral blood lymphocytes to low dose irradiation in vitro (adaptive potential), the RBM cell composition (during the period of the major exposure), and the peripheral blood cell composition (at a late time period coincident with the studies of induced radioresistance) has been found in the Techa riverside residents in the later periods after the onset of a long-term low-dose rate radiation exposure (55-60 years later) within a range of individual red bone marrow doses from 0.01 to 1.79 Gy. The nature of these dependences observed in chronically exposed individuals differs from that revealed in the controls. It can be suggested based on the results of the study that the capacity for the adaptive response shown by peripheral blood lymphocytes donated by exposed persons in the remote period after exposure can be regarded as a biological marker of the functional state of the hemopoietic stem cell pool.
PubMed ID
22384713 View in PubMed
Less detail

Affects of ionizing radiation on T-cell population lymphocyte: a risk factor of irritable bowel syndrome.

https://arctichealth.org/en/permalink/ahliterature97544
Source
Toxicol Ind Health. 2010 Jul;26(6):323-30
Publication Type
Article
Date
Jul-2010
Author
M R Sheikh Sajjadieh
L V Kuznetsova
V B Bojenko
Author Affiliation
Department of Clinical Immunology & Allergology, National Medical Academy for Post Graduate Education, Kiev, Ukraine. mohammad_esfahan@yahoo.com
Source
Toxicol Ind Health. 2010 Jul;26(6):323-30
Date
Jul-2010
Language
English
Publication Type
Article
Keywords
Adolescent
Antigens, CD3 - immunology
CD4-CD8 Ratio
CD4-Positive T-Lymphocytes - radiation effects
CD8-Positive T-Lymphocytes - radiation effects
Case-Control Studies
Cesium Radioisotopes - adverse effects
Chernobyl Nuclear Accident
Child
Child, Preschool
Dose-Response Relationship, Radiation
Humans
Immunity, Cellular - radiation effects
Irritable Bowel Syndrome - etiology
Lymphocyte Count
Risk factors
T-Lymphocytes - radiation effects
Abstract
Irritable bowel syndrome is observed mostly in Ukrainian children and may be related to adverse health effects as a result of the Chernobyl disaster. The aim of this study was to determine status of T-cell population lymphocytes in children with clinical symptom of irritable bowel syndrome. The test population consisted of 95 participants: 75 rural patients aged 4 to 18 who lived in a contaminated area exposed to natural environmental radiation with clinical symptom of irritable bowel syndrome (categorized in three groups) and 20 healthy urban participants from Kiev aged 5 to 15 as control group. Internal radiation activity has been measured by gamma-ray spectrometry. Peripheral blood leukocytes were analyzed for T-lymphocytes subset such as T-lymphocytes (CD3(+)), T-helper (CD4(+)) and T-cytotoxic (CD8(+)) and then CD4/CD8 ratio was calculated. Percentage of CD3(+) and CD4(+) in all study groups decreased significantly in comparison to control group (p
PubMed ID
20348276 View in PubMed
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399 records – page 1 of 40.